Gene: Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4) Rattus norvegicus
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Symbol: Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Description: ENCODES a protein that exhibits ATP binding (ortholog); creatine kinase activity (ortholog); microtubule binding (ortholog); INVOLVED IN negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of neuron projection development; negative regulation of neuron projection regeneration; PARTICIPATES IN ceramide signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH arteriovenous malformations of the brain (ortholog); Lung Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); focal adhesion (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A
AGR Description: Predicted to have ATP binding activity, microtubule binding activity, and transferase activity, transferring phosphorus-containing groups; involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and negative regulation of neuron projection regeneration; predicted to localize to the cytoplasm and focal adhesion; orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4).
Merged Description: Predicted to have ATP binding activity, microtubule binding activity, and transferase activity, transferring phosphorus-containing groups; involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and negative regulation of neuron projection regeneration; predicted to localize to the cytoplasm and focal adhesion; orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); PARTICIPATES IN ceramide signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; tumor necrosis factor mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC301363
Orthologs:
Homo sapiens (human) : MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)
Canis lupus familiaris (dog) : MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4)
Sus scrofa (pig) : MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0946,657,444 - 46,782,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0946,342,983 - 46,469,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,087,924 - 39,213,053 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1939,072,258 - 39,212,860 (+)NCBI
Celera939,949,780 - 40,073,740 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
  
More on Map4k4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305322
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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