Pias1 (protein inhibitor of activated STAT, 1) - Rat Genome Database

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Gene: Pias1 (protein inhibitor of activated STAT, 1) Rattus norvegicus
Analyze
Symbol: Pias1
Name: protein inhibitor of activated STAT, 1
RGD ID: 1307843
Description: Enables SUMO transferase activity and protein domain specific binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of nitrogen compound metabolic process; and visual learning. Located in nucleus. Biomarker of focal segmental glomerulosclerosis. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1); PARTICIPATES IN aldosterone signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; Hedgehog signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 SUMO-protein ligase PIAS1; LOC300772; protein inhibitor of activated STAT 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2863,338,150 - 63,451,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl863,338,150 - 63,438,905 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx868,853,069 - 68,953,867 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0867,125,523 - 67,226,318 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0864,995,537 - 65,096,314 (-)NCBIRnor_WKY
Rnor_6.0867,771,720 - 67,869,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,771,720 - 67,869,019 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0867,500,467 - 67,597,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,025,248 - 67,123,016 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,044,301 - 67,142,058 (-)NCBI
Celera862,756,508 - 62,854,013 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
dorsomorphin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP,ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
rifampicin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
theophylline  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (TAS)
nucleus  (IDA)
nucleus  (ISO)
nucleus  (ISO)
nucleus  (ISO)
PML body  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. Belaguli NS, etal., PLoS One. 2012;7(10):e48019. doi: 10.1371/journal.pone.0048019. Epub 2012 Oct 31.
2. SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway. Chen P, etal., Int J Mol Med. 2010 Oct;26(4):619-26.
3. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. Chen YC, etal., J Neurosci. 2014 Jul 16;34(29):9574-89. doi: 10.1523/JNEUROSCI.4302-13.2014.
4. Tollip is a mediator of protein sumoylation. Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. Kadare G, etal., J Biol Chem. 2003 Nov 28;278(48):47434-40. Epub 2003 Sep 18.
8. PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins. Kawai-Kowase K, etal., Mol Cell Biol. 2005 Sep;25(18):8009-23.
9. Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription. Kurihara I, etal., J Biol Chem. 2005 Feb 25;280(8):6721-30. Epub 2004 Dec 16.
10. Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis. Liang Y, etal., Pediatr Nephrol. 2009 Sep;24(9):1661-71. doi: 10.1007/s00467-009-1163-4. Epub 2009 Apr 7.
11. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. Rabellino A, etal., Cancer Res. 2012 May 1;72(9):2275-84. doi: 10.1158/0008-5472.CAN-11-3159. Epub 2012 Mar 9.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. Tang Z, etal., J Biol Chem. 2005 Nov 18;280(46):38153-9. Epub 2005 Sep 6.
18. Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats. Tsai MC, etal., J Pineal Res. 2011 Sep;51(2):233-45. doi: 10.1111/j.1600-079X.2011.00885.x. Epub 2011 May 4.
19. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
20. Inhibitors of cytokine signal transduction. Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.
21. Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during spermatogenesis in the rat. Yan W, etal., Gene Expr Patterns. 2003 Jun;3(3):301-8.
22. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:12356736   PMID:14752048   PMID:15572666   PMID:16127449   PMID:16522640   PMID:16816390   PMID:17087506   PMID:17283066   PMID:17696781   PMID:18555800   PMID:18579533   PMID:19744555  
PMID:20016603   PMID:20209145   PMID:20471636   PMID:21288202   PMID:21419645   PMID:21965678   PMID:22982248   PMID:24061474  


Genomics

Comparative Map Data
Pias1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2863,338,150 - 63,451,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl863,338,150 - 63,438,905 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx868,853,069 - 68,953,867 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0867,125,523 - 67,226,318 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0864,995,537 - 65,096,314 (-)NCBIRnor_WKY
Rnor_6.0867,771,720 - 67,869,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,771,720 - 67,869,019 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0867,500,467 - 67,597,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,025,248 - 67,123,016 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,044,301 - 67,142,058 (-)NCBI
Celera862,756,508 - 62,854,013 (-)NCBICelera
Cytogenetic Map8q24NCBI
PIAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381568,054,315 - 68,193,847 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1568,054,309 - 68,198,603 (+)EnsemblGRCh38hg38GRCh38
GRCh371568,346,653 - 68,486,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,133,626 - 66,267,467 (+)NCBINCBI36Build 36hg18NCBI36
Build 341566,133,625 - 66,267,456NCBI
Celera1545,234,605 - 45,365,328 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1545,180,222 - 45,311,150 (+)NCBIHuRef
CHM1_11568,465,362 - 68,598,367 (+)NCBICHM1_1
T2T-CHM13v2.01565,875,930 - 66,012,597 (+)NCBIT2T-CHM13v2.0
Pias1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39962,785,648 - 62,888,161 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl962,785,650 - 62,895,206 (-)EnsemblGRCm39 Ensembl
GRCm38962,878,366 - 62,980,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,878,368 - 62,987,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv37962,727,884 - 62,828,686 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36962,678,083 - 62,778,885 (-)NCBIMGSCv36mm8
Celera960,099,154 - 60,199,601 (-)NCBICelera
Cytogenetic Map9BNCBI
Pias1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554507,896,741 - 7,991,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554507,896,741 - 7,991,045 (-)NCBIChiLan1.0ChiLan1.0
PIAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11565,276,530 - 65,410,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1565,276,530 - 65,410,105 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01547,006,718 - 47,141,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PIAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13032,116,363 - 32,232,530 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3032,119,311 - 32,228,945 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3032,050,874 - 32,167,015 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03032,312,019 - 32,428,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3032,314,211 - 32,424,739 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13032,240,403 - 32,356,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03032,302,308 - 32,418,433 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03032,548,145 - 32,664,285 (+)NCBIUU_Cfam_GSD_1.0
Pias1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640110,076,935 - 110,207,569 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,925,153 - 28,055,632 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647127,925,153 - 28,055,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1165,957,132 - 166,087,239 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11165,957,114 - 166,087,242 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21183,734,088 - 183,951,464 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12615,294,296 - 15,432,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2615,297,934 - 15,432,659 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048126,035,605 - 126,174,441 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pias1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247814,893,308 - 5,046,582 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247814,893,308 - 5,046,928 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pias1
296 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:133
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000066009
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat

Markers in Region
BE097511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,398,745 - 63,398,909 (+)MAPPERmRatBN7.2
Rnor_6.0867,828,868 - 67,829,031NCBIRnor6.0
Rnor_5.0867,557,615 - 67,557,778UniSTSRnor5.0
RGSC_v3.4867,082,400 - 67,082,563UniSTSRGSC3.4
Celera862,813,661 - 62,813,824UniSTS
RH 3.4 Map8788.4UniSTS
Cytogenetic Map8q24UniSTS
AI179763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,405,614 - 63,405,764 (+)MAPPERmRatBN7.2
Rnor_6.0867,835,737 - 67,835,886NCBIRnor6.0
Rnor_5.0867,564,484 - 67,564,633UniSTSRnor5.0
RGSC_v3.4867,089,269 - 67,089,418UniSTSRGSC3.4
