Acadl (acyl-CoA dehydrogenase, long chain) - Rat Genome Database

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Gene: Acadl (acyl-CoA dehydrogenase, long chain) Rattus norvegicus
Analyze
Symbol: Acadl
Name: acyl-CoA dehydrogenase, long chain
RGD ID: 2011
Description: Enables identical protein binding activity; long-chain-acyl-CoA dehydrogenase activity; and nucleotide binding activity. Involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and long-chain fatty acid catabolic process. Located in mitochondrial matrix and mitochondrial membrane. Orthologous to human ACADL (acyl-CoA dehydrogenase long chain); PARTICIPATES IN fatty acid beta degradation pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; carnitine palmitoyltransferase I deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acetyl-Coenzyme A dehydrogenase, long-chain; ACOADA; Acyl Coenzyme A dehydrogenase long chain; Acyl Coenzyme A dehydrogenase, long chain; acyl-Coenzyme A dehydrogenase, long-chain; LCAD; LCAD long chain acyl-CoA dehydrogenase; LCAD, long chain acyl-CoA dehydrogenase; long-chain acyl-CoA dehydrogenase; long-chain specific acyl-CoA dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2968,333,981 - 68,372,149 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl968,333,980 - 68,372,220 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx976,823,956 - 76,861,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0981,952,887 - 81,990,335 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0980,351,815 - 80,389,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0973,833,368 - 73,871,857 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl973,833,388 - 73,871,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0973,434,371 - 73,472,895 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4965,613,130 - 65,651,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1965,760,111 - 65,798,754 (-)NCBI
Celera965,813,263 - 65,851,320 (-)NCBICelera
RH 3.4 Map9612.99RGD
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
aripiprazole  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
Di-n-hexyl phthalate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipoic acid  (EXP)
meldonium  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
oleic acid  (ISO)
omeprazole  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sirolimus  (EXP)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Acyl-CoA dehydrogenases. A mechanistic overview. Ghisla S and Thorpe C, Eur J Biochem. 2004 Feb;271(3):494-508.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation. Guerra C, etal., J Clin Invest. 1998 Nov 1;102(9):1724-31. doi: 10.1172/JCI4532.
5. Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Ikeda Y, etal., Arch Biochem Biophys. 1987 Feb 1;252(2):662-74.
6. Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. Ikeda Y, etal., J Biol Chem. 1985 Jan 25;260(2):1311-25.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family. Matsubara Y, etal., J Biol Chem 1989 Sep 25;264(27):16321-31.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Cloning of a cDNA for short/branched chain acyl-Coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity. Willard J, etal., Arch Biochem Biophys 1996 Jul 1;331(1):127-33.
Additional References at PubMed
PMID:8268228   PMID:9861014   PMID:14651853   PMID:15489334   PMID:15639194   PMID:18614015   PMID:21151927   PMID:23106098   PMID:26316108   PMID:26767982  


Genomics

Comparative Map Data
Acadl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2968,333,981 - 68,372,149 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl968,333,980 - 68,372,220 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx976,823,956 - 76,861,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0981,952,887 - 81,990,335 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0980,351,815 - 80,389,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0973,833,368 - 73,871,857 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl973,833,388 - 73,871,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0973,434,371 - 73,472,895 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4965,613,130 - 65,651,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1965,760,111 - 65,798,754 (-)NCBI
Celera965,813,263 - 65,851,320 (-)NCBICelera
RH 3.4 Map9612.99RGD
Cytogenetic Map9q32NCBI
ACADL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382210,187,923 - 210,225,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2210,187,126 - 210,225,447 (-)EnsemblGRCh38hg38GRCh38
GRCh372211,052,647 - 211,090,171 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362210,760,959 - 210,798,392 (-)NCBINCBI36Build 36hg18NCBI36
Build 342210,878,223 - 210,915,653NCBI
Celera2204,820,713 - 204,858,229 (-)NCBICelera
Cytogenetic Map2q34ENTREZGENE
HuRef2202,897,948 - 202,935,464 (-)NCBIHuRef
CHM1_12211,058,802 - 211,096,307 (-)NCBICHM1_1
T2T-CHM13v2.02210,668,601 - 210,706,298 (-)NCBIT2T-CHM13v2.0
Acadl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39166,869,998 - 66,902,468 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl166,869,998 - 66,902,436 (-)EnsemblGRCm39 Ensembl
GRCm38166,830,839 - 66,863,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl166,830,839 - 66,863,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv37166,877,427 - 66,909,841 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36166,764,061 - 66,796,475 (-)NCBIMGSCv36mm8
Celera167,346,353 - 67,377,247 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map133.64NCBI
Acadl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554575,266,033 - 5,300,056 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554575,266,032 - 5,300,632 (+)NCBIChiLan1.0ChiLan1.0
ACADL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B112,824,820 - 112,864,084 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B97,445,421 - 97,483,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B215,847,775 - 215,885,524 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B215,847,775 - 215,885,524 (-)Ensemblpanpan1.1panPan2
ACADL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13718,028,244 - 18,073,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3718,017,087 - 18,073,862 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3718,906,886 - 18,954,457 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03717,964,225 - 18,011,748 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3717,968,220 - 18,011,731 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13717,917,084 - 17,964,271 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03717,879,408 - 17,926,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03717,894,240 - 17,941,487 (-)NCBIUU_Cfam_GSD_1.0
Acadl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303166,499,563 - 166,529,186 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493684566,241 - 96,249 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493684566,674 - 96,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACADL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15112,933,506 - 112,969,577 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115112,935,631 - 112,969,381 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215124,759,345 - 124,793,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACADL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11095,886,502 - 95,925,928 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1095,887,465 - 95,925,578 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040103,432,787 - 103,482,132 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acadl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247656,018,534 - 6,050,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acadl
254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000017686
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
AW530440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2968,371,430 - 68,371,643 (+)MAPPERmRatBN7.2
Rnor_6.0973,871,139 - 73,871,351NCBIRnor6.0
Rnor_5.0973,434,877 - 73,435,089UniSTSRnor5.0
RGSC_v3.4965,651,057 - 65,651,269UniSTSRGSC3.4
Celera965,850,602 - 65,850,814UniSTS
RH 3.4 Map9597.4UniSTS
Cytogenetic Map9q32UniSTS
RH142293  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0973,465,420 - 73,467,333NCBIRnor5.0
RGSC_v3.4965,618,692 - 65,620,274UniSTSRGSC3.4
Celera965,818,825 - 65,820,407UniSTS
RH 3.4 Map9612.99UniSTS
Cytogenetic Map9q32UniSTS
ACADL  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2968,362,611 - 68,362,737 (+)MAPPERmRatBN7.2
Rnor_6.0973,862,321 - 73,862,446NCBIRnor6.0
Rnor_5.0973,443,782 - 73,443,907UniSTSRnor5.0
RGSC_v3.4965,642,239 - 65,642,364UniSTSRGSC3.4
Celera965,841,784 - 65,841,909UniSTS
Cytogenetic Map9q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5
Medium 3 38 57 41 19 41 8 11 66 35 41 11 8
Low 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017686   ⟹   ENSRNOP00000017686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl968,333,983 - 68,372,220 (-)Ensembl
Rnor_6.0 Ensembl973,833,388 - 73,871,888 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118459   ⟹   ENSRNOP00000097339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl968,333,980 - 68,367,608 (-)Ensembl
RefSeq Acc Id: NM_012819   ⟹   NP_036951
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2968,333,981 - 68,372,149 (-)NCBI
Rnor_6.0973,833,368 - 73,871,857 (-)NCBI
Rnor_5.0973,434,371 - 73,472,895 (+)NCBI
RGSC_v3.4965,613,130 - 65,651,775 (-)RGD
Celera965,813,263 - 65,851,320 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036951 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40668 (Get FASTA)   NCBI Sequence Viewer  
  AAA41514 (Get FASTA)   NCBI Sequence Viewer  
  AAH62006 (Get FASTA)   NCBI Sequence Viewer  
  EDL75290 (Get FASTA)   NCBI Sequence Viewer  
  EDL75291 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017686
  ENSRNOP00000097339.1
GenBank Protein P15650 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036951   ⟸   NM_012819
- Peptide Label: precursor
- UniProtKB: P15650 (UniProtKB/Swiss-Prot),   A6KFD6 (UniProtKB/TrEMBL),   A0A8I6GMH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017686   ⟸   ENSRNOT00000017686
RefSeq Acc Id: ENSRNOP00000097339   ⟸   ENSRNOT00000118459
Protein Domains
Acyl-CoA dehydrogenase/oxidase C-terminal   Acyl-CoA dehydrogenase/oxidase N-terminal   Acyl-CoA oxidase/dehydrogenase middle

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15650-F1-model_v2 AlphaFold P15650 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696724
Promoter ID:EPDNEW_R7249
Type:initiation region
Name:Acadl_1
Description:acyl-CoA dehydrogenase, long chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0973,871,908 - 73,871,968EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2011 AgrOrtholog
BioCyc Gene G2FUF-27289 BioCyc
Ensembl Genes ENSRNOG00000012966 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017686 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000118459.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599828 IMAGE-MGC_LOAD
InterPro Acyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH/oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LCAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25287 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72554 IMAGE-MGC_LOAD
NCBI Gene 25287 ENTREZGENE
PANTHER LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acyl-CoA_dh_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acadl PhenoGen
PROSITE ACYL_COA_DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYL_COA_DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012966 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC203790
UniProt A0A8I6GMH0 ENTREZGENE, UniProtKB/TrEMBL
  A6KFD6 ENTREZGENE, UniProtKB/TrEMBL
  A6KFD7_RAT UniProtKB/TrEMBL
  ACADL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acadl  acyl-CoA dehydrogenase, long chain  Acadl  acyl-Coenzyme A dehydrogenase, long-chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Acadl  acyl-Coenzyme A dehydrogenase, long-chain  Acadl  acetyl-Coenzyme A dehydrogenase, long-chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acadl  acetyl-Coenzyme A dehydrogenase, long-chain    Acyl Coenzyme A dehydrogenase, long chain  Name updated 629478 APPROVED
2002-06-10 Acadl  Acyl Coenzyme A dehydrogenase, long chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 631718
gene_function catalyzes the alpha,beta-dehydrogenation of acyl-CoA esters 631739
gene_homology has high similarity to acyl-CoA dehydrogenase family members short chain acyl-CoA (SCAD), medium chain acyl-CoA dehydrogenase (MCAD), and isovaleryl-CoA dehydrogenase (IVD) 631718
gene_process plays a role in fatty acid metabolism 631739
gene_product member of the acyl-CoA dehydrogenase family 631718
gene_protein 430 amino acid sequence with 30 amino acid leader sequence and 400 amino acid residues in the mature protein 631718