Gene: Ihh (Indian hedgehog signaling molecule) Rattus norvegicus
Analyze
Symbol:
Ihh
Name:
Indian hedgehog signaling molecule
RGD ID:
620021
Description:
Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including liver regeneration; maternal process involved in female pregnancy; and response to estradiol. Predicted to localize to extracellular matrix; extracellular space; and plasma membrane. Biomarker of osteoarthritis. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 1,2-dimethylhydrazine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Indian hedgehog; indian hedgehog homolog; Indian hedgehog homolog, (Drosophila)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
IHH (Indian hedgehog signaling molecule) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Ihh (Indian hedgehog) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ihh (Indian hedgehog signaling molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
IHH (Indian hedgehog signaling molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
IHH (Indian hedgehog signaling molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ihh (Indian hedgehog signaling molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
IHH (Indian hedgehog signaling molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
IHH (Indian hedgehog signaling molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ihh (Indian hedgehog signaling molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SHH (sonic hedgehog signaling molecule) HGNC
OrthoDB
Homo sapiens (human):
DHH (desert hedgehog signaling molecule) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
IHH (Indian hedgehog signaling molecule)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Mus musculus (house mouse):
Ihh (Indian hedgehog)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Danio rerio (zebrafish):
ihhb (Indian hedgehog signaling molecule b)
Alliance
DIOPT (Hieranoid|OMA|OrthoFinder|PANTHER|TreeFam)
Drosophila melanogaster (fruit fly):
hh
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Caenorhabditis elegans (roundworm):
grd-2
Alliance
DIOPT (Ensembl Compara|OrthoInspector|TreeFam)
Caenorhabditis elegans (roundworm):
grd-11
Alliance
DIOPT (Ensembl Compara|OrthoInspector|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 82,208,223 - 82,214,440 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 82,208,223 - 82,214,440 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 9 81,977,484 - 81,983,701 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 74,287,115 - 74,293,332 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 74,435,304 - 74,439,783 (-) NCBI Celera 9 74,074,990 - 74,081,207 (-) NCBI Celera Cytogenetic Map 9 q33 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
acrocapitofemoral dysplasia ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Acrocapitofemoral dysplasia ClinVar acrocapitofemoral dysplasia ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:607778 ClinVar PMID:12632327 brachydactyly ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Brachydactyly ClinVar brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Type A1 brachydactyly ClinVar PMID:28492532 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Type A1 brachydactyly ClinVar brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Type A1 brachydactyly ClinVar PMID:25741868 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Type A1 brachydactyly ClinVar PMID:11455389 , PMID:25741868 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:12384778 more ... brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:11455389 , PMID:19277064 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:19277064 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:16871364 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:11455389 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:11455389 , PMID:12525541 brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:11455389 more ... brachydactyly type A1 ISO RGD:1350368 8554872 ClinVar Annotator: match by OMIM:112500 ClinVar PMID:18629882 Cardiovascular Abnormalities ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Abnormality of cardiovascular system morphology ClinVar PMID:30311386 Hirschsprung Disease 1 ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Hirschsprung disease 1 ClinVar myofibrillar myopathy 1 ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Myofibrillar myopathy 1 ClinVar PMID:28492532 Neurodevelopmental Disorders ISO RGD:1350368 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
