Bmpr2 (bone morphogenetic protein receptor type 2) - Rat Genome Database

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Gene: Bmpr2 (bone morphogenetic protein receptor type 2) Rattus norvegicus
Analyze
Symbol: Bmpr2
Name: bone morphogenetic protein receptor type 2
RGD ID: 71082
Description: Enables growth factor binding activity. Involved in brain development and retina development in camera-type eye. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and caveola. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bmpr-II; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type II (serine/threonine kinase); bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Bmpr2em1Sage   Bmpr2em2Sage   Bmpr2em1Ang  
Genetic Models: SD-Bmpr2em1Ang+/- F344-Bmpr2em2Sage+/- F344-Bmpr2em1Sage+/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2961,192,718 - 61,307,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl961,190,566 - 61,301,809 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx969,692,580 - 69,800,850 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0974,808,556 - 74,916,402 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0973,126,851 - 73,235,117 (+)NCBIRnor_WKY
Rnor_6.0966,568,074 - 66,683,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0966,371,542 - 66,486,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4958,327,587 - 58,436,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1958,524,438 - 58,554,549 (+)NCBI
Celera958,627,253 - 58,735,336 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGS 15943  (ISO)
chloroprene  (EXP)
choline  (ISO)
chrysene  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coumestrol  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenfluramine  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fosinopril  (EXP)
hydrogen cyanide  (ISO)
iloprost  (ISO)
kenpaullone  (ISO)
L-methionine  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methacholine chloride  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
monocrotaline  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
resveratrol  (ISO)
Rutecarpine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
aortic valve development  (ISO)
artery development  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
blood vessel development  (IBA)
blood vessel remodeling  (ISO)
BMP signaling pathway  (IBA,ISO)
brain development  (IEP)
cardiac muscle tissue development  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to starvation  (ISO)
chondrocyte development  (ISO)
endocardial cushion development  (ISO)
endochondral bone morphogenesis  (ISS)
endothelial cell apoptotic process  (ISO)
endothelial cell proliferation  (ISO)
limb development  (ISO)
lung alveolus development  (ISO)
lymphangiogenesis  (ISO)
lymphatic endothelial cell differentiation  (ISO)
maternal placenta development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (ISO)
negative regulation of chondrocyte proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of vasoconstriction  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
positive regulation of axon extension involved in axon guidance  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cartilage development  (ISS)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein phosphorylation  (IBA)
proteoglycan biosynthetic process  (ISS)
pulmonary valve development  (ISO)
regulation of cell population proliferation  (ISO)
regulation of lung blood pressure  (ISO)
retina development in camera-type eye  (IEP)
retina vasculature development in camera-type eye  (ISO)
semi-lunar valve development  (ISO)
transmembrane receptor protein serine/threonine kinase signaling pathway  (ISO)
tricuspid valve morphogenesis  (ISO)
venous blood vessel development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Austin ED, etal., Respir Res. 2009 Sep 28;10:87.
2. Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys. Bosukonda D, etal., Kidney Int. 2000 Nov;58(5):1902-11.
3. Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia. Charytoniuk DA, etal., Neuroscience. 2000;100(1):33-43.
4. Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension. Cogan JD, etal., Genet Med. 2005 Mar;7(3):169-74.
5. Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. Dewachter L, etal., Eur Respir J. 2009 Nov;34(5):1100-10. Epub 2009 Mar 26.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension. Girerd B, etal., Respir Res. 2010 Jun 10;11:73.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Hong KH, etal., Circulation. 2008 Aug 12;118(7):722-30. Epub 2008 Jul 28.
10. Basal expression of bone morphogenetic protein receptor is reduced in mild asthma. Kariyawasam HH, etal., Am J Respir Crit Care Med. 2008 May 15;177(10):1074-81. Epub 2008 Feb 21.
11. Expression of serine/threonine kinase receptors in traumatic brain injury. Lewen A, etal., Neuroreport. 1997 Jan 20;8(2):475-9.
12. Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2. Lopez-Lopez JG, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):400-7. Epub 2011 Apr 26.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Bone morphogenetic protein receptor expressions in the adult rat brain. Miyagi M, etal., Neuroscience. 2011 Mar 10;176:93-109. Epub 2010 Dec 23.
15. A novel BMPR2 gene mutation associated with exercise-induced pulmonary hypertension in septal defects. Moller T, etal., Scand Cardiovasc J. 2010 Dec;44(6):331-6. Epub 2010 Nov 11.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Onishi T, etal., Bone. 1998 Jun;22(6):605-12.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro. Ramos M, etal., Vascul Pharmacol. 2006 Jan;44(1):50-9. Epub 2005 Nov 3.
22. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
23. Targeted gene delivery of BMPR2 attenuates pulmonary hypertension. Reynolds AM, etal., Eur Respir J. 2012 Feb;39(2):329-43. doi: 10.1183/09031936.00187310. Epub 2011 Jul 7.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Expression of serine/threonine kinase receptors including the bone morphogenetic factor type II receptor in the developing and adult rat brain. Soderstrom S, etal., Cell Tissue Res. 1996 Nov;286(2):269-79.
29. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
30. Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation. Tian W, etal., Circulation. 2019 Aug 29. doi: 10.1161/CIRCULATIONAHA.119.040629.
31. Identities and frequencies of BMPR2 mutations in Chinese patients with idiopathic pulmonary arterial hypertension. Wang H, etal., Clin Genet. 2010 Feb;77(2):189-92. Epub 2009 Dec 10.
32. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. West J, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L744-55. Epub 2008 Aug 22.
33. Expression of transforming growth factor-beta superfamily receptors in developing rat eyes. Yamada H, etal., Jpn J Ophthalmol. 1999 Jul-Aug;43(4):290-4.
Additional References at PubMed
PMID:9442116   PMID:10772805   PMID:11502704   PMID:12045205   PMID:12117821   PMID:12441304   PMID:12819188   PMID:15542835   PMID:15657086   PMID:17114649   PMID:17472960   PMID:17992660  
PMID:18063682   PMID:18326817   PMID:18364108   PMID:18367643   PMID:18436533   PMID:18552156   PMID:19153267   PMID:19366699   PMID:19409885   PMID:19440953   PMID:19669850   PMID:19903896  
PMID:21619414   PMID:21976273   PMID:22664934   PMID:23079343   PMID:23446737   PMID:23610558   PMID:23676498   PMID:23780850   PMID:24052814   PMID:25187962   PMID:25461595   PMID:25468996  
PMID:26076038   PMID:26535780   PMID:26598555   PMID:26774823   PMID:27177866   PMID:27622883   PMID:28187784   PMID:29478969   PMID:30575923   PMID:30586714   PMID:30610955   PMID:31850803  
PMID:32521690   PMID:34857612   PMID:35037801   PMID:35848848  


Genomics

Comparative Map Data
Bmpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2961,192,718 - 61,307,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl961,190,566 - 61,301,809 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx969,692,580 - 69,800,850 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0974,808,556 - 74,916,402 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0973,126,851 - 73,235,117 (+)NCBIRnor_WKY
Rnor_6.0966,568,074 - 66,683,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0966,371,542 - 66,486,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4958,327,587 - 58,436,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1958,524,438 - 58,554,549 (+)NCBI
Celera958,627,253 - 58,735,336 (+)NCBICelera
Cytogenetic Map9q31NCBI
BMPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382202,376,327 - 202,567,749 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2202,376,327 - 202,567,751 (+)EnsemblGRCh38hg38GRCh38
GRCh372203,241,050 - 203,432,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,949,916 - 203,140,719 (+)NCBINCBI36Build 36hg18NCBI36
Build 342203,067,104 - 203,257,979NCBI
Celera2196,992,827 - 197,184,404 (+)NCBICelera
Cytogenetic Map2q33.1-q33.2NCBI
HuRef2195,088,272 - 195,279,312 (+)NCBIHuRef
CHM1_12203,247,530 - 203,439,226 (+)NCBICHM1_1
T2T-CHM13v2.02202,857,368 - 203,049,012 (+)NCBIT2T-CHM13v2.0
Bmpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,802,721 - 59,917,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,802,559 - 59,918,173 (+)EnsemblGRCm39 Ensembl
GRCm38159,764,279 - 59,878,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,763,400 - 59,879,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,821,481 - 59,927,703 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,709,183 - 59,815,405 (+)NCBIMGSCv36mm8
Celera160,279,442 - 60,385,822 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.44NCBI
Bmpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545712,235,780 - 12,316,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545712,235,780 - 12,315,680 (-)NCBIChiLan1.0ChiLan1.0
BMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B207,780,568 - 207,968,900 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,780,741 - 207,961,072 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B89,631,622 - 89,823,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BMPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13711,342,292 - 11,540,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3711,342,384 - 11,533,024 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3712,225,170 - 12,423,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03711,278,198 - 11,476,750 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3711,278,288 - 11,476,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13711,228,404 - 11,433,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03711,207,452 - 11,404,742 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03711,200,863 - 11,398,681 (+)NCBIUU_Cfam_GSD_1.0
Bmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303159,573,093 - 159,741,130 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367261,543,245 - 1,704,541 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367261,543,263 - 1,711,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,970,428 - 106,135,730 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,971,577 - 106,132,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215117,426,776 - 117,589,050 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11088,103,442 - 88,302,578 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1088,106,072 - 88,303,734 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040111,076,327 - 111,285,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476513,857,062 - 13,947,683 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476513,849,689 - 13,950,839 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmpr2
282 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:35
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000035238
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat

Markers in Region
RH134140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,301,504 - 61,301,688 (+)MAPPERmRatBN7.2
Rnor_6.0966,677,246 - 66,677,429NCBIRnor6.0
Rnor_5.0966,480,348 - 66,480,531UniSTSRnor5.0
RGSC_v3.4958,436,817 - 58,437,000UniSTSRGSC3.4
Celera958,736,088 - 58,736,271UniSTS
RH 3.4 Map9514.9UniSTS
Cytogenetic Map9q31UniSTS
BF403103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,306,281 - 61,306,435 (+)MAPPERmRatBN7.2
Rnor_6.0966,682,023 - 66,682,176NCBIRnor6.0
Rnor_5.0966,485,125 - 66,485,278UniSTSRnor5.0
RGSC_v3.4958,441,597 - 58,441,750UniSTSRGSC3.4
Celera958,740,884 - 58,741,037UniSTS
RH 3.4 Map9496.5UniSTS
Cytogenetic Map9q31UniSTS
AW536011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,306,490 - 61,306,649 (+)MAPPERmRatBN7.2
Rnor_6.0966,682,232 - 66,682,390NCBIRnor6.0
Rnor_5.0966,485,334 - 66,485,492UniSTSRnor5.0
RGSC_v3.4958,441,806 - 58,441,964UniSTSRGSC3.4
Celera958,741,093 - 58,741,251UniSTS
RH 3.4 Map9495.8UniSTS
Cytogenetic Map9q31UniSTS
RH141266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,300,764 - 61,300,945 (+)MAPPERmRatBN7.2
Rnor_6.0966,676,506 - 66,676,686NCBIRnor6.0
Rnor_5.0966,479,608 - 66,479,788UniSTSRnor5.0
RGSC_v3.4958,436,069 - 58,436,249UniSTSRGSC3.4
Celera958,735,348 - 58,735,528UniSTS
RH 3.4 Map9495.8UniSTS
Cytogenetic Map9q31UniSTS
AI009781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,304,981 - 61,305,197 (+)MAPPERmRatBN7.2
Rnor_6.0966,680,723 - 66,680,938NCBIRnor6.0
