Gsta1 (glutathione S-transferase alpha 1) - Rat Genome Database

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Gene: Gsta1 (glutathione S-transferase alpha 1) Rattus norvegicus
Analyze
Symbol: Gsta1
Name: glutathione S-transferase alpha 1
RGD ID: 2753
Description: Exhibits glutathione binding activity and glutathione transferase activity. Involved in aging; response to nutrient levels; and xenobiotic catabolic process. Localizes to cytosol and organelle membrane. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to human GSTA1 (glutathione S-transferase alpha 1); PARTICIPATES IN glutathione conjugation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glutathione S-transferase A1; glutathione S-transferase A3; glutathione S-transferase A3 subunit; glutathione S-transferase A5; glutathione S-transferase alpha 3; glutathione S-transferase alpha-3; glutathione S-transferase Yc-1; glutathione S-transferase Yc1 subunit; glutathione S-transferase, alpha 1; glutathione transferase A3 subunit; Glutathione-S-transferase alpha type (Ya); Glutathione-S-transferase, alpha type (Ya); GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3; Gsta5; LOC108348061; MGC112704; Yc1
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,703,476 - 23,720,121 (-)NCBI
Rnor_6.0 Ensembl927,368,272 - 27,452,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0927,366,404 - 27,381,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0926,283,550 - 26,300,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,051,501 - 20,068,146 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1920,048,823 - 20,065,988 (-)NCBI
Celera921,278,681 - 21,295,265 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
1,2-Dibromo-3-chloropropane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
13-oxo-9,11-octadecadienoic acid  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine  (ISO)
2-allylphenol  (ISO)
2-hexenal  (EXP)
2-phenylpropanal  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylpyridine  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenol  (EXP)
4-Propylphenol  (ISO)
5-Hydroxythalidomide  (ISO)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
acetamide  (EXP)
acrolein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-linolenic acid  (ISO)
alpha-methyl-L-dopa  (ISO)
alternariol  (ISO)
amitrole  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3,17-dione  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzoic acid  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromosulfophthalein  (EXP,ISO)
bucladesine  (ISO)
busulfan  (ISO)
butane-2,3-dione  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholic acid  (EXP)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cumene hydroperoxide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (EXP)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
enzyme inhibitor  (EXP)
etacrynic acid  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
genistein  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 7647  (EXP,ISO)
herbicide  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hypericin  (ISO)
iodide salt  (EXP)
iomeprol  (EXP)
isomethyleugenol  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
KT 5720  (ISO)
L-ascorbic acid  (ISO)
lauroyl-CoA  (ISO)
lead diacetate  (EXP,ISO)
linoleic acid  (ISO)
lithocholic acid  (EXP,ISO)
LY294002  (ISO)
mefenamic acid  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methacrylate  (ISO)
microcystin RR  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
myristoyl-CoA  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-hydroxy-PhIP  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
oleoyl-CoA  (ISO)
oxaliplatin  (EXP)
palmitoyl ethanolamide  (EXP)
palmitoyl-CoA  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
parathion-methyl  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (EXP)
phenytoin  (ISO)
PhIP  (ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP)
prostaglandin A2  (ISO)
prostaglandin J2  (ISO)
pyrazines  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
rifampicin  (ISO)
rifamycins  (ISO)
rimonabant  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-hexylglutathione  (ISO)
stavudine  (EXP)
stearoyl-CoA  (ISO)
streptozocin  (EXP)
sulforaphane  (EXP,ISO)
sunitinib  (EXP)
tamoxifen  (EXP)
tert-butyl ethyl ether  (EXP)
tetrachloromethane  (EXP)
tetrahydrothiophene  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
topotecan  (EXP)
toremifene  (EXP)
triadimefon  (EXP)
Tris(1-aziridinyl)phosphine oxide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
xanthohumol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA,ISO)
organelle membrane  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Daniel V, etal., Arch Biochem Biophys 1983 Nov;227(1):266-71.
2. Fotouhi-Ardakani N and Batist G, Biochem J 1999 May 1;339 ( Pt 3):685-93.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Hayes JD, etal., J Biol Chem 1994 Aug 12;269(32):20707-17.
5. KEGG
6. Khrunin AV, etal., Pharmacogenomics J. 2010 Feb;10(1):54-61. Epub 2009 Sep 29.
7. Klinga-Levan K, etal., Hereditas 1993;119(3):285-96.
8. Koen YM, etal., Chem Res Toxicol. 2006 Nov;19(11):1426-34.
9. MGD data from the GO Consortium
10. Nakamura K, etal., Exp Eye Res. 2005 Dec;81(6):710-5. Epub 2005 Jun 20.
11. NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Odbayar TO, etal., Mol Cell Biochem. 2009 May;325(1-2):121-30. Epub 2009 Feb 4.
13. Polimanti R, etal., Clin Exp Pharmacol Physiol. 2010 Aug;37(8):870-2. Epub 2010 Mar 30.
14. RGD automated data pipeline
15. RGD automated import pipeline for gene-chemical interactions
16. Stella L, etal., J Biol Chem. 2007 Mar 2;282(9):6372-9. Epub 2006 Dec 30.
17. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
18. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Suzuki T, etal., Mol Endocrinol 2003 Jul;17(7):1203-15. Epub 2003 Apr 3.
