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Gene: Hspd1 (heat shock protein family D (Hsp60) member 1) Rattus norvegicus
Symbol: Hspd1
Name: heat shock protein family D (Hsp60) member 1
RGD ID: 621314
Description: Exhibits insulin binding activity; modification-dependent protein binding activity; and protease binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cytokine production; and response to ischemia. Localizes to several cellular components, including mitochondrial crista; peroxisomal matrix; and zymogen granule. Used to study Alzheimer's disease and low tension glaucoma. Biomarker of several diseases, including artery disease (multiple); hydrocephalus; hyperglycemia; pulmonary fibrosis; and varicocele. Human ortholog(s) of this gene implicated in artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1); PARTICIPATES IN RNA degradation pathway; tuberculosis pathway; type 1 diabetes mellitus pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,1-dichloroethene; 1-bromopropane.
Type: protein-coding
Also known as: 60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; chaperonin 60; CPN60; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1; heat shock protein 1 (chaperonin); heat shock protein 60 (liver); heat shock protein family D member 1; HSP-60; HSP-65; Hsp60; Hspd1-30p; mitochondrial matrix protein P1
Homo sapiens (human) : HSPD1 (heat shock protein family D (Hsp60) member 1)  HGNC  Alliance
Mus musculus (house mouse) : Hspd1 (heat shock protein 1 (chaperonin))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspd1 (heat shock protein family D (Hsp60) member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Canis lupus familiaris (dog) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspd1 (heat shock protein family D (Hsp60) member 1)
Sus scrofa (pig) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Chlorocebus sabaeus (African green monkey) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Heterocephalus glaber (naked mole-rat) : Hspd1 (heat shock protein family D (Hsp60) member 1)
more info ...
Related Pseudogenes: Hspd1-ps1   Hspd1-ps10   Hspd1-ps11   Hspd1-ps12   Hspd1-ps13   Hspd1-ps14   Hspd1-ps15   Hspd1-ps16   Hspd1-ps17   Hspd1-ps18   Hspd1-ps19   Hspd1-ps2   Hspd1-ps20   Hspd1-ps21   Hspd1-ps22   Hspd1-ps23   Hspd1-ps25   Hspd1-ps26   Hspd1-ps27   Hspd1-ps28   Hspd1-ps29   Hspd1-ps3   Hspd1-ps31   Hspd1-ps32   Hspd1-ps4   Hspd1-ps5   Hspd1-ps6   Hspd1-ps7   Hspd1-ps8   Hspd1-ps9  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0961,680,529 - 61,691,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,680,530 - 61,690,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0961,361,745 - 61,372,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,884,193 - 53,895,043 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1953,885,606 - 53,895,580 (-)NCBI
Celera954,060,669 - 54,071,096 (-)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hspd1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621314
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.