Sgo2 (shugoshin 2) - Rat Genome Database

Name: Sgo2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Sgo2 (shugoshin 2) Rattus norvegicus

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Symbol:

Sgo2

Name:

shugoshin 2

RGD ID:

1308450

Description:

Predicted to be involved in meiotic sister chromatid cohesion. Predicted to act upstream of or within several processes, including meiotic nuclear division; meiotic sister chromatid cohesion; and positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric. Predicted to be located in condensed chromosome, centromeric region and nuclear body. Predicted to be part of mitotic cohesin complex. Predicted to be active in kinetochore. Orthologous to human SGO2 (shugoshin 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC316425; Sgol2; shugoshin-like 2; shugoshin-like 2 (S. pombe)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SGO2 (shugoshin 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sgo2a (shugoshin 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sgo2 (shugoshin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SGO2 (shugoshin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SGO2 (shugoshin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sgo2 (shugoshin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SGO2 (shugoshin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SGO2 (shugoshin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sgo2 (shugoshin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TOP6BL (TOP6B like initiator of meiotic double strand breaks)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SGO2 (shugoshin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sgo2a (shugoshin 2A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sgo2b (shugoshin 2B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-57a22.11	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	67,032,083 - 67,067,439 (+)	NCBI		GRCr8
mRatBN7.2	9	59,548,605 - 59,573,229 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	59,548,683 - 59,573,229 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	68,050,804 - 68,073,293 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	73,166,717 - 73,189,206 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	71,484,820 - 71,507,309 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	64,898,380 - 64,923,023 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	64,898,459 - 64,923,012 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	64,695,921 - 64,720,561 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	56,664,634 - 56,681,534 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	56,809,175 - 56,834,098 (+)	NCBI
Celera	9	56,996,167 - 57,018,671 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Pulmonary Arterial Hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-methylcholine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

deguelin (ISO)

diallyl trisulfide (ISO)

dichloroacetic acid (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

dimethylarsinic acid (EXP)

doxorubicin (ISO)

Enterolactone (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fragrance (ISO)

furan (EXP)

gentamycin (EXP)

hydrogen peroxide (ISO)

irinotecan (ISO)

leflunomide (ISO)

lidocaine (EXP)

lucanthone (ISO)

methotrexate (ISO)

methylparaben (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

ochratoxin A (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triticonazole (EXP)

troglitazone (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

chromosome segregation (IEA)

female meiotic nuclear division (ISO)

maintenance of meiotic sister chromatid cohesion, centromeric (ISO)

male meiotic nuclear division (ISO)

meiotic sister chromatid cohesion (IBA)

meiotic sister chromatid cohesion involved in meiosis I (ISO)

meiotic sister chromatid cohesion, centromeric (ISO)

positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric (ISO)

protein localization (ISO)

Cellular Component

chromosome, centromeric region (ISO)

condensed chromosome, centromeric region (ISO)

kinetochore (IBA,ISO)

mitotic cohesin complex (ISO)

nuclear body (ISO)

nucleoplasm (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17205076	PMID:17485487	PMID:18084284	PMID:18765791	PMID:19283064	PMID:25533956

Genomics

Comparative Map Data

Sgo2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	67,032,083 - 67,067,439 (+)	NCBI		GRCr8
mRatBN7.2	9	59,548,605 - 59,573,229 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	59,548,683 - 59,573,229 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	68,050,804 - 68,073,293 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	73,166,717 - 73,189,206 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	71,484,820 - 71,507,309 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	64,898,380 - 64,923,023 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	64,898,459 - 64,923,012 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	64,695,921 - 64,720,561 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	56,664,634 - 56,681,534 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	56,809,175 - 56,834,098 (+)	NCBI
Celera	9	56,996,167 - 57,018,671 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

SGO2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	200,526,142 - 200,584,096 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	200,510,008 - 200,584,096 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	201,390,865 - 201,448,819 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	201,099,185 - 201,156,750 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	201,216,462 - 201,273,720	NCBI
Celera	2	195,145,716 - 195,203,700 (+)	NCBI		Celera
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	193,242,173 - 193,300,154 (+)	NCBI		HuRef
CHM1_1	2	201,396,844 - 201,454,804 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	200,993,676 - 201,067,575 (+)	NCBI		T2T-CHM13v2.0

