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Gene: Des (desmin) Mus musculus
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Symbol: Des
Name: desmin
Description: Predicted to have cytoskeletal protein binding activity and identical protein binding activity. Predicted to be involved in intermediate filament organization. Localizes to several cellular components, including the Z disc; fascia adherens; and sarcolemma. Colocalizes with the intermediate filament. Used to study cardiomyopathy; dilated cardiomyopathy 1I; and myofibrillar myopathy 1. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; dilated cardiomyopathy; dilated cardiomyopathy 1I; myofibrillar myopathy 1; and restrictive cardiomyopathy. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; musculature; and nephron. Orthologous to human DES (desmin).
Type: protein-coding
RefSeq Status: REVIEWED
Orthologs:
Homo sapiens (human) : DES (desmin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Des (desmin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Des (desmin)
Pan paniscus (bonobo/pygmy chimpanzee) : DES (desmin)
Canis lupus familiaris (dog) : DES (desmin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Des (desmin)
Sus scrofa (pig) : DES (desmin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38175,360,292 - 75,368,579 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37175,356,919 - 75,364,291 (+)NCBIGRCm37mm9NCBIm37
MGSCv36175,243,492 - 75,250,864 (+)NCBImm8
Celera175,850,876 - 75,859,163 (+)NCBICelera
Cytogenetic Map1 C4NCBI
cM Map138.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Des
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551179
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.