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Gene: Des (desmin) Mus musculus
Symbol: Des
Name: desmin
Description: Predicted to have cytoskeletal protein binding activity and identical protein binding activity. Predicted to be involved in intermediate filament organization. Localizes to several cellular components, including the Z disc; fascia adherens; and sarcolemma. Colocalizes with the intermediate filament. Used to study cardiomyopathy; dilated cardiomyopathy 1I; and myofibrillar myopathy 1. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; dilated cardiomyopathy; dilated cardiomyopathy 1I; myofibrillar myopathy 1; and restrictive cardiomyopathy. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; musculature; and nephron. Orthologous to human DES (desmin).
Type: protein-coding
RefSeq Status: REVIEWED
Homo sapiens (human) : DES (desmin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Des (desmin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Des (desmin)
Pan paniscus (bonobo/pygmy chimpanzee) : DES (desmin)
Canis lupus familiaris (dog) : DES (desmin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Des (desmin)
Sus scrofa (pig) : DES (desmin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38175,360,292 - 75,368,579 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37175,356,919 - 75,364,291 (+)NCBIGRCm37mm9NCBIm37
MGSCv36175,243,492 - 75,250,864 (+)NCBImm8
Celera175,850,876 - 75,859,163 (+)NCBICelera
Cytogenetic Map1 C4NCBI
cM Map138.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Des
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551179
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.