Rnor_5.0966,483,825 - 66,484,040UniSTSRnor5.0
RGSC_v3.4958,440,297 - 58,440,512UniSTSRGSC3.4
Celera958,739,565 - 58,739,780UniSTS
RH 3.4 Map9515.3UniSTS
Cytogenetic Map9q31UniSTS


Genetic Models
This gene Bmpr2 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 40 29 13 16 13 8 8 74 34 37 11 8
Low 3 3 28 28 3 28 3 1 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000035238   ⟹   ENSRNOP00000037011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl961,192,718 - 61,301,809 (+)Ensembl
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100349   ⟹   ENSRNOP00000095162
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl961,190,566 - 61,300,753 (+)Ensembl
RefSeq Acc Id: NM_080407   ⟹   NP_536332
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2961,192,718 - 61,300,753 (+)NCBI
Rnor_6.0966,568,074 - 66,676,494 (+)NCBI
Rnor_5.0966,371,542 - 66,486,121 (+)NCBI
RGSC_v3.4958,327,587 - 58,436,057 (+)RGD
Celera958,627,253 - 58,735,336 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244951   ⟹   XP_006245013
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2961,193,040 - 61,307,280 (+)NCBI
Rnor_6.0966,568,427 - 66,683,019 (+)NCBI
Rnor_5.0966,371,542 - 66,486,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244952   ⟹   XP_006245014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2961,193,040 - 61,307,280 (+)NCBI
Rnor_6.0966,568,427 - 66,683,019 (+)NCBI
Rnor_5.0966,371,542 - 66,486,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082970   ⟹   XP_038938898
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2961,243,173 - 61,307,280 (+)NCBI
Protein Sequences
Protein RefSeqs NP_536332 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245013 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245014 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938898 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB71720 (Get FASTA)   NCBI Sequence Viewer  
  EDL98946 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_536332   ⟸   NM_080407
- Peptide Label: precursor
- UniProtKB: F1LQC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245013   ⟸   XM_006244951
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AM39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245014   ⟸   XM_006244952
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000037011   ⟸   ENSRNOT00000035238
RefSeq Acc Id: XP_038938898   ⟸   XM_039082970
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000095162   ⟸   ENSRNOT00000100349
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQC5-F1-model_v2 AlphaFold F1LQC5 1-1038 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71082 AgrOrtholog
BioCyc Gene G2FUF-27392 BioCyc
Ensembl Genes ENSRNOG00000022196 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037011 ENTREZGENE
  ENSRNOP00000037011.5 UniProtKB/TrEMBL
  ENSRNOP00000095162 ENTREZGENE
  ENSRNOP00000095162.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035238 ENTREZGENE
  ENSRNOT00000035238.5 UniProtKB/TrEMBL
  ENSRNOT00000100349 ENTREZGENE
  ENSRNOT00000100349.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/TrEMBL
InterPro Activin_rcpt UniProtKB/TrEMBL
  BMPR2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
KEGG Report rno:140590 UniProtKB/TrEMBL
NCBI Gene 140590 ENTREZGENE
PANTHER PTHR23255 UniProtKB/TrEMBL
  PTHR23255:SF97 UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Bmpr2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF57302 UniProtKB/TrEMBL
UniProt A0A8I6AM39 ENTREZGENE, UniProtKB/TrEMBL
  F1LQC5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Bmpr2  bone morphogenetic protein receptor type 2  Bmpr2  bone morphogenetic protein receptor type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Bmpr2  bone morphogenetic protein receptor type II  Bmpr2  bone morphogenetic protein receptor, type II (serine/threonine kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Bmpr2  bone morphogenetic protein receptor, type II (serine/threonine kinase)  Bmpr2  bone morphogenic protein receptor, type II (serine/threonine kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Bmpr2  bone morphogenic protein receptor, type II (serine/threonine kinase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference