Fzd7 (frizzled class receptor 7) - Rat Genome Database

Name: Fzd7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fzd7 (frizzled class receptor 7) Rattus norvegicus

Analyze

Symbol:

Fzd7

Name:

frizzled class receptor 7

RGD ID:

2321905

Description:

Predicted to enable several functions, including PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; negative regulation of cell differentiation; and positive regulation of epithelial cell proliferation involved in wound healing. Predicted to act upstream of or within several processes, including T cell differentiation in thymus; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; and substrate adhesion-dependent cell spreading. Predicted to be located in recycling endosome membrane. Predicted to be active in plasma membrane. Orthologous to human FZD7 (frizzled class receptor 7); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

frizzled family receptor 7; frizzled-7; LOC100360552; rCG22430-like

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FZD7 (frizzled class receptor 7)	RGD	RGD
Mus musculus (house mouse):	Fzd7 (frizzled class receptor 7)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Fzd7 (frizzled class receptor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FZD7 (frizzled class receptor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FZD7 (frizzled class receptor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fzd7 (frizzled class receptor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FZD7 (frizzled class receptor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FZD7 (frizzled class receptor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fzd7 (frizzled class receptor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FZD7 (frizzled class receptor 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fzd7 (frizzled class receptor 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd7a (frizzled class receptor 7a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd7b (frizzled class receptor 7b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cfz-2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fz	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fzd7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	60,931,433 - 60,934,252 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	60,930,875 - 60,935,781 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	69,426,502 - 69,429,321 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	74,542,479 - 74,545,298 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	72,860,756 - 72,863,575 (+)	NCBI	Rnor_WKY
Rnor_6.0	9	66,305,731 - 66,308,550 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	66,305,731 - 66,308,550 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	66,111,942 - 66,114,761 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	58,063,740 - 58,066,559 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	58,367,412 - 58,370,231 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune lymphoproliferative syndrome type 2B (ISO)

Autoimmune Lymphoproliferative Syndrome, Type V (ISO)

common variable immunodeficiency 1 (ISO)

genetic disease (ISO)

nephroblastoma (ISO)

Neurodevelopmental Disorders (ISO)

primary pulmonary hypertension (ISO)

Pulmonary Arterial Hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1-naphthyl isothiocyanate (EXP)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

artesunate (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

cadmium dichloride (ISO)

captan (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

choline (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diazinon (EXP)

dibutyl phthalate (EXP)

diclofenac (ISO)

dieldrin (EXP)

diethyl malate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenamidone (ISO)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

formaldehyde (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

L-methionine (ISO)

leflunomide (ISO)

Licochalcone B (ISO)

menadione (ISO)

methylmercury chloride (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resorcinol (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sodium dodecyl sulfate (ISO)

succimer (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IBA,ISO)

mesenchymal to epithelial transition (ISO)

negative regulation of cardiac muscle cell differentiation (ISO)

negative regulation of cell-substrate adhesion (ISO)

negative regulation of ectodermal cell fate specification (ISO)

non-canonical Wnt signaling pathway (IBA,ISO)

non-canonical Wnt signaling pathway via JNK cascade (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of epithelial cell proliferation involved in wound healing (ISO)

positive regulation of phosphorylation (ISO)

regulation of canonical Wnt signaling pathway (ISO)

regulation of DNA-templated transcription (ISO)

skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration (ISO)

somatic stem cell division (ISO)

stem cell population maintenance (ISO)

substrate adhesion-dependent cell spreading (ISO)

T cell differentiation in thymus (ISO)

Cellular Component

intracellular membrane-bounded organelle (ISO)

plasma membrane (IBA,ISO)

recycling endosome membrane (ISO)

Molecular Function

frizzled binding (ISO)

PDZ domain binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

protein binding (ISO)

Wnt receptor activity (IBA,ISO)

Wnt-protein binding (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

syndecan signaling pathway (ISO)

Wnt signaling pathway (ISO)

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9707618	PMID:11265645	PMID:17016432	PMID:18156211	PMID:18215320	PMID:18256285	PMID:18313787	PMID:18681827	PMID:19001373	PMID:19188438	PMID:19388021	PMID:19497282
PMID:19773752	PMID:20802536	PMID:23939491	PMID:27386966	PMID:28733458

Genomics

Comparative Map Data

Fzd7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	60,931,433 - 60,934,252 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	60,930,875 - 60,935,781 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	69,426,502 - 69,429,321 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	74,542,479 - 74,545,298 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	72,860,756 - 72,863,575 (+)	NCBI	Rnor_WKY
Rnor_6.0	9	66,305,731 - 66,308,550 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	66,305,731 - 66,308,550 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	66,111,942 - 66,114,761 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	58,063,740 - 58,066,559 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	58,367,412 - 58,370,231 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

FZD7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	202,033,855 - 202,038,441 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	202,033,855 - 202,038,441 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	202,898,578 - 202,903,164 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	202,607,555 - 202,611,405 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	202,724,815 - 202,728,666	NCBI
Celera	2	196,651,081 - 196,654,931 (+)	NCBI		Celera
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	194,748,666 - 194,752,510 (+)	NCBI		HuRef
CHM1_1	2	202,905,837 - 202,909,687 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	202,514,735 - 202,519,312 (+)	NCBI		T2T-CHM13v2.0

Fzd7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	59,521,306 - 59,526,114 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	59,521,583 - 59,526,114 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	59,482,147 - 59,486,955 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	59,482,424 - 59,486,955 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	59,538,991 - 59,543,799 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	59,426,725 - 59,431,501 (+)	NCBI		MGSCv36	mm8
Celera	1	59,998,367 - 60,003,175 (+)	NCBI		Celera
Cytogenetic Map	1	C2	NCBI
cM Map	1	30.08	NCBI

Fzd7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	12,731,279 - 12,732,979 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	12,729,277 - 12,733,057 (-)	NCBI	ChiLan1.0	ChiLan1.0

FZD7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2B	104,675,070 - 104,679,149 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	89,290,929 - 89,294,873 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	207,444,640 - 207,448,359 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	207,439,942 - 207,446,283 (+)	Ensembl	panpan1.1		panPan2

FZD7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	11,054,572 - 11,061,173 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	11,053,521 - 11,060,821 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	11,938,845 - 11,942,706 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	10,991,423 - 10,995,284 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	37	10,942,332 - 10,946,193 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	10,920,748 - 10,924,609 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	10,913,988 - 10,917,849 (+)	NCBI		UU_Cfam_GSD_1.0

Fzd7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	159,286,392 - 159,306,586 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936726	1,256,678 - 1,275,467 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936726	1,256,684 - 1,275,324 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FZD7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	105,644,188 - 105,648,850 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	105,644,164 - 105,648,860 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	117,063,360 - 117,067,227 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FZD7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	87,734,263 - 87,738,676 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	87,734,872 - 87,736,596 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	111,676,427 - 111,681,183 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fzd7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624765	14,399,143 - 14,402,970 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fzd7
4 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	46
Interacting mature miRNAs:	53
Transcripts:	ENSRNOT00000021569
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	23754024	61381613	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat

Markers in Region

RH133859

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	60,935,354 - 60,935,560 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	66,309,652 - 66,309,857	NCBI	Rnor6.0
Rnor_5.0	9	66,115,863 - 66,116,068	UniSTS	Rnor5.0
RGSC_v3.4	9	58,067,661 - 58,067,866	UniSTS	RGSC3.4
Celera	9	58,371,333 - 58,371,538	UniSTS
RH 3.4 Map	9	495.8	UniSTS
Cytogenetic Map	9	q31	UniSTS

PMC316619P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	60,932,709 - 60,933,295 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	66,307,008 - 66,307,593	NCBI	Rnor6.0
Rnor_5.0	9	66,113,219 - 66,113,804	UniSTS	Rnor5.0
RGSC_v3.4	9	58,065,017 - 58,065,602	UniSTS	RGSC3.4
Celera	9	58,368,689 - 58,369,274	UniSTS

Fzd7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	60,932,797 - 60,932,983 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	66,307,096 - 66,307,281	NCBI	Rnor6.0
Rnor_5.0	9	66,113,307 - 66,113,492	UniSTS	Rnor5.0
RGSC_v3.4	9	58,065,105 - 58,065,290	UniSTS	RGSC3.4
Celera	9	58,368,777 - 58,368,962	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		4	13	6	1	6	8	11	22	21	29	9	8
Low	3	39	44	35	18	35			52	14	12	2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000021569 ⟹ ENSRNOP00000021569

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,930,875 - 60,935,781 (+)	Ensembl
Rnor_6.0 Ensembl	9	66,305,731 - 66,308,550 (+)	Ensembl

RefSeq Acc Id:

NM_001271185 ⟹ NP_001258114

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	60,931,433 - 60,934,252 (+)	NCBI
Rnor_6.0	9	66,305,731 - 66,308,550 (+)	NCBI
Rnor_5.0	9	66,111,942 - 66,114,761 (+)	NCBI
Celera	9	58,367,412 - 58,370,231 (+)	NCBI

Sequence:

show sequence

TTTGAAGGGTAACCGGAGACGCTTGTTGCTCGTCGCCGCAGAGAAAGCCGCACCGTTACGTCTC
GGCGGGGAGGGTAAGGCGACACCCCCCTCGGTCCCCCCACTCCAGGCCCAGGAGTTTGAACCCC
TGGAGGCCGCGTGAGTGCCACGCGGAGGCGGCTGCGGCGCCCCCTCGGCTGGCGGCCTCGCCCC
CGCTGTGCAGGCACCCTAGCACCCTCGGCTCCGCGCCGCCCACGGCCCGGCCCCGGCGCCGGGA
GGACTCTCATGCGCCGGGCGCGGCGGCGCCTCCCTGCATCCAAGCCGCTCCCCAGCGCCCCGTC
TTTTTCCTCCAGCTGAGAACGCCGCTGCACTCTCGGCCGGCGATGCGGGGCCCCGGCACGGAGG
CGTCGCACTCGCCCCTGGGCCTCTGTGCCTTGGTGCTTGCTCTTCTGGGCGCGCTGCCCACGGA
CACCGGAGCTCAACCATACCACGGCGAGAAAGGCATCTCGGTACCGGACCACGGCTTCTGCCAG
CCCATCTCCATCCCGTTGTGCACGGATATTGCCTACAACCAGACCATCCTGCCCAACCTGCTGG
GCCACACGAACCAAGAGGACGCGGGCCTCGAGGTGCACCAGTTCTACCCTCTGGTAAAGGTGCA
GTGTTCTCCCGAGCTGCGCTTCTTCTTATGCTCTATGTACGCACCCGTGTGCACCGTGCTCGAC
CAAGCCATTCCTCCGTGCCGTTCCTTGTGCGAGCGCGCCCGACAGGGCTGCGAGGCGCTCATGA
ACAAGTTCGGTTTCCAGTGGCCGGAGCGGCTGCGCTGCGAGAACTTCCCGGTGCACGGCGCCGG
CGAGATATGCGTGGGGCAGAACACGTCCGACGGCTCCGGGGGCGCAGGCGGTAGTCCCACCGCC
TACCCTACTGCTCCCTACCTGCCAGACCCGCCTTTCACTGCGATGTCCCCCTCAGATGGCAGAG
GCCGCTGGTCTTTCCCCTTCTCTTGCCCGCGTCAGCTCAAGGTCCCCCCCTACCTGGGCTACCG
TTTCCTAGGCGAGCGTGACTGCGGTGCCCCGTGTGAGCCAGGCCGTGCTAACGGCCTCATGTAC
TTTAAAGAAGAGGAGAGACGTTTCGCCCGCCTCTGGGTAGGTGTGTGGTCAGTGCTGTGCTGTG
CCTCGACGCTCTTCACGGTGCTCACCTACCTAGTGGACATGCGTCGCTTCAGCTATCCAGAGCG
ACCCATTATCTTCCTGTCGGGCTGCTACTTCATGGTGGCAGTGGCGCACGTGGCGGGCTTCCTG
CTAGAGGACCGTGCCGTGTGCGTGGAGCGCTTCTCGGACGATGGCTACCGCACGGTGGCGCAGG
GCACCAAGAAGGAGGGCTGCACCATCCTCTTCATGGTGCTTTACTTCTTCGGCATGGCCAGCTC
CATCTGGTGGGTCATTCTTTCCCTCACTTGGTTCCTGGCAGCTGGCATGAAGTGGGGCCACGAG
GCCATCGAGGCCAACTCGCAGTACTTTCATCTGGCCGCGTGGGCTGTGCCAGCGGTCAAGACAA
TCACCATCTTGGCCATGGGCCAGGTGGATGGTGACCTACTCAGTGGAGTGTGCTACGTGGGCCT
GTCTAGTGTGGATGCACTGCGGGGCTTCGTGCTGGCGCCCTTGTTCGTCTACCTCTTCATCGGT
ACGTCCTTCCTGTTGGCCGGCTTTGTGTCTCTCTTTCGCATCCGCACCATCATGAAGCACGATG
GCACCAAGACGGAGAAGCTGGAGAAGCTCATGGTGCGCATTGGCGTCTTCAGCGTGCTCTACAC
GGTCCCAGCCACCATCGTGCTGGCGTGCTACTTTTACGAGCAGGCCTTCCGCGAGCACTGGGAG
CGCACCTGGCTCCTGCAGACCTGCAAGAGCTACGCTGTGCCCTGCCCCCCGGGCCACTTCTCGC
CCATGAGCCCCGACTTTACAGTCTTCATGATCAAGTACCTGATGACCATGATCGTGGGCATCAC
TACCGGCTTCTGGATCTGGTCGGGCAAGACCCTGCAGTCATGGCGTCGCTTCTACCACAGACTC
AGCCACAGCAGCAAGGGGGAGACTGCGGTATGAGCCCTGGTCCTTACCCCACCCTTGCCACTTC
TACTCTTTCGCAGGAGGAGAGGCATGGTAGGGAAAGAACTGTTGGGTGGGGGGCTTGTTTCTGT
AAACTCCCTGCCCCCTCCACTGAGCTTTAATCTGGAAGTGAGAAGTTATTTGGAGGTGAGAAGA
AATTTGGGGTGAGAGATGGTCTTGAGAGGAGGCCCAAATGAAAAGGCGAAGGCAGTGGCTGAAA
AGACTCCTGGCTAAGACTTGCAGGACGATGCTAACTGTGAAAGACATGGGCTGGCTAGGGTCTA
AGGGAAAGGCTGAGATCAGAGACTGAGTTCGTCAGGCACCAGAGATGAGCCAGGGTTGTGAGTC
CAATCCCCTGCTGCAAGGCAAGTGGCTGTCCTCACTCCAGTGAGGGAGGGGGTGAGGGTGGGGG
AGGATACCGCTCTGTCTGCAGCCTAGGCTTTGTGGCCAAAATGGGGACCCCCTGCGGTGCCCTT
GTCAAGCGGTGGTCAAACCATAATCTCTTTTCACTGGGGCCAAACTGGAGCCCAGATGGGTTAA
TTTCCAGGGTCAGACCCCTTACAGTCCTCCTCCCGGACCCCCTCCCGCCTGTTTTTCCTTCCCT
ACTCCTTTCAAGTCTAGTAAAATAAGCATTTGGAAGGCGGGGGAGTCCTGTCTGCTAGAGTCCT
AACGCAGAGATGCCCGAGAAGGTTTCGGAGAGGAGGCCAAAGAGCCGAGTGGTAGATACAGTCT
GCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258114	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001258114 ⟸ NM_001271185
- Peptide Label:	precursor
- UniProtKB:	D4ACM8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRGPGTEASHSPLGLCALVLALLGALPTDTGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQ TILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERAR QGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTA MSPSDGRGRWSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVG VWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDD GYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAW AVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRI RTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVP CPPGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV hide sequence

RefSeq Acc Id:

ENSRNOP00000021569 ⟸ ENSRNOT00000021569

Protein Domains

FZ G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ACM8-F1-model_v2	AlphaFold	D4ACM8	1-572	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2321905	AgrOrtholog
BioCyc Gene	G2FUF-27409	BioCyc
Ensembl Genes	ENSRNOG00000016119	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000021569	ENTREZGENE
	ENSRNOP00000021569.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021569	ENTREZGENE
	ENSRNOT00000021569.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Frizzled	UniProtKB/TrEMBL
	Frizzled-7_CRD	UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/TrEMBL
	Frizzled_related	UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/TrEMBL
KEGG Report	rno:100360552	UniProtKB/TrEMBL
NCBI Gene	100360552	ENTREZGENE
PANTHER	Fz_related	UniProtKB/TrEMBL
	PTHR11309:SF31	UniProtKB/TrEMBL
Pfam	Frizzled	UniProtKB/TrEMBL
	PF01392	UniProtKB/TrEMBL
PhenoGen	Fzd7	PhenoGen
PRINTS	FRIZZLED	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/TrEMBL
	PS50038	UniProtKB/TrEMBL
SMART	FRI	UniProtKB/TrEMBL
	Frizzled	UniProtKB/TrEMBL
Superfamily-SCOP	Frizzled_Cys-rich	UniProtKB/TrEMBL
UniProt	D4ACM8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-02-06	Fzd7	frizzled class receptor 7	Fzd7	frizzled family receptor 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-09-05	Fzd7	frizzled family receptor 7	LOC100360552	rCG22430-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-06	LOC100360552	rCG22430-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)