Gene: Erbb4 (erb-b2 receptor tyrosine kinase 4) Rattus norvegicus
Analyze
Symbol:
Erbb4
Name:
erb-b2 receptor tyrosine kinase 4
Description:
Predicted to have several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including animal organ development; positive regulation of GABAergic synaptic transmission; and positive regulation of glucose import. Localizes to several cellular components, including the caveola; postsynaptic density; and postsynaptic membrane. Used to study visual epilepsy. Biomarker of congestive heart failure; median neuropathy; and radiculopathy. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19 and colorectal cancer. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; calcium/calcium-mediated signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
c-erbB-4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene 4
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ERBB4 (erb-b2 receptor tyrosine kinase 4) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Erbb4 (erb-b2 receptor tyrosine kinase 4) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Erbb4 (erb-b2 receptor tyrosine kinase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ERBB4 (erb-b2 receptor tyrosine kinase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ERBB4 (erb-b2 receptor tyrosine kinase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Erbb4 (erb-b2 receptor tyrosine kinase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ERBB4 (erb-b2 receptor tyrosine kinase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ERBB4 (erb-b2 receptor tyrosine kinase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Erbb4 (erb-b2 receptor tyrosine kinase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
EGFR (epidermal growth factor receptor) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
ERBB2 (erb-b2 receptor tyrosine kinase 2) HGNC
OrthoMCL
Homo sapiens (human):
ERBB3 (erb-b2 receptor tyrosine kinase 3) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
ERBB4 (erb-b2 receptor tyrosine kinase 4)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Erbb4 (erb-b2 receptor tyrosine kinase 4)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:ch73-383l1.1
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PhylomeDB)
Danio rerio (zebrafish):
erbb4a (erb-b2 receptor tyrosine kinase 4a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
erbb4b (erb-b2 receptor tyrosine kinase 4b)
Alliance
DIOPT (OrthoFinder, PANTHER, TreeFam)
Drosophila melanogaster (fruit fly):
Egfr
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
let-23
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Allele / Splice:
Erbb4Tn(sb-T2/Bart3)2.208Mcwi
Genetic Models:
F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 75,021,790 - 76,178,936 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 75,021,790 - 75,528,644 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 9 74,804,287 - 75,310,350 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 66,843,898 - 67,967,970 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 66,990,879 - 68,114,952 (-) NCBI Celera 9 67,006,553 - 68,064,842 (-) NCBI Celera Cytogenetic Map 9 q32-q33 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
amyotrophic lateral sclerosis type 19 ISO RGD:732538 8554872 ClinVar Annotator: match by term: Amyotrophic lateral sclerosis 19 ClinVar amyotrophic lateral sclerosis type 19 ISO RGD:732538 8554872 ClinVar Annotator: match by OMIM:615515 ClinVar PMID:24119685 melanoma ISO RGD:732538 8554872 ClinVar Annotator: match by term: Malignant melanoma ClinVar PMID:19718025 NATURAL KILLER CELL ENTEROPATHY ISO RGD:732538 8554872 ClinVar Annotator: match by term: Natural killer cell enteropathy ClinVar Neurodevelopmental Disorders ISO RGD:732538 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 skin melanoma ISO RGD:732538 8554872 ClinVar Annotator: match by term: Cutaneous melanoma ClinVar PMID:19718025 trichorhinophalangeal syndrome type I ISO RGD:732538 8554872 ClinVar Annotator: match by term: Trichorhinophalangeal dysplasia type I ClinVar PMID:25741868
Imported Annotations - CTD
atrial fibrillation ISO RGD:732538 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29892015 , PMID:30061737 Gallbladder Neoplasms ISO RGD:732538 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24997986 melanoma ISO RGD:732538 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19718025 Skin Neoplasms ISO RGD:732538 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19718025 Imported Annotations - OMIM
amyotrophic lateral sclerosis type 19 ISO RGD:732538 7240710 OMIM
(25R)-cholest-5-ene-3beta,26-diol decreases expression ISO RGD:732538 6480464 27-hydroxycholesterol results in decreased expression of ERBB4 mRNA CTD PMID:17872378 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of ERBB4 mRNA CTD PMID:29097150 17beta-estradiol multiple interactions ISO RGD:732538 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERBB4 mRNA more ... CTD PMID:19619570 more ... 17beta-estradiol decreases expression ISO RGD:732538 6480464 Estradiol results in decreased expression of ERBB4 mRNA CTD PMID:17872378 more ... 2,3',4,4',5-Pentachlorobiphenyl decreases expression ISO RGD:1551357 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732538 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERBB4 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1551357 6480464 Tetrachlorodibenzodioxin results in increased expression of ERBB4 mRNA CTD PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551357 6480464 Tetrachlorodibenzodioxin affects the expression of ERBB4 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1551357 6480464 Tetrachlorodibenzodioxin results in decreased expression of ERBB4 mRNA CTD PMID:21889950 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:732538 6480464 Tetrachlorodibenzodioxin results in decreased expression of ERBB4 mRNA CTD PMID:19619570 26-hydroxycholesterol decreases expression ISO RGD:732538 6480464 27-hydroxycholesterol results in decreased expression of ERBB4 mRNA CTD PMID:17872378 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:732538 6480464 bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of ERBB4 protein] CTD PMID:9685416 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of ERBB4 mRNA CTD PMID:28522335 4-hydroxynon-2-enal decreases expression ISO RGD:732538 6480464 4-hydroxy-2-nonenal results in decreased expression of ERBB4 mRNA CTD PMID:12419474 5-fluorouracil multiple interactions ISO RGD:732538 6480464 ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ERBB4 mRNA CTD PMID:24780913 aflatoxin B1 decreases expression ISO RGD:732538 6480464 Aflatoxin B1 results in decreased expression of ERBB4 mRNA CTD PMID:22100608 aflatoxin B1 decreases methylation ISO RGD:732538 6480464 Aflatoxin B1 results in decreased methylation of ERBB4 gene, Aflatoxin B1 results in decreased methylation of ERBB4 intron CTD PMID:27153756 , PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:732538 6480464 Tretinoin results in increased expression of ERBB4 mRNA CTD PMID:21934132 all-trans-retinoic acid decreases expression ISO RGD:732538 6480464 Tretinoin results in decreased expression of ERBB4 mRNA CTD PMID:23724009 androgen antagonist multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ERBB4 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of ERBB4 mRNA CTD PMID:25607892 antirheumatic drug increases expression ISO RGD:732538 6480464 Antirheumatic Agents results in increased expression of ERBB4 mRNA CTD PMID:24449571 arsane affects expression ISO RGD:732538 6480464 Arsenic affects the expression of ERBB4 protein CTD PMID:24675094 arsane affects methylation ISO RGD:732538 6480464 Arsenic affects the methylation of ERBB4 gene CTD PMID:25304211 arsenic atom affects expression ISO RGD:732538 6480464 Arsenic affects the expression of ERBB4 protein CTD PMID:24675094 arsenic atom affects methylation ISO RGD:732538 6480464 Arsenic affects the methylation of ERBB4 gene CTD PMID:25304211 arsenous acid increases expression ISO RGD:732538 6480464 Arsenic Trioxide results in increased expression of ERBB4 mRNA CTD PMID:19769630 , PMID:20458559 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:732538 6480464 IL10 protein affects the reaction [Mustard Gas affects the expression of ERBB4 mRNA] CTD PMID:16173061 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ERBB4 mRNA more ... CTD PMID:25607892 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ERBB4 mRNA CTD PMID:30816183 bisphenol A decreases expression ISO RGD:1551357 6480464 bisphenol A results in decreased expression of ERBB4 mRNA CTD PMID:30951980 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of ERBB4 gene CTD PMID:28505145 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ERBB4 mRNA CTD PMID:29097150 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ERBB4 mRNA CTD PMID:25181051 bisphenol F decreases expression ISO RGD:1551357 6480464 bisphenol F results in decreased expression of ERBB4 mRNA CTD PMID:30951980 clozapine multiple interactions EXP 6480464 Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 