Col3a1 (collagen type III alpha 1 chain) - Rat Genome Database

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Gene: Col3a1 (collagen type III alpha 1 chain) Rattus norvegicus
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Symbol: Col3a1
Name: collagen type III alpha 1 chain
RGD ID: 71029
Description: Predicted to enable several functions, including integrin binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in response to mechanical stimulus and skeletal system development. Located in collagen-containing extracellular matrix. Biomarker of several diseases, including bladder neck obstruction; glomerulosclerosis; obesity; rheumatic heart disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Ehlers-Danlos syndrome hypermobility type; end stage renal disease; and vascular type Ehlers-Danlos syndrome. Orthologous to human COL3A1 (collagen type III alpha 1 chain); PARTICIPATES IN endothelin signaling pathway; syndecan signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: collagen alpha-1(III) chain; collagen, type III, alpha 1; MGC93704; procollagen type III alpha 1; procollagen, type III, alpha 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Vetf6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8954,866,646 - 54,902,578 (+)NCBIGRCr8
mRatBN7.2947,374,611 - 47,410,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl947,374,593 - 47,410,547 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx955,898,776 - 55,934,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,021,593 - 61,057,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,317,605 - 59,353,483 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,023,295 - 52,059,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,023,295 - 52,059,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0951,689,492 - 51,725,418 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4944,281,582 - 44,317,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1944,310,161 - 44,319,243 (+)NCBI
Celera945,061,755 - 45,097,754 (+)NCBICelera
RH 3.4 Map9388.09RGD
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Otitis Media  (ISO)
alcoholic liver cirrhosis  (ISO)
Aneurysm  (ISO)
aortic aneurysm  (ISO)
aortic disease  (ISO)
aortic valve insufficiency  (ISO)
ARTERIAL DISSECTION  (ISO)
bladder neck obstruction  (IEP)
Cardiac Fibrosis  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
connective tissue disease  (ISO)
Contracture  (IEP)
Disproportionate Tall Stature  (ISO)
Ehlers-Danlos syndrome  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
Ehlers-Danlos syndrome hypermobility type  (ISO)
Ehlers-Danlos Syndrome Type 4  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
epilepsy  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
facioscapulohumeral muscular dystrophy  (ISO)
Familial Thoracic Aortic Aneurysm 1  (ISO)
Familial Thoracic Aortic Aneurysm 2  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
glomerulosclerosis  (IEP)
hereditary spastic paraplegia 4  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
immunodeficiency 31B  (ISO)
Keloid  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Loeys-Dietz syndrome  (ISO)
Lung Reperfusion Injury  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
Maxillofacial Abnormalities  (IDA)
megacolon  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (IEP)
nephrosclerosis  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IEP)
Peritoneal Fibrosis  (IEP)
Polymicrogyria with or without Vascular-Type Ehlers-Danlos Syndrome  (ISO)
pulmonary fibrosis  (ISO)
renal fibrosis  (ISO)
rheumatic heart disease  (IEP)
schizophrenia  (ISO)
steatotic liver disease  (ISO)
systemic scleroderma  (ISS)
thoracic aortic aneurysm  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (IEP)
ureteral obstruction  (ISO)
vascular type Ehlers-Danlos syndrome  (ISO,ISS)
Ventral Hernia  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
Activin A  (EXP)
adenine  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ambroxol  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP,ISO)
amphibole asbestos  (EXP,ISO)
andrographolide  (EXP,ISO)
angiotensin II  (ISO)
anthocyanin  (ISO)
apocynin  (EXP)
arotinoid acid  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azelastine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boron nitride  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camostat  (EXP)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
captopril  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
carvedilol  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
CHIR 99021  (ISO)
chloroprene  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDT  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
elemental carbon  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP)
eplerenone  (EXP)
eprosartan  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP)
Evodiamine  (EXP)
excitatory amino acid agonist  (ISO)
fasudil  (ISO)
fenofibrate  (ISO)
fentanyl  (EXP)
ferric oxide  (EXP)
fingolimod hydrochloride  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
goralatide  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (ISO)
indole-3-acetic acid  (EXP)
indometacin  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
L-arginine  (EXP,ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
limonene  (EXP)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP,ISO)
manidipine  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
methyltestosterone  (ISO)
metoprolol  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
Morroniside  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
Nandrolone decanoate  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
Plantamajoside  (ISO)
poly(guanylic acid)  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
puerarin  (EXP)
quercetin  (ISO)
quercitrin  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
Salvianolic acid A  (ISO)
saralasin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium hydroxide  (EXP)
sorafenib  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
topotecan  (EXP,ISO)
toxaphene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (EXP)
water  (EXP)
XAV939  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2. Alterations in chromatin are associated with increases in collagen III expression in aging nephropathy. Abrass CK, etal., Am J Physiol Renal Physiol. 2011 Feb;300(2):F531-9. doi: 10.1152/ajprenal.00237.2010. Epub 2010 Jul 7.
3. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
4. High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy. Dower K, etal., PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.
5. Regulation of alpha 2(I), alpha 1(III), and alpha 2(V) collagen mRNAs by estradiol in the immature rat uterus. Frankel FR, etal., DNA 1988 Jun;7(5):347-54.
6. Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. Gaikwad AB, etal., Biochem J. 2010 Dec 1;432(2):333-41. doi: 10.1042/BJ20100414.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Cloning of cDNA for rat pro alpha 1(III) collagen mRNA. Different expression patterns of type I and type III collagen and fibronectin genes in experimental granulation tissue. Glumoff V, etal., Biochim Biophys Acta 1994 Jan 18;1217(1):41-8.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Interleukin-1beta enhanced action of kinins on extracellular matrix of spontaneous hypertensive rat cardiac fibroblasts. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
11. Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model. Kanazawa K, etal., Int J Clin Exp Pathol. 2015 Apr 1;8(4):3426-40. eCollection 2015.
12. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
13. Inheritance of an RNA splicing mutation (G+ 1 IVS20) in the type III procollagen gene (COL3A1) in a family having aortic aneurysms and easy bruisability: phenotypic overlap between familial arterial aneurysms and Ehlers-Danlos syndrome type IV. Kontusaari S, etal., Am J Hum Genet 1990 Jul;47(1):112-20.
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
16. Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection. Ling XB, etal., J Am Soc Nephrol. 2010 Apr;21(4):646-53. doi: 10.1681/ASN.2009080876. Epub 2010 Feb 11.
17. Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1. Marks SC Jr, etal., Dev Dyn 1999 Jun;215(2):117-25.
18. Gene Data Set MGD Curation, June 12, 2002
19. Enhanced expression of heat shock protein 47 in rat model of peritoneal fibrosis. Mishima Y, etal., Perit Dial Int. 2003 Jan-Feb;23(1):14-22.
20. A family with Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen. Narcisi P, etal., Hum Mol Genet. 1994 Sep;3(9):1617-20.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats. Nishino T, etal., Kidney Int. 2003 Sep;64(3):887-96. doi: 10.1046/j.1523-1755.2003.00169.x.
23. The spectrum, management and clinical outcome of Ehlers-Danlos syndrome type IV: a 30-year experience. Oderich GS, etal., J Vasc Surg. 2005 Jul;42(1):98-106.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
26. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type. Pepin M, etal., N Engl J Med 2000 Mar 9;342(10):673-80.
27. Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins. Phua YL, etal., J Pathol. 2013 Apr;229(5):685-96. doi: 10.1002/path.4155. Epub 2013 Feb 22.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. A 27-bp deletion from one allele of the type III collagen gene (COL3A1) in a large family with Ehlers-Danlos syndrome type IV. Richards AJ, etal., Hum Genet. 1992 Jan;88(3):325-30.
34. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
35. Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome. Smith LB, etal., Cardiovasc Res. 2011 Apr 1;90(1):182-90. doi: 10.1093/cvr/cvq356. Epub 2010 Nov 10.
36. Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons. Sun HB, etal., J Orthop Res. 2010 Oct;28(10):1380-6. doi: 10.1002/jor.21132.
37. Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Tao H, etal., Cardiovasc Pathol. 2016 Sep-Oct;25(5):381-9. doi: 10.1016/j.carpath.2016.05.005. Epub 2016 Jun 2.
38. Decreased hernia recurrence using autologous platelet-rich plasma (PRP) with Strattice mesh in a rodent ventral hernia model. Van Eps J, etal., Surg Endosc. 2015 Nov 17.
39. Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329.
40. Collagen mRNA expression during tissue development: the temporospacial order coordinates bone morphogenesis with collagen fiber formation. Wurtz T, etal., Matrix Biol 1998 Oct;17(5):349-60.
41. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
42. microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling. Yang F, etal., J Cardiovasc Pharmacol. 2015 May;65(5):456-64. doi: 10.1097/FJC.0000000000000214.
43. Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors. Yoshida T, etal., Int J Mol Med. 2009 Jun;23(6):785-92.
44. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
Additional References at PubMed
PMID:1466622   PMID:2209468   PMID:7487954   PMID:7546986   PMID:7825727   PMID:8686743   PMID:8900172   PMID:8984825   PMID:9036918   PMID:9050868   PMID:9076960   PMID:9573018  
PMID:10022501   PMID:12477932   PMID:12810172   PMID:12810173   PMID:14559231   PMID:14575307   PMID:14736764   PMID:14970208   PMID:15489334   PMID:16360482   PMID:16754721   PMID:16912226  
PMID:17206378   PMID:17407709   PMID:17576241   PMID:17662583   PMID:18471258   PMID:18726071   PMID:19393425   PMID:19426591   PMID:19932771   PMID:20388018   PMID:20548288   PMID:21166192  
PMID:21729992   PMID:21768377   PMID:23658023   PMID:24006456   PMID:25784725   PMID:27068509   PMID:27363275   PMID:27559042   PMID:28320405   PMID:28436683   PMID:29286102   PMID:29476059  
PMID:32328952  


Genomics

Comparative Map Data
Col3a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8954,866,646 - 54,902,578 (+)NCBIGRCr8
mRatBN7.2947,374,611 - 47,410,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl947,374,593 - 47,410,547 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx955,898,776 - 55,934,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,021,593 - 61,057,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,317,605 - 59,353,483 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,023,295 - 52,059,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,023,295 - 52,059,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0951,689,492 - 51,725,418 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4944,281,582 - 44,317,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1944,310,161 - 44,319,243 (+)NCBI
Celera945,061,755 - 45,097,754 (+)NCBICelera
RH 3.4 Map9388.09RGD
Cytogenetic Map9q22NCBI
COL3A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382188,974,373 - 189,012,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2188,974,373 - 189,012,746 (+)EnsemblGRCh38hg38GRCh38
GRCh372189,839,099 - 189,877,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362189,547,344 - 189,585,717 (+)NCBINCBI36Build 36hg18NCBI36
Build 342189,664,604 - 189,702,978NCBI
Celera2183,433,958 - 183,472,272 (+)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2181,698,732 - 181,737,119 (+)NCBIHuRef
CHM1_12189,845,032 - 189,883,377 (+)NCBICHM1_1
T2T-CHM13v2.02189,463,283 - 189,501,589 (+)NCBIT2T-CHM13v2.0
Col3a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39145,350,698 - 45,388,866 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl145,350,698 - 45,388,866 (+)EnsemblGRCm39 Ensembl
GRCm38145,311,538 - 45,349,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl145,311,538 - 45,349,706 (+)EnsemblGRCm38mm10GRCm38
MGSCv37145,368,383 - 45,406,551 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36145,256,192 - 45,293,566 (+)NCBIMGSCv36mm8
Celera145,612,466 - 45,650,861 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.67NCBI
Col3a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554039,721,114 - 9,757,887 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554039,720,831 - 9,758,019 (-)NCBIChiLan1.0ChiLan1.0
COL3A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21391,670,594 - 91,708,230 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B91,685,668 - 91,723,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B76,285,115 - 76,322,703 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B194,204,613 - 194,242,956 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B194,204,613 - 194,242,956 (+)Ensemblpanpan1.1panPan2
COL3A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13630,488,250 - 30,526,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3630,488,488 - 30,536,765 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3630,394,214 - 30,431,773 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03630,718,700 - 30,756,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3630,718,908 - 30,756,954 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13630,779,325 - 30,816,837 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03630,715,289 - 30,752,838 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03630,884,313 - 30,921,873 (+)NCBIUU_Cfam_GSD_1.0
Col3a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303147,914,117 - 147,951,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365068,886,494 - 8,923,930 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365068,886,494 - 8,923,921 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COL3A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1593,526,603 - 93,596,363 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11593,556,914 - 93,595,678 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215104,067,018 - 104,105,776 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COL3A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11074,455,133 - 74,493,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040124,979,692 - 125,017,963 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Col3a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248991,192,360 - 1,230,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248991,192,078 - 1,230,528 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Col3a1
152 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:128
