Fn1 (fibronectin 1) - Rat Genome Database

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Gene: Fn1 (fibronectin 1) Rattus norvegicus
Symbol: Fn1
Name: fibronectin 1
RGD ID: 2624
Description: Enables mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to lipid; cellular response to mercury ion; and cellular response to peptide. Located in basement membrane and extracellular space. Used to study diabetic angiopathy; hypertension; and renovascular hypertension. Biomarker of several diseases, including artery disease (multiple); calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1); PARTICIPATES IN syndecan signaling pathway; cell-extracellular matrix signaling pathway; Entamoebiasis pathway; INTERACTS WITH (R)-lipoic acid; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FIBNEC; fibronectin; fibronectin 2; fibronectin 3; FN; fn-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2973,196,044 - 73,264,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,196,044 - 73,264,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,661,421 - 81,730,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,790,269 - 86,858,938 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0985,180,537 - 85,249,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,900,111 - 78,969,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,900,103 - 78,969,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,674,437 - 78,743,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,702,181 - 70,771,155 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,849,162 - 70,918,137 (-)NCBI
Celera970,607,233 - 70,675,716 (-)NCBICelera
RH 3.4 Map9673.9RGD
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
Acute Otitis Media  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve insufficiency  (ISO)
brain disease  (ISO)
Breast Neoplasms  (ISO)
calcium oxalate nephrolithiasis  (IEP,ISO)
carcinoma  (ISO)
Cardiac Fibrosis  (IEP)
Chronic Intermittent Hypoxia  (IEP)
chronic kidney disease  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (IDA)
Diabetic Nephropathies  (IEP,ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP,IMP)
Experimental Mammary Neoplasms  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
Glomerulopathy with Giant Fibrillar Deposits  (ISO)
hypertension  (IAGP,IEP,ISO)
IgA glomerulonephritis  (ISO)
iron deficiency anemia  (IEP)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IDA)
malignant mesothelioma  (ISO)
megacolon  (ISO)
membranoproliferative glomerulonephritis  (IEP)
myocardial infarction  (IEP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
renovascular hypertension  (IDA)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spondyloepimetaphyseal dysplasia, Strudwick type  (ISO)
spondylometaphyseal dysplasia  (ISO)
spondylometaphyseal dysplasia corner fracture type  (ISO)
Spontaneous Abortions  (ISO)
Staphylococcal Pneumonia  (IDA)
Sturge-Weber syndrome  (ISO)
submandibular gland disease  (IEP)
ureteral obstruction  (IEP,ISO)
urinary bladder cancer  (ISO)
VACTERL association  (IEP)
X-linked Alport syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-amygdalin  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-naphthylamine  (ISO)
2-nitrofluorene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-aminobenzamide  (EXP,ISO)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetone  (ISO)
acetylsalicylic acid  (EXP)
aconitine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amphetamine  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (EXP,ISO)
arecoline  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
asbestos  (ISO)
Atractylodin  (ISO)
atrazine  (ISO)
bacitracin  (EXP)
baicalein  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
Benzenesulfonamide  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
beta-D-glucosamine  (EXP,ISO)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (ISO)
brucine  (ISO)
bucladesine  (ISO)
butanal  (ISO)
butane  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carvedilol  (EXP)
celastrol  (EXP,ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
Clofop  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinous acid  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP)
diquat  (ISO)
diuron  (EXP,ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
emodin  (EXP)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
eplerenone  (EXP)
eprosartan  (EXP)
esculetin  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
farrerol  (EXP)
fasudil  (EXP)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
fenoldopam  (EXP)
flavonol  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
furan  (EXP)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gefitinib  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gestodene  (ISO)
gingerol  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP)
Glutathione ethyl ester  (EXP)
glyburide  (EXP)
glyphosate  (ISO)
graphene oxide  (ISO)
heptachlor  (EXP,ISO)
hexachlorobenzene  (EXP)
Honokiol  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflavones  (EXP,ISO)
isopentane  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (EXP)
kaempferol  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
loliolide  (ISO)
losartan  (EXP)
LY-2157299  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP)
manumycin A  (EXP)
masoprocol  (ISO)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melatonin  (EXP)
melittin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
MK-2206  (EXP,ISO)
monocrotaline  (EXP,ISO)
morphine  (ISO)
myricetin  (EXP)
N,N-dimethylsphingosine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrogen dioxide  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
olanzapine  (ISO)
organoselenium compound  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
Paeonol  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentane  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
potassium iodide  (EXP)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propene  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
propofol  (ISO)
propranolol  (ISO)
pyridoxal 5'-phosphate  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
ridaforolimus  (ISO)
rosiglitazone  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salidroside  (EXP)
salubrinal  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hydrogencarbonate  (EXP)
sorafenib  (ISO)
sorbinil  (ISO)
sphingosine 1-phosphate  (EXP)
SR 144528  (ISO)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraethylenepentamine  (ISO)
tetramethylpyrazine  (EXP,ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
topotecan  (EXP)
trandolapril  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
Triton X-100  (ISO)
troglitazone  (ISO)
troleandomycin  (EXP)
Tungsten carbide  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
venom  (ISO)
verapamil  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
Y-27632  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
angiogenesis  (IEA)
biological process involved in interaction with symbiont  (IEA)
calcium-independent cell-matrix adhesion  (IEA,ISO)
cell adhesion  (IEA,ISO)
cell-matrix adhesion  (IBA,IMP,ISO)
cell-substrate junction assembly  (IBA,IEA,ISO)
cellular response to amyloid-beta  (IEP)
cellular response to angiotensin  (IEP)
cellular response to BMP stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to interleukin-1  (IMP)
cellular response to lipopolysaccharide  (IEP)
cellular response to mercury ion  (IDA)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to prostaglandin E stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to vascular endothelial growth factor stimulus  (IEP)
endodermal cell differentiation  (IEA,ISO)
extracellular matrix organization  (IMP)
glial cell migration  (IDA)
heart development  (IBA)
integrin activation  (IEA,ISO)
integrin-mediated signaling pathway  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of collagen biosynthetic process  (IMP)
negative regulation of monocyte activation  (IEA,ISO)
negative regulation of transforming growth factor beta production  (IEA,ISO)
nervous system development  (IBA)
neural crest cell migration involved in autonomic nervous system development  (IEA,ISO)
ossification  (TAS)
positive regulation of axon extension  (IEA,ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemotaxis  (IDA)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of substrate-dependent cell migration, cell attachment to substrate  (IEA,ISO)
regulation of cell shape  (IEA)
regulation of ERK1 and ERK2 cascade  (IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
response to activity  (IEP)
response to glucocorticoid  (IEP)
response to iron ion  (IEP)
response to ischemia  (IEP)
response to ozone  (IEP)
response to xenobiotic stimulus  (IEP)
substrate adhesion-dependent cell spreading  (IEA,ISO)
wound healing  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
3. Distribution patterns of TGF-alpha, laminin and fibronectin and their relationship with folliculogenesis in rat ovary. Akkoyunlu G, etal., Acta Histochem. 2003;105(4):295-301.
4. Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury. Amersi F, etal., Am J Pathol. 2003 Apr;162(4):1229-39.
5. Dexamethasone-induced prenatal alveolar wall thinning is associated with a decrease in EIIIA+ fibronectin isoform in the fetal rat lung. Arai H, etal., Biol Neonate. 2005;87(2):113-20. Epub 2004 Nov 11.
6. Cooperation of fibronectin with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells. Ayaki M, etal., Biochim Biophys Acta. 2000 Jan 10;1495(1):40-50.
7. Differential expression of thrombospondin and cellular fibronectin during remodeling in proliferative glomerulonephritis. Barnes JL, etal., J Histochem Cytochem. 1999 Apr;47(4):533-44.
8. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Carlson ES, etal., Brain Res. 2008 Aug 7.
9. Increased expression of the Ed-B-containing fibronectin (an embryonic isoform of fibronectin) in human osteoarthritic cartilage. Chevalier X, etal., Br J Rheumatol. 1996 May;35(5):407-15.
10. Synergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through extracellular signal-regulated kinase pathway. Choung PH, etal., Biochem Biophys Res Commun 2002 Jul 26;295(4):898-902.
11. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
12. Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue. Comi AM, etal., Pediatr Res 2003 May;53(5):762-9. Epub 2003 Mar 5.
13. Inhibition of NAD(P)H oxidase reduces fibronectin expression in stroke-prone renovascular hypertensive rat brain. Cui C, etal., Clin Exp Pharmacol Physiol. 2007 Apr;34(4):304-9.
14. Fibronectin splice variants--prognostic markers for the stage of renal interstitial fibrosis in the rat. Eismann U, etal., Nephron. 2002 Oct;92(2):379-88.
15. Diagnostic value of fibronectin and mutant p53 in the urine of patients with bladder cancer: impact on clinicopathological features and disease recurrence. Eissa S, etal., Med Oncol. 2010 Dec;27(4):1286-94. doi: 10.1007/s12032-009-9375-9. Epub 2009 Dec 11.
16. Plasma fibronectin concentration in patients with chronic renal failure and treated with haemodialysis. Eriksen HO, etal., Scand J Clin Lab Invest. 1983 Dec;43(8):723-6.
17. SGK1-mediated fibronectin formation in diabetic nephropathy. Feng Y, etal., Cell Physiol Biochem. 2005;16(4-6):237-44.
18. Interleukin-1 increases fibronectin production by cultured rat cardiac fibroblasts. Fernandez L and Mosquera JA, Pathobiology. 2002-2003;70(4):191-6.
19. Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. Fiorucci S, etal., J Pharmacol Exp Ther. 2005 Oct;315(1):58-68. Epub 2005 Jun 24.
20. Important role for fibronectin-EIIIA during renal tubular repair and cellular recovery in uranyl acetate-induced acute renal failure of rats. Fujimoto T, etal., Virchows Arch. 2003 Aug;443(2):194-205. Epub 2003 Jul 17.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model. Gay-Jordi G, etal., PLoS One. 2013;8(2):e55427. doi: 10.1371/journal.pone.0055427. Epub 2013 Feb 1.
23. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
24. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
25. Enhancement of fibronectin expression in rat lung by ozone and an inflammatory stimulus. Gupta SK, etal., Am J Physiol. 1998 Aug;275(2 Pt 1):L330-5.
26. Expression of fibronectin isoforms bearing the alternatively spliced EIIIA, EIIIB, and V segments in corneal alkali burn and keratectomy wound models in the rat. Havrlikova K, etal., Cornea. 2004 Nov;23(8):812-8.
27. Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis. Hsu CC and Lai SC, Int J Exp Pathol. 2007 Dec;88(6):437-43.
28. Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models. Huang K, etal., PLoS One. 2012;7(8):e43874. doi: 10.1371/journal.pone.0043874. Epub 2012 Aug 24.
29. Elevated urinary fibronectin excretion predicts poor outcome in patients with primary chronic glomerulonephritis. Idasiak-Piechocka I, etal., Nephron Clin Pract. 2010;116(1):c47-52. doi: 10.1159/000314550. Epub 2010 May 12.
30. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. Jarnagin WR, etal., J Cell Biol. 1994 Dec;127(6 Pt 2):2037-48.
31. Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes. Jia JB, etal., World J Gastroenterol. 1998 Aug;4(4):329-331.
32. Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells. Jiang T, etal., Nephrology (Carlton). 2006 Apr;11(2):105-12.
33. Clusterin attenuates the development of renal fibrosis. Jung GS, etal., J Am Soc Nephrol. 2012 Jan;23(1):73-85. doi: 10.1681/ASN.2011010048. Epub 2011 Nov 3.
