GPRC5B (G protein-coupled receptor class C group 5 member B) - Rat Genome Database

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Gene: GPRC5B (G protein-coupled receptor class C group 5 member B) Homo sapiens
Analyze
Symbol: GPRC5B
Name: G protein-coupled receptor class C group 5 member B
RGD ID: 1319887
HGNC Page HGNC:13308
Description: Enables protein kinase activator activity and protein tyrosine kinase binding activity. Involved in cell volume homeostasis. Located in several cellular components, including extracellular exosome; membrane raft; and nuclear lumen. Implicated in megalencephalic leukoencephalopathy with subcortical cysts.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A-69G12.1; G protein-coupled receptor, class C, group 5, member B; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 5, member B; G-protein coupled receptor family C group 5 member B; MLC3; RAIG-2; RAIG2; retinoic acid responsive gene protein; retinoic acid-induced gene 2 protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381619,856,691 - 19,885,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1619,856,691 - 19,886,167 (-)EnsemblGRCh38hg38GRCh38
GRCh371619,868,013 - 19,896,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361619,777,794 - 19,803,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 341619,777,795 - 19,803,652NCBI
Celera1619,019,238 - 19,045,130 (-)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1618,406,875 - 18,420,767 (-)NCBIHuRef
CHM1_11619,957,576 - 19,983,445 (-)NCBICHM1_1
T2T-CHM13v2.01619,787,483 - 19,816,404 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atazanavir sulfate  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP)
clobetasol  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (EXP)
deoxycholic acid  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (EXP,ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (EXP)
furan  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
lipopolysaccharide  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
menadione  (EXP)
morphine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
O-methyleugenol  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
progesterone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
sevoflurane  (ISO)
sinapic acid  (ISO)
sodium arsenite  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
Sunset Yellow FCF  (EXP)
tartrazine  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
valproic acid  (EXP)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10493829   PMID:10783259   PMID:10945465   PMID:12477932   PMID:14702039   PMID:15489334   PMID:16303743   PMID:16344560   PMID:16502470   PMID:18029348   PMID:19056867   PMID:20301707  
PMID:20424473   PMID:20935630   PMID:21557262   PMID:21873635   PMID:21988832   PMID:23169819   PMID:23251661   PMID:23376485   PMID:23533145   PMID:23563607   PMID:24404583   PMID:24412205  
PMID:24561123   PMID:24729846   PMID:25231870   PMID:26186194   PMID:28298427   PMID:28514442   PMID:29987050   PMID:30021884   PMID:30086884   PMID:30639242   PMID:30947744   PMID:31104767  
PMID:31285284   PMID:31941358   PMID:33961781   PMID:34100078   PMID:35044719   PMID:35046932   PMID:36682796   PMID:37143309   PMID:37616343  


Genomics

Comparative Map Data
GPRC5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381619,856,691 - 19,885,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1619,856,691 - 19,886,167 (-)EnsemblGRCh38hg38GRCh38
GRCh371619,868,013 - 19,896,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361619,777,794 - 19,803,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 341619,777,795 - 19,803,652NCBI
Celera1619,019,238 - 19,045,130 (-)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1618,406,875 - 18,420,767 (-)NCBIHuRef
CHM1_11619,957,576 - 19,983,445 (-)NCBICHM1_1
T2T-CHM13v2.01619,787,483 - 19,816,404 (-)NCBIT2T-CHM13v2.0
Gprc5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397118,571,263 - 118,594,434 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7118,571,270 - 118,594,434 (-)EnsemblGRCm39 Ensembl
GRCm387118,972,040 - 118,995,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7118,972,047 - 118,995,211 (-)EnsemblGRCm38mm10GRCm38
MGSCv377126,115,554 - 126,138,725 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367118,763,196 - 118,786,304 (-)NCBIMGSCv36mm8
Celera7118,918,444 - 118,941,648 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map763.72NCBI
Gprc5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,748,247 - 182,772,711 (-)NCBIGRCr8
mRatBN7.21173,316,904 - 173,340,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,316,907 - 173,340,932 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1181,627,326 - 181,651,333 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01188,813,438 - 188,837,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,545,836 - 181,569,872 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,688,743 - 188,713,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,688,743 - 188,713,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01195,631,489 - 195,656,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41177,205,905 - 177,230,442 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11177,347,290 - 177,394,956 (-)NCBI
Celera1171,079,932 - 171,104,476 (-)NCBICelera
Cytogenetic Map1q35NCBI
Gprc5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554423,548,478 - 3,571,341 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554423,548,478 - 3,571,341 (-)NCBIChiLan1.0ChiLan1.0
GPRC5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21821,123,584 - 21,150,738 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11625,645,239 - 25,671,883 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01618,425,987 - 18,454,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11619,959,077 - 19,985,538 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1619,959,077 - 19,985,538 (-)Ensemblpanpan1.1panPan2
GPRC5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1625,412,968 - 25,435,895 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl625,411,595 - 25,432,824 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha626,776,412 - 26,799,194 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0625,567,735 - 25,590,548 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl625,567,749 - 25,590,546 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1625,367,935 - 25,390,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0625,263,337 - 25,286,128 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0625,651,743 - 25,674,546 (+)NCBIUU_Cfam_GSD_1.0
Gprc5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344117,367,984 - 117,387,438 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365015,461,736 - 5,485,356 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365015,465,844 - 5,485,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRC5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl325,870,403 - 25,896,106 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1325,870,369 - 25,896,113 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,736,185 - 26,750,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPRC5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1518,138,173 - 18,166,048 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl518,141,230 - 18,165,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606811,758,575 - 11,786,797 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gprc5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,164,467 - 3,176,119 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,163,265 - 3,184,978 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPRC5B
38 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.11-12.1(chr16:14954894-28306843)x3 copy number gain See cases [RCV000051828] Chr16:14954894..28306843 [GRCh38]
Chr16:15048751..28318164 [GRCh37]
Chr16:14956252..28225665 [NCBI36]
Chr16:16p13.11-12.1		 pathogenic
NM_016235.2(GPRC5B):c.728C>T (p.Ser243Phe) single nucleotide variant Malignant melanoma [RCV000062983] Chr16:19872118 [GRCh38]
Chr16:19883440 [GRCh37]
Chr16:19790941 [NCBI36]
Chr16:16p12.3		 not provided
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:19590412-29814175)x3 copy number gain Breast ductal adenocarcinoma [RCV000207226] Chr16:19590412..29814175 [GRCh37]
Chr16:16p12.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p12.3-11.2(chr16:19424115-30142220)x3 copy number gain See cases [RCV000449403] Chr16:19424115..30142220 [GRCh37]
Chr16:16p12.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2		 pathogenic
NM_016235.3(GPRC5B):c.523ATC[3] (p.Ile176_Ala177insIle) microsatellite Megalencephalic leukoencephalopathy with subcortical cysts 3 [RCV003315380] Chr16:19872317..19872318 [GRCh38]
Chr16:19883639..19883640 [GRCh37]
Chr16:16p12.3		 pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:18238275-30177240)x3 copy number gain See cases [RCV000512428] Chr16:18238275..30177240 [GRCh37]
Chr16:16p12.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_016235.3(GPRC5B):c.528_530dup (p.Ala177_Val178insAla) duplication Megalencephalic leukoencephalopathy with subcortical cysts 3 [RCV003315381] Chr16:19872315..19872316 [GRCh38]
Chr16:19883637..19883638 [GRCh37]
Chr16:16p12.3		 pathogenic
NM_001304771.1(GPRC5B):c.59A>T (p.Asp20Val) single nucleotide variant not provided [RCV000947683] Chr16:19885536 [GRCh38]
Chr16:19896858 [GRCh37]
Chr16:16p12.3		 benign
NM_016235.3(GPRC5B):c.177G>A (p.Val59=) single nucleotide variant not provided [RCV000882472] Chr16:19872669 [GRCh38]
Chr16:19883991 [GRCh37]
Chr16:16p12.3		 benign
NM_016235.3(GPRC5B):c.1149C>T (p.Val383=) single nucleotide variant not provided [RCV000948973] Chr16:19861855 [GRCh38]
Chr16:19873177 [GRCh37]
Chr16:16p12.3		 benign
NM_016235.3(GPRC5B):c.1104C>T (p.Ser368=) single nucleotide variant not provided [RCV000917599] Chr16:19861900 [GRCh38]
Chr16:19873222 [GRCh37]
Chr16:16p12.3		 likely benign
NM_016235.3(GPRC5B):c.439G>A (p.Val147Met) single nucleotide variant not provided [RCV000891122] Chr16:19872407 [GRCh38]
Chr16:19883729 [GRCh37]
Chr16:16p12.3		 benign
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic|likely pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
NM_016235.3(GPRC5B):c.670G>A (p.Gly224Ser) single nucleotide variant not specified [RCV004191471] Chr16:19872176 [GRCh38]
Chr16:19883498 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.455G>A (p.Arg152Gln) single nucleotide variant not specified [RCV004220156] Chr16:19872391 [GRCh38]
Chr16:19883713 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.983G>A (p.Arg328Gln) single nucleotide variant not specified [RCV004158392] Chr16:19871863 [GRCh38]
Chr16:19883185 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.850G>A (p.Val284Ile) single nucleotide variant not specified [RCV004181834] Chr16:19871996 [GRCh38]
Chr16:19883318 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.919T>A (p.Tyr307Asn) single nucleotide variant not specified [RCV004156743] Chr16:19871927 [GRCh38]
Chr16:19883249 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.38A>G (p.Gln13Arg) single nucleotide variant not specified [RCV004097133] Chr16:19872808 [GRCh38]
Chr16:19884130 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.932C>T (p.Ser311Leu) single nucleotide variant not specified [RCV004229519] Chr16:19871914 [GRCh38]
Chr16:19883236 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.1100C>T (p.Pro367Leu) single nucleotide variant not specified [RCV004095312] Chr16:19861904 [GRCh38]
Chr16:19873226 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.787C>A (p.Gln263Lys) single nucleotide variant not specified [RCV004221259] Chr16:19872059 [GRCh38]
