Gls (glutaminase) - Rat Genome Database

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Gene: Gls (glutaminase) Rattus norvegicus
Analyze
Symbol: Gls
Name: glutaminase
RGD ID: 2707
Description: Predicted to enable glutaminase activity and identical protein binding activity. Predicted to be involved in glutamine family amino acid metabolic process; intracellular glutamate homeostasis; and protein homotetramerization. Predicted to act upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; arginine and proline metabolic pathway; D-glutamine and D-glutamate metabolic pathway; INTERACTS WITH (R)-lipoic acid; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Glut; glutaminase kidney isoform, mitochondrial; K-glutaminase; kidney-type glutaminase; L-glutamine amidohydrolase; RATGLUT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2949,344,616 - 49,416,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,894,412 - 57,966,467 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0963,017,246 - 63,089,303 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0961,313,233 - 61,385,290 (+)NCBIRnor_WKY
Rnor_6.0954,212,622 - 54,284,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,923,145 - 53,995,543 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,380,165 - 46,452,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,381,578 - 46,454,381 (+)NCBI
Celera947,008,653 - 47,080,221 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitraz  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP,ISO)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
fenamidone  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Heliotrine  (ISO)
hexadecanoic acid  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
idazoxan  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
linuron  (EXP)
lipoic acid  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
O-palmitoylcarnitine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenylarsonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
quartz  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
mitochondrial matrix  (IEA)
mitochondrion  (IDA,IEA,ISO)
synapse  (IEA,ISO)

Molecular Function
glutaminase activity  (IBA,IEA,ISO,ISS,TAS)
identical protein binding  (ISO)
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. Buschdorf JP, etal., J Cell Sci. 2006 Aug 15;119(Pt 16):3337-50.
2. Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. Buschdorf JP, etal., PLoS One. 2008 Jul 16;3(7):e2686. doi: 10.1371/journal.pone.0002686.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Complexity and species variation of the kidney-type glutaminase gene. Porter LD, etal., Physiol Genomics 2002;9(3):157-66.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Isolation, characterization, and in vitro expression of a cDNA that encodes the kidney isoenzyme of the mitochondrial glutaminase. Shapiro RA, etal., J Biol Chem 1991 Oct 5;266(28):18792-6.
14. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
Additional References at PubMed
PMID:1991024   PMID:3401701   PMID:14686922   PMID:16219914   PMID:16641247   PMID:17986214   PMID:21734190   PMID:22049910   PMID:22225880   PMID:22228304   PMID:24086752   PMID:25297978  
PMID:27514492   PMID:28770953   PMID:30239721   PMID:31344597  


Genomics

Comparative Map Data
Gls
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2949,344,616 - 49,416,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,894,412 - 57,966,467 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0963,017,246 - 63,089,303 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0961,313,233 - 61,385,290 (+)NCBIRnor_WKY
Rnor_6.0954,212,622 - 54,284,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,923,145 - 53,995,543 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,380,165 - 46,452,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,381,578 - 46,454,381 (+)NCBI
Celera947,008,653 - 47,080,221 (+)NCBICelera
Cytogenetic Map9q22NCBI
GLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,880,821 - 190,965,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2190,880,821 - 190,965,552 (+)EnsemblGRCh38hg38GRCh38
GRCh372191,745,547 - 191,830,278 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,453,792 - 191,538,021 (+)NCBINCBI36Build 36hg18NCBI36
Build 342191,571,102 - 191,655,771NCBI
Celera2185,340,136 - 185,424,375 (+)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,605,181 - 183,689,941 (+)NCBIHuRef
CHM1_12191,751,387 - 191,836,127 (+)NCBICHM1_1
T2T-CHM13v2.02191,369,931 - 191,454,659 (+)NCBIT2T-CHM13v2.0
Gls
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,202,608 - 52,274,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,202,607 - 52,272,391 (-)EnsemblGRCm39 Ensembl
GRCm38152,163,449 - 52,235,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,163,448 - 52,233,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv37152,220,293 - 52,290,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,110,128 - 52,177,777 (-)NCBIMGSCv36mm8
Celera152,701,920 - 52,771,737 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.86NCBI
Gls
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,195,255 - 8,261,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,195,241 - 8,261,402 (-)NCBIChiLan1.0ChiLan1.0
GLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B196,098,910 - 196,183,332 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,098,910 - 196,183,323 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B78,182,117 - 78,267,071 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,433,640 - 1,508,347 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,433,398 - 1,508,146 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,381,805 - 2,456,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,321,277 - 1,395,855 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,321,033 - 1,397,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,330,931 - 1,405,450 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,298,679 - 1,373,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,327,448 - 1,402,011 (+)NCBIUU_Cfam_GSD_1.0
Gls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,524,201 - 149,600,982 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,237,099 - 7,313,976 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365067,237,099 - 7,314,011 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,513,446 - 95,598,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,513,414 - 95,606,029 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215106,832,208 - 106,866,986 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,402,201 - 76,489,063 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,402,195 - 76,486,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,988,383 - 123,074,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gls
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,108,566 - 5,202,240 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,106,419 - 5,202,445 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gls
183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000032525
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
6903937Bp356Blood pressure QTL 3560.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94790220852283252Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat

Markers in Region
D9Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,415,692 - 49,415,876 (+)MAPPERmRatBN7.2
Rnor_6.0954,283,672 - 54,283,855NCBIRnor6.0
Rnor_5.0953,994,336 - 53,994,519UniSTSRnor5.0
RGSC_v3.4946,451,767 - 46,451,950UniSTSRGSC3.4
Celera947,079,018 - 47,079,197UniSTS
Cytogenetic Map9q31-q32UniSTS
RH143479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,395,321 - 49,395,464 (+)MAPPERmRatBN7.2
Rnor_6.0954,263,304 - 54,263,446NCBIRnor6.0
Rnor_5.0953,973,965 - 53,974,107UniSTSRnor5.0
RGSC_v3.4946,431,395 - 46,431,537UniSTSRGSC3.4
Celera947,059,485 - 47,059,627UniSTS
Cytogenetic Map9q31-q32UniSTS
RH135102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,343,952 - 49,344,132 (+)MAPPERmRatBN7.2
Rnor_6.0954,211,939 - 54,212,118NCBIRnor6.0
Rnor_5.0953,922,132 - 53,922,311UniSTSRnor5.0
Rnor_5.0953,816,470 - 53,816,649UniSTSRnor5.0
RGSC_v3.4946,379,337 - 46,379,516UniSTSRGSC3.4
Celera947,007,825 - 47,008,004UniSTS
Cytogenetic Map9q31-q32UniSTS
RH137240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,392,381 - 49,392,566 (+)MAPPERmRatBN7.2
Rnor_6.0954,260,364 - 54,260,548NCBIRnor6.0
Rnor_5.0953,971,025 - 53,971,209UniSTSRnor5.0
RGSC_v3.4946,428,455 - 46,428,639UniSTSRGSC3.4
Celera947,056,545 - 47,056,729UniSTS
Cytogenetic Map9q31-q32UniSTS
RH139095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,395,440 - 49,395,663 (+)MAPPERmRatBN7.2
Rnor_6.0954,263,423 - 54,263,645NCBIRnor6.0
Rnor_5.0953,974,084 - 53,974,306UniSTSRnor5.0
RGSC_v3.4946,431,514 - 46,431,736UniSTSRGSC3.4
Celera947,059,604 - 47,059,826UniSTS
Cytogenetic Map9q31-q32UniSTS
Gls  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,414,585 - 49,415,449 (+)MAPPERmRatBN7.2
Rnor_6.0954,282,565 - 54,283,428NCBIRnor6.0
Rnor_5.0953,993,229 - 53,994,092UniSTSRnor5.0
RGSC_v3.4946,450,660 - 46,451,523UniSTSRGSC3.4
Celera947,077,911 - 47,078,774UniSTS
Cytogenetic Map9q31-q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 32 16 19 16 8 9 74 35 36 11 8
Low 3 25 25 25 2 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF302091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY083459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB776615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000078073   ⟹   ENSRNOP00000075466
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,344,781 - 49,392,804 (+)Ensembl
Rnor_6.0 Ensembl954,212,767 - 54,260,786 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090026   ⟹   ENSRNOP00000071972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)Ensembl
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110936   ⟹   ENSRNOP00000093636
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)Ensembl
RefSeq Acc Id: NM_001109968   ⟹   NP_001103438
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,344,616 - 49,392,804 (+)NCBI
Rnor_6.0954,212,767 - 54,260,786 (+)NCBI
Rnor_5.0953,923,145 - 53,995,543 (+)NCBI
RGSC_v3.4946,380,165 - 46,452,974 (+)RGD
Celera947,008,653 - 47,056,967 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012569   ⟹   NP_036701
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,344,616 - 49,416,900 (+)NCBI
Rnor_6.0954,212,767 - 54,284,879 (+)NCBI
Rnor_5.0953,923,145 - 53,995,543 (+)NCBI
RGSC_v3.4946,380,165 - 46,452,974 (+)RGD
Celera947,008,653 - 47,080,221 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767075   ⟹   XP_008765297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,344,634 - 49,392,804 (+)NCBI
Rnor_6.0954,212,622 - 54,260,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083004   ⟹   XP_038938932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,359,552 - 49,414,641 (+)NCBI
RefSeq Acc Id: XM_039083005   ⟹   XP_038938933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,344,633 - 49,387,035 (+)NCBI
RefSeq Acc Id: XM_039083006   ⟹   XP_038938934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,344,632 - 49,380,531 (+)NCBI
RefSeq Acc Id: XM_039083007   ⟹   XP_038938935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,344,633 - 49,376,277 (+)NCBI
RefSeq Acc Id: XM_039083008   ⟹   XP_038938936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,344,633 - 49,380,531 (+)NCBI
RefSeq Acc Id: XM_039083009   ⟹   XP_038938937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,376,386 - 49,414,641 (+)NCBI
RefSeq Acc Id: XM_039083010   ⟹   XP_038938938
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2949,376,217 - 49,414,641 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036701   ⟸   NM_012569
- Peptide Label: isoform a
- UniProtKB: A0A0G2K1T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103438   ⟸   NM_001109968
- Peptide Label: isoform b
- UniProtKB: A0A0G2KAN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765297   ⟸   XM_008767075
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071972   ⟸   ENSRNOT00000090026
RefSeq Acc Id: ENSRNOP00000075466   ⟸   ENSRNOT00000078073
RefSeq Acc Id: XP_038938934   ⟸   XM_039083006
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038938933   ⟸   XM_039083005
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938936   ⟸   XM_039083008
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038938935   ⟸   XM_039083007
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038938932   ⟸   XM_039083004
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938938   ⟸   XM_039083010
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038938937   ⟸   XM_039083009
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000093636   ⟸   ENSRNOT00000110936
Protein Domains
EF-hand_14