34. Plasma levels of cellular fibronectin in diabetes. Kanters SD, etal., Diabetes Care. 2001 Feb;24(2):323-7.
35. Rapamycin inhibits platelet-derived growth factor-induced collagen, but not fibronectin, synthesis in rat mesangial cells. Kim MS, etal., Yonsei Med J. 2004 Dec 31;45(6):1121-6.
36. The neuroprotective effects of fibronectin mats and fibronectin peptides following spinal cord injury in the rat. King VR, etal., Neuroscience. 2010 Jun 30;168(2):523-30. doi: 10.1016/j.neuroscience.2010.03.040. Epub 2010 Mar 25.
37. Diabetes-induced renal injury in rats is attenuated by suramin. Korrapati MC, etal., J Pharmacol Exp Ther. 2012 Oct;343(1):34-43. doi: 10.1124/jpet.112.196964. Epub 2012 Jun 26.
38. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
39. NF-kappaB activates fibronectin gene expression in rat hepatocytes. Lee BH, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1218-24.
40. Kidney expression of RhoA, TGF-beta1, and fibronectin in human IgA nephropathy. Mattii L, etal., Nephron Exp Nephrol. 2005;101(1):e16-23. Epub 2005 May 27.
41. Increased virulence of a fibronectin-binding protein mutant of Staphylococcus aureus in a rat model of pneumonia. McElroy MC, etal., Infect Immun. 2002 Jul;70(7):3865-73.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Fibronectin modulation by A beta amyloid peptide (25-35) in cultured astrocytes of newborn rat cortex. Moreno-Flores MT, etal., Neurosci Lett. 2001 Nov 13;314(1-2):87-91.
44. Increased fibronectin expression in developing embryos is associated with abnormal notochord in the Adriamycin rat model. Mortell A, etal., Pediatr Surg Int. 2004 Apr;20(4):276-82. Epub 2004 Feb 18.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. A HindIII polymorphism of fibronectin gene is associated with nephrolithiasis. Onaran M, etal., Urology. 2009 Nov;74(5):1004-7. doi: 10.1016/j.urology.2009.05.010. Epub 2009 Jul 17.
49. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
50. Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFbeta1 expression and activation of p38-MAPK and ERK1/2. Pan Z, etal., Br J Pharmacol. 2011 Feb;162(3):688-700. doi: 10.1111/j.1476-5381.2010.01070.x.
51. An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl(4)-induced rat cirrhosis. Perez-Carreon JI, etal., Int J Biochem Cell Biol. 2010 Feb;42(2):287-96. Epub 2009 Nov 13.
52. Fibronectin expression in proximal tubules from ischemic rat kidneys without reperfusion. Petrini G, etal., Mol Cell Biochem. 2002 Dec;241(1-2):21-7.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
55. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats. Roy S, etal., Diabetes. 2003 May;52(5):1229-34.
58. Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride. Saball E, etal., Mol Cell Biochem 2001 Oct;226(1-2):67-75.
59. Three different fibronectin mRNAs arise by alternative splicing within the coding region. Schwarzbauer JE, etal., Cell 1983 Dec;35(2 Pt 1):421-31.
60. Multiple sites of alternative splicing of the rat fibronectin gene transcript. Schwarzbauer JE, etal., EMBO J 1987 Sep;6(9):2573-80.
61. A 10-kda fragment of fibronectin type III domain is a neutrophil chemoattractant purified from conditioned medium of rat granulation tissue. Shiota S, etal., Biol Pharm Bull. 2001 Jul;24(7):835-7.
62. Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Sottile J and Hocking DC, Mol Biol Cell 2002 Oct;13(10):3546-59.
63. Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts. Tang CH, etal., J Biol Chem. 2005 Jun 17;280(24):22907-16. Epub 2005 Apr 15.
64. Enhancement of fibronectin synthesis and fibrillogenesis by BMP-4 in cultured rat osteoblast. Tang CH, etal., J Bone Miner Res. 2003 Mar;18(3):502-11.