Celera862,820,530 - 62,820,679UniSTS
RH 3.4 Map8790.6UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 48 32 19 32 4 4 74 35 41 11 4
Low 11 9 9 9 4 7 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066009   ⟹   ENSRNOP00000059152
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl863,341,822 - 63,411,842 (-)Ensembl
Rnor_6.0 Ensembl867,771,720 - 67,869,019 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097366   ⟹   ENSRNOP00000077365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl863,343,686 - 63,438,905 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100439   ⟹   ENSRNOP00000093422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl863,338,150 - 63,438,894 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105202   ⟹   ENSRNOP00000093933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl863,338,150 - 63,415,004 (-)Ensembl
RefSeq Acc Id: NM_001106829   ⟹   NP_001100299
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,338,150 - 63,438,894 (-)NCBI
Rnor_6.0867,771,720 - 67,869,015 (-)NCBI
Rnor_5.0867,500,467 - 67,597,762 (-)NCBI
RGSC_v3.4867,025,248 - 67,123,016 (-)RGD
Celera862,756,508 - 62,854,013 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081107   ⟹   XP_038937035
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,338,150 - 63,413,132 (-)NCBI
RefSeq Acc Id: XM_039081108   ⟹   XP_038937036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,338,150 - 63,440,378 (-)NCBI
RefSeq Acc Id: XM_039081109   ⟹   XP_038937037
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,338,150 - 63,451,670 (-)NCBI
RefSeq Acc Id: XM_039081110   ⟹   XP_038937038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,338,150 - 63,438,998 (-)NCBI
RefSeq Acc Id: XM_039081111   ⟹   XP_038937039
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,338,150 - 63,438,474 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100299   ⟸   NM_001106829
- UniProtKB: A0A8I6AIY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059152   ⟸   ENSRNOT00000066009
RefSeq Acc Id: XP_038937037   ⟸   XM_039081109
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937036   ⟸   XM_039081108
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937038   ⟸   XM_039081110
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038937039   ⟸   XM_039081111
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937035   ⟸   XM_039081107
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000093422   ⟸   ENSRNOT00000100439
RefSeq Acc Id: ENSRNOP00000077365   ⟸   ENSRNOT00000097366
RefSeq Acc Id: ENSRNOP00000093933   ⟸   ENSRNOT00000105202
Protein Domains
PINIT   SAP   SP-RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9T0-F1-model_v2 AlphaFold G3V9T0 1-651 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696057
Promoter ID:EPDNEW_R6582
Type:multiple initiation site
Name:Pias1_1
Description:protein inhibitor of activated STAT, 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0867,869,015 - 67,869,075EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307843 AgrOrtholog
BioCyc Gene G2FUF-30146 BioCyc
Ensembl Genes ENSRNOG00000034272 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059152 ENTREZGENE
  ENSRNOP00000059152.2 UniProtKB/TrEMBL
  ENSRNOP00000077365 ENTREZGENE
  ENSRNOP00000077365.1 UniProtKB/TrEMBL
  ENSRNOP00000093422 ENTREZGENE
  ENSRNOP00000093422.1 UniProtKB/TrEMBL
  ENSRNOP00000093933 ENTREZGENE
  ENSRNOP00000093933.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066009 ENTREZGENE
  ENSRNOT00000066009.2 UniProtKB/TrEMBL
  ENSRNOT00000097366 ENTREZGENE
  ENSRNOT00000097366.1 UniProtKB/TrEMBL
  ENSRNOT00000100439 ENTREZGENE
  ENSRNOT00000100439.1 UniProtKB/TrEMBL
  ENSRNOT00000105202 ENTREZGENE
  ENSRNOT00000105202.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  2.60.120.780 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro PINIT UniProtKB/TrEMBL
  PINIT_sf UniProtKB/TrEMBL
  SAP_dom UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
  Znf_MIZ UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:300772 UniProtKB/TrEMBL
NCBI Gene 300772 ENTREZGENE
PANTHER PTHR10782:SF11 UniProtKB/TrEMBL
  ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam PINIT UniProtKB/TrEMBL
  zf-MIZ UniProtKB/TrEMBL
PhenoGen Pias1 PhenoGen
PROSITE PINIT UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
  ZF_SP_RING UniProtKB/TrEMBL
SMART SAP UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/TrEMBL
UniProt A0A8I5Y680_RAT UniProtKB/TrEMBL
  A0A8I6AIY4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJT7_RAT UniProtKB/TrEMBL
  A9UK05_RAT UniProtKB/TrEMBL
  G3V9T0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-06 Pias1  protein inhibitor of activated STAT, 1  Pias1  protein inhibitor of activated STAT 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-06 Pias1  protein inhibitor of activated STAT, 1  Pias1  protein inhibitor of activated STAT, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pias1  protein inhibitor of activated STAT 1   Pias1_predicted  protein inhibitor of activated STAT 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pias1_predicted  protein inhibitor of activated STAT 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED