Mir206 (microRNA 206) - Rat Genome Database

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Gene: Mir206 (microRNA 206) Rattus norvegicus
Symbol: Mir206
Name: microRNA 206
RGD ID: 2325550
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of cell adhesion molecule production; negative regulation of cell migration involved in sprouting angiogenesis; and regulation of gene expression. Predicted to act upstream of or within several processes, including cellular response to estrogen stimulus; cellular response to leukemia inhibitory factor; and sensory perception of sound. Predicted to be located in nucleus. Predicted to be part of RISC complex. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human MIR206 (microRNA 206); INTERACTS WITH 2,5-hexanedione; atrazine; cadmium dichloride.
Type: ncrna (Ensembl: miRNA)
Previously known as: microRNA mir-206; rno-mir-206
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2923,094,249 - 23,094,332 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,094,249 - 23,094,332 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,591,767 - 31,591,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,712,487 - 36,712,570 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,027,758 - 35,027,841 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,791,764 - 26,791,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,791,764 - 26,791,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,648,214 - 25,648,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera920,674,100 - 20,674,183 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)


References - curated
# Reference Title Reference Citation
1. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Ehinger Y, etal., Addict Biol. 2020 Mar 5:e12890. doi: 10.1111/adb.12890.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Prognostic significance of combined microRNA-206 and CyclinD2 in gastric cancer patients after curative surgery: A retrospective cohort study. Shi H, etal., Biomed Pharmacother. 2015 Apr;71:210-5. doi: 10.1016/j.biopha.2014.12.037. Epub 2015 Jan 9.
4. miR-206 inhibits gastric cancer proliferation in part by repressing cyclinD2. Zhang L, etal., Cancer Lett. 2013 May 10;332(1):94-101. doi: 10.1016/j.canlet.2013.01.023. Epub 2013 Jan 21.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:18791161   PMID:19245789   PMID:20403161   PMID:20439489   PMID:22000014   PMID:23337359   PMID:23628900   PMID:23646144   PMID:24672003  
PMID:24839168   PMID:25481410   PMID:26333362   PMID:26691660   PMID:27103465   PMID:27706732   PMID:27907012   PMID:28130187   PMID:28328152   PMID:29207029   PMID:30119135   PMID:30335903  
PMID:31148248   PMID:31608712   PMID:31894853   PMID:33204065   PMID:33610591   PMID:35092560   PMID:35781830  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2923,094,249 - 23,094,332 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,094,249 - 23,094,332 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,591,767 - 31,591,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,712,487 - 36,712,570 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,027,758 - 35,027,841 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,791,764 - 26,791,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,791,764 - 26,791,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,648,214 - 25,648,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera920,674,100 - 20,674,183 (+)NCBICelera
Cytogenetic Map9q13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38652,144,349 - 52,144,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,144,349 - 52,144,434 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,009,147 - 52,009,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,117,105 - 52,117,190 (+)NCBINCBI36Build 36hg18NCBI36
Celera653,670,284 - 53,670,369 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,840,140 - 51,840,225 (+)NCBIHuRef
CHM1_1652,011,355 - 52,011,440 (+)NCBICHM1_1
T2T-CHM13v2.0651,983,057 - 51,983,142 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39120,749,234 - 20,749,306 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,749,234 - 20,749,306 (+)EnsemblGRCm39 Ensembl
GRCm38120,679,010 - 20,679,082 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,679,010 - 20,679,082 (+)EnsemblGRCm38mm10GRCm38
MGSCv37120,669,091 - 20,669,163 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera120,553,851 - 20,553,923 (+)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.41NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11219,805,523 - 19,805,582 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,805,523 - 19,805,582 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,701,736 - 19,701,795 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,304,504 - 20,304,563 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1220,304,504 - 20,304,563 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11219,809,950 - 19,810,009 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01219,912,903 - 19,912,962 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,050,920 - 20,050,979 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl745,976,293 - 45,976,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1745,976,293 - 45,976,372 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,426,445 - 52,426,524 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Pax3rno-miR-206-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21730146
Igf1rno-miR-206-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19245789
Tppprno-miR-206-3pMirtarbaseexternal_infoImmunoblot//Immunocytochemistry//Luciferase reportFunctional MTI19606501

Predicted Targets
Summary Value
Count of predictions:13684
Count of gene targets:7212
Count of transcripts:7724
Interacting mature miRNAs:rno-miR-206-3p, rno-miR-206-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system renal system reproductive system appendage
Medium 1 1 1
Low 2 3 3 1 3 7 8 1 7
Below cutoff 1 1


Nucleotide Sequences
RefSeq Transcripts NR_031921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053621
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,094,249 - 23,094,332 (+)Ensembl
Rnor_6.0 Ensembl926,791,764 - 26,791,847 (+)Ensembl
RefSeq Acc Id: NR_031921
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,094,249 - 23,094,332 (+)NCBI
Rnor_6.0926,791,764 - 26,791,847 (+)NCBI
Rnor_5.0925,648,214 - 25,648,297 (+)NCBI
Celera920,674,100 - 20,674,183 (+)NCBI

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325550 AgrOrtholog
BioCyc Gene G2FUF-28038 BioCyc
Ensembl Genes ENSRNOG00000035498 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053621 ENTREZGENE
miRBase MI0000948 ENTREZGENE
NCBI Gene 100314052 ENTREZGENE
PhenoGen Mir206 PhenoGen
RNAcentral URS000034B6F5 RNACentral
  URS000075A7ED RNACentral
  URS000075DB46 RNACentral

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir206  microRNA 206  Mir206  microRNA mir-206  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir206  microRNA mir-206      Symbol and Name status set to provisional 70820 PROVISIONAL