Myo1b (myosin Ib) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Myo1b (myosin Ib) Rattus norvegicus
Analyze
Symbol: Myo1b
Name: myosin Ib
RGD ID: 70994
Description: Enables several functions, including actin filament binding activity; anion binding activity; and calmodulin binding activity. Involved in actin filament bundle assembly and actin filament-based movement. Located in several cellular components, including apical part of cell; brush border; and filopodium. Orthologous to human MYO1B (myosin IB); INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MMI-alpha; MMIa; myosin heavy chain myr 1; myosin I alpha; myosin-Ib; Myr1; unconventional myosin-Ib
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Myo1b_v2   Myo1b_v1   Myo1b_v3  
Candidate Gene For: Vetf6
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8957,182,059 - 57,344,335 (+)NCBIGRCr8
mRatBN7.2949,690,043 - 49,852,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,226,269 - 58,386,333 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,349,103 - 63,509,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,645,084 - 61,805,158 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,706,005 - 54,766,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,558,202 - 54,766,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0954,267,753 - 54,414,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,756,678 - 46,917,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,758,091 - 46,918,583 (+)NCBI
Celera947,338,666 - 47,497,975 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dimethylarsinous acid  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
herbicide  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
malathion  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesotrione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Batters C, etal., Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1895-905.
2. Ischemia disrupts myosin I beta in renal tubules. Boyd-White J, etal., Am J Physiol Cell Physiol 2001 Oct;281(4):C1326-35.
3. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. Chinthalapudi K, etal., J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16.
4. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, etal., J Assoc Res Otolaryngol 2002 Dec;3(4):375-89. Epub 2002 Feb 27.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Localization of myosin 1b to actin protrusions requires phosphoinositide binding. Komaba S and Coluccio LM, J Biol Chem. 2010 Sep 3;285(36):27686-93. doi: 10.1074/jbc.M109.087270. Epub 2010 Jul 7.
7. Control of myosin-I force sensing by alternative splicing. Laakso JM, etal., Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):698-702. doi: 10.1073/pnas.0911426107. Epub 2009 Dec 22.
8. Myosin surface loop 4 modulates inhibition of actomyosin 1b ATPase activity by tropomyosin. Lieto-Trivedi A, etal., Biochemistry. 2007 Mar 13;46(10):2779-86. Epub 2007 Feb 14.
9. Biochemical and motile properties of Myo1b splice isoforms. Lin T, etal., J Biol Chem. 2005 Dec 16;280(50):41562-7. Epub 2005 Oct 26.
10. Gene Data Set MGD Curation, June 12, 2002
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Identification, characterization and cloning of myr 1, a mammalian myosin-I. Ruppert C, etal., J Cell Biol 1993 Mar;120(6):1393-403.
14. Mammalian class I myosin, Myo1b, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy. Stafford WF, etal., Biophys J. 2005 Jan;88(1):384-91. Epub 2004 Oct 8.