Chr16:19883381 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.442C>T (p.Arg148Trp) single nucleotide variant not specified [RCV004603386] Chr16:19872404 [GRCh38]
Chr16:19883726 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.208A>T (p.Thr70Ser) single nucleotide variant not specified [RCV004350735] Chr16:19872638 [GRCh38]
Chr16:19883960 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.1193C>T (p.Thr398Ile) single nucleotide variant not specified [RCV004346395] Chr16:19860519 [GRCh38]
Chr16:19871841 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.661A>C (p.Thr221Pro) single nucleotide variant not specified [RCV004354281] Chr16:19872185 [GRCh38]
Chr16:19883507 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.136G>A (p.Val46Met) single nucleotide variant not specified [RCV004391293] Chr16:19872710 [GRCh38]
Chr16:19884032 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.755C>T (p.Thr252Ile) single nucleotide variant not specified [RCV004391296] Chr16:19872091 [GRCh38]
Chr16:19883413 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.91G>A (p.Ala31Thr) single nucleotide variant not specified [RCV004391298] Chr16:19872755 [GRCh38]
Chr16:19884077 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.961G>A (p.Glu321Lys) single nucleotide variant not specified [RCV004391299] Chr16:19871885 [GRCh38]
Chr16:19883207 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.862G>A (p.Ala288Thr) single nucleotide variant not specified [RCV004391297] Chr16:19871984 [GRCh38]
Chr16:19883306 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.1078A>C (p.Ser360Arg) single nucleotide variant not specified [RCV004632586] Chr16:19861926 [GRCh38]
Chr16:19873248 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.58C>G (p.Leu20Val) single nucleotide variant not specified [RCV004632587] Chr16:19872788 [GRCh38]
Chr16:19884110 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.613A>G (p.Ile205Val) single nucleotide variant not specified [RCV004632588] Chr16:19872233 [GRCh38]
Chr16:19883555 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.332T>C (p.Phe111Ser) single nucleotide variant not specified [RCV004632589] Chr16:19872514 [GRCh38]
Chr16:19883836 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.157G>A (p.Ala53Thr) single nucleotide variant not specified [RCV004928199] Chr16:19872689 [GRCh38]
Chr16:19884011 [GRCh37]
Chr16:16p12.3		 likely benign
NM_016235.3(GPRC5B):c.127C>A (p.Pro43Thr) single nucleotide variant not specified [RCV004928200] Chr16:19872719 [GRCh38]
Chr16:19884041 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.464C>T (p.Thr155Met) single nucleotide variant not specified [RCV004922528] Chr16:19872382 [GRCh38]
Chr16:19883704 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.1202A>C (p.His401Pro) single nucleotide variant not specified [RCV004922529] Chr16:19860510 [GRCh38]
Chr16:19871832 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.238C>G (p.Arg80Gly) single nucleotide variant not specified [RCV004922530] Chr16:19872608 [GRCh38]
Chr16:19883930 [GRCh37]
Chr16:16p12.3		 uncertain significance
NM_016235.3(GPRC5B):c.451G>C (p.Val151Leu) single nucleotide variant not specified [RCV004922531] Chr16:19872395 [GRCh38]
Chr16:19883717 [GRCh37]
Chr16:16p12.3		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:4393
Count of miRNA genes:1146
Interacting mature miRNAs:1448
Transcripts:ENST00000300571, ENST00000535671, ENST00000537135, ENST00000562348, ENST00000562469, ENST00000564449, ENST00000566822, ENST00000568214, ENST00000569102, ENST00000569479, ENST00000569847, ENST00000570142
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597348362GWAS1444436_Hbody mass index QTL GWAS1444436 (human)6e-17body mass indexbody mass index (BMI) (CMO:0000105)161987204219872043Human
597147574GWAS1243648_Hbody mass index QTL GWAS1243648 (human)4e-08body mass indexbody mass index (BMI) (CMO:0000105)161986269019862691Human