endometriosis ISO RGD:1350368 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21063030 gastrointestinal stromal tumor ISO RGD:1350368 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27793025 ovarian cyst ISO RGD:1350368 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21239663 Imported Annotations - MGI
annular pancreas ISS RGD:1552237 13592920 OMIM:167750 MouseDO Hirschsprung's disease ISS RGD:1552237 13592920 OMIM:142623 more ... MouseDO Imported Annotations - OMIM
acrocapitofemoral dysplasia ISO RGD:1350368 7240710 OMIM brachydactyly type A1 ISO RGD:1350368 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of IHH mRNA] CTD PMID:31150632 (2,4,5-trichlorophenoxy)acetic acid increases expression ISO RGD:1552237 6480464 2 more ... CTD PMID:18579281 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of IHH mRNA CTD PMID:27782041 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in decreased expression of IHH mRNA CTD PMID:27840820 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of IHH mRNA CTD PMID:17109907 17alpha-ethynylestradiol multiple interactions EXP 6480464 fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of IHH mRNA] CTD PMID:17109907 17beta-estradiol multiple interactions ISO RGD:1552237 6480464 [Estradiol co-treated with Progesterone co-treated with Corn Oil] results in increased expression of IHH mRNA more ... CTD PMID:22958837 more ... 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of IHH mRNA CTD PMID:26945725 17beta-estradiol multiple interactions EXP 6480464 Estradiol promotes the reaction [Plant Preparations results in decreased expression of IHH mRNA] CTD PMID:26945725 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of IHH mRNA CTD PMID:20232216 17beta-estradiol multiple interactions ISO RGD:1350368 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of IHH mRNA CTD PMID:20660070 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of IHH mRNA CTD PMID:32109520 2,3,7,8-Tetrachlorodibenzofuran increases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of IHH mRNA CTD PMID:21346803 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of IHH mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of IHH mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:32119087 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of IHH mRNA CTD PMID:21346803 4-hydroxyphenyl retinamide increases expression ISO RGD:1552237 6480464 Fenretinide results in increased expression of IHH mRNA CTD PMID:28973697 5-fluorouracil decreases expression ISO RGD:1350368 6480464 Fluorouracil results in decreased expression of IHH mRNA, Fluorouracil results in decreased expression of IHH protein CTD PMID:25190613 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of IHH mRNA CTD PMID:24780913 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of IHH mRNA CTD PMID:28959563 acrylamide increases expression ISO RGD:1552237 6480464 Acrylamide results in increased expression of IHH mRNA CTD PMID:30807115 aldrin increases expression ISO RGD:1552237 6480464 Aldrin results in increased expression of IHH mRNA CTD PMID:18579281 all-trans-retinoic acid decreases expression ISO RGD:1552237 6480464 Tretinoin results in decreased expression of IHH mRNA CTD PMID:16350840 all-trans-retinoic acid multiple interactions ISO RGD:1350368 6480464 [4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of IHH mRNA] CTD PMID:31711903 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of IHH mRNA CTD PMID:16483693 arsane multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein CTD PMID:23604592 arsenic atom multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein CTD PMID:23604592 arsenite(3-) increases methylation ISO RGD:1350368 6480464 arsenite results in increased methylation of IHH promoter CTD PMID:23974009 arsenous acid increases expression ISO RGD:1552237 6480464 Arsenic Trioxide results in increased expression of IHH mRNA CTD PMID:29767511 benzo[a]pyrene increases expression ISO RGD:1552237 6480464 Benzo(a)pyrene results in increased expression of IHH mRNA CTD PMID:22228805 benzo[a]pyrene increases methylation ISO RGD:1350368 6480464 Benzo(a)pyrene results in increased methylation of IHH exon, Benzo(a)pyrene results in increased methylation of IHH promoter CTD PMID:27901495 benzo[b]fluoranthene increases expression ISO RGD:1552237 6480464 benzo(b)fluoranthene results in increased expression of IHH mRNA CTD PMID:26377693 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IHH mRNA CTD PMID:18164116 bis(2-chloroethyl) sulfide increases expression ISO RGD:1552237 6480464 Mustard Gas results in increased expression of IHH mRNA CTD PMID:15674843 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IHH mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of IHH mRNA CTD PMID:30816183 bromobenzene decreases expression EXP 6480464 bromobenzene results in decreased expression of IHH mRNA CTD PMID:32479839 cadmium atom multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein CTD PMID:23604592 cadmium dichloride multiple interactions EXP 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of IHH protein CTD PMID:23604592 CHIR 99021 multiple interactions ISO RGD:1350368 6480464 4-(5-benzo(1 more ... CTD PMID:31711903 CHIR 99021 increases expression ISO RGD:1350368 6480464 Chir 99021 results in increased expression of IHH mRNA CTD PMID:31711903 chloroethene increases expression ISO RGD:1552237 6480464 Vinyl Chloride results in increased expression of IHH mRNA CTD PMID:18579281 choline multiple interactions ISO RGD:1552237 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IHH mRNA CTD PMID:20938992 chromium(6+) multiple interactions ISO RGD:1552237 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of IHH mRNA CTD PMID:31756458 copper atom increases expression EXP 6480464 Copper results in increased expression of IHH mRNA CTD PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of IHH mRNA CTD PMID:30556269 copper(II) sulfate increases expression ISO RGD:1552237 6480464 Copper Sulfate results in increased expression of IHH mRNA CTD PMID:18579281 Deguelin increases expression ISO RGD:1350368 6480464 deguelin results in increased expression of IHH mRNA CTD PMID:19861542 dexamethasone increases expression ISO RGD:1350368 6480464 Dexamethasone results in increased expression of IHH mRNA CTD PMID:27608943 dextran sulfate multiple interactions ISO RGD:1552237 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IHH mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:1552237 6480464 Arsenic Trioxide results in increased expression of IHH mRNA CTD PMID:29767511 dichloroacetic acid decreases expression ISO RGD:1552237 6480464 Dichloroacetic Acid results in decreased expression of IHH mRNA CTD PMID:28962523 diuron increases expression EXP 6480464 Diuron results in increased expression of IHH mRNA CTD PMID:25152437 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of IHH mRNA CTD PMID:29391264 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of IHH mRNA CTD PMID:23962444 folic acid multiple interactions ISO RGD:1552237 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IHH mRNA CTD PMID:20938992 fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of IHH mRNA] CTD PMID:17109907 fulvestrant decreases expression EXP 6480464 fulvestrant results in decreased expression of IHH mRNA CTD PMID:20232216 genistein affects expression ISO RGD:1552237 6480464 Genistein affects the expression of IHH mRNA CTD PMID:21810550 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of IHH mRNA CTD PMID:24915197 L-ascorbic acid increases expression ISO RGD:1552237 6480464 Ascorbic Acid results in increased expression of IHH mRNA CTD PMID:20530736 L-methionine multiple interactions ISO RGD:1552237 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IHH mRNA CTD PMID:20938992 lead diacetate multiple interactions EXP 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of IHH protein CTD PMID:23604592 lead(0) multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein CTD PMID:23604592 lead(2+) multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein CTD PMID:23604592 methotrexate affects expression ISO RGD:1552237 6480464 Methotrexate affects the expression of IHH mRNA CTD PMID:18502557 Monobutylphthalate increases expression EXP 6480464 monobutyl phthalate results in increased expression of IHH mRNA CTD PMID:29162477 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IHH mRNA CTD PMID:18164116 N-nitrosodiethylamine multiple interactions ISO RGD:1552237 6480464 [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of IHH gene CTD PMID:23968726 nicotine increases expression EXP 6480464 Nicotine results in increased expression of IHH mRNA CTD PMID:27782041 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of IHH mRNA CTD PMID:23358140 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of