Sgo2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	58,024,499 - 58,065,436 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	58,035,130 - 58,065,058 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	57,985,340 - 58,026,277 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	57,995,971 - 58,025,899 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	58,042,184 - 58,083,121 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	57,940,612 - 57,970,443 (+)	NCBI		MGSCv36	mm8
Celera	1	58,499,153 - 58,539,977 (+)	NCBI		Celera
Cytogenetic Map	1	C1.3	NCBI
cM Map	1	28.86	NCBI

Sgo2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955403	879,354 - 905,605 (-)	NCBI	ChiLan1.0	ChiLan1.0

SGO2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	103,149,050 - 103,206,672 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	103,164,049 - 103,221,650 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	87,779,677 - 87,837,285 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	205,943,126 - 205,994,531 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	205,943,783 - 205,994,197 (+)	Ensembl	panpan1.1		panPan2

SGO2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	9,611,843 - 9,653,169 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	9,611,939 - 9,767,044 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	10,498,290 - 10,539,605 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	9,511,109 - 9,552,420 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	9,511,173 - 9,552,395 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	9,499,086 - 9,540,357 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	9,471,294 - 9,512,536 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	9,469,608 - 9,511,797 (+)	NCBI		UU_Cfam_GSD_1.0

Sgo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	157,649,125 - 157,686,308 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936825	341,283 - 373,012 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936825	350,390 - 373,005 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SGO2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	104,099,384 - 104,150,720 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	104,099,378 - 104,150,723 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	115,371,377 - 115,424,516 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SGO2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	86,019,474 - 86,075,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	86,025,030 - 86,067,458 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	113,364,364 - 113,418,131 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sgo2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624889	540,008 - 559,035 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624889	540,680 - 563,110 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sgo2
68 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	15
Count of miRNA genes:	14
Interacting mature miRNAs:	15
Transcripts:	ENSRNOT00000029526
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	23754024	61381613	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	48	113	89	88	57	25	57	6	214	95	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000029526 ⟹ ENSRNOP00000037361

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	59,548,683 - 59,573,229 (+)	Ensembl
Rnor_6.0 Ensembl	9	64,898,459 - 64,922,821 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	64,915,174 - 64,923,012 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092889

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	64,903,128 - 64,903,761 (+)	Ensembl

RefSeq Acc Id:

NM_001271191 ⟹ NP_001258120

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,044,944 - 67,067,439 (+)	NCBI
mRatBN7.2	9	59,550,731 - 59,573,229 (+)	NCBI
Rnor_6.0	9	64,900,528 - 64,923,023 (+)	NCBI
Rnor_5.0	9	64,695,921 - 64,720,561 (+)	NCBI
Celera	9	56,996,167 - 57,018,671 (+)	NCBI

Sequence:

