Aox1 (aldehyde oxidase 1) - Rat Genome Database

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Gene: Aox1 (aldehyde oxidase 1) Rattus norvegicus
Analyze
Symbol: Aox1
Name: aldehyde oxidase 1
RGD ID: 620528
Description: Enables aldehyde oxidase activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde oxidase; aldehyde oxidase (female form); azaheterocycle hydroxylase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,073,831 - 67,152,980 (+)NCBIGRCr8
mRatBN7.2959,579,621 - 59,658,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,579,649 - 59,658,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,079,746 - 68,155,526 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,195,659 - 73,271,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,513,768 - 71,589,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0964,929,682 - 65,007,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl964,929,721 - 65,007,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0964,726,609 - 64,804,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4956,693,698 - 56,774,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1956,840,679 - 56,921,097 (+)NCBI
Celera957,025,110 - 57,102,310 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,4-dioxane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
dibenzofurans  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
galactose  (ISO)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
leflunomide  (EXP)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP,ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
succimer  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungstate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zaleplon  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. Aliciguzel Y, etal., J Lab Clin Med 2003 Sep;142(3):172-7.
2. Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis. Berger R, etal., Somat Cell Mol Genet 1995 Mar;21(2):121-31.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Xanthine oxidase and aldehyde oxidase: a simple procedure for the simultaneous purification from rat liver. Maia L and Mira L, Arch Biochem Biophys 2002 Apr 1;400(1):48-53.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1). Differences in redox status may distinguish male and female forms of hepatic APX. Wright RM, etal., J Biol Chem 1999 Feb 5;274(6):3878-86.
Additional References at PubMed
PMID:518535   PMID:6372555   PMID:10190983   PMID:10377246   PMID:17639027   PMID:18098066   PMID:19056867   PMID:19401776   PMID:19801639   PMID:20444863   PMID:20700607   PMID:22031625  
PMID:22231435   PMID:22279051   PMID:22522748   PMID:22705828   PMID:22996261   PMID:23462233   PMID:23857892   PMID:25537183   PMID:26322824   PMID:26842593  


Genomics

Comparative Map Data
Aox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,073,831 - 67,152,980 (+)NCBIGRCr8
mRatBN7.2959,579,621 - 59,658,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,579,649 - 59,658,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,079,746 - 68,155,526 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,195,659 - 73,271,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,513,768 - 71,589,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0964,929,682 - 65,007,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl964,929,721 - 65,007,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0964,726,609 - 64,804,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4956,693,698 - 56,774,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1956,840,679 - 56,921,097 (+)NCBI
Celera957,025,110 - 57,102,310 (+)NCBICelera
Cytogenetic Map9q31NCBI
AOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382200,586,014 - 200,682,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2200,586,014 - 200,677,064 (+)EnsemblGRCh38hg38GRCh38
GRCh372201,450,737 - 201,536,218 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,158,976 - 201,244,463 (+)NCBINCBI36Build 36hg18NCBI36
Build 342201,276,043 - 201,361,720NCBI
Celera2195,205,613 - 195,291,094 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,302,067 - 193,387,763 (+)NCBIHuRef
CHM1_12201,456,717 - 201,542,113 (+)NCBICHM1_1
T2T-CHM13v2.02201,069,494 - 201,165,683 (+)NCBIT2T-CHM13v2.0
Aox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,068,963 - 58,145,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,069,090 - 58,145,572 (+)EnsemblGRCm39 Ensembl
GRCm38158,029,809 - 58,106,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,029,931 - 58,106,413 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,086,813 - 58,163,254 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36157,974,550 - 58,050,959 (+)NCBIMGSCv36mm8
Celera158,543,669 - 58,620,236 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map128.86NCBI
Aox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403828,066 - 872,218 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403827,538 - 875,856 (-)NCBIChiLan1.0ChiLan1.0
AOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213103,208,614 - 103,294,161 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B103,223,614 - 103,309,164 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B87,839,376 - 87,924,823 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B205,996,604 - 206,083,897 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B205,996,604 - 206,083,897 (+)Ensemblpanpan1.1panPan2
AOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1379,912,731 - 9,992,322 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl379,913,675 - 9,992,319 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3710,799,110 - 10,877,517 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0379,818,121 - 9,897,733 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl379,819,065 - 9,897,732 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1379,800,648 - 9,879,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0379,778,952 - 9,857,094 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0379,772,362 - 9,850,965 (+)NCBIUU_Cfam_GSD_1.0
Aox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303157,695,152 - 157,763,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936825263,081 - 332,622 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936825263,725 - 332,424 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,157,527 - 104,236,006 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,157,748 - 104,234,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215115,429,739 - 115,506,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Aox1
429 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:21
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000068633
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat

Markers in Region
AW533952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,614,886 - 59,615,047 (+)MAPPERmRatBN7.2
Rnor_6.0964,965,031 - 64,965,191NCBIRnor6.0
Rnor_5.0964,761,947 - 64,762,107UniSTSRnor5.0
RGSC_v3.4956,729,520 - 56,729,680UniSTSRGSC3.4
Celera957,060,263 - 57,060,423UniSTS
RH 3.4 Map9483.3UniSTS
Cytogenetic Map9q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 23 3 23 4 1 17 8
Low 3 19 21 16 16 16 8 11 52 34 20 3 8
Below cutoff 24 2 2 2 14 4

Sequence


RefSeq Acc Id: ENSRNOT00000068633   ⟹   ENSRNOP00000059651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl959,593,781 - 59,658,770 (+)Ensembl
Rnor_6.0 Ensembl964,929,721 - 65,007,870 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl964,986,555 - 64,987,451 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl964,981,112 - 64,981,636 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102452   ⟹   ENSRNOP00000077590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl959,579,649 - 59,658,770 (+)Ensembl
RefSeq Acc Id: NM_019363   ⟹   NP_062236
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,073,891 - 67,152,980 (+)NCBI
mRatBN7.2959,579,681 - 59,658,772 (+)NCBI
Rnor_6.0964,929,721 - 65,007,870 (+)NCBI
Rnor_5.0964,726,609 - 64,804,786 (+)NCBI
RGSC_v3.4956,693,698 - 56,774,115 (+)RGD
Celera957,025,110 - 57,102,310 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084139   ⟹   XP_038940067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,088,376 - 67,152,980 (+)NCBI
mRatBN7.2959,597,366 - 59,658,772 (+)NCBI
RefSeq Acc Id: XR_594396
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,073,831 - 67,151,099 (+)NCBI
mRatBN7.2959,579,621 - 59,658,772 (+)NCBI
Rnor_6.0964,929,682 - 65,007,872 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062236 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940067 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD16999 (Get FASTA)   NCBI Sequence Viewer  
  AAD17000 (Get FASTA)   NCBI Sequence Viewer  
  EDL99010 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059651
  ENSRNOP00000059651.4
  ENSRNOP00000077590
  ENSRNOP00000077590.1
GenBank Protein Q9Z0U5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062236   ⟸   NM_019363
- UniProtKB: Q9Z0U5 (UniProtKB/Swiss-Prot),   Q9R240 (UniProtKB/Swiss-Prot),   A6IP50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059651   ⟸   ENSRNOT00000068633
RefSeq Acc Id: XP_038940067   ⟸   XM_039084139
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y9M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077590   ⟸   ENSRNOT00000102452
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0U5-F1-model_v2 AlphaFold Q9Z0U5 1-1333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696682
Promoter ID:EPDNEW_R7207
Type:multiple initiation site
Name:Aox1_1
Description:aldehyde oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0964,929,696 - 64,929,756EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620528 AgrOrtholog
BioCyc Gene G2FUF-27464 BioCyc
Ensembl Genes ENSRNOG00000015354 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068633 ENTREZGENE
  ENSRNOT00000068633.5 UniProtKB/TrEMBL
  ENSRNOT00000102452.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.43.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.465.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  [2Fe-2S]-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO dehydrogenase flavoprotein, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2Fe-2S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe2S_fd_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_MoCoBD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mopterin_DH_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_Mopterin_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54349 UniProtKB/Swiss-Prot
NCBI Gene 54349 ENTREZGENE
PANTHER ALDEHYDE OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XANTHINE DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Xan_dh_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoCoBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AOX1 RGD
PhenoGen Aox1 PhenoGen
PIRSF Xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2FE2S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOLYBDOPTERIN_EUK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015354 RatGTEx
SMART Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y9M0 ENTREZGENE, UniProtKB/TrEMBL
  A6IP50 ENTREZGENE, UniProtKB/TrEMBL
  AOXA_RAT UniProtKB/Swiss-Prot
  F1LRQ1_RAT UniProtKB/TrEMBL
  Q9R240 ENTREZGENE
  Q9Z0U5 ENTREZGENE
UniProt Secondary Q9R240 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Aox1  aldehyde oxidase 1    aldehyde oxidase  Name updated 1299863 APPROVED
2002-08-07 Aox1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 150 kDa 632256
gene_protein kinetic differences exist between male and female rat liver and caused by differences in redox state 632256