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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Creb1increases phosphorylationEXP 6480464CTDmethylmercuric chloride results in increased phosphorylation of CREB1 proteinPMID:32061141
Creb1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein]; methylmercuric chloride results in decreased expression of and results in increased phosphorylation of CREB1 protein; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein]PMID:32061141 PMID:36813253
Creb1decreases expressionISOCREB1 (Homo sapiens)6480464CTDmethylmercuric chloride results in decreased expression of CREB1 mRNAPMID:28001369
Creb1decreases phosphorylationISOCreb1 (Mus musculus)6480464CTDmethylmercuric chloride results in decreased phosphorylation of CREB1 proteinPMID:33301842
Creb1multiple interactionsISOCREB1 (Homo sapiens)6480464CTDmethylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]PMID:36565944
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