Additional References at PubMed
PMID:11208135   PMID:12490950   PMID:15980431   PMID:16219689   PMID:16981718   PMID:19056867   PMID:19199708   PMID:21666684   PMID:22114352   PMID:24625528   PMID:25468996   PMID:26195670  
PMID:26940917   PMID:33826361   PMID:33930467   PMID:35352799  


Genomics

Comparative Map Data
Myo1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8957,182,059 - 57,344,335 (+)NCBIGRCr8
mRatBN7.2949,690,043 - 49,852,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,226,269 - 58,386,333 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,349,103 - 63,509,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,645,084 - 61,805,158 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,706,005 - 54,766,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,558,202 - 54,766,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0954,267,753 - 54,414,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,756,678 - 46,917,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,758,091 - 46,918,583 (+)NCBI
Celera947,338,666 - 47,497,975 (+)NCBICelera
Cytogenetic Map9q22NCBI
MYO1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382191,245,404 - 191,425,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2191,245,185 - 191,425,389 (+)EnsemblGRCh38hg38GRCh38
GRCh372192,110,130 - 192,290,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,818,375 - 191,998,287 (+)NCBINCBI36Build 36hg18NCBI36
Build 342191,935,635 - 192,115,548NCBI
Celera2185,704,728 - 185,884,766 (+)NCBICelera
Cytogenetic Map2q32.3NCBI
HuRef2183,969,542 - 184,149,826 (+)NCBIHuRef
CHM1_12192,115,938 - 192,295,960 (+)NCBICHM1_1
T2T-CHM13v2.02191,734,489 - 191,914,303 (+)NCBIT2T-CHM13v2.0
Myo1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39151,788,915 - 51,955,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl151,788,924 - 51,955,230 (-)EnsemblGRCm39 Ensembl
GRCm38151,749,758 - 51,916,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl151,749,765 - 51,916,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv37151,806,609 - 51,972,818 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36151,694,310 - 51,860,497 (-)NCBIMGSCv36mm8
Celera152,287,894 - 52,454,494 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.58NCBI
Myo1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554037,826,058 - 7,966,624 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554037,826,058 - 7,966,457 (-)NCBIChiLan1.0ChiLan1.0
MYO1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,929,632 - 94,109,104 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,944,469 - 94,124,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,549,494 - 78,728,819 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,465,078 - 196,644,188 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,465,078 - 196,644,188 (+)Ensemblpanpan1.1panPan2
MYO1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,748,287 - 1,921,360 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,747,974 - 1,920,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,693,497 - 2,869,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,632,808 - 1,808,623 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,632,819 - 1,808,620 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,642,176 - 1,819,468 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,610,548 - 1,786,134 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,638,672 - 1,814,273 (+)NCBIUU_Cfam_GSD_1.0
Myo1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,833,909 - 150,005,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365066,832,670 - 7,004,273 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365066,832,132 - 7,004,262 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,874,412 - 96,066,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,874,398 - 96,066,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215107,300,243 - 107,411,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,773,372 - 76,951,006 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,773,042 - 76,951,235 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,527,490 - 122,705,871 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248544,738,061 - 4,896,030 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo1b
1569 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:69
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000068433
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
6903937Bp356Blood pressure QTL 3560.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94790220852283252Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
RH124549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,851,840 - 49,852,063 (+)MAPPERmRatBN7.2
Rnor_6.0954,767,097 - 54,767,319NCBIRnor6.0
Rnor_6.0954,706,393 - 54,706,615NCBIRnor6.0
Rnor_5.0954,415,307 - 54,415,529UniSTSRnor5.0
Rnor_5.0954,473,434 - 54,473,656UniSTSRnor5.0
RGSC_v3.4946,918,212 - 46,918,434UniSTSRGSC3.4
Celera947,499,018 - 47,499,240UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001432365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000068433   ⟹   ENSRNOP00000061523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Rnor_6.0 Ensembl954,558,202 - 54,766,054 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098464   ⟹   ENSRNOP00000091336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108379   ⟹   ENSRNOP00000095448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114644   ⟹   ENSRNOP00000088031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118845   ⟹   ENSRNOP00000082803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,690,086 - 49,850,798 (+)Ensembl
