Prss40 (protease, serine, 40) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Prss40 (protease, serine, 40) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss40
Name: protease, serine, 40
RGD ID: 1561330
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316318; RGD1561330; serine protease 40; similar to TESP2; Tesp2; testicular serine protease 2
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2936,762,170 - 36,770,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,762,173 - 36,770,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx945,259,087 - 45,267,892 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0950,390,263 - 50,399,068 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0948,672,189 - 48,680,988 (-)NCBIRnor_WKY
Rnor_6.0941,061,116 - 41,069,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,061,116 - 41,069,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,731,239 - 40,739,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,297,863 - 33,305,899 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,548,166 - 34,555,665 (-)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:21873635  


Genomics

Variants

.
Variants in Prss40
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000018758
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium 7
Low
Below cutoff 1 1 1 1 1 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018758   ⟹   ENSRNOP00000018758
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl936,762,173 - 36,770,979 (-)Ensembl
Rnor_6.0 Ensembl941,061,116 - 41,069,929 (-)Ensembl
RefSeq Acc Id: NM_001108209   ⟹   NP_001101679
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2936,762,173 - 36,770,979 (-)NCBI
Rnor_6.0941,061,116 - 41,069,929 (-)NCBI
Rnor_5.0940,731,239 - 40,739,928 (-)NCBI
RGSC_v3.4933,297,863 - 33,305,899 (-)RGD
Celera934,548,166 - 34,555,665 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083559   ⟹   XP_038939487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2936,762,170 - 36,770,913 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101679 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99304 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101679   ⟸   NM_001108209
- Peptide Label: precursor
- UniProtKB: D3ZR46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018758   ⟸   ENSRNOT00000018758
RefSeq Acc Id: XP_038939487   ⟸   XM_039083559
- Peptide Label: isoform X1
Protein Domains
Peptidase S1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561330 AgrOrtholog
BioCyc Gene G2FUF-27856 BioCyc
Ensembl Genes ENSRNOG00000014001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018758 ENTREZGENE
  ENSRNOP00000018758.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018758 ENTREZGENE
  ENSRNOT00000018758.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:316318 UniProtKB/TrEMBL
NCBI Gene 316318 ENTREZGENE
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss40 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt D3ZR46 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Prss40  protease, serine, 40  Tesp2  testicular serine protease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Tesp2  testicular serine protease 2  RGD1561330_predicted  similar to TESP2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561330_predicted  similar to TESP2 (predicted)  LOC316318  similar to TESP2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC316318  similar to TESP2      Symbol and Name status set to provisional 70820 PROVISIONAL