Abcb6 (ATP binding cassette subfamily B member 6) - Rat Genome Database

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Gene: Abcb6 (ATP binding cassette subfamily B member 6) Rattus norvegicus
Analyze
Symbol: Abcb6
Name: ATP binding cassette subfamily B member 6
RGD ID: 71077
Description: Predicted to enable several functions, including ABC-type heme transporter activity; ATP binding activity; and ATP hydrolysis activity. Involved in cellular copper ion homeostasis. Located in endosome membrane and mitochondrion. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (Langereis blood group)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ABC-type heme transporter ABCB6; ATP-binding cassette sub-family B member 6; ATP-binding cassette sub-family B member 6, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 6; ATP-binding cassette, subfamily B (MDR/TAP), member 6; mammalian mitochondrial ABC protein 3; MGC93242; MTABC3; ubiquitously-expressed mammalian ABC half transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,668,554 - 76,677,263 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,668,554 - 76,676,924 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,113,131 - 85,121,409 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0990,242,022 - 90,250,300 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0988,628,235 - 88,636,513 (-)NCBIRnor_WKY
Rnor_6.0982,373,950 - 82,382,228 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,373,946 - 82,382,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,143,211 - 82,151,489 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,454,805 - 74,463,083 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera974,239,003 - 74,247,281 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
amitrole  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bupropion  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
ferroheme b  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
heme b  (ISO)
ifosfamide  (ISO)
ivermectin  (ISO)
leflunomide  (EXP,ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
midazolam  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrazinecarboxamide  (EXP)
reactive oxygen species  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP)
Tungsten carbide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis. Furuya KN, etal., Cancer Res 1997 Sep 1;57(17):3708-16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cDNA cloning and tissue distribution of mRNA encoding a novel ATP-binding cassette (ABC) half-transporter. Hirsch-Ernst KI, etal., Biochem Biophys Res Commun 1998 Aug 10;249(1):151-5.
5. Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6. Jalil YA, etal., Am J Physiol Cell Physiol. 2008 Feb;294(2):C579-90. doi: 10.1152/ajpcell.00612.2006. Epub 2007 Dec 26.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. Mitsuhashi N, etal., J Biol Chem 2000 Jun 9;275(23):17536-40.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16390497   PMID:17006453   PMID:17661442   PMID:18279659   PMID:18614015   PMID:19056867   PMID:22100072   PMID:22226084   PMID:23519333  


