Crygd (crystallin, gamma D) - Rat Genome Database

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Gene: Crygd (crystallin, gamma D) Rattus norvegicus
Analyze
Symbol: Crygd
Name: crystallin, gamma D
RGD ID: 2422
Description: A structural constituent of eye lens. Involved in lens fiber cell differentiation and response to peptide hormone. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cryg4; Crystallin gamma polypeptide 4; Crystallin, gamma polypeptide 4; gamma-crystallin 2-2; gamma-crystallin D; gamma-D-crystallin; Len
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,935,798 - 73,937,409 (-)NCBIGRCr8
mRatBN7.2966,442,057 - 66,443,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,442,054 - 66,444,067 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,955,290 - 74,956,901 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,090,585 - 80,092,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,499,024 - 78,500,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,776,568 - 71,778,323 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,764,318 - 71,778,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,790,042 - 70,803,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,711,051 - 63,712,662 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,858,032 - 63,859,644 (-)NCBI
Celera963,837,702 - 63,839,313 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CrygdRatcataract  TAS 1298817 RGD 
CrygdRatcataract 7 susceptibilityISORGD:7358331601016DNA:transversion:exon:p.P23T (human)RGD 
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CrygdRatcataract  ISORGD:7358338554872ClinVar Annotator: match by term: Cataract | ClinVar Annotator: match by term: Congenital cataractClinVarPMID:12011157|PMID:12676897|PMID:17724170|PMID:21827768|PMID:25403472|PMID:25741868|PMID:26694549|PMID:28474685|PMID:28492532
CrygdRatcataract 4 multiple types  ISORGD:7358338554872ClinVar Annotator: match by term: CATARACT 4, MULTIPLE TYPES, WITH OR WITHOUT MICROCORNEA | ClinVar more ...ClinVarPMID:10521291|PMID:10688888|PMID:10915766|PMID:11371638|PMID:12011157|PMID:12676897|PMID:16446699|PMID:17564961|PMID:17724170|PMID:18587492|PMID:19382745|PMID:19390652|PMID:19668596|PMID:21527994|PMID:21827768|PMID:22219628|PMID:22995991|PMID:23508780|PMID:2350878024465161|PMID:23936409|PMID:24465161|PMID:25403472|PMID:25741868|PMID:26694549|PMID:28450710|PMID:28474685|PMID:28492532|PMID:29914532|PMID:32830442|PMID:33243271|PMID:9927684
CrygdRatCataract, Congenital Dominant Non Nuclear  ISORGD:7358338554872ClinVar Annotator: match by term: Autosomal dominant nonnuclear polymorphic congenital cataractClinVarPMID:10521291|PMID:12011157|PMID:12676897|PMID:17724170|PMID:18587492|PMID:19390652|PMID:21827768|PMID:22995991|PMID:23508780|PMID:2350878024465161|PMID:23936409|PMID:24465161|PMID:25403472|PMID:25741868|PMID:26694549|PMID:28474685|PMID:28492532|PMID:29914532|PMID:32830442|PMID:33243271
CrygdRatCrystalline Aculeiform Cataract  ISORGD:7358338554872ClinVar Annotator: match by term: Aculeiform cataractClinVarPMID:10521291|PMID:10688888|PMID:10704279|PMID:10915766|PMID:11371638|PMID:12011157|PMID:12676897|PMID:16446699|PMID:17724170|PMID:18587492|PMID:19382745|PMID:19390652|PMID:19668596|PMID:21527994|PMID:21827768|PMID:22219628|PMID:22995991|PMID:23508780|PMID:2350878024465161|PMID:23936409|PMID:24465161|PMID:25403472|PMID:25741868|PMID:26694549|PMID:27455011|PMID:28166811|PMID:28450710|PMID:28474685|PMID:28492532|PMID:29914532|PMID:32830442|PMID:33243271|PMID:33460241|PMID:9927684
CrygdRatgenetic disease  ISORGD:7358338554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:18587492|PMID:23508780|PMID:2350878024465161|PMID:23936409|PMID:24465161|PMID:25741868|PMID:28166811|PMID:28492532|PMID:29914532|PMID:32830442|PMID:33243271