copper(II) sulfate decreases expression ISO RGD:732538 6480464 Copper Sulfate results in decreased expression of ERBB4 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:732538 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of ERBB4 mRNA CTD PMID:19167446 cyclophosphamide multiple interactions ISO RGD:732538 6480464 ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 dexamethasone increases expression ISO RGD:732538 6480464 Dexamethasone results in increased expression of ERBB4 mRNA CTD PMID:16144937 dextran sulfate multiple interactions ISO RGD:1551357 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ERBB4 mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:732538 6480464 Arsenic Trioxide results in increased expression of ERBB4 mRNA CTD PMID:19769630 , PMID:20458559 dibutyl phthalate increases expression ISO RGD:1551357 6480464 Dibutyl Phthalate results in increased expression of ERBB4 mRNA CTD PMID:17361019 dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 doxorubicin multiple interactions ISO RGD:732538 6480464 ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 doxorubicin decreases expression ISO RGD:732538 6480464 Doxorubicin results in decreased expression of ERBB4 mRNA CTD PMID:29803840 enzacamene multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ERBB4 mRNA more ... CTD PMID:25607892 epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 ethanol increases expression ISO RGD:1551357 6480464 Ethanol results in increased expression of ERBB4 mRNA CTD PMID:30319688 etoposide decreases expression ISO RGD:732538 6480464 Etoposide results in decreased expression of ERBB4 mRNA CTD PMID:15228094 GW 4064 decreases expression ISO RGD:1551357 6480464 GW 4064 results in decreased expression of ERBB4 mRNA CTD PMID:26655953 haloperidol increases expression EXP 6480464 Haloperidol results in increased expression of ERBB4 protein CTD PMID:18184445 haloperidol multiple interactions EXP 6480464 Haloperidol results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 ibuprofen affects cleavage ISO RGD:732538 6480464 Ibuprofen affects the cleavage of ERBB4 protein CTD PMID:12777371 irinotecan increases expression ISO RGD:732538 6480464 Irinotecan metabolite results in increased expression of ERBB4 mRNA, Irinotecan results in increased expression of ERBB4 mRNA CTD PMID:15956246 ketamine decreases expression ISO RGD:1551357 6480464 Ketamine results in decreased expression of ERBB4 mRNA CTD PMID:20000043 linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 lipopolysaccharide multiple interactions ISO RGD:1551357 6480464 [Lipopolysaccharides co-treated with ERBB4] affects the expression of TNF protein more ... CTD PMID:21724861 methylmercury chloride decreases expression ISO RGD:732538 6480464 methylmercuric chloride results in decreased expression of ERBB4 mRNA CTD PMID:28001369 miconazole increases expression EXP 6480464 Miconazole results in increased expression of ERBB4 mRNA CTD PMID:22262564 miconazole decreases expression ISO RGD:1551357 6480464 Miconazole results in decreased expression of ERBB4 mRNA CTD PMID:27462272 mono(2-ethylhexyl) phthalate increases expression ISO RGD:1551357 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of ERBB4 mRNA CTD PMID:22401849 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:732538 6480464 Methylnitronitrosoguanidine results in increased expression of ERBB4 mRNA CTD PMID:12634122 nickel atom decreases expression ISO RGD:732538 6480464 Nickel results in decreased expression of ERBB4 mRNA CTD PMID:24768652 , PMID:25583101 ochratoxin A decreases expression ISO RGD:732538 6480464 ochratoxin A results in decreased expression of ERBB4 mRNA CTD PMID:22124623 paclitaxel multiple interactions ISO RGD:732538 6480464 ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ERBB4 mRNA CTD PMID:25607892 paracetamol affects expression ISO RGD:1551357 6480464 Acetaminophen affects the expression of ERBB4 mRNA CTD PMID:17562736 paracetamol multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ERBB4 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of ERBB4 mRNA CTD PMID:25607892 paraquat increases expression ISO RGD:1551357 6480464 Paraquat results in increased expression of ERBB4 mRNA CTD PMID:22563483 phenylarsine oxide multiple interactions ISO RGD:732538 6480464 oxophenylarsine results in increased cleavage of and results in increased phosphorylation of ERBB4 protein CTD PMID:9685416 phorbol 13-acetate 12-myristate increases cleavage ISO RGD:732538 6480464 Tetradecanoylphorbol Acetate results in increased