Gls (glutaminase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gls (glutaminase) Mus musculus
Analyze
Symbol: Gls
Name: glutaminase
RGD ID: 10659
MGI Page MGI
Description: Enables glutaminase activity and identical protein binding activity. Involved in glutamate biosynthetic process; glutamine catabolic process; and protein homotetramerization. Acts upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330442B14; AI314027; B230365M23Rik; expressed sequence AI314027; glutaminase kidney isoform, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,202,608 - 52,274,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,202,607 - 52,272,391 (-)EnsemblGRCm39 Ensembl
GRCm38152,163,449 - 52,235,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,163,448 - 52,233,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv37152,220,293 - 52,290,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,110,128 - 52,177,777 (-)NCBIMGSCv36mm8
Celera152,701,920 - 52,771,737 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitraz  (ISO)
ammonia  (EXP)
ammonium chloride  (EXP,ISO)
amphotericin B  (ISO)
androgen antagonist  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
fenamidone  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Heliotrine  (ISO)
hexadecanoic acid  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
idazoxan  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lactacystin  (ISO)
lanthanum trichloride  (ISO)
lead(0)  (ISO)
linuron  (ISO)
lipoic acid  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
O-palmitoylcarnitine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenylarsonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
quartz  (EXP)
quercetin  (ISO)
rimonabant  (EXP)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (EXP)
sunitinib  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Yasue M, etal., Cytogenet Cell Genet 1991;57(2-3):142-8
Additional References at PubMed
PMID:1347472   PMID:1671668   PMID:1889815   PMID:2571577   PMID:6430047   PMID:7959748   PMID:8007943   PMID:8088797   PMID:8094303   PMID:8244386   PMID:8530022   PMID:8617499  
PMID:8626800   PMID:8672127   PMID:8751373   PMID:8824815   PMID:8884266   PMID:8889548   PMID:9107685   PMID:9126479   PMID:9170104   PMID:9457670   PMID:9828143   PMID:10349636  
PMID:10441734   PMID:10857751   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:15368895   PMID:16039563   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:16641247   PMID:16899818   PMID:17928434   PMID:18844999   PMID:19516252   PMID:21873635   PMID:22225880   PMID:22228304   PMID:22431402   PMID:22979984   PMID:23246912   PMID:23376484  
PMID:23578284   PMID:24695699   PMID:24952961   PMID:25163927   PMID:25453483   PMID:25737280   PMID:25743253   PMID:25915584   PMID:26778975   PMID:27272503   PMID:27542409   PMID:28130547  
PMID:28196863   PMID:28399896   PMID:28427419   PMID:28624534   PMID:28659375   PMID:28659379   PMID:28703706   PMID:29199018   PMID:29222160   PMID:29972793   PMID:30068389   PMID:30392958  
PMID:30472430   PMID:30550785   PMID:30773468   PMID:31211512   PMID:31233276   PMID:31316350   PMID:31871054   PMID:31948748   PMID:32084378   PMID:32325033   PMID:32694609   PMID:33116312  
PMID:33517883   PMID:33672789   PMID:33991485   PMID:34321999   PMID:34678461   PMID:34709266   PMID:35012549   PMID:35211629   PMID:35237793   PMID:35504291   PMID:35580611   PMID:36288696  
PMID:36293380   PMID:36417873   PMID:36526153   PMID:37341499   PMID:37384529   PMID:37432749   PMID:38355793   PMID:38898113   PMID:38906371   PMID:39159042   PMID:39271775   PMID:39303037  


Genomics

Comparative Map Data
Gls
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,202,608 - 52,274,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,202,607 - 52,272,391 (-)EnsemblGRCm39 Ensembl
GRCm38152,163,449 - 52,235,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,163,448 - 52,233,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv37152,220,293 - 52,290,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,110,128 - 52,177,777 (-)NCBIMGSCv36mm8
Celera152,701,920 - 52,771,737 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.86NCBI
GLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,880,821 - 190,965,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,880,821 - 190,965,552 (+)EnsemblGRCh38hg38GRCh38
GRCh372191,745,547 - 191,830,278 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,453,792 - 191,538,021 (+)NCBINCBI36Build 36hg18NCBI36
Build 342191,571,102 - 191,655,771NCBI
Celera2185,340,136 - 185,424,375 (+)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,605,181 - 183,689,941 (+)NCBIHuRef
CHM1_12191,751,387 - 191,836,127 (+)NCBICHM1_1
T2T-CHM13v2.02191,369,931 - 191,454,659 (+)NCBIT2T-CHM13v2.0
Gls
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,836,584 - 56,908,861 (+)NCBIGRCr8
mRatBN7.2949,344,616 - 49,416,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,894,412 - 57,966,467 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,017,246 - 63,089,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,313,233 - 61,385,290 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,212,622 - 54,284,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,923,145 - 53,995,543 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,380,165 - 46,452,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,381,578 - 46,454,381 (+)NCBI
Celera947,008,653 - 47,080,221 (+)NCBICelera
Cytogenetic Map9q22NCBI
Gls
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,195,255 - 8,261,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,195,241 - 8,261,402 (-)NCBIChiLan1.0ChiLan1.0
GLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,562,487 - 93,647,465 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,577,451 - 93,662,449 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,182,117 - 78,267,071 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,098,910 - 196,183,332 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,098,910 - 196,183,323 (+)Ensemblpanpan1.1panPan2
GLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,433,640 - 1,508,347 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,433,398 - 1,508,146 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,381,805 - 2,456,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,321,277 - 1,395,855 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,321,033 - 1,397,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,330,931 - 1,405,450 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,298,679 - 1,373,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,327,448 - 1,402,011 (+)NCBIUU_Cfam_GSD_1.0
Gls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,524,201 - 149,600,982 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,237,099 - 7,313,976 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,237,099 - 7,314,011 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,513,446 - 95,598,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,513,414 - 95,606,029 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215106,832,208 - 106,866,986 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,402,201 - 76,489,063 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,402,195 - 76,486,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,988,383 - 123,074,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gls
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,108,566 - 5,202,240 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,106,419 - 5,202,445 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gls
2920 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4320
Count of miRNA genes:903
Interacting mature miRNAs:1304
Transcripts:ENSMUST00000114509, ENSMUST00000114510, ENSMUST00000114512, ENSMUST00000114513, ENSMUST00000123324, ENSMUST00000126221, ENSMUST00000129107, ENSMUST00000136654, ENSMUST00000138906, ENSMUST00000139273, ENSMUST00000142976, ENSMUST00000145514, ENSMUST00000147825, ENSMUST00000148917, ENSMUST00000151694, ENSMUST00000155587, ENSMUST00000156887
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
12879917Shm3_msperm head morphology 3 (mouse)14418690462946882Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse

Markers in Region
AI314027  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,163,725 - 52,163,900UniSTSGRCm38
MGSCv37152,220,569 - 52,220,744UniSTSGRCm37
Celera152,702,196 - 52,702,371UniSTS
Cytogenetic Map1C1.1UniSTS
Gls  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,165,147 - 52,166,017UniSTSGRCm38
MGSCv37152,221,991 - 52,222,861UniSTSGRCm37
Celera152,703,618 - 52,704,488UniSTS
Cytogenetic Map1C1.1UniSTS
cM Map125.9UniSTS
RH137240  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,185,523 - 52,185,699UniSTSGRCm38
MGSCv37152,242,367 - 52,242,543UniSTSGRCm37
Celera152,723,994 - 52,724,170UniSTS
Cytogenetic Map1C1.1UniSTS
D1Ncl2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38152,175,927 - 52,176,086UniSTSGRCm38
MGSCv37152,232,771 - 52,232,930UniSTSGRCm37
