Fzd5 (frizzled class receptor 5) - Rat Genome Database

Name: Fzd5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fzd5 (frizzled class receptor 5) Rattus norvegicus

Analyze

Symbol:

Fzd5

Name:

frizzled class receptor 5

RGD ID:

631406

Description:

Enables Wnt-protein binding activity. Involved in presynapse assembly. Is active in glutamatergic synapse. Orthologous to human FZD5 (frizzled class receptor 5); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

frizzled family receptor 5; frizzled homolog 5; frizzled homolog 5 (Drosophila); frizzled-5; fz-5

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FZD5 (frizzled class receptor 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Fzd5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fzd5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FZD5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FZD5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fzd5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FZD5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FZD5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fzd5 (frizzled class receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FZD8 (frizzled class receptor 8)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	FZD5 (frizzled class receptor 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fzd5 (frizzled class receptor 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd5 (frizzled class receptor 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cfz-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fz2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	66,117,370 - 66,119,127 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	66,113,112 - 66,121,457 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	74,637,916 - 74,639,673 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	79,767,933 - 79,769,690 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	78,172,390 - 78,174,147 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	71,443,784 - 71,445,541 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	71,443,588 - 71,445,739 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	71,120,245 - 71,122,004 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	63,386,990 - 63,388,747 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	63,533,971 - 63,535,729 (-)	NCBI
Celera	9	63,522,584 - 63,524,341 (-)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bladder exstrophy-epispadias-cloacal exstrophy complex (ISO)

coloboma (ISO)

COVID-19 (ISO)

Neurodevelopmental Disorders (ISO)

primary pulmonary hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

atrazine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbamazepine (ISO)

chlorpyrifos (EXP,ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP,ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

diclofenac (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

etacrynic acid (ISO)

Ethylenethiourea (EXP,ISO)

etoposide (ISO)

folic acid (ISO)

genistein (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

isotretinoin (ISO)

leflunomide (ISO)

methyl methanesulfonate (ISO)

nickel atom (EXP)

niclosamide (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

testosterone (ISO)

Tetrachlorobisphenol A (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA,ISO)

anterior/posterior axis specification, embryo (IEA,ISO)

apoptotic process involved in morphogenesis (IEA,ISO)

biological_process (ND)

branching involved in labyrinthine layer morphogenesis (IEA,ISO)

canonical Wnt signaling pathway (IBA,IEA,ISO)

cell maturation (ISO)

cellular response to molecule of bacterial origin (IEA,ISO)

chorionic trophoblast cell differentiation (IEA,ISO)

embryonic axis specification (ISO)

embryonic camera-type eye development (ISO)

embryonic camera-type eye morphogenesis (IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

glandular epithelial cell maturation (IEA,ISO)

intestinal epithelial cell maturation (IEA,ISO)

labyrinthine layer blood vessel development (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

positive regulation of interleukin-1 beta production (IEA,ISO)

positive regulation of JUN kinase activity (IEA,ISO)

positive regulation of protein targeting to mitochondrion (ISO)

positive regulation of T cell cytokine production (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of tumor necrosis factor production (IEA,ISO)

positive regulation of type II interferon production (IEA,ISO)

post-embryonic camera-type eye development (IEA,ISO)

presynapse assembly (EXP,IDA,IMP)

regulation of autophagy of mitochondrion (ISO)

regulation of bicellular tight junction assembly (IEA,ISO)

regulation of chorionic trophoblast cell proliferation (IEA,ISO)

Spemann organizer formation (IEA,ISO)

syncytiotrophoblast cell differentiation involved in labyrinthine layer development (IEA,ISO)

T cell differentiation in thymus (IEA,ISO)

vasculature development (ISO)

Wnt signaling pathway (ISO)

Cellular Component

axon (IEA)

bicellular tight junction (IEA,ISO)

cell surface (IEA,ISO)

cellular_component (ND)

dendrite (IEA)

early endosome (IEA,ISO)

glutamatergic synapse (EXP,IDA,IEP,IMP)

Golgi apparatus (IEA,ISO)

Golgi membrane (IEA)

membrane (IBA)

perikaryon (IEA)

perinuclear region of cytoplasm (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

synapse (IDA,IEP)