show sequence

ATGGAGTACCCAGGGATAGAAGATGACTCTGTTTCCTCTGGAATTAAGAGACGAGTGAAGGATA
GAATTGCAAAGACAAAGTTGAATGTTTCTCTTGCTTCAAAGATCAAAACAAAAATATTAAACAA
TTCTTCTATTTTCAAGATCTCTCTAAAGCACAACAACAGAGCATTAGCTCGGGCCCTTAGTAAA
GAGAAAGAGAATTCTCGAAGAATCACTACCGAAAAGGTGCAATTACAGAAAGAAGTAGAGAAAC
TGAATTTTGAGAATACCTTTCTTCGCTTAAAACTAAATAATCTGAATAAGAAGCTGATAGAAAT
AGAATCACAAGTGAGCAATAGTTTGTTAACTGCAATTGAAATGAGCAGTCTTTCTGAGTTCCAT
CAAAGTTCTTTTCTCCTGTCAGCTAACAAGAAAAAAAGGGTCAGTAAACAATGCAAGCCTGCAC
ACCTTCCATATGCAAGAGTTCTAATAACTTCAGAAAATGATGATGATGATGATGATGGTGATGA
TGATAAATGGAAAACAAAATGTAACAACAGAACTGTATCAAAGACATCACCTGATAGTACCTCT
TCTGTATCAAGACAGTCTTTATCCTTACATCAGTGTAATTTGGAAGTATTCCTTCCTCAAGAAG
ATAATCAGAAAACATGTGAATCAGGTCATTCAGAATATACTTCAAGTGTTGATGTACTTCCTAA
TGAGAGCCATTACCACTCAGATCAAAGTCCTAAGAGTTTTCTGAGTAAGATGAAAGATGCTCCG
TCTCCCAGCCCCATAAAGGAAAAATTGTCACTTGGTAATGTGACTAAGAGGAAGAAGTGTGTGT
CTTCAGCTGCAGACATTCTGCATGTGGCAGATTTAGATCACCAATCAATTTCAAGTCCAGGATC
AAATTGGAATAATGAGATAAATGGTTGTACTAATGAAACCAGTAATAACGTGCAAAGAAATACA
GAGTGTTTTCCTGACTTACCTTCTGAGTCTTCCAGTGGTCCTAATGTAAAGTGCATGGAACAAG
TACAGAAGAACACTGATACCTTTCACTTGCAGAAAACTGTGTATGAAGACGCTGACATGGAGTT
AACTGCTACTGACATAGGCAAGATTGTAACAATTTCAAAAAGCAATAAAAGTCAAAATAAGAAA
AAGGCAGATTGTAGAAAGGAGACTTTCAGAAAAGTGAAAGGTCCAAGCTCTGATAGGAAGAAAG
AAAGATCAAAGAGAAAATGTAAAGCTAGTTCGGAAGGTGCTGAGGGAAAGACTGAAAACAGACC
AGAGAGAGGCTCTGGTGTCCTAGATGGCAGAGGGGATTCAGAAGATCCAAACTGTATTTCCAAT
AGTGAACAGCCATCTCAGGTAAACATGCAGAAGGAAATAACCTTCCAGAAGAGCTCAGATCAGG
AGAACGTTCAAAATCAAAGGAGGAGGCAAACGTATACGACAGATGAGCAGGAGGAAACAAACCC
TTTCTCCAGATGTTCAGTCAAATTCCTTCAAGATGGTAAATTTGATCCGTATCAGAACACCCTA
CACTGTGATTTAAGTAAGCCTTCTCGGCAGACATTTGTGATTCAAACATCAGAAAAAGATAACT
TACTGCCAAACCAAGACAATAAAGAGAACATTTCTGAAAACCTAGAAGATGCAAATGAATTTCA
TATAGCTCATCTTTCCATCAAAGATAATGAAAATGTATGTGACCATGAAACTCAAACAATTTTG
GACTTGAAAAAGAATGTCAATGCTCAGCAAAATCAAACAAAAATAAATAAGACTAAGCAGAAAA
TAAATCGAAGAACCAAAATAATTTCTATTACAAACCAAATAAATGAGGATAATGATAAAGATAT
TCACGTCCTAGAAAAAGGCAACTTTCCCTTCCAAACCCAAGCAAATAAAGAAACCACCAGTGGA
AACCTAGAAGCTTCAAAAGAATTTGAAACACCTCTTTACACAAGAGACAGTGGAAGCTTACATG
ACTGTAACACCCAGAATGTTCTGGATCTGCACAAGCAAATCACTAGTATATACCCTGGTCAGAA
TAAGTCCCAAATTAGCAAAATCCCTAGACAGAAGCTAAGTCGCAAGACAGAAGTAATTTCTGAA
GTGAATTGTTTTAGTAATGACAGAGATGTCCTTTGTTCAGAAAAGGATGAGTCTTTCTTGCTAC
AAAAGGATAAAGAGATCCCTGGAACCTTGAAAGACGTAAGCGAGTTTGATAAGCCTGCTTTTTA
TAACAAAGATAGTGTGAAGTCATGTGATTTTAAGGCTGAACCGTTGTTGGGGTTGAAAAGACAT
GACCCTAATATGCCACCTGCTTGTCAAGCTGACTCAAAGGTAGATAAGAAGCTTAGACAAAAGG
TGAAGCGAAAGACAGAAATAATTTCTAAAATCAACCAGATACATAAAAATGATGAAGGAAGTGC
ACATGACCCATTAAATAAGGAGCTCCGTCAGAAGGTTAGTATATCAAAAATCATTTCTGAAATG
AACCAAATATATGAGACTATTAATGAAGATGGGAATGCCTTTAAAAGCTCGCTCAAACATTGCC
AAGATGTTATGAGTTGTGACTTTGGGAAAAAAACCAGTAACGAAGAGGAAAATCATGATCTGAC
TCCAGATCTTTGCTCACTAGTTAAGAAACCAAGGAAAAAGGTATCATGTAAAGCAGGGAACAGT
TTGACAGGAGATAAGAACAGGTGTATTTTGCAGTTAACAGGTTCTTCACAGGAGTCCGTCACCT
TGGACTCTGGCTTAAAACACGGTCCAAATGAAGCAGATTCTGGCCCTGGAGAGCAGACTAACCT
GCCAAAGAAGCAGAAACCAAGCACTGTGAGTACACTGGGAGACGCCTTCTCTCTGAGTGTGGTA
AGAGAAGGAAGCCACCCAGCCCAGACAGGTAGTAAAGTGACATCCAAGTCAAAGAAAAGAAAGA
CCCCTCTAAGATCCTCTGATACCCGTGGAGCAGTGGAGAGAACACCAAACACTGATGGCATTAC
GGCAGTTTACTTCCAACAGACTGAGAAGGAGAACTATTTGGAGAATGAGAAAATTGCCAAGAGT
AAGCCAGACTTTCGCTCAAAGGTGTTGAAACCTTTATCTGAGATATGTTCATCTAACATAAAGA
ATTCTTCCTTGGGCAGTATGTGTGAGAGTTCTGTGCCTTTGAGTACTTTTTCTAGTAAACCCCT
GATGCTAGAAGAAAGTTCTTCCCTGGACAGTACATGCATCTTTCCAGTAGGTGATGGTGCCCAT
GAAAAGTTAAAGGAAGGCACTCCTACATCCCACCGCAGGACACAGAAGTCAAGACCAGGTAGCA
GAACATCCCTGGTCTTGGTGGATAACAGTTCTGTTTCTAGTAACACTGCTAACCCTGAAAATGA
GTCAGAAAGGCACTCTTCACACCAGATGAGGAGGAAAAGACAGTGCACCCCTCTCAACCTGACC
GAACCAAGCCTTAGAAGCAAGATGAGAAGATGAAGTGCAGGTGAAGTGGATACAGATCCTAGTT
TTTCCAAGTTCCCAAAGCACAAGTCAGAGCAGAAGTATAAGTAGAACATGAAACAAGTATTCGG
TTGCTTGAGTTTTGTACATGAAGAAGTATTCTGTTACCTTTTCTTTTCTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTGGGCCTTTCATGGATTAATGCTTTCTCTATTCTTACATTG
AGATGTATGTGCATAAAATAGCTGTATCTTAAATAATAAACTTTTTTAAAAAACATTTGTCATC
AC