Celera152,714,398 - 52,714,557UniSTS
Cytogenetic Map1C1.1UniSTS
cM Map125.9UniSTS
Gls  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C1.1UniSTS
cM Map125.9UniSTS
Gls  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C1.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF038395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE849049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000114509
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,224,439 - 52,239,641 (-)Ensembl
GRCm38.p6 Ensembl152,185,280 - 52,200,482 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114510   ⟹   ENSMUSP00000110155
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,223,263 - 52,272,391 (-)Ensembl
GRCm38.p6 Ensembl152,184,104 - 52,233,232 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114512   ⟹   ENSMUSP00000110157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,205,100 - 52,271,455 (-)Ensembl
GRCm38.p6 Ensembl152,165,941 - 52,232,296 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114513   ⟹   ENSMUSP00000110158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,202,607 - 52,272,382 (-)Ensembl
GRCm38.p6 Ensembl152,163,448 - 52,233,223 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,228,627 - 52,236,533 (-)Ensembl
GRCm38.p6 Ensembl152,189,468 - 52,197,374 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126221
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,205,441 - 52,208,304 (-)Ensembl
GRCm38.p6 Ensembl152,166,282 - 52,169,145 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129107   ⟹   ENSMUSP00000121408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,226,842 - 52,230,068 (-)Ensembl
GRCm38.p6 Ensembl152,187,683 - 52,190,909 (-)Ensembl
Ensembl Acc Id: ENSMUST00000136654
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,205,423 - 52,208,134 (-)Ensembl
GRCm38.p6 Ensembl152,166,264 - 52,168,975 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138906
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,207,606 - 52,230,069 (-)Ensembl
GRCm38.p6 Ensembl152,168,447 - 52,190,910 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139273
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,230,359 - 52,254,753 (-)Ensembl
GRCm38.p6 Ensembl152,191,200 - 52,215,594 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142976
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,253,677 - 52,271,970 (-)Ensembl
GRCm38.p6 Ensembl152,214,518 - 52,232,811 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145514
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,244,340 - 52,253,692 (-)Ensembl
GRCm38.p6 Ensembl152,205,181 - 52,214,533 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147825
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,243,329 - 52,254,753 (-)Ensembl
GRCm38.p6 Ensembl152,204,170 - 52,215,594 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,235,637 - 52,239,533 (-)Ensembl
GRCm38.p6 Ensembl152,196,478 - 52,200,374 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,246,460 - 52,255,102 (-)Ensembl
GRCm38.p6 Ensembl152,207,301 - 52,215,943 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155587   ⟹   ENSMUSP00000115358
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,224,439 - 52,251,368 (-)Ensembl
GRCm38.p6 Ensembl152,185,280 - 52,212,209 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156887   ⟹   ENSMUSP00000116901
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl152,205,287 - 52,230,068 (-)Ensembl
GRCm38.p6 Ensembl152,166,128 - 52,190,909 (-)Ensembl
RefSeq Acc Id: NM_001081081   ⟹   NP_001074550
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,202,608 - 52,272,391 (-)NCBI
GRCm38152,163,449 - 52,233,232 (-)NCBI
MGSCv37152,220,293 - 52,290,076 (-)RGD
Celera152,701,920 - 52,771,737 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001113383   ⟹   NP_001106854
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,224,440 - 52,272,391 (-)NCBI
GRCm38152,185,281 - 52,233,232 (-)NCBI
MGSCv37152,220,293 - 52,290,076 (-)RGD
Celera152,701,920 - 52,771,737 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495701   ⟹   XP_006495764
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,224,439 - 52,274,168 (-)NCBI
GRCm38152,185,280 - 52,235,009 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006495702   ⟹   XP_006495765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,203,689 - 52,272,046 (-)NCBI
GRCm38152,164,530 - 52,232,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006495704   ⟹   XP_006495767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,240,898 - 52,274,168 (-)NCBI