Molecular Function

amyloid-beta binding (IEA,ISO)

G protein-coupled receptor activity (IEA)

lipid binding (IEA)

protein binding (ISO)

protein kinase binding (IEA,ISO)

protein-containing complex binding (IEA,ISO)

ubiquitin protein ligase binding (IEA,ISO)

Wnt receptor activity (IBA,IEA,ISO)

Wnt-protein binding (IBA,IEA,IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Wnt signaling pathway (IEA,ISO)

Wnt signaling, canonical pathway (ISO)

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.	Caricasole A, etal., J Biol Chem 2003 Sep 26;278(39):37024-31.
2.	Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells.	Carmon KS and Loose DS, Mol Cancer Res. 2008 Jun;6(6):1017-28.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	The Wnt Homepage	Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
12.	Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis.	Sahores M, etal., Development. 2010 Jul;137(13):2215-25. doi: 10.1242/dev.046722.

Additional References at PubMed

PMID:9054360	PMID:10906785	PMID:11029007	PMID:11092808	PMID:11265645	PMID:11520064	PMID:12121999	PMID:12490564	PMID:15195140	PMID:15459103	PMID:15778706	PMID:16601243
PMID:16890161	PMID:18174455	PMID:18234671	PMID:18606138	PMID:18791178	PMID:18832390	PMID:19643732	PMID:21857966	PMID:22575959	PMID:23610556	PMID:24080158	PMID:24205342
PMID:24912190	PMID:28733458	PMID:29477872

Genomics

Comparative Map Data

Fzd5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	66,117,370 - 66,119,127 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	66,113,112 - 66,121,457 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	74,637,916 - 74,639,673 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	79,767,933 - 79,769,690 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	78,172,390 - 78,174,147 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	71,443,784 - 71,445,541 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	71,443,588 - 71,445,739 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	71,120,245 - 71,122,004 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	63,386,990 - 63,388,747 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	63,533,971 - 63,535,729 (-)	NCBI
Celera	9	63,522,584 - 63,524,341 (-)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

FZD5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	207,762,598 - 207,769,906 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	207,762,598 - 207,769,906 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	208,627,322 - 208,634,630 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	208,335,555 - 208,342,388 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	208,456,793 - 208,459,624	NCBI
Celera	2	202,389,191 - 202,396,022 (-)	NCBI		Celera
Cytogenetic Map	2	q33.3	NCBI
HuRef	2	200,469,499 - 200,476,330 (-)	NCBI		HuRef
CHM1_1	2	208,633,224 - 208,640,055 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	208,236,810 - 208,244,116 (-)	NCBI		T2T-CHM13v2.0

Fzd5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	64,769,717 - 64,776,909 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	64,769,717 - 64,776,910 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	64,730,558 - 64,737,750 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	64,730,558 - 64,737,751 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	64,777,132 - 64,784,324 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	64,668,689 - 64,672,026 (-)	NCBI		MGSCv36	mm8
Celera	1	65,232,287 - 65,239,483 (-)	NCBI		Celera
Cytogenetic Map	1	C2	NCBI
cM Map	1	32.74	NCBI

Fzd5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	7,282,403 - 7,288,918 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	7,282,403 - 7,288,918 (+)	NCBI	ChiLan1.0	ChiLan1.0

FZD5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	213,128,615 - 213,135,569 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	213,133,017 - 213,134,774 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	95,003,246 - 95,010,577 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

FZD5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	16,123,788 - 16,126,634 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	16,123,798 - 16,125,567 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	17,009,102 - 17,009,792 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	16,060,681 - 16,061,372 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	37	16,006,509 - 16,007,199 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	15,979,569 - 15,980,242 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	15,988,871 - 15,989,561 (-)	NCBI		UU_Cfam_GSD_1.0

Fzd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	164,270,066 - 164,280,869 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936631	3,911,693 - 3,915,560 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936631	3,909,046 - 3,915,939 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FZD5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	110,914,009 - 110,921,353 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	110,913,990 - 110,921,388 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	122,425,111 - 122,429,729 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FZD5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	93,545,792 - 93,553,092 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	93,550,189 - 93,551,946 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	105,817,194 - 105,824,526 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fzd5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	8,222,237 - 8,228,050 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624765	8,222,193 - 8,228,530 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fzd5
3 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	50
Interacting mature miRNAs:	53
Transcripts:	ENSRNOT00000019698
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	62072275	96470995	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	62072275	96470995	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat

Markers in Region

Fzd5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	66,119,076 - 66,120,205 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	71,445,491 - 71,446,619	NCBI	Rnor6.0
Rnor_5.0	9	71,119,093 - 71,120,297	UniSTS	Rnor5.0
RGSC_v3.4	9	63,388,697 - 63,389,826	UniSTS	RGSC3.4
Celera	9	63,524,291 - 63,525,400	UniSTS
Cytogenetic Map	9	q32	UniSTS

Fzd5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	66,117,859 - 66,118,056 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	71,444,274 - 71,444,470	NCBI	Rnor6.0
Rnor_5.0	9	71,121,318 - 71,121,514	UniSTS	Rnor5.0
RGSC_v3.4	9	63,387,480 - 63,387,676	UniSTS	RGSC3.4
Celera	9	63,523,074 - 63,523,270	UniSTS
Cytogenetic Map	9	q32	UniSTS

Fzd5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	66,118,143 - 66,118,310 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	71,444,558 - 71,444,724	NCBI	Rnor6.0
Rnor_5.0	9	71,121,064 - 71,121,230	UniSTS	Rnor5.0
RGSC_v3.4	9	63,387,764 - 63,387,930	UniSTS	RGSC3.4
Celera	9	63,523,358 - 63,523,524	UniSTS
Cytogenetic Map	9	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	14	17	14	1	14			2	2
Low	1	29	40	27	18	27			69	33	38	11
Below cutoff							8	10	3		3		8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB052909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC111319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000019698 ⟹ ENSRNOP00000070441

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	66,113,112 - 66,121,457 (-)	Ensembl
Rnor_6.0 Ensembl	9	71,443,588 - 71,445,739 (-)	Ensembl

RefSeq Acc Id:

NM_173838 ⟹ NP_776210

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	66,117,370 - 66,119,127 (-)	NCBI
Rnor_6.0	9	71,443,784 - 71,445,541 (-)	NCBI
Rnor_5.0	9	71,120,245 - 71,122,004 (+)	NCBI
RGSC_v3.4	9	63,386,990 - 63,388,747 (-)	RGD
Celera	9	63,522,584 - 63,524,341 (-)	RGD

Sequence:

