GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Creb1 | increases expression | EXP | | 6480464 | CTD | perfluorooctane sulfonic acid results in increased expression of CREB1 mRNA; perfluorooctane sulfonic acid results in increased expression of CREB1 protein | PMID:19756518 PMID:20127074 PMID:20937303 | Creb1 | increases phosphorylation | ISO | Creb1 (Mus musculus) | 6480464 | CTD | perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein | PMID:33359577 | Creb1 | multiple interactions | ISO | Creb1 (Mus musculus) | 6480464 | CTD | [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein]; [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CREB1 mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of CREB1 mRNA; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein]; perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]; perfluorooctane sulfonic acid inhibits the reaction [CRTC2 protein binds to CREB1 protein modified form]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein] | PMID:33359577 PMID:36331819 | | ||||||||||||||||||||||
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