CrygdRatHigh Myopia  ISORGD:7358338554872ClinVar Annotator: match by term: High myopiaClinVarPMID:28492532
CrygdRatJoubert Syndrome 17  ISORGD:7358338554872ClinVar Annotator: match by term: Joubert syndrome 17ClinVarPMID:19390652|PMID:22995991|PMID:25741868|PMID:28492532
CrygdRatNeurodevelopmental Disorders  ISORGD:7358338554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
CrygdRatprimary pulmonary hypertension  ISORGD:7358338554872ClinVar Annotator: match by term: Primary pulmonary hypertensionClinVarPMID:28492532|PMID:31727138
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Source
Original Reference(s)
CrygdRatcataract  ISORGD:73583311554173CTD Direct Evidence: marker/mechanismCTDPMID:9927684|PMID:30242128
CrygdRatHepatomegaly  ISORGD:73583311554173CTD Direct Evidence: marker/mechanismCTDPMID:28108177
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CrygdRatcataract 2 multiple types  ISSRGD:1040913592920OMIM:604307MouseDO 
CrygdRatcataract 4 multiple types  ISSRGD:1040913592920OMIM:115700MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
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Source
Original Reference(s)
CrygdRatcataract 4 multiple types  ISORGD:7358337240710 OMIM 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CrygdRat1,2-dimethylhydrazine decreases expressionISORGD:1040964804641,2-Dimethylhydrazine results in decreased expression of CRYGD mRNACTDPMID:22206623
CrygdRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CRYGD mRNACTDPMID:20959002
CrygdRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:104096480464CRYGD promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]CTDPMID:23997114
CrygdRat6-propyl-2-thiouracil affects expressionEXP 6480464Propylthiouracil affects the expression of CRYGD mRNACTDPMID:24780913
CrygdRatacrylamide decreases expressionISORGD:7358336480464Acrylamide results in decreased expression of CRYGD mRNACTDPMID:32763439
CrygdRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CRYGD mRNACTDPMID:16483693
CrygdRatantirheumatic drug increases expressionISORGD:7358336480464Antirheumatic Agents results in increased expression of CRYGD mRNACTDPMID:24449571
CrygdRatbenzo[a]pyrene affects methylationISORGD:7358336480464Benzo(a)pyrene affects the methylation of CRYGD promoterCTDPMID:27901495
CrygdRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CRYGD mRNACTDPMID:25181051|PMID:34947998
CrygdRatbisphenol A increases expressionISORGD:104096480464bisphenol A results in increased expression of CRYGD mRNACTDPMID:32156529
CrygdRatbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of CRYGD mRNACTDPMID:30816183|PMID:32528016
CrygdRatCGP 52608 multiple interactionsISORGD:7358336480464CGP 52608 promotes the reaction [RORA protein binds to CRYGD gene]CTDPMID:28238834
CrygdRatclofibrate increases expressionISORGD:104096480464Clofibrate results in increased expression of CRYGD mRNACTDPMID:17585979
CrygdRatcobalt dichloride decreases expressionISORGD:104096480464cobaltous chloride results in decreased expression of CRYGD mRNACTDPMID:21139344
CrygdRatcopper atom increases expressionEXP 6480464Copper deficiency results in increased expression of CRYGD mRNACTDPMID:26033743
CrygdRatcopper(0) increases expressionEXP 6480464Copper deficiency results in increased expression of CRYGD mRNACTDPMID:26033743
CrygdRatethylparaben decreases expressionISORGD:7358336480464ethyl-p-hydroxybenzoate results in decreased expression of CRYGD mRNACTDPMID:37690743
CrygdRatflavonoids decreases expressionEXP 6480464Flavonoids results in decreased expression of CRYGD mRNACTDPMID:18035473
CrygdRatglutathione disulfide increases oxidationISORGD:7358336480464Glutathione Disulfide results in increased oxidation of CRYGD protein mutant formCTDPMID:30242128
CrygdRatochratoxin A decreases expressionEXP 6480464ochratoxin A results in decreased expression of CRYGD mRNACTDPMID:23358140

