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Gene: Fn1 (fibronectin 1) Rattus norvegicus
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Symbol: Fn1
Name: fibronectin 1
Description: Exhibits mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to lipid; and cellular response to peptide. Localizes to basement membrane and extracellular space. Used to study diabetic angiopathy and renovascular hypertension. Biomarker of several diseases, including calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; submandibular gland disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis and membranoproliferative glomerulonephritis. Orthologous to human FN1 (fibronectin 1); PARTICIPATES IN syndecan signaling pathway; cell-extracellular matrix signaling pathway; Entamoebiasis pathway; INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FIBNEC; fibronectin; fibronectin 2; fibronectin 3; FN; fn-1
Orthologs:
Homo sapiens (human) : FN1 (fibronectin 1)  HGNC  Alliance
Mus musculus (house mouse) : Fn1 (fibronectin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fn1 (fibronectin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FN1 (fibronectin 1)
Canis lupus familiaris (dog) : FN1 (fibronectin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fn1 (fibronectin 1)
Sus scrofa (pig) : FN1 (fibronectin 1)
Chlorocebus sabaeus (African green monkey) : FN1 (fibronectin 1)
Heterocephalus glaber (naked mole-rat) : Fn1 (fibronectin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0978,900,111 - 78,969,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,900,103 - 78,969,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,674,437 - 78,743,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,702,181 - 70,771,155 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1970,849,162 - 70,918,137 (-)NCBI
Celera970,607,233 - 70,675,716 (-)NCBICelera
Cytogenetic Map9q33NCBI
RH 3.4 Map9673.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2624
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.