20. Taylor JB, etal., Biochem J 1984 Apr 1;219(1):223-31.
21. Telakowski-Hopkins CA, etal., J Biol Chem 1985 May 10;260(9):5820-5.
22. Tu CP, etal., J Biol Chem 1984 Aug 10;259(15):9434-9.
23. Wang RW, etal., Arch Biochem Biophys 1989 Mar;269(2):536-43.
Additional References at PubMed
PMID:1953636   PMID:2186703   PMID:6325423   PMID:9084911   PMID:10677856   PMID:11152686   PMID:11851347   PMID:15035604   PMID:15489334   PMID:16624487   PMID:19056867   PMID:20606271  
PMID:21492153   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Gsta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,703,476 - 23,720,121 (-)NCBI
Rnor_6.0 Ensembl927,368,272 - 27,452,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0927,366,404 - 27,381,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0926,283,550 - 26,300,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,051,501 - 20,068,146 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1920,048,823 - 20,065,988 (-)NCBI
Celera921,278,681 - 21,295,265 (-)NCBICelera
Cytogenetic Map9q13NCBI
GSTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,791,371 - 52,803,860 (-)EnsemblGRCh38hg38GRCh38
GRCh38652,791,371 - 52,803,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,656,169 - 52,668,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,764,347 - 52,776,616 (-)NCBINCBI36hg18NCBI36
Build 34652,764,347 - 52,776,616NCBI
Celera654,317,257 - 54,329,719 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,486,923 - 52,499,385 (-)NCBIHuRef
CHM1_1652,658,375 - 52,670,890 (-)NCBICHM1_1


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9129467098Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9140383872Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9140383872Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9140383872Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9145029794Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9235572247355722Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9235572247355722Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9288097747375681Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9288097747880977Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9498609549986095Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9498609549986095Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)91221677157216771Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)91242546357425463Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)91242546357425463Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91555490147249201Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91952048945029794Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92488509969885099Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92569237370692373Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92575432054885226Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000018325
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 7 5 1
Medium 1 8 43 32 13 32 4 5 25 23 30 11 4
Low 2 21 9 4 6 4 4 6 31 12 6 4
Below cutoff 12 12 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018325   ⟹   ENSRNOP00000018325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl927,436,258 - 27,452,902 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085195   ⟹   ENSRNOP00000069606
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl927,368,272 - 27,447,877 (-)Ensembl
RefSeq Acc Id: NM_031509   ⟹   NP_113697
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,703,476 - 23,720,121 (-)NCBI
Rnor_6.0927,366,404 - 27,381,004 (-)NCBI
Rnor_5.0926,283,550 - 26,300,195 (-)NCBI
RGSC_v3.4920,051,501 - 20,068,146 (-)RGD
Celera921,278,681 - 21,295,265 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113697   ⟸   NM_031509
- UniProtKB: P04904 (UniProtKB/Swiss-Prot),   B6DYP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018325   ⟸   ENSRNOT00000018325
RefSeq Acc Id: ENSRNOP00000069606   ⟸   ENSRNOT00000085195
Protein Domains
GST C-terminal   GST N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2753 AgrOrtholog
Ensembl Genes ENSRNOG00000013484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018325 UniProtKB/Swiss-Prot
  ENSRNOP00000069606 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018325 UniProtKB/Swiss-Prot
  ENSRNOT00000085195 UniProtKB/TrEMBL
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922234 IMAGE-MGC_LOAD
  IMAGE:7322480 IMAGE-MGC_LOAD
  IMAGE:7324340 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:108348061 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:24421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108659 IMAGE-MGC_LOAD
  MGC:112704 IMAGE-MGC_LOAD
  MGC:72773 IMAGE-MGC_LOAD
NCBI Gene 24421 ENTREZGENE
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GSTA1 RGD
PhenoGen Gsta1 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVT2_RAT UniProtKB/TrEMBL
  B6DYP8 ENTREZGENE, UniProtKB/TrEMBL
  GSTA3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6LD92 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gsta1  glutathione S-transferase alpha 1  LOC108348061  glutathione S-transferase alpha-3  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108348061  glutathione S-transferase alpha-3      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-10-22 Gsta1  glutathione S-transferase alpha 1  Gsta1  glutathione S-transferase A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Gsta1  glutathione S-transferase A1  Gsta1  glutathione S-transferase, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Gsta1  glutathione S-transferase, alpha 1  Gsta3  glutathione S-transferase A3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gsta3  glutathione S-transferase A3      Symbol and Name updated 1299863 APPROVED
2004-09-10 Gsta5  glutathione S-transferase A5  Gsta1  glutathione S-transferase, alpha 1   Symbol and Name updated 1299863 APPROVED
2002-11-06 Gsta1  glutathione S-transferase, alpha 1     Glutathione-S-transferase, alpha type (Ya)  Name updated 625702 APPROVED
2002-06-10 Gsta1  Glutathione-S-transferase, alpha type (Ya)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and fibroblast cells 70479
gene_process functions in converting fat soluble chemicals to water-soluble to inhibit build-up of hydrophobic compounds in adipose 70479
gene_product member of the alpha class of glutathione S-transferases 633003