65. Fibronectin as a potent inhibitor of calcium oxalate urolithiasis. Tsujihata M, etal., J Urol. 2000 Nov;164(5):1718-23.
66. Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular gland. Ueda K, etal., Int J Oral Maxillofac Surg. 2009 Jan;38(1):79-84. doi: 10.1016/j.ijom.2008.11.004. Epub 2008 Dec 18.
67. Fibronectin 1 mRNA expression correlates with advanced disease in renal cancer. Waalkes S, etal., BMC Cancer. 2010 Sep 22;10:503. doi: 10.1186/1471-2407-10-503.
68. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Wang C, etal., Diabetes Metab Res Rev. 2012 May;28(4):329-37. doi: 10.1002/dmrr.2279.
69. Fibronectin and focal adhesion kinase small interfering RNA modulate rat retinal Muller cells adhesion and migration. Wang XL, etal., Cell Mol Neurobiol. 2009 Jun;29(4):549-56. Epub 2009 Jan 27.
70. Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329.
71. Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts. Woods A, etal., Arch Biochem Biophys. 2000 Feb 1;374(1):66-72.
72. Knockdown of fibronectin induces mitochondria-dependent apoptosis in rat mesangial cells. Wu D, etal., J Am Soc Nephrol. 2005 Mar;16(3):646-57. Epub 2005 Jan 26.
73. A potential role for caveolin-1 in VEGF-induced fibronectin upregulation in mesangial cells: involvement of VEGFR2 and Src. Wu TT, etal., Am J Physiol Renal Physiol. 2012 Dec 26.
74. Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer. Xia J, etal., Cancer Lett. 2016 Oct 10;381(1):31-40. doi: 10.1016/j.canlet.2016.07.014. Epub 2016 Jul 16.
75. Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-kappaB signaling pathway in rat glomerular mesangial cells. Xie X, etal., Mol Cell Endocrinol. 2012 Oct 15;362(1-2):183-93. doi: 10.1016/j.mce.2012.06.008. Epub 2012 Jun 22.
76. Angiotensin II receptor blockade improves matrix metalloproteinases/tissue inhibitor of matrix metalloproteinase-1 balance and restores fibronectin expression in rat infarcted myocardium. Yang D, etal., Biochem Biophys Res Commun. 2009 Oct 23;388(3):606-11. Epub 2009 Aug 18.
77. Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II. Yoneda A, etal., Mol Biol Cell. 2007 Jan;18(1):66-75. Epub 2006 Oct 25.
78. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
79. Expression of fibronectin splice variants in the postischemic rat kidney. Zuk A, etal., Am J Physiol Renal Physiol. 2001 Jun;280(6):F1037-53.
Additional References at PubMed
PMID:1632457   PMID:2209468   PMID:3119323   PMID:3863113   PMID:3997886   PMID:6089177   PMID:7519849   PMID:8984825   PMID:9421166   PMID:9441684   PMID:9632774   PMID:10742111  
PMID:11511678   PMID:11792823   PMID:11914376   PMID:12021259   PMID:12160302   PMID:12167537   PMID:12421310   PMID:12847088   PMID:12867986   PMID:12879062   PMID:14587027   PMID:15065125  
PMID:15068706   PMID:15292204   PMID:15308636   PMID:15604136   PMID:15677465   PMID:15728191   PMID:16061471   PMID:16157329   PMID:16159961   PMID:16236823   PMID:16316526   PMID:16534777  
PMID:16572112   PMID:16677310   PMID:17021600   PMID:17252537   PMID:17609505   PMID:17715430   PMID:17849409   PMID:17914904   PMID:17953369   PMID:18042364   PMID:18160478   PMID:18379124  
PMID:18559979   PMID:19056867   PMID:19366727   PMID:19429745   PMID:19546347   PMID:19607919   PMID:19651211   PMID:19738201   PMID:19826086   PMID:19931242   PMID:20049771   PMID:20380796  
PMID:20541508   PMID:20551380   PMID:20810141   PMID:21098642   PMID:21099277   PMID:21141136   PMID:21276792   PMID:21586275   PMID:21613793   PMID:21940672   PMID:22516433   PMID:22759963  
PMID:22812390   PMID:22821713   PMID:22897220   PMID:22900368   PMID:22904348   PMID:22952693   PMID:22984613   PMID:23154389   PMID:23211306   PMID:23533145   PMID:23658023   PMID:23940049  
PMID:23979707   PMID:24006456   PMID:24191021   PMID:24658351   PMID:24691542   PMID:24752318   PMID:25028133   PMID:25192797   PMID:25375034   PMID:25538336   PMID:25674202   PMID:25834989  
PMID:26093969   PMID:26571399   PMID:26728369   PMID:27053343   PMID:27068509   PMID:27530924   PMID:27559042   PMID:27572112   PMID:28712960   PMID:29030641   PMID:30926678   PMID:31760535  
PMID:32910242   PMID:34729793   PMID:35092560  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2973,196,044 - 73,264,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,196,044 - 73,264,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,661,421 - 81,730,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,790,269 - 86,858,938 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0985,180,537 - 85,249,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,900,111 - 78,969,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,900,103 - 78,969,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,674,437 - 78,743,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,702,181 - 70,771,155 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,849,162 - 70,918,137 (-)NCBI
Celera970,607,233 - 70,675,716 (-)NCBICelera
RH 3.4 Map9673.9RGD
Cytogenetic Map9q33NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382215,360,865 - 215,436,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2215,360,440 - 215,436,073 (-)EnsemblGRCh38hg38GRCh38
GRCh372216,225,588 - 216,300,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,933,422 - 216,009,036 (-)NCBINCBI36Build 36hg18NCBI36
Build 342216,050,686 - 216,126,297NCBI
Celera2209,994,808 - 210,070,377 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,082,209 - 208,158,070 (-)NCBIHuRef
CHM1_12216,231,077 - 216,306,650 (-)NCBICHM1_1
T2T-CHM13v2.02215,845,895 - 215,921,094 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39171,624,632 - 71,692,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl171,624,679 - 71,692,359 (-)EnsemblGRCm39 Ensembl
GRCm38171,585,473 - 71,653,280 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,585,520 - 71,653,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv37171,632,097 - 71,699,745 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36171,518,731 - 71,586,379 (-)NCBIMGSCv36mm8
Celera172,141,007 - 72,208,976 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.05NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955457629,518 - 696,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955457629,599 - 694,948 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12B118,005,563 - 118,080,823 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B102,623,568 - 102,698,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B221,208,431 - 221,284,003 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,208,431 - 221,284,003 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13722,456,854 - 22,522,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3722,420,428 - 22,523,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,283,410 - 23,349,813 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03722,479,930 - 22,546,207 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3722,479,939 - 22,546,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13722,368,332 - 22,434,691 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03722,319,732 - 22,386,105 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03722,336,313 - 22,402,763 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303170,852,488 - 170,917,088 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365861,708,684 - 1,773,383 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15117,658,099 - 117,731,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,658,158 - 117,737,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215130,357,895 - 130,430,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110101,177,867 - 101,254,613 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10101,176,789 - 101,254,633 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604098,128,602 - 98,204,117 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624765707,755 - 775,056 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624765707,872 - 775,056 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Fn1
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:155
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000019772, ENSRNOT00000057585
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2973,196,262 - 73,196,659 (+)MAPPERmRatBN7.2
Rnor_6.0978,900,332 - 78,900,728NCBIRnor6.0
Rnor_5.0978,674,658 - 78,675,054UniSTSRnor5.0
RGSC_v3.4970,702,400 - 70,702,796UniSTSRGSC3.4
Celera970,607,452 - 70,607,848UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2973,207,612 - 73,207,962 (+)MAPPERmRatBN7.2
