Bp393 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp393 (Blood pressure QTL 393) Rattus norvegicus

Symbol: Bp393
Name: Blood pressure QTL 393
RGD ID: 11353949
Previously known as: BP QTL2
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8990,624,517 - 92,642,305RGD_MAPPER_PIPELINE
mRatBN7.2940,194,188 - 85,194,188RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0946,579,769 - 91,579,769RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0987,395,337 - 91,313,982RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4981,204,760 - 83,316,504RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.SHR-(D9Rat7-D9Rat84)/Mco 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models. Kumarasamy S, etal., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4.
2. High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass. Nie Y, etal., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
41266326LOC120094719uncharacterized LOC12009471999061039290631159Rat
11449647LOC108352031glyceraldehyde-3-phosphate dehydrogenase pseudogene99081346090814476Rat
7570114LOC102553709uncharacterized LOC10255370999089458190932043Rat
2922Irs1insulin receptor substrate 199100113791053959Rat
1306477Rhbdd1rhomboid domain containing 199107678691196719Rat
1305355Col4a4collagen type IV alpha 4 chain99128132491323577Rat
71085Col4a3collagen type IV alpha 3 chain99132399091453088Rat
1310230Mffmitochondrial fission factor99145593191484171Rat
1588633Tm4sf20transmembrane 4 L six family member 2099148684791500745Rat
41118077LOC120094722uncharacterized LOC12009472299148830891496759Rat
1560041Agfg1ArfGAP with FG repeats 199157296291630688Rat
402115117LOC134480298keratin-associated protein 5-2-like99171390191715112Rat
1311413Slc19a3solute carrier family 19 member 399172379991747499Rat
3646Ccl20C-C motif chemokine ligand 2099183713991839736Rat
1561436Daw1dynein assembly factor with WD repeats 199188365691920733Rat
1311951SphkapSPHK1 interactor, AKAP domain containing99195749792105834Rat
1334135Or5ak27-ps1olfactory receptor family 5 subfamily AK member 27, pseudogene 199249928492500072Rat
41331248LOC120094919small nucleolar RNA SNORA1799262405392624179Rat
41106528LOC120094724uncharacterized LOC12009472499247889392487279Rat
41300199LOC120094721uncharacterized LOC12009472199127714191316383Rat
402121386LOC134480597small cysteine and glycine repeat-containing protein 6-like99150438191504815Rat
41192800LOC120094723uncharacterized LOC12009472399152203491529198Rat
402165020LOC134480401keratin-associated protein 5-2-like99163935191656884Rat
402458355LOC134480297small cysteine and glycine repeat-containing protein 6-like99166044091660910Rat
11476313LOC10835200460S ribosomal protein L30-like99171031791713566Rat
402321851LOC134480299small cysteine and glycine repeat-containing protein 6-like99176711591768197Rat
402189516LOC134480300small ribosomal subunit protein uS4-like99234794892348175Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36838D9Rat5116999196297591963144Ratregion
37724D9Rat8420899264209792642305Ratregion
34955D9Rat5216999062451790624686Ratregion
39384D9Rat14523399073918990739422Ratregion
Position Markers

Flank 1: (D9Rat52)
Rat AssemblyChrPosition (strand)Source
GRCr8990,624,517 - 90,624,686 (+)Marker Load Pipeline
Rnor_5.0987,395,337 - 87,395,775NCBI
RGSC_v3.4981,204,760 - 81,205,197RGD
RGSC_v3.1981,388,179 - 81,388,616RGD
RH 3.4 Map9716.2RGD
RH 3.4 Map9716.2UniSTS
FHH x ACI Map956.73UniSTS
FHH x ACI Map956.73RGD
Flank 2: (D9Rat84)
Rat AssemblyChrPosition (strand)Source
GRCr8992,642,097 - 92,642,305 (+)Marker Load Pipeline
mRatBN7.2985,193,982 - 85,194,188 (+)MAPPER
Rnor_6.0991,579,562 - 91,579,769NCBI
Rnor_5.0991,313,775 - 91,313,982UniSTS
RGSC_v3.4983,316,296 - 83,316,504RGD
RGSC_v3.4983,316,297 - 83,316,504UniSTS
Celera982,625,459 - 82,625,666UniSTS
RGSC_v3.1983,499,715 - 83,499,923RGD
SHRSP x BN Map953.5199RGD
SHRSP x BN Map953.5199UniSTS
FHH x ACI Map956.65RGD


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)98672213292642305Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)99062451792642305Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general A parental congenic strain was crossed with SS/Jr rats to generate an F1 population, which was intercrossed to obtain an F2 population. These rats with various introgressed regions were backcrossed to SS/Jr, sorted by genotyping and intercrossed to obtain homozygous congenic animals. 11353859
qtl_general measurement method: 2% NaCl diet was started at 40-42 days of age. Tail cuff-based blood pressure measurements (CODA tail-cuff BP system, Kent Scientific) were taken. At age 64-66 days rats were surgically implanted with C-40 transmitters (Data Sciences International, St. Paul, MN) and BP recorded after a 4 day recovery. 11353859