hide sequence

RefSeq Acc Id:

XM_063267191 ⟹ XP_063123261

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,042,776 - 67,067,428 (+)	NCBI

RefSeq Acc Id:

XM_063267192 ⟹ XP_063123262

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,032,083 - 67,067,428 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001258120	(Get FASTA)	NCBI Sequence Viewer
	XP_063123261	(Get FASTA)	NCBI Sequence Viewer
	XP_063123262	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL99015	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037361.5

RefSeq Acc Id:

NP_001258120 ⟸ NM_001271191

- UniProtKB:

D3ZWI4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEYPGIEDDSVSSGIKRRVKDRIAKTKLNVSLASKIKTKILNNSSIFKISLKHNNRALARALSK
EKENSRRITTEKVQLQKEVEKLNFENTFLRLKLNNLNKKLIEIESQVSNSLLTAIEMSSLSEFH
QSSFLLSANKKKRVSKQCKPAHLPYARVLITSENDDDDDDGDDDKWKTKCNNRTVSKTSPDSTS
SVSRQSLSLHQCNLEVFLPQEDNQKTCESGHSEYTSSVDVLPNESHYHSDQSPKSFLSKMKDAP
SPSPIKEKLSLGNVTKRKKCVSSAADILHVADLDHQSISSPGSNWNNEINGCTNETSNNVQRNT
ECFPDLPSESSSGPNVKCMEQVQKNTDTFHLQKTVYEDADMELTATDIGKIVTISKSNKSQNKK
KADCRKETFRKVKGPSSDRKKERSKRKCKASSEGAEGKTENRPERGSGVLDGRGDSEDPNCISN
SEQPSQVNMQKEITFQKSSDQENVQNQRRRQTYTTDEQEETNPFSRCSVKFLQDGKFDPYQNTL
HCDLSKPSRQTFVIQTSEKDNLLPNQDNKENISENLEDANEFHIAHLSIKDNENVCDHETQTIL
DLKKNVNAQQNQTKINKTKQKINRRTKIISITNQINEDNDKDIHVLEKGNFPFQTQANKETTSG
NLEASKEFETPLYTRDSGSLHDCNTQNVLDLHKQITSIYPGQNKSQISKIPRQKLSRKTEVISE
VNCFSNDRDVLCSEKDESFLLQKDKEIPGTLKDVSEFDKPAFYNKDSVKSCDFKAEPLLGLKRH
DPNMPPACQADSKVDKKLRQKVKRKTEIISKINQIHKNDEGSAHDPLNKELRQKVSISKIISEM
NQIYETINEDGNAFKSSLKHCQDVMSCDFGKKTSNEEENHDLTPDLCSLVKKPRKKVSCKAGNS
LTGDKNRCILQLTGSSQESVTLDSGLKHGPNEADSGPGEQTNLPKKQKPSTVSTLGDAFSLSVV
REGSHPAQTGSKVTSKSKKRKTPLRSSDTRGAVERTPNTDGITAVYFQQTEKENYLENEKIAKS
KPDFRSKVLKPLSEICSSNIKNSSLGSMCESSVPLSTFSSKPLMLEESSSLDSTCIFPVGDGAH
EKLKEGTPTSHRRTQKSRPGSRTSLVLVDNSSVSSNTANPENESERHSSHQMRRKRQCTPLNLT
EPSLRSKMRR

hide sequence

Ensembl Acc Id:

ENSRNOP00000037361 ⟸ ENSRNOT00000029526

RefSeq Acc Id:	XP_063123262 ⟸ XM_063267192
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063123261 ⟸ XM_063267191
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZWI4-F1-model_v2	AlphaFold	D3ZWI4	1-1162	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696681

Promoter ID:

EPDNEW_R7206

Type:

initiation region

Name:

Sgo2_1

Description:

shugoshin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	64,898,441 - 64,898,501	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308450	AgrOrtholog
BioCyc Gene	G2FUF-27465	BioCyc
Ensembl Genes	ENSRNOG00000027035	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000029526.7	UniProtKB/TrEMBL
InterPro	Shugoshin	UniProtKB/TrEMBL
KEGG Report	rno:316425	UniProtKB/TrEMBL
NCBI Gene	316425	ENTREZGENE
PANTHER	PTHR21577	UniProtKB/TrEMBL
	SHUGOSHIN 1-RELATED	UniProtKB/TrEMBL
PhenoGen	Sgo2	PhenoGen
RatGTEx	ENSRNOG00000027035	RatGTEx
UniProt	D3ZWI4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-29	Sgo2	shugoshin 2	Sgol2	shugoshin-like 2 (S. pombe)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Sgol2	shugoshin-like 2 (S. pombe)	Sgol2_predicted	shugoshin-like 2 (S. pombe) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sgol2_predicted	shugoshin-like 2 (S. pombe) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar