Gene: Erbb4 (erb-b2 receptor tyrosine kinase 4) Rattus norvegicus
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Symbol: Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); protein homodimerization activity (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN mammary gland development; negative regulation of muscle cell apoptotic process; odontogenesis; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; calcium/calcium-mediated signaling pathway; endocytosis pathway; ASSOCIATED WITH congestive heart failure; Diabetic Cardiomyopathies; median neuropathy; FOUND IN caveola; cytoplasm; membrane raft; INTERACTS WITH 17alpha-ethynylestradiol; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil
AGR Description: Predicted to have several functions, including epidermal growth factor receptor binding activity, protein homodimerization activity, and transcription regulatory region DNA binding activity; involved in several processes, including animal organ development, negative regulation of muscle cell apoptotic process, and nervous system development; localizes to several cellular components, including the caveola, cytoplasm, and nucleus; used to study visual epilepsy; biomarker of congestive heart failure, median neuropathy, and radiculopathy; orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4).
Merged Description: Predicted to have several functions, including epidermal growth factor receptor binding activity, protein homodimerization activity, and transcription regulatory region DNA binding activity; involved in several processes, including animal organ development, negative regulation of muscle cell apoptotic process, and nervous system development; localizes to several cellular components, including the caveola, cytoplasm, and nucleus; used to study visual epilepsy; biomarker of congestive heart failure, median neuropathy, and radiculopathy; orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; calcium/calcium-mediated signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-erbB-4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene 4
Orthologs:
Homo sapiens (human) : ERBB4 (erb-b2 receptor tyrosine kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Erbb4 (erb-b2 receptor tyrosine kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb4 (erb-b2 receptor tyrosine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Canis lupus familiaris (dog) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb4 (erb-b2 receptor tyrosine kinase 4)
Sus scrofa (pig) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
more info ...
Allele / Splice: Erbb4Tn(sb-T2/Bart3)2.208Mcwi  
Genetic Models: F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0975,021,790 - 76,178,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0974,804,287 - 75,310,350 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4966,843,898 - 67,967,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1966,990,879 - 68,114,952 (-)NCBI
Celera967,006,553 - 68,064,842 (-)NCBICelera
Cytogenetic Map9q32-q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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QTLs in Region (Rnor_6.0)
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Sequence

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Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
  
More on Erbb4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620486
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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