Kcnq5 (potassium voltage-gated channel subfamily Q member 5) - Rat Genome Database

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Gene: Kcnq5 (potassium voltage-gated channel subfamily Q member 5) Rattus norvegicus
Analyze
Symbol: Kcnq5
Name: potassium voltage-gated channel subfamily Q member 5
RGD ID: 628848
Description: Exhibits voltage-gated potassium channel activity. Involved in potassium ion transport. Predicted to localize to clathrin coat and voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Kcnq5l; LOC689123; potassium channel, voltage-gated KQT-like subfamily Q, member 5; potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, KQT-like subfamily, member 5; potassium voltage-gated channel, subfamily Q, member 5; potassium voltage-gated channel, subfamily Q, member 5-like; similar to Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel alpha subunit KvLQT5) (KQT-like 5)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,830,185 - 24,395,984 (-)NCBI
Rnor_6.0 Ensembl927,562,959 - 27,761,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0927,565,869 - 28,141,114 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0926,413,162 - 26,986,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,181,402 - 20,767,644 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1920,293,226 - 20,293,677 (-)NCBI
Celera921,408,169 - 21,967,095 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10787416   PMID:11159685   PMID:15632090   PMID:15963599   PMID:17071736   PMID:17322297   PMID:18048450   PMID:18331828   PMID:18786918   PMID:19246091   PMID:20151361  
PMID:20624791   PMID:21666672   PMID:21750731   PMID:24297175   PMID:24446351   PMID:24558103   PMID:24855057   PMID:25421809   PMID:25616413   PMID:28189443   PMID:28669405   PMID:31570602  


Genomics

Comparative Map Data
Kcnq5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,830,185 - 24,395,984 (-)NCBI
Rnor_6.0 Ensembl927,562,959 - 27,761,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0927,565,869 - 28,141,114 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0926,413,162 - 26,986,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,181,402 - 20,767,644 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1920,293,226 - 20,293,677 (-)NCBI
Celera921,408,169 - 21,967,095 (-)NCBICelera
Cytogenetic Map9q13NCBI
KCNQ5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl672,621,792 - 73,198,853 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl672,621,792 - 73,198,851 (+)EnsemblGRCh38hg38GRCh38
GRCh38672,621,843 - 73,198,853 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37673,331,792 - 73,908,576 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36673,388,556 - 73,962,301 (+)NCBINCBI36hg18NCBI36
Build 34673,388,555 - 73,962,301NCBI
Celera673,724,971 - 74,301,723 (+)NCBI
Cytogenetic Map6q13NCBI
HuRef670,530,024 - 71,107,055 (+)NCBIHuRef
CHM1_1673,498,230 - 74,075,278 (+)NCBICHM1_1
Kcnq5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39121,468,623 - 22,032,874 (-)NCBIGRCm39mm39
GRCm39 Ensembl121,468,627 - 22,032,166 (-)Ensembl
GRCm38121,398,399 - 21,962,650 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl121,398,403 - 21,961,942 (-)EnsemblGRCm38mm10GRCm38
MGSCv37121,388,484 - 21,952,023 (-)NCBIGRCm37mm9NCBIm37
MGSCv36121,387,314 - 21,946,732 (-)NCBImm8
Celera121,280,293 - 21,849,214 (-)NCBICelera
Cytogenetic Map1A4NCBI
Kcnq5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554887,406,635 - 7,927,532 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554887,406,633 - 7,928,526 (+)NCBIChiLan1.0ChiLan1.0
KCNQ5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1673,741,208 - 74,315,757 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl673,742,191 - 74,312,344 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0670,448,161 - 71,025,173 (+)NCBIMhudiblu_PPA_v0panPan3
KCNQ5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11234,872,514 - 35,364,794 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1234,872,581 - 35,362,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1234,737,803 - 35,233,429 (+)NCBI
ROS_Cfam_1.01235,413,242 - 35,916,493 (+)NCBI
UMICH_Zoey_3.11234,948,630 - 35,457,677 (+)NCBI
UNSW_CanFamBas_1.01234,986,659 - 35,479,229 (+)NCBI
UU_Cfam_GSD_1.01235,098,552 - 35,603,898 (+)NCBI
Kcnq5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494670,125,573 - 70,658,239 (+)NCBI
SpeTri2.0NW_0049366184,283,240 - 4,815,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl152,435,434 - 52,939,824 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1152,435,332 - 52,939,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2158,773,511 - 59,277,120 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNQ5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1171,932,962 - 2,495,926 (-)NCBI
ChlSab1.1 Ensembl171,930,803 - 2,128,570 (-)Ensembl
Kcnq5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248196,886,328 - 7,365,537 (-)NCBI