597086364GWAS1182438_HL-Selectin measurement QTL GWAS1182438 (human)0.000002L-Selectin measurement161986022419860225Human

Markers in Region
RH64900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371619,884,023 - 19,884,149UniSTSGRCh37
Build 361619,791,524 - 19,791,650RGDNCBI36
Celera1619,032,978 - 19,033,104RGD
Cytogenetic Map16p12UniSTS
HuRef1618,420,622 - 18,420,748UniSTS
RH64917  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371619,870,458 - 19,870,588UniSTSGRCh37
Build 361619,777,959 - 19,778,089RGDNCBI36
Celera1619,019,403 - 19,019,533RGD
Cytogenetic Map16p12UniSTS
HuRef1618,407,040 - 18,407,170UniSTS
D16S2597E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371619,870,348 - 19,870,481UniSTSGRCh37
Build 361619,777,849 - 19,777,982RGDNCBI36
Celera1619,019,293 - 19,019,426RGD
Cytogenetic Map16p12UniSTS
HuRef1618,406,930 - 18,407,063UniSTS
D16S3003E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371619,870,344 - 19,870,425UniSTSGRCh37
Build 361619,777,845 - 19,777,926RGDNCBI36
Celera1619,019,289 - 19,019,370RGD
Cytogenetic Map16p12UniSTS
HuRef1618,406,926 - 18,407,007UniSTS
RH78263  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371619,871,351 - 19,871,502UniSTSGRCh37
Build 361619,778,852 - 19,779,003RGDNCBI36
Celera1619,020,296 - 19,020,447RGD
Cytogenetic Map16p12UniSTS
HuRef1618,407,933 - 18,408,084UniSTS
GeneMap99-GB4 RH Map16183.53UniSTS
NCBI RH Map16177.4UniSTS
SHGC-30161  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371619,871,363 - 19,871,512UniSTSGRCh37
Build 361619,778,864 - 19,779,013RGDNCBI36
Celera1619,020,308 - 19,020,457RGD
Cytogenetic Map16p12UniSTS
HuRef1618,407,945 - 18,408,094UniSTS
GeneMap99-G3 RH Map161047.0UniSTS
A002I06  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371619,870,441 - 19,870,615UniSTSGRCh37
Build 361619,777,942 - 19,778,116RGDNCBI36
Celera1619,019,386 - 19,019,560RGD
Cytogenetic Map16p12UniSTS
HuRef1618,407,023 - 18,407,197UniSTS
GeneMap99-GB4 RH Map16185.37UniSTS
Whitehead-RH Map1695.4UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2411 2788 2237 4971 1723 2345 6 624 1642 465 2269 6986 6173 50 3733 1 852 1740 1610 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001304771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF181862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF202640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI462652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA141861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC344063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ529380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000300571   ⟹   ENSP00000300571
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,856,691 - 19,884,848 (-)Ensembl
Ensembl Acc Id: ENST00000535671   ⟹   ENSP00000442858
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,858,498 - 19,872,845 (-)Ensembl
Ensembl Acc Id: ENST00000562348
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,858,971 - 19,862,340 (-)Ensembl
Ensembl Acc Id: ENST00000562469   ⟹   ENSP00000455960
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,872,401 - 19,884,904 (-)Ensembl
Ensembl Acc Id: ENST00000564449   ⟹   ENSP00000457018
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,872,769 - 19,885,525 (-)Ensembl
Ensembl Acc Id: ENST00000566822   ⟹   ENSP00000454667
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,872,313 - 19,882,360 (-)Ensembl
Ensembl Acc Id: ENST00000568214   ⟹   ENSP00000457080
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,872,576 - 19,886,155 (-)Ensembl
Ensembl Acc Id: ENST00000569102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,857,299 - 19,858,046 (-)Ensembl
Ensembl Acc Id: ENST00000569479   ⟹   ENSP00000454727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,858,971 - 19,886,167 (-)Ensembl
Ensembl Acc Id: ENST00000569847   ⟹   ENSP00000457283
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,860,408 - 19,885,727 (-)Ensembl