IHH mRNA CTD PMID:23665939 paracetamol affects expression ISO RGD:1552237 6480464 Acetaminophen affects the expression of IHH mRNA CTD PMID:17562736 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of IHH mRNA CTD PMID:30723492 , PMID:32479839 phenobarbital multiple interactions ISO RGD:1552237 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IHH mRNA], NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of IHH mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:1552237 6480464 Phenobarbital affects the expression of IHH mRNA CTD PMID:23091169 phenobarbital increases expression ISO RGD:1552237 6480464 Phenobarbital results in increased expression of IHH mRNA CTD PMID:19482888 phenytoin increases expression ISO RGD:1552237 6480464 Phenytoin results in increased expression of IHH mRNA CTD PMID:16141649 piperonyl butoxide multiple interactions ISO RGD:1552237 6480464 [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of IHH gene CTD PMID:23968726 pirinixic acid decreases expression ISO RGD:1552237 6480464 pirinixic acid results in decreased expression of IHH mRNA CTD PMID:17950772 potassium dichromate decreases expression ISO RGD:1552237 6480464 Potassium Dichromate results in decreased expression of IHH mRNA CTD PMID:23608068 potassium dichromate multiple interactions ISO RGD:1552237 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of IHH mRNA CTD PMID:31756458 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:1552237 6480464 Pregnenolone Carbonitrile results in decreased expression of IHH mRNA CTD PMID:28903501 progesterone multiple interactions ISO RGD:1552237 6480464 [Estradiol co-treated with Progesterone co-treated with Corn Oil] results in increased expression of IHH mRNA more ... CTD PMID:22958837 more ... progesterone multiple interactions ISO RGD:1350368 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of IHH mRNA CTD PMID:20660070 progesterone increases expression ISO RGD:1552237 6480464 Progesterone results in increased expression of IHH, Progesterone results in increased expression of IHH mRNA CTD PMID:20232216 , PMID:22238285 progesterone affects expression ISO RGD:1552237 6480464 Progesterone affects the expression of IHH CTD PMID:16794005 Ptaquiloside decreases expression ISO RGD:1552237 6480464 ptaquiloside results in decreased expression of IHH mRNA CTD PMID:23274088 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of IHH protein CTD PMID:28431985 resveratrol decreases expression ISO RGD:1350368 6480464 resveratrol results in decreased expression of IHH mRNA, resveratrol results in decreased expression of IHH protein CTD PMID:25190613 SB 431542 multiple interactions ISO RGD:1350368 6480464 4-(5-benzo(1 more ... CTD PMID:31711903 sodium arsenite multiple interactions EXP 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of IHH protein CTD PMID:23604592 sodium fluoride increases expression ISO RGD:1552237 6480464 Sodium Fluoride results in increased expression of IHH mRNA CTD PMID:27862939 succimer multiple interactions ISO RGD:1552237 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IHH mRNA CTD PMID:26378955 tetrachloroethene decreases expression ISO RGD:1552237 6480464 Tetrachloroethylene results in decreased expression of IHH mRNA CTD PMID:28973375 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of IHH mRNA CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:1552237 6480464 Carbon Tetrachloride results in increased expression of IHH protein CTD PMID:31816328 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of IHH mRNA] CTD PMID:31150632 theophylline increases expression ISO RGD:1350368 6480464 Theophylline results in increased expression of IHH mRNA CTD PMID:16083514 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of IHH mRNA CTD PMID:30012374 titanium dioxide multiple interactions ISO RGD:1552237 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IHH mRNA CTD PMID:29950665 tributylstannane increases expression ISO RGD:1552237 6480464 tributyltin results in increased expression of IHH mRNA CTD PMID:31939706 trichloroethene decreases expression ISO RGD:1552237 6480464 Trichloroethylene results in decreased expression of IHH mRNA CTD PMID:25549359 , PMID:27618143 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of IHH mRNA CTD PMID:27618143 trichloroethene increases methylation ISO RGD:1552237 6480464 Trichloroethylene results in increased methylation of IHH gene, Trichloroethylene results in increased methylation of IHH promoter CTD PMID:25549359 , PMID:27618143 urethane increases expression ISO RGD:1350368 6480464 Urethane results in increased expression of IHH mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1552237 6480464 Valproic Acid affects the expression of IHH mRNA CTD PMID:17963808 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of IHH mRNA CTD PMID:23034163