cleavage of ERBB4 protein CTD PMID:9685416 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:732538 6480464 bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of ERBB4 protein] CTD PMID:9685416 ponatinib decreases activity ISO RGD:732538 6480464 ponatinib results in decreased activity of ERBB4 protein CTD PMID:19878872 prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 progesterone decreases expression ISO RGD:1551357 6480464 Progesterone results in decreased expression of ERBB4 mRNA CTD PMID:22238285 pyrrolidine dithiocarbamate multiple interactions EXP 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [pervanadate results in increased cleavage of ERBB4 protein] CTD PMID:9685416 pyrrolidine dithiocarbamate multiple interactions ISO RGD:732538 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [pervanadate results in increased cleavage of ERBB4 protein] CTD PMID:9685416 raloxifene multiple interactions ISO RGD:732538 6480464 Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of ERBB4 mRNA] CTD PMID:21185374 resveratrol multiple interactions ISO RGD:732538 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of ERBB4 mRNA CTD PMID:19167446 risperidone multiple interactions EXP 6480464 Risperidone results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 sodium arsenite multiple interactions ISO RGD:732538 6480464 [sodium arsenite affects the acetylation of H3-4 protein] which affects the methylation of ERBB4 promoter CTD PMID:18448484 succimer multiple interactions ISO RGD:732538 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ERBB4 mRNA CTD PMID:26378955 sulindac sulfide affects cleavage ISO RGD:732538 6480464 sulindac sulfide affects the cleavage of ERBB4 protein CTD PMID:12777371 sunitinib decreases expression ISO RGD:732538 6480464 Sunitinib results in decreased expression of ERBB4 mRNA CTD PMID:31533062 tert-butyl hydroperoxide decreases expression ISO RGD:732538 6480464 tert-Butylhydroperoxide results in decreased expression of ERBB4 mRNA CTD PMID:12419474 titanium dioxide multiple interactions ISO RGD:1551357 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ERBB4 mRNA CTD PMID:29950665 trichostatin A decreases expression ISO RGD:732538 6480464 trichostatin A results in decreased expression of ERBB4 mRNA CTD PMID:24935251 valproic acid increases expression ISO RGD:732538 6480464 Valproic Acid results in increased expression of ERBB4 mRNA CTD PMID:23179753 more ... valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of ERBB4 mRNA CTD PMID:29427782 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of ERBB4 mRNA CTD PMID:29427782 valproic acid decreases expression ISO RGD:732538 6480464 Valproic Acid results in decreased expression of ERBB4 mRNA CTD PMID:26272509 vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of ERBB4 mRNA CTD PMID:23555832 vorinostat decreases expression ISO RGD:732538 6480464 vorinostat results in decreased expression of ERBB4 mRNA CTD PMID:27188386
Biological Process cardiac muscle tissue regeneration ISO RGD:1551357 1624291 (MGI:MGI:4430666, PMID:19632177) RGD MGI:MGI:4430666 , PMID:19632177 cardiac muscle tissue regeneration ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cardiac muscle tissue regeneration IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell fate commitment ISO RGD:1551357 1624291 (MGI:MGI:2445853, PMID:12399441) RGD MGI:MGI:2445853 , PMID:12399441 cell fate commitment IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell migration ISO RGD:732538 1624291 (PMID:9135143) RGD PMID:9135143 cell migration ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to epidermal growth factor stimulus ISO RGD:1551357 1624291 (MGI:MGI:82360, PMID:8702723) RGD MGI:MGI:82360 , PMID:8702723 cellular response to epidermal growth factor stimulus IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 central nervous system morphogenesis ISO RGD:1551357 1624291 (MGI:MGI:1352955, PMID:10655590) RGD MGI:MGI:1352955 , PMID:10655590 central nervous system morphogenesis ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 central nervous system morphogenesis IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic pattern specification ISO RGD:1551357 1624291 (MGI:MGI:1352955, PMID:10655590) RGD MGI:MGI:1352955 , PMID:10655590 embryonic pattern specification ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 embryonic pattern specification IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 establishment of planar polarity involved in nephron morphogenesis ISO RGD:1551357 1624291 MGI:MGI:2445461 more ... RGD MGI:MGI:5305530 , PMID:22076439 heart development ISO RGD:1551357 1624291 MGI:MGI:1929607 (MGI:MGI:77495 , PMID:7477376) RGD MGI:MGI:77495 , PMID:7477376 heart development ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 heart development IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 lactation ISO RGD:732538 1624291 (PMID:15534001) RGD PMID:15534001 lactation ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 lactation IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 lactation IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 lactation ISO RGD:1551357 1624291 (MGI:MGI:5297795, PMID:10508857) RGD MGI:MGI:5297795 , PMID:10508857 mammary gland alveolus development ISO RGD:1551357 1624291 (MGI:MGI:5297795, PMID:10508857) RGD MGI:MGI:5297795 , PMID:10508857 mammary gland alveolus development ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mammary gland alveolus development IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 mammary gland development IEP 2290014 RGD mammary gland epithelial cell differentiation ISO RGD:1551357 1624291 (MGI:MGI:3689173, PMID:16837552) RGD MGI:MGI:3689173 , PMID:16837552 mammary gland epithelial cell differentiation ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mammary gland epithelial cell differentiation IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrial fragmentation involved in apoptotic process ISO RGD:732538 1624291 (PMID:16778220) RGD PMID:16778220 mitochondrial fragmentation involved in apoptotic process ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitochondrial fragmentation involved in apoptotic process IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 multicellular organism development IBA FB:FBgn0003733 more ... 13792537 PMID:21873635 GO_Central negative regulation of apoptotic process ISO RGD:1551357 1624291 (MGI:MGI:5317079, PMID:20943952) RGD MGI:MGI:5317079 , PMID:20943952 negative regulation of apoptotic process ISS UniProtKB:Q15303-1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of apoptotic process ISO RGD:732538 1624291 (PMID:10722704) RGD PMID:10722704 negative regulation of cell population proliferation ISO RGD:732538 1624291 (PMID:17120616) RGD PMID:17120616 negative regulation of cell population proliferation ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell population proliferation IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of muscle cell apoptotic process IMP 2289997 RGD negative regulation of neuron migration ISO RGD:1551357 1624291 MGI:MGI:1929607 (MGI:MGI:5320808 , PMID:22376909) RGD MGI:MGI:5320808 , PMID:22376909 negative regulation of neuron migration IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 nervous system development ISO RGD:1551357 1624291 MGI:MGI:1929607 (MGI:MGI:77495 , PMID:7477376) RGD MGI:MGI:77495 , PMID:7477376 nervous system development ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 neural crest cell migration ISO RGD:1551357 1624291 (MGI:MGI:1352955, PMID:10655590) RGD MGI:MGI:1352955 , PMID:10655590 neural crest cell migration ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 neural crest cell migration IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 odontogenesis NAS 727391 RGD odontogenesis IEP 727391 RGD olfactory bulb interneuron differentiation ISO RGD:1551357 1624291 (MGI:MGI:3527369, PMID:15543145) RGD MGI:MGI:3527369 , PMID:15543145 olfactory bulb interneuron differentiation ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 olfactory bulb interneuron differentiation IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-tyrosine autophosphorylation ISO RGD:1551357 1624291 (MGI:MGI:5317079, PMID:20943952) RGD MGI:MGI:5317079 , PMID:20943952 peptidyl-tyrosine phosphorylation ISO RGD:732538 1624291 (PMID:18334220) RGD PMID:18334220 peptidyl-tyrosine phosphorylation IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-tyrosine phosphorylation ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of apoptotic process ISO RGD:1551357 1624291 (MGI:MGI:5317079, PMID:20943952) RGD MGI:MGI:5317079 , PMID:20943952 positive regulation of cardiac muscle cell proliferation ISO RGD:1551357 1624291 (MGI:MGI:4430666, PMID:19632177) RGD MGI:MGI:4430666 , PMID:19632177 positive regulation of cardiac muscle cell proliferation ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of cardiac muscle cell proliferation IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell migration IMP 2289957 RGD positive regulation of cell population proliferation ISO RGD:1551357 1624291 (MGI:MGI:5317079, PMID:20943952) RGD MGI:MGI:5317079 , PMID:20943952 positive regulation of cell population proliferation ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of cell population proliferation IBA FB:FBgn0003731 more ... 