GRCm38152,200,101 - 52,235,009 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316236   ⟹   XP_017171725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,202,608 - 52,240,378 (-)NCBI
GRCm38152,164,530 - 52,204,316 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160625   ⟹   XP_036016518
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39152,203,689 - 52,272,383 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001074550   ⟸   NM_001081081
- Peptide Label: isoform 1
- UniProtKB: E9PUF0 (UniProtKB/Swiss-Prot),   Q69ZX9 (UniProtKB/Swiss-Prot),   D3Z7P3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106854   ⟸   NM_001113383
- Peptide Label: isoform 2
- UniProtKB: D3Z7P3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006495765   ⟸   XM_006495702
- Peptide Label: isoform X2
- UniProtKB: D3Z7P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495764   ⟸   XM_006495701
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006495767   ⟸   XM_006495704
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017171725   ⟸   XM_017316236
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSMUSP00000121408   ⟸   ENSMUST00000129107
Ensembl Acc Id: ENSMUSP00000110158   ⟸   ENSMUST00000114513
Ensembl Acc Id: ENSMUSP00000110157   ⟸   ENSMUST00000114512
Ensembl Acc Id: ENSMUSP00000110155   ⟸   ENSMUST00000114510
Ensembl Acc Id: ENSMUSP00000116901   ⟸   ENSMUST00000156887
Ensembl Acc Id: ENSMUSP00000115358   ⟸   ENSMUST00000155587
RefSeq Acc Id: XP_036016518   ⟸   XM_036160625
- Peptide Label: isoform X2
- UniProtKB: D3Z7P4 (UniProtKB/TrEMBL)
Protein Domains
Glutaminase EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z7P3-F1-model_v2 AlphaFold D3Z7P3 1-674 view protein structure

Promoters
RGD ID:6817763
Promoter ID:MM_KWN:697
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000050775,   OTTMUST00000050776
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,225,256 - 52,226,957 (-)MPROMDB
RGD ID:6873672
Promoter ID:EPDNEW_M287
Type:initiation region
Name:Gls_1
Description:Mus musculus glutaminase , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38152,233,218 - 52,233,278EPDNEW
RGD ID:6817761
Promoter ID:MM_KWN:698
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000050772,   OTTMUST00000050773,   OTTMUST00000050774
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,247,656 - 52,248,156 (-)MPROMDB
RGD ID:6817759
Promoter ID:MM_KWN:699
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000050771
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,253,981 - 52,254,482 (-)MPROMDB
RGD ID:6817758
Promoter ID:MM_KWN:703
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:OTTMUST00000050762
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,271,491 - 52,271,991 (-)MPROMDB
RGD ID:6817757
Promoter ID:MM_KWN:705
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000114510,   ENSMUST00000114512,   OTTMUST00000050744,   OTTMUST00000050768
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36152,289,066 - 52,290,647 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95752 AgrOrtholog
Ensembl Genes ENSMUSG00000026103 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000114510 ENTREZGENE
  ENSMUST00000114510.8 UniProtKB/Swiss-Prot
  ENSMUST00000114512 ENTREZGENE
  ENSMUST00000114512.8 UniProtKB/TrEMBL
  ENSMUST00000114513 ENTREZGENE
  ENSMUST00000114513.9 UniProtKB/Swiss-Prot
  ENSMUST00000129107.2 UniProtKB/TrEMBL
  ENSMUST00000155587.8 UniProtKB/TrEMBL
  ENSMUST00000156887.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.238.210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.710.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-lactam/transpept-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase_EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14660 UniProtKB/Swiss-Prot
MGD MGI:95752 ENTREZGENE
NCBI Gene 14660 ENTREZGENE
PANTHER GLUTAMINASE KIDNEY ISOFORM, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12544 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gls PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z7P3 ENTREZGENE
  D3Z7P4 ENTREZGENE, UniProtKB/TrEMBL
  E9PUF0 ENTREZGENE
  F6RDM4_MOUSE UniProtKB/TrEMBL
  F6U529_MOUSE UniProtKB/TrEMBL
  F7B327_MOUSE UniProtKB/TrEMBL
  GLSK_MOUSE UniProtKB/Swiss-Prot
  Q69ZX9 ENTREZGENE
UniProt Secondary E9PUF0 UniProtKB/Swiss-Prot
  Q69ZX9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Gls  glutaminase  AI314027  expressed sequence AI314027  Data merged from RGD:1610078 737654 PROVISIONAL