Biological Process bone resorption ISO RGD:1552237 1624291 (MGI:MGI:1335697, PMID:10208865) RGD MGI:MGI:1335697 , PMID:10208865 branching involved in blood vessel morphogenesis ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3574706 , PMID:15689378) RGD MGI:MGI:3574706 , PMID:15689378 camera-type eye development ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 camera-type eye photoreceptor cell fate commitment ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 cartilage development ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3695832 , PMID:17191253) RGD MGI:MGI:3695832 , PMID:17191253 cartilage development ISO RGD:1350368 1624291 (PMID:17889828) RGD PMID:17889828 cell differentiation ISO RGD:1552237 1624291 (MGI:MGI:3583389, PMID:15951842) RGD MGI:MGI:3583389 , PMID:15951842 cell fate specification ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 cell fate specification IBA MGI:MGI:96533 more ... 13792537 PMID:21873635 GO_Central cell maturation ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3511731 , PMID:15576404) RGD MGI:MGI:3511731 , PMID:15576404 cell-cell signaling IEA InterPro:IPR000320 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 chondrocyte differentiation involved in endochondral bone morphogenesis ISO RGD:1552237 1624291 (MGI:MGI:5698232, PMID:25639508) RGD MGI:MGI:5698232 , PMID:25639508 chondrocyte proliferation ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:4999722 , PMID:16935278) RGD MGI:MGI:4999722 , PMID:16935278 embryonic camera-type eye morphogenesis ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 embryonic digestive tract morphogenesis ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:1858523 , PMID:10821773) RGD MGI:MGI:1858523 , PMID:10821773 embryonic digit morphogenesis ISO RGD:1552237 1624291 MGI:MGI:1347521 more ... RGD MGI:MGI:4822496 , PMID:20660756 embryonic digit morphogenesis ISO RGD:1350368 1624291 (PMID:17889828) RGD PMID:17889828 embryonic pattern specification ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 embryonic skeletal joint development ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3695832 , PMID:17191253) RGD MGI:MGI:3695832 , PMID:17191253 epithelial cell morphogenesis ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 epithelial cell-cell adhesion ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 head morphogenesis ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:4999722 , PMID:16935278) RGD MGI:MGI:4999722 , PMID:16935278 heart looping ISO RGD:1552237 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 in utero embryonic development ISO RGD:1552237 1624291 (MGI:MGI:3766861, PMID:17881493) RGD MGI:MGI:3766861 , PMID:17881493 intein-mediated protein splicing IEA InterPro:IPR006141 1600115 GO_REF:0000002 InterPro GO_REF:0000002 liver regeneration IEP 12911223 RGD maternal process involved in female pregnancy IEP 2306316 RGD morphogenesis of a branching structure ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:1926239 , PMID:11044404) RGD MGI:MGI:1926239 , PMID:11044404 multicellular organism growth ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:1858523 , PMID:10821773) RGD MGI:MGI:1858523 , PMID:10821773 negative regulation of alpha-beta T cell differentiation ISO RGD:1552237 1624291 (MGI:MGI:3836494, PMID:19109233) RGD MGI:MGI:3836494 , PMID:19109233 negative regulation of apoptotic process IMP 1600038 RGD negative regulation of cell differentiation ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3608261 , PMID:16284117) RGD MGI:MGI:3608261 , PMID:16284117 negative regulation of eye pigmentation ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807630 , PMID:17464332) RGD MGI:MGI:3807630 , PMID:17464332 negative regulation of immature T cell proliferation in thymus ISO RGD:1552237 1624291 (MGI:MGI:3836494, PMID:19109233) RGD MGI:MGI:3836494 , PMID:19109233 negative regulation of T cell differentiation in thymus ISO RGD:1552237 1624291 (MGI:MGI:3836494, PMID:19109233) RGD MGI:MGI:3836494 , PMID:19109233 neuron development ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:1858523 , PMID:10821773) RGD MGI:MGI:1858523 , PMID:10821773 ossification ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:2154465 , PMID:11748145) RGD MGI:MGI:2154465 , PMID:11748145 osteoblast differentiation ISO RGD:1552237 1624291 MGI:MGI:1928765 more ... RGD MGI:MGI:3036410 more ... pancreas development ISO RGD:1552237 1624291 MGI:MGI:1934258 more ... RGD MGI:MGI:1858523 more ... pattern specification process ISO RGD:1552237 1624291 MGI:MGI:1857644 (MGI:MGI:1277795 , PMID:9671585) RGD MGI:MGI:1277795 , PMID:9671585 positive regulation of alpha-beta T cell differentiation ISO RGD:1552237 1624291 (MGI:MGI:3836494, PMID:19109233) RGD MGI:MGI:3836494 , PMID:19109233 positive regulation of cell population proliferation ISO RGD:1552237 1624291 MGI:MGI:1934258 more ... RGD MGI:MGI:3608261 more ... positive regulation of collagen biosynthetic process ISO RGD:1552237 1624291 (MGI:MGI:1335697, PMID:10208865) RGD MGI:MGI:1335697 , PMID:10208865 positive regulation of epithelial cell proliferation IMP 1600038 RGD positive regulation of mesenchymal cell proliferation ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 positive regulation of smoothened signaling pathway ISO RGD:1552237 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 positive regulation of T cell differentiation in thymus ISO RGD:1552237 1624291 (MGI:MGI:3836494, PMID:19109233) RGD MGI:MGI:3836494 , PMID:19109233 positive regulation of transcription by RNA polymerase II ISO RGD:1552237 1624291 MGI:MGI:98297 (MGI:MGI:3766861 , PMID:17881493) RGD MGI:MGI:3766861 , PMID:17881493 protein autoprocessing IEA InterPro:IPR001767 1600115 GO_REF:0000002 InterPro GO_REF:0000002 proteoglycan metabolic process ISO RGD:1552237 1624291 MGI:MGI:88177 (MGI:MGI:4999722 , PMID:16935278) RGD MGI:MGI:4999722 , PMID:16935278 regulation of gene expression IBA MGI:MGI:96533 more ... 13792537 PMID:21873635 GO_Central regulation of growth ISO RGD:1552237 1624291 MGI:MGI:104903 (MGI:MGI:4430672 , PMID:19590577) RGD MGI:MGI:4430672 , PMID:19590577 response to estradiol IEP 1601055 RGD response to mechanical stimulus IEP 12911206 RGD retinal pigment epithelium development ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3807419 , PMID:18582859) RGD MGI:MGI:3807419 , PMID:18582859 skeletal system development ISO RGD:1552237 1624291 MGI:MGI:2176264 more ... RGD MGI:MGI:3608181 , PMID:16278811 skeletal system development ISO RGD:1350368 1624291 (PMID:21537345) RGD PMID:21537345 smooth muscle tissue development ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:1858523 , PMID:10821773) RGD MGI:MGI:1858523 , PMID:10821773 smoothened signaling pathway ISO RGD:1350368 1624291 (PMID:21537345) RGD PMID:21537345 smoothened signaling pathway IBA FB:FBgn0004644 more ... 13792537 PMID:21873635 GO_Central smoothened signaling pathway ISO RGD:1552237 1624291 MGI:MGI:104903 (MGI:MGI:4430672 more ... RGD MGI:MGI:4430672 more ... somite development ISO RGD:1552237 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 vasculature development ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3766861 , PMID:17881493) RGD MGI:MGI:3766861 , PMID:17881493 vitelline membrane formation ISO RGD:1552237 1624291 MGI:MGI:1934258 (MGI:MGI:3766861 , PMID:17881493) RGD MGI:MGI:3766861 , PMID:17881493 Cellular Component cellular_component ND 1598407 07/2017: no relevant rat data RGD extracellular matrix ISO RGD:1552237 1624291 (MGI:MGI:2149274, PMID:11476578) RGD MGI:MGI:2149274 , PMID:11476578 extracellular space IBA FB:FBgn0004644 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISO RGD:1350368 1624291 (PMID:21537345) RGD PMID:21537345 Molecular Function calcium ion binding ISO RGD:1350368 1624291 (PMID:21537345) RGD PMID:21537345 calcium ion binding IBA PANTHER:PTN001726121 more ... 13792537 PMID:21873635 GO_Central molecular_function ND 1598407 07/2017: no relevant rat data RGD patched binding ISO RGD:1552237 1624291 UniProtKB:Q13635 more ... RGD MGI:MGI:1313055 , PMID:9811851 patched binding IBA MGI:MGI:94891 more ... 13792537 PMID:21873635 GO_Central patched binding ISO RGD:1350368 1624291 UniProtKB:Q61115 (PMID:21537345) RGD PMID:21537345 peptidase activity IEA UniRule:UR000042763 1600115 GO_REF:0000104 UniProt GO_REF:0000104 protein binding ISO RGD:1552237 1624291 PR:Q9JJS0 more ... RGD MGI:MGI:1333378 more ... protein binding ISO RGD:1350368 1624291 UniProtKB:Q9BWV1 (PMID:20519495) RGD PMID:20519495
Gene-Chemical Interaction Annotations