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13264-F1-model_v2 AlphaFold P13264 1-674 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2707 AgrOrtholog
BioCyc Gene G2FUF-27608 BioCyc
BioCyc Pathway CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  GLUTAMINDEG-PWY [L-glutamine degradation I] BioCyc
  PWY-5921 [glutaminyl-tRNAgln biosynthesis via transamidation] BioCyc
Ensembl Genes ENSRNOG00000056246 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071972 ENTREZGENE
  ENSRNOP00000071972.1 UniProtKB/TrEMBL
  ENSRNOP00000075466 ENTREZGENE
  ENSRNOP00000075466.1 UniProtKB/TrEMBL
  ENSRNOP00000093636.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078073 ENTREZGENE
  ENSRNOT00000078073.2 UniProtKB/TrEMBL
  ENSRNOT00000090026 ENTREZGENE
  ENSRNOT00000090026.2 UniProtKB/TrEMBL
  ENSRNOT00000110936.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.710.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-lactam/transpept-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase_EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24398 UniProtKB/Swiss-Prot
NCBI Gene 24398 ENTREZGENE
PANTHER PTHR12544 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gls PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs Gln_ase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1T0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AXB6_RAT UniProtKB/TrEMBL
  GLSK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8R421 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gls  glutaminase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function synthesizes glutamate from glutamine  
gene_process implicated in behavior disturbances in which glutamate acts as a neurotransmitter