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Gene: Des (desmin) Rattus norvegicus
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Symbol: Des
Name: desmin
Description: Predicted to have cytoskeletal protein binding activity and identical protein binding activity. Predicted to be involved in intermediate filament organization. Localizes to the Z disc; gap junction; and type III intermediate filament. Predicted to colocalize with the intermediate filament. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; dilated cardiomyopathy; dilated cardiomyopathy 1I; myofibrillar myopathy 1; and restrictive cardiomyopathy. Orthologous to human DES (desmin); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; (R)-rosmarinic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Orthologs:
Homo sapiens (human) : DES (desmin)  HGNC  Alliance
Mus musculus (house mouse) : Des (desmin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Des (desmin)
Pan paniscus (bonobo/pygmy chimpanzee) : DES (desmin)
Canis lupus familiaris (dog) : DES (desmin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Des (desmin)
Sus scrofa (pig) : DES (desmin)
more info ...
Allele / Splice: Desm1Mcwi  
Genetic Models: FHH-Desm1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0982,556,574 - 82,564,288 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,556,573 - 82,564,294 (+)Ensembl
Rnor_5.0982,325,835 - 82,333,549 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,637,783 - 74,645,499 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,784,772 - 74,792,478 (+)NCBI
Celera974,421,090 - 74,428,604 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Des
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620686
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.