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000004956
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
RH134399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2947,410,158 - 47,410,359 (+)MAPPERmRatBN7.2
Rnor_6.0952,058,833 - 52,059,033NCBIRnor6.0
Rnor_5.0951,725,030 - 51,725,230UniSTSRnor5.0
RGSC_v3.4944,317,443 - 44,317,643UniSTSRGSC3.4
Celera945,097,366 - 45,097,566UniSTS
Cytogenetic Map9q22UniSTS
X57983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2947,410,341 - 47,410,514 (+)MAPPERmRatBN7.2
Rnor_6.0952,059,016 - 52,059,188NCBIRnor6.0
Rnor_5.0951,725,213 - 51,725,385UniSTSRnor5.0
RGSC_v3.4944,317,626 - 44,317,798UniSTSRGSC3.4
Celera945,097,549 - 45,097,721UniSTS
Cytogenetic Map9q22UniSTS
RH142444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2947,410,305 - 47,410,464 (+)MAPPERmRatBN7.2
Rnor_6.0952,058,980 - 52,059,138NCBIRnor6.0
Rnor_5.0951,725,177 - 51,725,335UniSTSRnor5.0
RGSC_v3.4944,317,590 - 44,317,748UniSTSRGSC3.4
Celera945,097,513 - 45,097,671UniSTS
RH 3.4 Map9388.09UniSTS
Cytogenetic Map9q22UniSTS
GDB:181238  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2947,409,198 - 47,410,233 (+)MAPPERmRatBN7.2
Rnor_6.0952,057,873 - 52,058,907NCBIRnor6.0
Rnor_5.0951,724,070 - 51,725,104UniSTSRnor5.0
RGSC_v3.4944,316,483 - 44,317,517UniSTSRGSC3.4
Celera945,096,406 - 45,097,440UniSTS
Cytogenetic Map9q22UniSTS
UniSTS:531307  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8954,876,046 - 54,876,762 (+)Marker Load Pipeline
mRatBN7.2947,384,011 - 47,384,727 (+)MAPPERmRatBN7.2
Rnor_6.0952,032,688 - 52,033,403NCBIRnor6.0
Rnor_5.0951,698,885 - 51,699,600UniSTSRnor5.0
Celera945,071,203 - 45,071,918UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_032085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ005395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004956   ⟹   ENSRNOP00000004956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl947,374,593 - 47,410,547 (+)Ensembl
Rnor_6.0 Ensembl952,023,295 - 52,059,217 (+)Ensembl
RefSeq Acc Id: NM_032085   ⟹   NP_114474
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8954,866,646 - 54,902,578 (+)NCBI
mRatBN7.2947,374,611 - 47,410,547 (+)NCBI
Rnor_6.0952,023,295 - 52,059,221 (+)NCBI
Rnor_5.0951,689,492 - 51,725,418 (+)NCBI
RGSC_v3.4944,281,582 - 44,317,831 (+)RGD
Celera945,061,755 - 45,097,754 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114474 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40942 (Get FASTA)   NCBI Sequence Viewer  
  AAH87039 (Get FASTA)   NCBI Sequence Viewer  
  CAA06510 (Get FASTA)   NCBI Sequence Viewer  
  CAA49832 (Get FASTA)   NCBI Sequence Viewer  
  EDL99128 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004956.4
  ENSRNOP00000109888
GenBank Protein P13941 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114474   ⟸   NM_032085
- Peptide Label: precursor
- UniProtKB: O70604 (UniProtKB/Swiss-Prot),   Q5PQT6 (UniProtKB/Swiss-Prot),   P13941 (UniProtKB/Swiss-Prot),   A6INT2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004956   ⟸   ENSRNOT00000004956
Protein Domains
Fibrillar collagen NC1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13941-F1-model_v2 AlphaFold P13941 1-1463 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696646
Promoter ID:EPDNEW_R7170
Type:initiation region
Name:Col3a1_1
Description:collagen type III alpha 1 chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0952,023,281 - 52,023,341EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71029 AgrOrtholog
BioCyc Gene G2FUF-27640 BioCyc
Ensembl Genes ENSRNOG00000003357 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004956.5 UniProtKB/Swiss-Prot
  ENSRNOT00000127195 ENTREZGENE
Gene3D-CATH 2.60.120.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097081 IMAGE-MGC_LOAD
InterPro Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen_Structural_Proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fib_collagen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84032 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93704 IMAGE-MGC_LOAD
NCBI Gene 84032 ENTREZGENE
PANTHER COLLAGEN TYPE XIII ALPHA 1 CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SI:CH211-266K2.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COLFI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Col3a1 PhenoGen
PROSITE NC1_FIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003357 RatGTEx
SMART COLFI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6INT2 ENTREZGENE, UniProtKB/TrEMBL
  CO3A1_RAT UniProtKB/Swiss-Prot
  O70604 ENTREZGENE
  P13941 ENTREZGENE
  Q5PQT6 ENTREZGENE
UniProt Secondary O70604 UniProtKB/Swiss-Prot
  Q5PQT6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Col3a1  collagen type III alpha 1 chain  Col3a1  collagen, type III, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Col3a1  collagen, type III, alpha 1   Col3a1  procollagen, type III, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Col3a1  procollagen, type III, alpha 1    collagen, type III, alpha 1  Name updated 1299863 APPROVED
2002-07-09 Col3a1  collagen, type III, alpha 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is higher in unstimulated, cultured cardiac fibroblasts from adult SHR rats than in those from WKY rats 1358958
gene_regulation Bradykinin attenuates mRNA expression in cultured cardiac fibroblasts from SHR but not WKY rats 1358958