13792537 PMID:21873635 GO_Central positive regulation of cell population proliferation ISO RGD:732538 1624291 (PMID:8617750), (PMID:9135143) RGD PMID:8617750 , PMID:9135143 positive regulation of cell population proliferation NOT ISO RGD:1551357 1624291 (MGI:MGI:5317079, PMID:20943952) RGD MGI:MGI:5317079 , PMID:20943952 positive regulation of epithelial cell proliferation IMP 2289988 RGD positive regulation of ERK1 and ERK2 cascade ISO RGD:732538 1624291 (PMID:10348342) RGD PMID:10348342 positive regulation of ERK1 and ERK2 cascade ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of ERK1 and ERK2 cascade IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of glucose import IMP 2289995 RGD positive regulation of kinase activity IBA PANTHER:PTN002356460 , UniProtKB:Q16832 13792537 PMID:21873635 GO_Central positive regulation of phosphatidylinositol 3-kinase activity ISO RGD:732538 1624291 (PMID:10353604) RGD PMID:10353604 positive regulation of phosphatidylinositol 3-kinase activity ISS UniProtKB:Q15303-1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of phosphatidylinositol 3-kinase activity NOT ISO RGD:732538 1624291 (PMID:10353604) RGD PMID:10353604 positive regulation of phosphatidylinositol 3-kinase signaling ISO RGD:1551357 1624291 MGI:MGI:96083 (MGI:MGI:3796800 , PMID:18458158) RGD MGI:MGI:3796800 , PMID:18458158 positive regulation of phosphatidylinositol 3-kinase signaling IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein localization to cell surface ISO RGD:1551357 1624291 MGI:MGI:96083 (MGI:MGI:3796800 , PMID:18458158) RGD MGI:MGI:3796800 , PMID:18458158 positive regulation of protein localization to cell surface IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of receptor signaling pathway via JAK-STAT ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of receptor signaling pathway via JAK-STAT ISO RGD:732538 1624291 (PMID:15534001) RGD PMID:15534001 positive regulation of receptor signaling pathway via JAK-STAT ISO RGD:1551357 1624291 (MGI:MGI:3689173, PMID:16837552) RGD MGI:MGI:3689173 , PMID:16837552 positive regulation of receptor signaling pathway via JAK-STAT ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of synaptic transmission, GABAergic IMP 2289989 RGD positive regulation of transcription, DNA-templated ISO RGD:732538 1624291 (PMID:15534001) RGD PMID:15534001 positive regulation of transcription, DNA-templated ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription, DNA-templated ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription, DNA-templated IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription, DNA-templated IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription, DNA-templated ISO RGD:1551357 1624291 (MGI:MGI:3689173, PMID:16837552) RGD MGI:MGI:3689173 , PMID:16837552 positive regulation of tyrosine phosphorylation of STAT protein ISO RGD:1551357 1624291 (MGI:MGI:3689173 more ... RGD MGI:MGI:3689173 more ... positive regulation of tyrosine phosphorylation of STAT protein ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of tyrosine phosphorylation of STAT protein ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of tyrosine phosphorylation of STAT protein IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of tyrosine phosphorylation of STAT protein IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of tyrosine phosphorylation of STAT protein ISO RGD:732538 1624291 (PMID:16837552) RGD PMID:16837552 protein autophosphorylation ISO RGD:732538 1624291 (PMID:18334220) RGD PMID:18334220 protein autophosphorylation IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein autophosphorylation ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of cell migration ISO RGD:1551357 1624291 (MGI:MGI:3527369, PMID:15543145) RGD MGI:MGI:3527369 , PMID:15543145 regulation of cell migration ISS UniProtKB:Q61527 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to drug IEP 2289940 RGD response to hydrogen peroxide IEP 2289996 RGD response to progesterone IEP 2289991 RGD signal transduction ISO RGD:732538 1624291 (PMID:10572067) RGD PMID:10572067 surfactant homeostasis IMP 2289988 RGD synapse assembly IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 synapse assembly ISO RGD:1551357 1624291 (MGI:MGI:4443139, PMID:20393464) RGD MGI:MGI:4443139 , PMID:20393464 synapse maturation