Genomics

Comparative Map Data
Abcb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,668,554 - 76,677,263 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,668,554 - 76,676,924 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,113,131 - 85,121,409 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0990,242,022 - 90,250,300 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0988,628,235 - 88,636,513 (-)NCBIRnor_WKY
Rnor_6.0982,373,950 - 82,382,228 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,373,946 - 82,382,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,143,211 - 82,151,489 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,454,805 - 74,463,083 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera974,239,003 - 74,247,281 (-)NCBICelera
Cytogenetic Map9q33NCBI
ABCB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,209,772 - 219,218,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2219,209,772 - 219,218,994 (-)EnsemblGRCh38hg38GRCh38
GRCh372220,074,494 - 220,083,680 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,782,738 - 219,791,916 (-)NCBINCBI36Build 36hg18NCBI36
Build 342219,899,998 - 219,909,177NCBI
Celera2213,844,200 - 213,853,379 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,927,785 - 211,937,009 (-)NCBIHuRef
CHM1_12220,080,323 - 220,089,548 (-)NCBICHM1_1
T2T-CHM13v2.02219,694,538 - 219,703,724 (-)NCBIT2T-CHM13v2.0
Abcb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,148,284 - 75,157,066 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,148,361 - 75,157,036 (-)EnsemblGRCm39 Ensembl
GRCm38175,171,640 - 75,180,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,171,717 - 75,180,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37175,168,214 - 75,176,857 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36175,054,787 - 75,063,430 (-)NCBIMGSCv36mm8
Celera175,662,505 - 75,671,146 (-)NCBICelera
Cytogenetic Map1C4NCBI
Abcb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,215,408 - 14,222,172 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,215,104 - 14,222,338 (+)NCBIChiLan1.0ChiLan1.0
ABCB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B225,058,771 - 225,067,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,058,771 - 225,067,626 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,467,345 - 106,476,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ABCB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,760,478 - 25,767,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,760,477 - 25,769,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,586,363 - 26,593,649 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,775,702 - 25,782,979 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,775,712 - 25,783,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,680,124 - 25,687,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,615,230 - 25,622,496 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,636,067 - 25,643,357 (-)NCBIUU_Cfam_GSD_1.0
Abcb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,285,868 - 175,292,790 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365691,628,649 - 1,635,599 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,246,187 - 121,254,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,246,180 - 121,254,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,280,959 - 134,289,134 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,113,729 - 105,122,948 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,112,797 - 105,122,358 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,273,392 - 94,282,846 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,797,943 - 5,808,448 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248235,797,897 - 5,805,055 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
BE098749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,668,634 - 76,668,974 (+)MAPPERmRatBN7.2
Rnor_6.0982,374,031 - 82,374,370NCBIRnor6.0
Rnor_5.0982,143,292 - 82,143,631UniSTSRnor5.0
RGSC_v3.4974,454,886 - 74,455,225UniSTSRGSC3.4
Celera974,239,084 - 74,239,423UniSTS
RH 3.4 Map9742.48UniSTS
Cytogenetic Map9q33UniSTS
BQ193984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,676,981 - 76,677,143 (+)MAPPERmRatBN7.2
Rnor_6.0982,382,378 - 82,382,539NCBIRnor6.0
Rnor_5.0982,151,639 - 82,151,800UniSTSRnor5.0
RGSC_v3.4974,463,233 - 74,463,394UniSTSRGSC3.4
Celera974,247,431 - 74,247,592UniSTS
RH 3.4 Map9768.5UniSTS
Cytogenetic Map9q33UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97665062976771824Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:105
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000025627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 49 41 11 41 8 11 74 35 41 11 8
Low 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025627   ⟹   ENSRNOP00000025627
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,668,554 - 76,676,924 (-)Ensembl
Rnor_6.0 Ensembl982,373,946 - 82,382,272 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084769   ⟹   ENSRNOP00000073171
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,668,677 - 76,676,924 (-)Ensembl
Rnor_6.0 Ensembl982,373,963 - 82,377,010 (-)Ensembl
RefSeq Acc Id: NM_080582   ⟹   NP_542149
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,668,554 - 76,676,832 (-)NCBI
Rnor_6.0982,373,950 - 82,382,228 (-)NCBI
Rnor_5.0982,143,211 - 82,151,489 (-)NCBI
RGSC_v3.4974,454,805 - 74,463,083 (-)RGD
Celera974,239,003 - 74,247,281 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082971   ⟹   XP_038938899
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,669,097 - 76,677,263 (-)NCBI
RefSeq Acc Id: XM_039082972   ⟹   XP_038938900
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,668,554 - 76,674,819 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_542149   ⟸   NM_080582
- UniProtKB: O70595 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073171   ⟸   ENSRNOT00000084769
RefSeq Acc Id: ENSRNOP00000025627   ⟸   ENSRNOT00000025627
RefSeq Acc Id: XP_038938900   ⟸   XM_039082972
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938899   ⟸   XM_039082971
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70595-F1-model_v2 AlphaFold O70595 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696769
Promoter ID:EPDNEW_R7293
Type:initiation region
Name:Abcb6_1
Description:ATP binding cassette subfamily B member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,382,332 - 82,382,392EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71077 AgrOrtholog
BioCyc Gene G2FUF-27093 BioCyc
Ensembl Genes ENSRNOG00000018697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025627 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073171 ENTREZGENE
  ENSRNOP00000073171.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025627 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000084769 ENTREZGENE
  ENSRNOT00000084769.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190755 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140669 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93242 IMAGE-MGC_LOAD
NCBI Gene 140669 ENTREZGENE
PANTHER PTHR24221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abcb6 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4U1_RAT UniProtKB/TrEMBL
  ABCB6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-19 Abcb6  ATP binding cassette subfamily B member 6  Abcb6  ATP-binding cassette, subfamily B (MDR/TAP), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcb6  ATP-binding cassette, subfamily B (MDR/TAP), member 6  Abcb6  ATP-binding cassette, sub-family B (MDR/TAP), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Abcb6  ATP-binding cassette, sub-family B (MDR/TAP), member 6      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression in frank hepatic carcinomas 631984
gene_domains contains an N-terminal membrane anchor domain and a single conserved C-terminal nucleotide binding fold 70650
gene_expression expressed in all tissues, abundant in testis 70650
gene_homology functionally simliar to fission yeast hmt1 transporter 70650
gene_homology functionally simliar to fission yeast hmt1 transporter 631984
gene_protein 836 amino acids 70650