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Biological Process
1 to 13 of 13 rows

  
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
CrygdRatcellular response to reactive oxygen species involved_inISORGD:7358331624291 PMID:8943244RGDPMID:8943244
CrygdRateye development acts_upstream_of_or_withinIEAUniProtKB:P04342|ensembl:ENSMUSP000000453271600115GO_REF:0000107EnsemblGO_REF:0000107
CrygdRateye development acts_upstream_of_or_withinISORGD:104091624291MGI:2387106 PMID:15037589RGDPMID:15037589
CrygdRatlens development in camera-type eye  IEP 2303725 RGD 
CrygdRatlens development in camera-type eye acts_upstream_of_or_withinIEAUniProtKB:P04342|ensembl:ENSMUSP000000453271600115GO_REF:0000107EnsemblGO_REF:0000107
CrygdRatlens development in camera-type eye acts_upstream_of_or_withinISORGD:104091624291MGI:1858026|MGI:3762620 PMID:10704279, PMID:17652744RGDPMID:10704279|PMID:17652744
CrygdRatlens development in camera-type eye involved_inIBAMGI:104336|MGI:1298216|MGI:88521|MGI:88522|MGI:88524|MGI:88525|PANTHER:PTN001721602|RGD:1584991|RGD:1586353|RGD:1595217|RGD:2415|RGD:2421|RGD:2422|RGD:24231600115GO_REF:0000033GO_CentralGO_REF:0000033
CrygdRatlens fiber cell differentiation  IDA 1601018 RGD 
CrygdRatlens fiber cell differentiation acts_upstream_of_or_withinIEAUniProtKB:P04342|ensembl:ENSMUSP000000453271600115GO_REF:0000107EnsemblGO_REF:0000107
CrygdRatlens fiber cell differentiation acts_upstream_of_or_withinISORGD:104091624291MGI:3762620 PMID:17652744RGDPMID:17652744
CrygdRatresponse to peptide hormone  IEP 1601018 RGD 
CrygdRatvisual perception involved_inISORGD:7358331624291 PMID:12011157, PMID:12676897, PMID:9927684RGDPMID:12011157|PMID:12676897|PMID:9927684
CrygdRatvisual perception involved_inIBAMGI:88519|PANTHER:PTN001721602|UniProtKB:P07315|UniProtKB:P07320|UniProtKB:P536731600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
CrygdRatcytoplasm located_inIEAUniProtKB:P04342|ensembl:ENSMUSP000000453271600115GO_REF:0000107EnsemblGO_REF:0000107
CrygdRatcytoplasm located_inISORGD:104091624291 PMID:17652744RGDPMID:17652744
CrygdRatnucleus located_inIEAUniProtKB:P04342|ensembl:ENSMUSP000000453271600115GO_REF:0000107EnsemblGO_REF:0000107
CrygdRatnucleus located_inISORGD:104091624291 PMID:17652744RGDPMID:17652744

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CrygdRatprotein binding enablesISORGD:7358331624291UniProtKB:P02489|UniProtKB:P23927|UniProtKB:P24623 PMID:22289178, PMID:8943244RGDPMID:22289178|PMID:8943244
CrygdRatstructural constituent of eye lens  IMP 1298817 RGD 
CrygdRatstructural constituent of eye lens enablesISORGD:104091624291 PMID:17652744RGDPMID:17652744
CrygdRatstructural constituent of eye lens enablesIEAUniProtKB-KW:KW-02731600115GO_REF:0000043UniProtGO_REF:0000043
CrygdRatstructural constituent of eye lens enablesIBAMGI:1298216|MGI:88519|MGI:88522|MGI:88524|PANTHER:PTN001721602|RGD:2416|RGD:2422|RGD:61962|RGD:619801600115GO_REF:0000033GO_CentralGO_REF:0000033
CrygdRatstructural constituent of eye lens enablesIEAUniProtKB:P04342|ensembl:ENSMUSP000000453271600115GO_REF:0000107EnsemblGO_REF:0000107