IMP 2289990 RGD telencephalon development IEP 2290000 RGD transmembrane receptor protein tyrosine kinase signaling pathway TAS 629530 RGD transmembrane receptor protein tyrosine kinase signaling pathway IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central transmembrane receptor protein tyrosine kinase signaling pathway ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transmembrane receptor protein tyrosine kinase signaling pathway IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 transmembrane receptor protein tyrosine kinase signaling pathway ISO RGD:732538 1624291 (PMID:10353604), (PMID:18334220) RGD PMID:10353604 , PMID:18334220 Cellular Component basal plasma membrane IBA PANTHER:PTN000698827 , RGD:2561 13792537 PMID:21873635 GO_Central basolateral plasma membrane ISO RGD:732538 1624291 (PMID:12646923) RGD PMID:12646923 basolateral plasma membrane IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 caveola IDA 2290016 RGD cytoplasm IDA 2289956 RGD cytoplasm ISO RGD:8930882 1624291 RGD RGD:11556218 GABA-ergic synapse IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 GABA-ergic synapse ISO RGD:1551357 1624291 (MGI:MGI:4443139, PMID:20393464) RGD MGI:MGI:4443139 , PMID:20393464 glutamatergic synapse IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse ISO RGD:1551357 1624291 (MGI:MGI:4443139, PMID:20393464) RGD MGI:MGI:4443139 , PMID:20393464 integral component of plasma membrane IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central integral component of postsynaptic density membrane IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of postsynaptic density membrane ISO RGD:1551357 1624291 (MGI:MGI:4443139, PMID:20393464) RGD MGI:MGI:4443139 , PMID:20393464 integral component of presynaptic membrane IEA UniProtKB:Q61527 , ensembl:ENSMUSP000001141231600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of presynaptic membrane ISO RGD:1551357 1624291 (MGI:MGI:4443139, PMID:20393464) RGD MGI:MGI:4443139 , PMID:20393464 membrane raft IDA 2289998 RGD mitochondrion ISO RGD:732538 1624291 (PMID:16778220) RGD PMID:16778220 mitochondrion IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 2289954 RGD nucleus IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:732538 1624291 (PMID:15534001) RGD PMID:15534001 nucleus ISO RGD:8930882 1624291 RGD RGD:11556218 plasma membrane TAS 629530 RGD plasma membrane IDA 2289956 RGD postsynaptic density IDA 2289998 RGD postsynaptic membrane IDA 13601992 PMID:15219672 UniProt receptor complex ISO RGD:732538 1624291 (PMID:23382219) RGD PMID:23382219 receptor complex IBA FB:FBgn0015380 more ... 13792537 PMID:21873635 GO_Central receptor complex IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 epidermal growth factor receptor binding ISO RGD:732538 1624291 UniProtKB:P00533 (PMID:8617750) RGD PMID:8617750 epidermal growth factor receptor binding IBA PANTHER:PTN000698903 , UniProtKB:Q15303 13792537 PMID:21873635 GO_Central epidermal growth factor receptor binding IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI RGD:3612 5688294 RGD protein binding IPI UniProtKB:A0A0G2KB67 13601992 PMID:15219672 UniProt protein binding ISO RGD:1551357 1624291 UniProtKB:Q9NZC7 (MGI:MGI:5294301 , PMID:16061658) RGD MGI:MGI:5294301 , PMID:16061658 protein binding ISO RGD:732538 1624291 UniProtKB:O00308 more ... RGD PMID:10572067 more ... protein binding IPI RGD:3153 9686424 RGD protein homodimerization activity ISO RGD:732538 1624291 UniProtKB:Q15303 (PMID:18334220) RGD PMID:18334220 protein homodimerization activity IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein tyrosine kinase activity ISO RGD:732538 1624291 (PMID:18334220) RGD PMID:18334220 protein tyrosine kinase activity ISO RGD:1551357 1624291 (MGI:MGI:5317079, PMID:20943952) RGD MGI:MGI:5317079 , PMID:20943952 transcription regulatory region DNA binding ISO RGD:732538 1624291 (PMID:15534001) RGD PMID:15534001 transcription regulatory region DNA binding IEA UniProtKB:Q15303 , ensembl:ENSP000003422351600115 GO_REF:0000107 Ensembl GO_REF:0000107 transmembrane receptor protein tyrosine kinase activity ISO RGD:732538 1624291 (PMID:18334220) RGD PMID:18334220 transmembrane receptor protein tyrosine kinase activity IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central transmembrane receptor protein tyrosine kinase activity ISS UniProtKB:Q15303 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transmembrane receptor protein tyrosine kinase activity IEA EC:2.7.10.1 1600115 GO_REF:0000003 UniProt GO_REF:0000003
Gene-Chemical Interaction Annotations
