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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Creb1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of CREB1 mRNAPMID:32255272
Creb1decreases phosphorylationEXP 6480464CTDBenzo(a)pyrene results in decreased phosphorylation of CREB1 proteinPMID:32255272
Creb1affects activityISOCREB1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the activity of CREB1 proteinPMID:20624995
Creb1decreases expressionISOCREB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CREB1 mRNAPMID:18247414
Creb1increases expressionISOCreb1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CREB1 mRNAPMID:22228805
Creb1increases phosphorylationISOCreb1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased phosphorylation of CREB1 proteinPMID:35920545
Creb1multiple interactionsISOCREB1 (Homo sapiens)6480464CTDCREB1 protein affects the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; CREB1 protein affects the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]PMID:33421718
Creb1multiple interactionsISOCreb1 (Mus musculus)6480464CTDDiosmin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of CREB1 protein]PMID:35920545
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