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#
Reference Title
Reference Citation
1. Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region. den Dunnen JT, etal., Gene 1989 May 30;78(2):201-13.
2. The sequence of regulatory events controlling the expression of the gamma D-crystallin gene during fibroblast growth factor-mediated rat lens fiber cell differentiation. Dirks RP, etal., Dev Biol. 1996 Jan 10;173(1):14-25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts. Nandrot E, etal., J Med Genet. 2003 Apr;40(4):262-7.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. High level expression of rat gamma-D-crystallin in Escherichia coli. Ooki K, etal., Biochimie 1994;76(5):398-403.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Differential synthesis of crystallins in the developing rat eye lens. Voorter CE, etal., Exp Eye Res. 1990 Apr;50(4):429-37.
1 to 14 of 14 rows
PMID:3783678   PMID:8943244   PMID:9927684   PMID:10704279   PMID:12011157   PMID:15037589   PMID:17652744   PMID:23404175  



Crygd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,935,798 - 73,937,409 (-)NCBIGRCr8
mRatBN7.2966,442,057 - 66,443,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,442,054 - 66,444,067 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,955,290 - 74,956,901 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,090,585 - 80,092,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,499,024 - 78,500,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,776,568 - 71,778,323 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,764,318 - 71,778,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,790,042 - 70,803,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,711,051 - 63,712,662 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,858,032 - 63,859,644 (-)NCBI
Celera963,837,702 - 63,839,313 (-)NCBICelera
Cytogenetic Map9q32NCBI
CRYGD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,121,607 - 208,124,524 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,121,607 - 208,124,524 (-)EnsemblGRCh38hg38GRCh38
GRCh372208,986,331 - 208,989,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,694,577 - 208,697,458 (-)NCBINCBI36Build 36hg18NCBI36
Build 342208,811,837 - 208,814,719NCBI
Celera2202,754,599 - 202,757,581 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,834,785 - 200,837,767 (-)NCBIHuRef
CHM1_12208,992,125 - 208,995,102 (-)NCBICHM1_1
T2T-CHM13v2.02208,601,624 - 208,604,541 (-)NCBIT2T-CHM13v2.0
Crygd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,101,001 - 65,102,598 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,101,031 - 65,102,611 (-)EnsemblGRCm39 Ensembl
GRCm38165,061,838 - 65,063,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,061,872 - 65,063,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,108,412 - 65,110,014 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,996,119 - 64,997,685 (-)NCBIMGSCv36mm8
Celera165,554,907 - 65,556,511 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.8NCBI
LOC100978046
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,727,056 - 110,730,505 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,742,032 - 110,745,236 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,352,149 - 95,356,237 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,476,336 - 213,479,279 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,476,336 - 213,479,279 (-)Ensemblpanpan1.1panPan2
CRYGD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,424,884 - 16,433,479 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,307,807 - 17,316,401 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,360,607 - 16,369,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,360,585 - 16,362,369 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,305,289 - 16,313,857 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,278,488 - 16,287,054 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,287,674 - 16,296,225 (-)NCBIUU_Cfam_GSD_1.0
LOC100519628
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,242,765 - 111,244,775 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115111,242,765 - 111,244,738 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103217728
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,903,173 - 93,908,652 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040105,459,291 - 105,463,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Crygd
8 total Variants

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:76
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000050886, ENSRNOT00000064562
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat

1 to 10 of 32 rows
D9Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8973,969,072 - 73,969,193 (+)Marker Load Pipeline
mRatBN7.2966,475,328 - 66,475,449 (+)MAPPERmRatBN7.2
Rnor_6.0971,821,468 - 71,821,588NCBIRnor6.0
Rnor_5.0970,749,367 - 70,749,487UniSTSRnor5.0
Celera963,870,765 - 63,870,885UniSTS
RH 3.4 Map9566.7RGD
RH 3.4 Map9566.7UniSTS
RH 2.0 Map9621.6RGD
D9Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8973,930,789 - 73,930,979 (+)Marker Load Pipeline
mRatBN7.2966,437,052 - 66,437,242 (+)MAPPERmRatBN7.2
Rnor_6.0971,771,288 - 71,771,476NCBIRnor6.0
Rnor_5.0970,797,216 - 70,797,404UniSTSRnor5.0
RGSC_v3.4963,705,761 - 63,705,951RGDRGSC3.4
RGSC_v3.4963,705,762 - 63,705,951UniSTSRGSC3.4
RGSC_v3.1963,852,743 - 63,852,933RGD
Celera963,832,694 - 63,832,883UniSTS
RH 3.4 Map9588.2UniSTS
RH 3.4 Map9588.2RGD
RH 2.0 Map9632.5RGD
SHRSP x BN Map945.5498RGD
FHH x ACI Map942.29RGD
Cytogenetic Map9 RGD




appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
11 49 77 27 34 18 17 18 4 114 76 72 12 33 16



Ensembl Acc Id: ENSRNOT00000050886   ⟹   ENSRNOP00000051301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,442,057 - 66,443,668 (-)Ensembl
Rnor_6.0 Ensembl971,776,568 - 71,778,323 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000064562   ⟹   ENSRNOP00000060248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl971,764,318 - 71,778,188 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107623   ⟹   ENSRNOP00000082230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,442,054 - 66,444,067 (-)Ensembl
RefSeq Acc Id: NM_033095   ⟹   NP_149086
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,935,798 - 73,937,409 (-)NCBI
mRatBN7.2966,442,057 - 66,443,668 (-)NCBI
Rnor_6.0971,776,568 - 71,778,323 (-)NCBI
Rnor_5.0970,790,042 - 70,803,964 (+)NCBI
RGSC_v3.4963,711,051 - 63,712,662 (-)RGD
Celera963,837,702 - 63,839,313 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266627   ⟹   XP_063122697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,935,798 - 73,937,389 (-)NCBI
Protein RefSeqs NP_149086 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122697 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40984 (Get FASTA)   NCBI Sequence Viewer  
  CAA40458 (Get FASTA)   NCBI Sequence Viewer  
  EDL98869 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051301
  ENSRNOP00000051301.3
GenBank Protein P10067 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_149086   ⟸   NM_033095
- UniProtKB: P10067 (UniProtKB/Swiss-Prot),   A6IPJ1 (UniProtKB/TrEMBL),   A0A8I5ZXH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051301   ⟸   ENSRNOT00000050886
Ensembl Acc Id: ENSRNOP00000060248   ⟸   ENSRNOT00000064562
Ensembl Acc Id: ENSRNOP00000082230   ⟸   ENSRNOT00000107623
RefSeq Acc Id: XP_063122697   ⟸   XM_063266627
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZXH9 (UniProtKB/TrEMBL)
Beta/gamma crystallin 'Greek key'

Name Modeler Protein Id AA Range Protein Structure
AF-P10067-F1-model_v2 AlphaFold P10067 1-174 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696718
Promoter ID:EPDNEW_R7242
Type:single initiation site
Name:Crygd_1
Description:crystallin, gamma D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0971,778,323 - 71,778,383EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27305 BioCyc
Ensembl Genes ENSRNOG00000032219 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050886 ENTREZGENE
  ENSRNOT00000050886.3 UniProtKB/Swiss-Prot
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot
InterPro Beta/Gamma-Crystallin UniProtKB/Swiss-Prot
  Beta/gamma_crystallin UniProtKB/Swiss-Prot
  G_crystallin-like UniProtKB/Swiss-Prot
KEGG Report rno:24278 UniProtKB/Swiss-Prot
NCBI Gene 24278 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot
  GAMMA-CRYSTALLIN D UniProtKB/Swiss-Prot
Pfam Crystall UniProtKB/Swiss-Prot
PhenoGen Crygd PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032219 RatGTEx
SMART XTALbg UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot
UniProt A0A8I5ZXH9 ENTREZGENE, UniProtKB/TrEMBL
  A6IPJ1 ENTREZGENE, UniProtKB/TrEMBL
  CRGD_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Crygd  crystallin, gamma D    Crystallin, gamma polypeptide 4  Name updated 625702 APPROVED
2002-06-10 Crygd  Crystallin, gamma polypeptide 4      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease may be involved in cataract formation 1298817
gene_expression expressed in lens of eye 1298817