GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Creb1 | decreases expression | EXP | | 6480464 | CTD | Manganese results in decreased expression of CREB1 mRNA; Manganese results in decreased expression of CREB1 protein | PMID:29205667 | Creb1 | decreases phosphorylation | EXP | | 6480464 | CTD | Manganese results in decreased phosphorylation of CREB1 protein | PMID:31161640 | Creb1 | increases phosphorylation | EXP | | 6480464 | CTD | Manganese results in increased phosphorylation of CREB1 protein | PMID:16787641 | Creb1 | multiple interactions | EXP | | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein] | PMID:16787641 PMID:30951808 PMID:31161640 | Creb1 | multiple interactions | ISO | CREB1 (Homo sapiens) | 6480464 | CTD | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein] | PMID:31676349 PMID:32659473 | Creb1 | multiple interactions | ISO | Creb1 (Mus musculus) | 6480464 | CTD | [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein] | PMID:30951808 PMID:31676349 | | ||||||||||||||||||||||
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