RefSeq Acc Id: NM_053986   ⟹   NP_446438
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,062 - 57,342,760 (+)NCBI
mRatBN7.2949,690,086 - 49,850,798 (+)NCBI
Rnor_6.0954,706,005 - 54,766,054 (+)NCBI
Rnor_5.0954,267,753 - 54,414,264 (+)NCBI
RGSC_v3.4946,756,678 - 46,917,169 (+)RGD
Celera947,338,666 - 47,497,975 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082950   ⟹   XP_038938878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
mRatBN7.2949,690,044 - 49,852,373 (+)NCBI
RefSeq Acc Id: XM_039082953   ⟹   XP_038938881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
mRatBN7.2949,690,045 - 49,852,373 (+)NCBI
RefSeq Acc Id: XM_039082955   ⟹   XP_038938883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
mRatBN7.2949,690,045 - 49,852,373 (+)NCBI
RefSeq Acc Id: XM_063266574   ⟹   XP_063122644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,204,144 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266575   ⟹   XP_063122645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266576   ⟹   XP_063122646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,204,144 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266577   ⟹   XP_063122647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,204,144 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266578   ⟹   XP_063122648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,182,059 - 57,344,335 (+)NCBI
RefSeq Acc Id: XM_063266579   ⟹   XP_063122649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,291,696 - 57,344,335 (+)NCBI
RefSeq Acc Id: NP_446438   ⟸   NM_053986
- UniProtKB: Q05096 (UniProtKB/Swiss-Prot),   A0A8I6GGN1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061523   ⟸   ENSRNOT00000068433
RefSeq Acc Id: XP_038938878   ⟸   XM_039082950
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938881   ⟸   XM_039082953
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GLM5 (UniProtKB/TrEMBL),   A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938883   ⟸   XM_039082955
- Peptide Label: isoform X6
- UniProtKB: A0A8I6G7W8 (UniProtKB/TrEMBL),   A0A8I6GGN1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095448   ⟸   ENSRNOT00000108379
Ensembl Acc Id: ENSRNOP00000088031   ⟸   ENSRNOT00000114644
Ensembl Acc Id: ENSRNOP00000091336   ⟸   ENSRNOT00000098464
Ensembl Acc Id: ENSRNOP00000082803   ⟸   ENSRNOT00000118845
RefSeq Acc Id: XP_063122645   ⟸   XM_063266575
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122648   ⟸   XM_063266578
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122644   ⟸   XM_063266574
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122646   ⟸   XM_063266576
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122647   ⟸   XM_063266577
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GGN1 (UniProtKB/TrEMBL),   A0A8I6AFE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122649   ⟸   XM_063266579
- Peptide Label: isoform X8
Protein Domains
IQ   Myosin motor   TH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05096-F1-model_v2 AlphaFold Q05096 1-1136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70994 AgrOrtholog
BioCyc Gene G2FUF-27603 BioCyc
Ensembl Genes ENSRNOG00000048152 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004604 UniProtKB/Swiss-Prot
  ENSRNOG00060018388 UniProtKB/Swiss-Prot
  ENSRNOG00065003112 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068433.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098464.1 UniProtKB/TrEMBL
  ENSRNOT00000108379.1 UniProtKB/TrEMBL
  ENSRNOT00000114644.1 UniProtKB/TrEMBL
  ENSRNOT00000118845.1 UniProtKB/TrEMBL
  ENSRNOT00055007325 UniProtKB/Swiss-Prot
  ENSRNOT00060032040 UniProtKB/Swiss-Prot
  ENSRNOT00065004410 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYSc_Myo1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117057 UniProtKB/Swiss-Prot
NCBI Gene 117057 ENTREZGENE
PANTHER MYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UNCONVENTIONAL MYOSIN-IB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UNCONVENTIONAL MYOSIN-IB ISOFORM X1 UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myo1b PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048152 RatGTEx
  ENSRNOG00055004604 RatGTEx
  ENSRNOG00060018388 RatGTEx
  ENSRNOG00065003112 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AFE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7W8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GGN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLM5 ENTREZGENE, UniProtKB/TrEMBL
  A6INX0_RAT UniProtKB/TrEMBL
  MYO1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Myo1b  myosin Ib      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the brush border of the proximal tubules 628448
gene_domains has 3 domains; the NH2 terminus is a 70-80 kDa region which has the actin and ATP binding site, an alpha helical neck containing 1-6 isoleucine-glutamine motifs and the carboxyl end domain comprised of amino acids that can interact with acidic phospholipi 628448
gene_function acts as an actin based motor 628448
gene_homology has sequence similarity to myosin-1 motor domains 70796
gene_process involved in the transportation of proteins into and throughout the brush border 628448
gene_process plays a role in endocytosis and intracellular trafficking 628448
gene_product member of the myosin superfamily 628448
gene_transcript alternative splice forms myr 1a, myr 1b, and myr 1c vary in their number of potential calmodulin/light chain binding sites 70796