Ensembl Acc Id: ENST00000570142   ⟹   ENSP00000456724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1619,872,587 - 19,884,864 (-)Ensembl
RefSeq Acc Id: NM_001304771   ⟹   NP_001291700
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381619,858,971 - 19,885,634 (-)NCBI
CHM1_11619,957,576 - 19,984,242 (-)NCBI
T2T-CHM13v2.01619,789,763 - 19,816,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016235   ⟹   NP_057319
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381619,856,691 - 19,884,848 (-)NCBI
GRCh371619,870,293 - 19,897,049 (-)NCBI
Build 361619,777,794 - 19,803,652 (-)NCBI Archive
Celera1619,019,238 - 19,045,130 (-)RGD
HuRef1618,406,875 - 18,420,767 (-)RGD
CHM1_11619,957,576 - 19,983,527 (-)NCBI
T2T-CHM13v2.01619,787,483 - 19,815,618 (-)NCBI
Sequence:
RefSeq Acc Id: NP_057319   ⟸   NM_016235
- Peptide Label: isoform 1 precursor
- UniProtKB: O75205 (UniProtKB/Swiss-Prot),   D2DFB0 (UniProtKB/Swiss-Prot),   Q8NBZ8 (UniProtKB/Swiss-Prot),   Q9NZH0 (UniProtKB/Swiss-Prot),   B7Z831 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291700   ⟸   NM_001304771
- Peptide Label: isoform 2
- UniProtKB: B7Z831 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000454727   ⟸   ENST00000569479
Ensembl Acc Id: ENSP00000457283   ⟸   ENST00000569847
Ensembl Acc Id: ENSP00000456724   ⟸   ENST00000570142
Ensembl Acc Id: ENSP00000442858   ⟸   ENST00000535671
Ensembl Acc Id: ENSP00000455960   ⟸   ENST00000562469
Ensembl Acc Id: ENSP00000457018   ⟸   ENST00000564449
Ensembl Acc Id: ENSP00000300571   ⟸   ENST00000300571
Ensembl Acc Id: ENSP00000454667   ⟸   ENST00000566822
Ensembl Acc Id: ENSP00000457080   ⟸   ENST00000568214
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NZH0-F1-model_v2 AlphaFold Q9NZH0 1-403 view protein structure

Promoters
RGD ID:6793167
Promoter ID:HG_KWN:23191
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   K562
Transcripts:OTTHUMT00000254285
Position:
Human AssemblyChrPosition (strand)Source
Build 361619,803,394 - 19,803,894 (-)MPROMDB
RGD ID:7231493
Promoter ID:EPDNEW_H21491
Type:initiation region
Name:GPRC5B_1
Description:G protein-coupled receptor class C group 5 member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381619,884,845 - 19,884,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13308 AgrOrtholog
COSMIC GPRC5B COSMIC
Ensembl Genes ENSG00000167191 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000300571 ENTREZGENE
  ENST00000300571.7 UniProtKB/Swiss-Prot
  ENST00000535671.5 UniProtKB/Swiss-Prot
  ENST00000569479.5 UniProtKB/Swiss-Prot
  ENST00000569847.1 UniProtKB/Swiss-Prot
GTEx ENSG00000167191 GTEx
HGNC ID HGNC:13308 ENTREZGENE
Human Proteome Map GPRC5B Human Proteome Map
InterPro GPCR_3_C UniProtKB/Swiss-Prot
  RA-inducible_GPCR3 UniProtKB/Swiss-Prot
KEGG Report hsa:51704 UniProtKB/Swiss-Prot
NCBI Gene 51704 ENTREZGENE
OMIM 605948 OMIM
PANTHER G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5 UniProtKB/Swiss-Prot
  G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER B UniProtKB/Swiss-Prot
Pfam 7tm_3 UniProtKB/Swiss-Prot
PharmGKB PA28938 PharmGKB
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot
UniProt B7Z831 ENTREZGENE, UniProtKB/TrEMBL
  D2DFB0 ENTREZGENE
  GPC5B_HUMAN UniProtKB/Swiss-Prot
  H3BN33_HUMAN UniProtKB/TrEMBL
  H3BQV9_HUMAN UniProtKB/TrEMBL
  H3BSJ1_HUMAN UniProtKB/TrEMBL
  H3BT47_HUMAN UniProtKB/TrEMBL
  H3BT93_HUMAN UniProtKB/TrEMBL
  O75205 ENTREZGENE
  Q8NBZ8 ENTREZGENE
  Q9NZH0 ENTREZGENE
UniProt Secondary D2DFB0 UniProtKB/Swiss-Prot
  O75205 UniProtKB/Swiss-Prot
  Q8NBZ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 GPRC5B  G protein-coupled receptor class C group 5 member B  GPRC5B  G protein-coupled receptor, class C, group 5, member B  Symbol and/or name change 5135510 APPROVED
2014-02-04 GPRC5B  G protein-coupled receptor, class C, group 5, member B  GPRC5B  G protein-coupled receptor, family C, group 5, member B  Symbol and/or name change 5135510 APPROVED