show sequence

ATGGCTAGACCCGACCCGTCCGCGCCGCCCTCTCTTCTGCTGCTGTTGCTGGCACAGCTGGTGG
GCCGGGCAGCGGCCGCCTCCAAGGCCCCAGTGTGCCAGGAAATCACGGTGCCCATGTGCCGCGG
CATCGGCTACAACCTGACGCACATGCCCAACCAGTTCAACCATGACACTCAGGACGAAGCAGGC
CTGGAGGTGCACCAATTCTGGCCGCTGGTGGAGATCCACTGTTCCCCGGACCTGCGCTTCTTCC
TGTGCTCCATGTACACGCCCATCTGCTTGCCTGACTACCACAAGCCGCTACCACCGTGCCGCTC
CGTGTGCGAGCGCGCCAAGGCCGGCTGCTCGCCACTCATGCGCCAGTACGGCTTCGCCTGGCCC
GAGCGCATGAGCTGCGACCGCCTCCCAGTGCTGGGCGGCGACGCTGAGGTTCTGTGCATGGATT
ATAACCGAAGTGAAGCCACCACCGCGTCCCCTAAGTCCTTCCCGGCCAAACCCACACTCCCAGG
ACCACCAGGGGCGCCATCTTCCGGGGGCGAATGTCCCTCGGGAGGCCCGTCTGTGTGCACGTGC
CGCGAGCCCTTCGTGCCCATCCTGAAGGAGTCACACCCACTCTACAACAAGGTGCGCACCGGCC
AAGTGCCCAACTGCGCAGTGCCCTGCTACCAGCCGTCCTTCAGCCCGGATGAGCGCACGTTCGC
CACCTTCTGGATTGGCCTGTGGTCTGTGCTGTGCTTCATCTCCACGTCCACCACTGTAGCGACC
TTCCTCATTGACATGGAACGATTCCGCTACCCTGAGCGCCCCATCATCTTCCTGTCTGCGTGCT
ACCTGTGTGTGTCACTGGGATTCTTGGTGCGCCTGGTTGTAGGCCATGCCAGCGTCGCCTGCAG
CCGAGAGCACAGCCACATTCACTATGAGACTACCGGCCCTGCGCTGTGCACAGTCGTCTTCCTC
TTAGTCTACTTCTTTGGCATGGCCAGCTCCATCTGGTGGGTCATCCTGTCGCTCACCTGGTTCT
TGGCGGCTGGCATGAAGTGGGGCAATGAAGCCATCGCAGGCTATGCACAGTACTTCCACCTTGC
TGCCTGGCTCATCCCCAGCGTCAAGTCCATTACGGCGCTGGCACTGAGCTCCGTGGACGGAGAC
CCAGTGGCTGGCGTCTGTTATGTGGGCAACCAAAACCTGAACTCGCTACGAGGCTTTGTCTTGG
GCCCACTGGTGCTGTACCTGTTGGTGGGCACGCTCTTCCTTCTGGCAGGCTTCGTGTCACTCTT
CCGCATCCGGAGCGTCATCAAGCAGGGTGGCACTAAGACGGACAAGCTAGAGAAGCTCATGATC
CGCATTGGCATCTTCACTCTGCTCTACACGGTGCCAGCCAGCATCGTGGTGGCCTGCTACCTGT
ATGAACAGCACTATCGGGAGAGCTGGGAGGCAGCCCTCACCTGCGCGTGTCCGGGGTCGGACGC
TGGCCAGCCACGCGCCAAACCCGAGTACTGGGTGCTCATGCTCAAGTACTTCATGTGCCTGGTG
GTGGGCATCACGTCGGGAGTCTGGATCTGGTCCGGAAAGACCCTGGAGTCTTGGCGGCGCTTCA
CCAGCCGCTGCTGCTGCAGCTCTCGACGGGGCCATAAAAGCGGTGGCGCTATGGTCGCAGGAGA
CTATGCGGAGGCCAGCGCCGCACTCACTGGCAGGACCGGGCCGCCGGGCCCCGCGGCCGCATAC
CACAAGCAAGTGTCCCTGTCGCACGTATAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_776210	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC53980	(Get FASTA)	NCBI Sequence Viewer
	Q8CHL0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_776210 ⟸ NM_173838
- Peptide Label:	precursor
- UniProtKB:	A0A0G2JXX8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAG LEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWP ERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGECPSGGPSVCTC REPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVAT FLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFL LVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGD PVAGVCYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMI RIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGSDAGQPRAKPEYWVLMLKYFMCLV VGITSGVWIWSGKTLESWRRFTSRCCCSSRRGHKSGGAMVAGDYAEASAALTGRTGPPGPAAAY HKQVSLSHV hide sequence

RefSeq Acc Id:

ENSRNOP00000070441 ⟸ ENSRNOT00000019698

Protein Domains

FZ G_PROTEIN_RECEP_F2_4

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8CHL0-F1-model_v2	AlphaFold	Q8CHL0	1-585	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631406	AgrOrtholog
BioCyc Gene	G2FUF-27314	BioCyc
Ensembl Genes	ENSRNOG00000014678	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000070441	ENTREZGENE
	ENSRNOP00000070441.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019698	ENTREZGENE
	ENSRNOT00000019698.5	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Frizzled/SFRP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled/Smoothened_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FZ5_CRD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:317674	UniProtKB/Swiss-Prot
NCBI Gene	317674	ENTREZGENE
PANTHER	PTHR11309	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Frizzled	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF01392	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fzd5	PhenoGen
PRINTS	FRIZZLED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50038	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	FRI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF63501	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JXX8	ENTREZGENE, UniProtKB/TrEMBL
	FZD5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-02-06	Fzd5	frizzled class receptor 5	Fzd5	frizzled family receptor 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Fzd5	frizzled family receptor 5	Fzd5	frizzled homolog 5 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	Fzd5	frizzled homolog 5 (Drosophila)			Symbol and Name status set to approved	625702	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)