Gene: Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4) Rattus norvegicus
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Symbol: Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Description: ENCODES a protein that exhibits ATP binding (ortholog); creatine kinase activity (ortholog); microtubule binding (ortholog); INVOLVED IN negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of neuron projection development; negative regulation of neuron projection regeneration; PARTICIPATES IN ceramide signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH arteriovenous malformations of the brain (ortholog); Lung Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); focal adhesion (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A
AGR Description: Predicted to have ATP binding activity, microtubule binding activity, and transferase activity, transferring phosphorus-containing groups; involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and negative regulation of neuron projection regeneration; predicted to localize to the cytoplasm and focal adhesion; orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4).
Merged Description: Predicted to have ATP binding activity, microtubule binding activity, and transferase activity, transferring phosphorus-containing groups; involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and negative regulation of neuron projection regeneration; predicted to localize to the cytoplasm and focal adhesion; orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); PARTICIPATES IN ceramide signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; tumor necrosis factor mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC301363
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0946,657,444 - 46,782,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0946,342,983 - 46,469,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,087,924 - 39,213,053 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1939,072,258 - 39,212,860 (+)NCBI
Celera939,949,780 - 40,073,740 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Map4k4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305322
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.