Prss40 (protease, serine, 40) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prss40 (protease, serine, 40) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss40
Name: protease, serine, 40
RGD ID: 1561330
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316318; RGD1561330; serine protease 40; similar to TESP2; Tesp2; testicular serine protease 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,258,081 - 44,266,893 (-)NCBIGRCr8
mRatBN7.2936,762,170 - 36,770,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,762,173 - 36,770,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx945,259,087 - 45,267,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0950,390,263 - 50,399,068 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0948,672,189 - 48,680,988 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0941,061,116 - 41,069,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,061,116 - 41,069,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,731,239 - 40,739,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,297,863 - 33,305,899 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,548,166 - 34,555,665 (-)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prss40Ratproteolysis involved_inIEAInterPro:IPR0012541600115GO_REF:0000002InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prss40Ratserine-type endopeptidase activity enablesIEAInterPro:IPR0012541600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. GOA pipeline RGD automated data pipeline
PMID:21873635  



.

.
Variants in Prss40
92 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
9 40739836 40739837 C T snv IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000018758
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat

1 to 10 of 30 rows



alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 1 6 2 1 2 5 2 6 1 28 1



Ensembl Acc Id: ENSRNOT00000018758   ⟹   ENSRNOP00000018758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl936,762,173 - 36,770,979 (-)Ensembl
Rnor_6.0 Ensembl941,061,116 - 41,069,929 (-)Ensembl
RefSeq Acc Id: NM_001108209   ⟹   NP_001101679
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,258,088 - 44,266,893 (-)NCBI
mRatBN7.2936,762,173 - 36,770,979 (-)NCBI
Rnor_6.0941,061,116 - 41,069,929 (-)NCBI
Rnor_5.0940,731,239 - 40,739,928 (-)NCBI
RGSC_v3.4933,297,863 - 33,305,899 (-)RGD
Celera934,548,166 - 34,555,665 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083559   ⟹   XP_038939487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,258,081 - 44,266,827 (-)NCBI
mRatBN7.2936,762,170 - 36,770,913 (-)NCBI
RefSeq Acc Id: XM_063267143   ⟹   XP_063123213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,258,081 - 44,266,816 (-)NCBI
Protein RefSeqs NP_001101679 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939487 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123213 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018758
  ENSRNOP00000018758.5
RefSeq Acc Id: NP_001101679   ⟸   NM_001108209
- Peptide Label: precursor
- UniProtKB: D3ZR46 (UniProtKB/TrEMBL),   A6INA6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018758   ⟸   ENSRNOT00000018758
RefSeq Acc Id: XP_038939487   ⟸   XM_039083559
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063123213   ⟸   XM_063267143
- Peptide Label: isoform X1
Peptidase S1


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27856 BioCyc
Ensembl Genes ENSRNOG00000014001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018758 ENTREZGENE
  ENSRNOT00000018758.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:316318 UniProtKB/TrEMBL
NCBI Gene 316318 ENTREZGENE
PANTHER PROTEASE, SERINE 47 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss40 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014001 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A6INA6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZR46 ENTREZGENE, UniProtKB/TrEMBL
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Prss40  protease, serine, 40  Tesp2  testicular serine protease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Tesp2  testicular serine protease 2  RGD1561330_predicted  similar to TESP2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561330_predicted  similar to TESP2 (predicted)  LOC316318  similar to TESP2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC316318  similar to TESP2      Symbol and Name status set to provisional 70820 PROVISIONAL