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Gene: Gls (glutaminase) Mus musculus
Symbol: Gls
Name: glutaminase
Description: Exhibits glutaminase activity and identical protein binding activity. Involved in several processes, including glutamine family amino acid metabolic process; protein homotetramerization; and regulation of respiratory gaseous exchange by nervous system process. Predicted to localize to mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Orthologous to human GLS (glutaminase); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; arginine and proline metabolic pathway; D-glutamine and D-glutamate metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6330442B14; AI314027; B230365M23Rik; expressed sequence AI314027; glutaminase kidney isoform, mitochondrial
Homo sapiens (human) : GLS (glutaminase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gls (glutaminase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gls (glutaminase)
Pan paniscus (bonobo/pygmy chimpanzee) : GLS (glutaminase)
Canis lupus familiaris (dog) : GLS (glutaminase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gls (glutaminase)
Sus scrofa (pig) : GLS (glutaminase)
Chlorocebus sabaeus (African green monkey) : GLS (glutaminase)
Heterocephalus glaber (naked mole-rat) : Gls (glutaminase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl152,163,448 - 52,233,232 (-)EnsemblGRCm38mm10GRCm38
GRCm38152,163,449 - 52,235,009 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37152,220,293 - 52,290,076 (-)NCBIGRCm37mm9NCBIm37
MGSCv36152,110,128 - 52,177,777 (-)NCBImm8
Celera152,701,920 - 52,771,737 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Gls
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10659
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.