Rnor_6.0978,911,682 - 78,912,031NCBIRnor6.0
Rnor_5.0978,686,008 - 78,686,357UniSTSRnor5.0
RGSC_v3.4970,713,750 - 70,714,099UniSTSRGSC3.4
Celera970,618,802 - 70,619,151UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2973,196,243 - 73,196,433 (+)MAPPERmRatBN7.2
Rnor_6.0978,900,313 - 78,900,502NCBIRnor6.0
Rnor_5.0978,674,639 - 78,674,828UniSTSRnor5.0
RGSC_v3.4970,702,381 - 70,702,570UniSTSRGSC3.4
Celera970,607,433 - 70,607,622UniSTS
RH 3.4 Map9677.79UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2973,196,331 - 73,196,632 (+)MAPPERmRatBN7.2
Rnor_6.0978,900,401 - 78,900,701NCBIRnor6.0
Rnor_5.0978,674,727 - 78,675,027UniSTSRnor5.0
RGSC_v3.4970,702,469 - 70,702,769UniSTSRGSC3.4
Celera970,607,521 - 70,607,821UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2973,232,814 - 73,233,058 (+)MAPPERmRatBN7.2
Rnor_6.0978,936,868 - 78,937,111NCBIRnor6.0
Rnor_5.0978,711,194 - 78,711,437UniSTSRnor5.0
RGSC_v3.4970,738,950 - 70,739,193UniSTSRGSC3.4
Celera970,643,875 - 70,644,118UniSTS
RH 3.4 Map9670.0UniSTS
Cytogenetic Map9q33UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 42 56 41 19 41 8 11 68 35 33 11 8
Low 1 1 6 8
Below cutoff


Nucleotide Sequences
RefSeq Transcripts NM_019143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF061156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U82612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000019772   ⟹   ENSRNOP00000019772
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,196,044 - 73,264,677 (-)Ensembl
Rnor_6.0 Ensembl978,900,113 - 78,969,013 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000057585   ⟹   ENSRNOP00000054395
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,196,044 - 73,264,677 (-)Ensembl
Rnor_6.0 Ensembl978,900,103 - 78,969,078 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102568   ⟹   ENSRNOP00000082339
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,196,044 - 73,264,677 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110905   ⟹   ENSRNOP00000087332
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,196,045 - 73,264,678 (-)Ensembl
RefSeq Acc Id: NM_019143   ⟹   NP_062016
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,044 - 73,264,677 (-)NCBI
Rnor_6.0978,900,113 - 78,969,013 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RGSC_v3.4970,702,181 - 70,771,155 (-)RGD
Celera970,607,233 - 70,675,716 (-)RGD
RefSeq Acc Id: XM_006245150   ⟹   XP_006245212
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,695 (-)NCBI
Rnor_6.0978,900,111 - 78,969,018 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245151   ⟹   XP_006245213
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,695 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245152   ⟹   XP_006245214
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,694 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245153   ⟹   XP_006245215
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,694 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245154   ⟹   XP_006245216
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,695 (-)NCBI
Rnor_6.0978,900,111 - 78,969,018 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245156   ⟹   XP_006245218
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,694 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245157   ⟹   XP_006245219
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,694 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245158   ⟹   XP_006245220
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,694 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_006245159   ⟹   XP_006245221
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,694 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
Rnor_5.0978,674,437 - 78,743,423 (-)NCBI
RefSeq Acc Id: XM_017596301   ⟹   XP_017451790
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,695 (-)NCBI
Rnor_6.0978,900,111 - 78,969,017 (-)NCBI
RefSeq Acc Id: XM_039083090   ⟹   XP_038939018