Position Markers
D9Rat180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2924,116,078 - 24,116,997 (+)MAPPER
mRatBN7.2924,116,762 - 24,116,997 (+)MAPPER
Rnor_6.0927,858,560 - 27,859,505NCBIRnor6.0
Rnor_6.0927,859,271 - 27,859,505NCBIRnor6.0
Rnor_5.0926,705,889 - 26,706,123UniSTSRnor5.0
Rnor_5.0926,705,178 - 26,706,123UniSTSRnor5.0
RGSC_v3.4920,474,388 - 20,474,623RGDRGSC3.4
RGSC_v3.4920,474,389 - 20,474,623UniSTSRGSC3.4
RGSC_v3.1920,475,802 - 20,476,037RGD
Celera921,690,031 - 21,690,263UniSTS
SHRSP x BN Map920.1098RGD
SHRSP x BN Map920.1098UniSTS
Cytogenetic Map9q13UniSTS
D9Got31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2924,297,837 - 24,298,072 (+)MAPPER
Rnor_6.0928,045,520 - 28,045,754NCBIRnor6.0
Rnor_5.0926,890,948 - 26,891,182UniSTSRnor5.0
Celera921,870,523 - 21,870,757UniSTS
RH 3.4 Map9224.5RGD
RH 3.4 Map9224.5UniSTS
RH 2.0 Map9187.0RGD
Cytogenetic Map9q13UniSTS
RH138014  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2924,075,461 - 24,075,696 (+)MAPPER
Rnor_6.0927,817,440 - 27,817,674NCBIRnor6.0
Rnor_5.0926,665,206 - 26,665,440UniSTSRnor5.0
Celera921,649,469 - 21,649,703UniSTS
RH 3.4 Map9229.29UniSTS
Cytogenetic Map9q13UniSTS
RH131959  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2924,387,590 - 24,387,771 (+)MAPPER
Rnor_6.0928,133,826 - 28,134,006NCBIRnor6.0
Rnor_5.0926,979,169 - 26,979,349UniSTSRnor5.0
RGSC_v3.4920,760,376 - 20,760,556UniSTSRGSC3.4
Celera921,959,807 - 21,959,987UniSTS
RH 3.4 Map9237.0UniSTS
Cytogenetic Map9q13UniSTS
BE106461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2923,914,507 - 23,914,657 (+)MAPPER
Rnor_6.0927,647,434 - 27,647,583NCBIRnor6.0
Rnor_5.0926,494,727 - 26,494,876UniSTSRnor5.0
RGSC_v3.4920,262,523 - 20,262,672UniSTSRGSC3.4
Celera921,489,344 - 21,489,493UniSTS
RH 3.4 Map9229.5UniSTS
Cytogenetic Map9q13UniSTS
RH141099  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2923,833,570 - 23,833,750 (+)MAPPER
Rnor_6.0927,566,353 - 27,566,532NCBIRnor6.0
Rnor_5.0926,413,646 - 26,413,825UniSTSRnor5.0
RGSC_v3.4920,181,586 - 20,181,765UniSTSRGSC3.4
Celera921,408,653 - 21,408,832UniSTS
RH 3.4 Map9229.6UniSTS
Cytogenetic Map9q13UniSTS
AU049631  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2923,970,175 - 23,970,321 (+)MAPPER
mRatBN7.2923,970,175 - 23,970,479 (+)MAPPER
Rnor_6.0927,703,085 - 27,703,228NCBIRnor6.0
Rnor_6.0927,703,085 - 27,703,411NCBIRnor6.0
Rnor_5.0926,550,378 - 26,550,704UniSTSRnor5.0
Rnor_5.0926,550,378 - 26,550,521UniSTSRnor5.0
RGSC_v3.4920,318,182 - 20,318,327UniSTSRGSC3.4
Celera921,544,941 - 21,545,086UniSTS
Cytogenetic Map9q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9129467098Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9140383872Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9140383872Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9140383872Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9145029794Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9235572247355722Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9235572247355722Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9288097747375681Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9288097747880977Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9498609549986095Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9498609549986095Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)91221677157216771Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)91242546357425463Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)91242546357425463Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91555490147249201Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91952048945029794Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92488509969885099Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92569237370692373Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92575432054885226Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92748603663264281Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92748603666757620Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92748615588333183Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:70
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000018552, ENSRNOT00000040034
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 3 3 39 1 3
Low 3 22 21 6 19 6 5 8 35 27 41 10 5
Below cutoff 17 31 30 30 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018552   ⟹   ENSRNOP00000018552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl927,565,869 - 27,761,365 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000040034   ⟹   ENSRNOP00000047562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl927,562,959 - 27,761,733 (-)Ensembl
RefSeq Acc Id: NM_001134643   ⟹   NP_001128115
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,833,087 - 24,394,880 (-)NCBI
Rnor_6.0927,565,869 - 28,141,114 (-)NCBI
Rnor_5.0926,413,162 - 26,986,457 (-)NCBI
Celera921,408,169 - 21,967,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083094   ⟹   XP_038939022
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,830,185 - 24,395,887 (-)NCBI
RefSeq Acc Id: XM_039083095   ⟹   XP_038939023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,830,185 - 24,395,887 (-)NCBI
RefSeq Acc Id: XM_039083096   ⟹   XP_038939024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,830,185 - 23,901,503 (-)NCBI
RefSeq Acc Id: XM_039083097   ⟹   XP_038939025
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2923,906,602 - 24,395,984 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001128115   ⟸   NM_001134643
- Sequence:
RefSeq Acc Id: ENSRNOP00000018552   ⟸   ENSRNOT00000018552
RefSeq Acc Id: ENSRNOP00000047562   ⟸   ENSRNOT00000040034
RefSeq Acc Id: XP_038939023   ⟸   XM_039083095
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038939022   ⟸   XM_039083094
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038939024   ⟸   XM_039083096
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038939025   ⟸   XM_039083097
- Peptide Label: isoform X4
Protein Domains
Ion_trans   KCNQ_channel

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628848 AgrOrtholog
Ensembl Genes ENSRNOG00000013781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018552 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000047562 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018552 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000040034 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ2 UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/TrEMBL
  KCNQ5 UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/TrEMBL
NCBI Gene 259273 ENTREZGENE
PANTHER PTHR11537 UniProtKB/TrEMBL
  PTHR11537:SF128 UniProtKB/TrEMBL
  PTHR11537:SF6 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/TrEMBL
PhenoGen Kcnq5 PhenoGen
PRINTS KCNQCHANNEL UniProtKB/TrEMBL
UniProt F1LSD6_RAT UniProtKB/TrEMBL
  F1LY25_RAT UniProtKB/TrEMBL
  Q8K3W7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnq5  potassium voltage-gated channel subfamily Q member 5  Kcnq5  potassium channel, voltage-gated KQT-like subfamily Q, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnq5  potassium channel, voltage-gated KQT-like subfamily Q, member 5  Kcnq5  potassium voltage-gated channel, KQT-like subfamily, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-18 Kcnq5l  potassium voltage-gated channel, subfamily Q, member 5-like  Kcnq5  potassium voltage-gated channel, KQT-like subfamily, member 5  Data Merged 737654 APPROVED
2012-07-18 Kcnq5  potassium voltage-gated channel, KQT-like subfamily, member 5  Kcnq5l  potassium voltage-gated channel, subfamily Q, member 5-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kcnq5  potassium voltage-gated channel, KQT-like subfamily, member 5  Kcnq5  potassium voltage-gated channel, subfamily Q, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Kcnq5  potassium voltage-gated channel, subfamily Q, member 5  LOC689123  similar to Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel alpha subunit KvLQT5) (KQT-like 5)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Kcnq5l  potassium voltage-gated channel, subfamily Q, member 5-like  Kcnq5  potassium voltage-gated channel, subfamily Q, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689123  similar to Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel alpha subunit KvLQT5) (KQT-like 5)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Kcnq5  potassium voltage-gated channel, subfamily Q, member 5    potassium voltage-gated channel, KQT-like subfamily, member 5  Name updated 1299863 APPROVED
2003-02-27 Kcnq5  potassium voltage-gated channel, KQT-like subfamily, member 5      Symbol and Name status set to provisional 70820 PROVISIONAL