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,196,045 - 73,264,695 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062016 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245212 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245213 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245214 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245215 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245216 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245218 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245219 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245220 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245221 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451790 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939018 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41166 (Get FASTA)   NCBI Sequence Viewer  
  AAA41167 (Get FASTA)   NCBI Sequence Viewer  
  AAA41168 (Get FASTA)   NCBI Sequence Viewer  
  AAA41169 (Get FASTA)   NCBI Sequence Viewer  
  AAA41170 (Get FASTA)   NCBI Sequence Viewer  
  AAB19112 (Get FASTA)   NCBI Sequence Viewer  
  AAB40865 (Get FASTA)   NCBI Sequence Viewer  
  CAA29278 (Get FASTA)   NCBI Sequence Viewer  
  CAA29279 (Get FASTA)   NCBI Sequence Viewer  
  CAA29281 (Get FASTA)   NCBI Sequence Viewer  
  CAA34020 (Get FASTA)   NCBI Sequence Viewer  
  EDL75259 (Get FASTA)   NCBI Sequence Viewer  
  EDL75260 (Get FASTA)   NCBI Sequence Viewer  
  EDL75261 (Get FASTA)   NCBI Sequence Viewer  
  EDL75262 (Get FASTA)   NCBI Sequence Viewer  
  EDL75263 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019772
GenBank Protein P04937 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062016   ⟸   NM_019143
- Peptide Label: precursor
- UniProtKB: Q6LDX9 (UniProtKB/Swiss-Prot),   P04937 (UniProtKB/Swiss-Prot),   A0A096P6L8 (UniProtKB/TrEMBL),   A6KFG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245220   ⟸   XM_006245158
- Peptide Label: isoform X10
- UniProtKB: A6KFG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245215   ⟸   XM_006245153
- Peptide Label: isoform X5
- UniProtKB: Q6LDX9 (UniProtKB/Swiss-Prot),   P04937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245214   ⟸   XM_006245152
- Peptide Label: isoform X3
- UniProtKB: Q6LDX9 (UniProtKB/Swiss-Prot),   P04937 (UniProtKB/Swiss-Prot),   A0A8I6A5M1 (UniProtKB/TrEMBL),   A6KFG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245213   ⟸   XM_006245151
- Peptide Label: isoform X2
- UniProtKB: F1LST1 (UniProtKB/TrEMBL),   A6KFG6 (UniProtKB/TrEMBL),   A0A8I5ZXR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245216   ⟸   XM_006245154
- Peptide Label: isoform X6
- UniProtKB: A6KFG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245212   ⟸   XM_006245150
- Peptide Label: isoform X1
- UniProtKB: Q6LDX9 (UniProtKB/Swiss-Prot),   P04937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245221   ⟸   XM_006245159
- Peptide Label: isoform X11
- UniProtKB: A6KFG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245219   ⟸   XM_006245157
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZXR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245218   ⟸   XM_006245156
- Peptide Label: isoform X7
- UniProtKB: A6KFG4 (UniProtKB/TrEMBL),   A0A8I5ZXR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451790   ⟸   XM_017596301
- Peptide Label: isoform X9
- UniProtKB: A6KFG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054395   ⟸   ENSRNOT00000057585
RefSeq Acc Id: ENSRNOP00000019772   ⟸   ENSRNOT00000019772
RefSeq Acc Id: XP_038939018   ⟸   XM_039083090
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZXR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087332   ⟸   ENSRNOT00000110905
RefSeq Acc Id: ENSRNOP00000082339   ⟸   ENSRNOT00000102568
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04937-F1-model_v2 AlphaFold P04937 1-2477 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696734
Promoter ID:EPDNEW_R7259
Type:multiple initiation site
Description:fibronectin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0978,969,014 - 78,969,074EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2624 AgrOrtholog
BioCyc Gene G2FUF-27250 BioCyc
Ensembl Genes ENSRNOG00000014288 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019772 ENTREZGENE
  ENSRNOT00000019772.7 UniProtKB/TrEMBL
  ENSRNOT00000057585.5 UniProtKB/TrEMBL
  ENSRNOT00000102568.1 UniProtKB/TrEMBL
  ENSRNOT00000110905.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibronectin_type1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL