Hspd1 (heat shock protein family D (Hsp60) member 1)

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Gene: Hspd1 (heat shock protein family D (Hsp60) member 1) Chinchilla lanigera

Analyze

Symbol:

Hspd1

Name:

heat shock protein family D (Hsp60) member 1

RGD ID:

9039765

Description:

ENCODES a protein that exhibits apolipoprotein A-I binding (ortholog); apolipoprotein binding (ortholog); chaperone binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); adhesion of symbiont to host (ortholog); apoptotic mitochondrial changes (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); adenocarcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cell surface (ortholog); clathrin-coated pit (ortholog); coated vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

60 kDa heat shock protein, mitochondrial; heat shock 60kDa protein 1 (chaperonin)

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	3,063,133 - 3,073,419 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	3,062,724 - 3,073,419 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

adenocarcinoma (ISO)

Alzheimer's disease (ISO)

Animal Toxoplasmosis (ISO)

Aortic Valve, Calcification of (ISO)

aphthous stomatitis (ISO)

arteriosclerosis (ISO)

autistic disorder (ISO)

cardiomyopathy (ISO)

carotid artery disease (ISO)

coronary artery disease (ISO)

Coronary Disease (ISO)

cystic fibrosis (ISO)

Down syndrome (ISO)

Endotoxemia (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Orchitis (ISO)

Experimental Diabetes Mellitus (ISO)

Fetal Death (ISO)

glucose intolerance (ISO)

Hashimoto Disease (ISO)

Hemorrhage (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 10 (ISO)

hereditary spastic paraplegia 13 (ISO)

human immunodeficiency virus infectious disease (ISO)

hydrocephalus (ISO)

Hypercholesterolemia (ISO)

hyperglycemia (ISO)

hypertension (ISO)

hypertrophic cardiomyopathy (ISO)

hypomyelinating leukodystrophy 4 (ISO)

Hypoxia (ISO)

Insulin Resistance (ISO)

juvenile rheumatoid arthritis (ISO)

low tension glaucoma (ISO)

middle cerebral artery infarction (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Neurodevelopmental Disorders (ISO)

Oral Ulcer (ISO)

paraplegia (ISO)

Parkinson's disease (ISO)

pulmonary fibrosis (ISO)

renal cell carcinoma (ISO)

rheumatoid arthritis (ISO)

Sepsis (ISO)

Stomach Neoplasms (ISO)

Subarachnoid Hemorrhage (ISO)

systemic lupus erythematosus (ISO)

Transplant Rejection (ISO)

varicocele (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of cysteine-type endopeptidase activity involved in apoptotic process (ISO)

adhesion of symbiont to host (ISO)

apoptotic mitochondrial changes (ISO)

B cell activation (ISO)

B cell proliferation (ISO)

biological process involved in interaction with symbiont (ISO)

cellular response to heat (ISO)

cellular response to interleukin-7 (ISO)

isotype switching to IgG isotypes (ISO)

MyD88-dependent toll-like receptor signaling pathway (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of apoptotic process in bone marrow cell (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of reactive oxygen species biosynthetic process (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of inflammatory response (ISO)

positive regulation of interferon-alpha production (ISO)

positive regulation of interferon-gamma production (ISO)

positive regulation of interleukin-10 production (ISO)

positive regulation of interleukin-12 production (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of macrophage activation (ISO)

positive regulation of T cell activation (ISO)

positive regulation of T cell mediated immune response to tumor cell (ISO)

positive regulation of tumor necrosis factor production (ISO)

protein refolding (ISO)

protein stabilization (ISO)

response to activity (ISO)

response to ATP (ISO)

response to cocaine (ISO)

response to drug (ISO)

response to estrogen (ISO)

response to glucocorticoid (ISO)

response to heat (ISO)

response to hydrogen peroxide (ISO)

response to hypoxia (ISO)

response to ischemia (ISO)

response to lipopolysaccharide (ISO)

response to organic cyclic compound (ISO)

response to organic substance (ISO)

response to unfolded protein (ISO)

T cell activation (ISO)

Cellular Component

cell surface (ISO)

clathrin-coated pit (ISO)

coated vesicle (ISO)

cytoplasm (ISO)

cytosol (ISO)

early endosome (ISO)

extracellular exosome (ISO)

extracellular space (ISO)

Golgi apparatus (ISO)

Golgi cisterna (ISO)

intracellular membrane-bounded organelle (ISO)

lipopolysaccharide receptor complex (ISO)

membrane (ISO)

membrane raft (ISO)

mitochondrial crista (ISO)

mitochondrial inner membrane (ISO)

mitochondrial matrix (ISO)

mitochondrion (ISO)

peroxisomal matrix (ISO)

plasma membrane (ISO)

protein-containing complex (ISO)

rough endoplasmic reticulum (ISO)

secretory granule (ISO)

zymogen granule (ISO)

Molecular Function

apolipoprotein A-I binding (ISO)

apolipoprotein binding (ISO)

chaperone binding (ISO)

double-stranded RNA binding (ISO)

enzyme binding (ISO)

high-density lipoprotein particle binding (ISO)

lipopolysaccharide binding (ISO)

modification-dependent protein binding (ISO)

p53 binding (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

ubiquitin protein ligase binding (ISO)

References

References - curated


1.	Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2.	OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data

Hspd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	3,063,133 - 3,073,419 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	3,062,724 - 3,073,419 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSPD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	197,486,584 - 197,516,737 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	197,486,584 - 197,500,274 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	198,351,308 - 198,364,998 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	198,059,553 - 198,073,243 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	198,176,815 - 198,190,504	NCBI
Celera	2	192,107,181 - 192,120,871 (-)	NCBI
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	190,203,711 - 190,217,402 (-)	NCBI		HuRef
CHM1_1	2	198,357,144 - 198,370,838 (-)	NCBI		CHM1_1

Hspd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	55,116,992 - 55,127,402 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	1	55,116,994 - 55,127,402 (-)	Ensembl
GRCm38	1	55,077,833 - 55,088,243 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	55,077,835 - 55,088,243 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	55,134,678 - 55,144,776 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	55,022,380 - 55,032,390 (-)	NCBI			mm8
Celera	1	55,597,904 - 55,608,002 (-)	NCBI		Celera
Cytogenetic Map	1	C1.2	NCBI

Hspd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	56,579,195 - 56,590,011 (-)	NCBI
Rnor_6.0 Ensembl	9	61,680,530 - 61,690,956 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	9	61,680,529 - 61,691,202 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	61,361,745 - 61,372,414 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	53,884,193 - 53,895,043 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	9	53,885,606 - 53,895,580 (-)	NCBI
Celera	9	54,060,669 - 54,071,096 (-)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

HSPD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	202,623,497 - 202,637,045 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	202,623,497 - 202,636,959 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	84,729,615 - 84,743,352 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

HSPD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	7,010,421 - 7,025,912 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Hspd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936506	1,678,069 - 1,687,632 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSPD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	101,360,094 - 101,373,527 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	101,360,355 - 101,373,498 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	112,534,459 - 112,547,603 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSPD1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	83,003,266 - 83,017,397 (-)	NCBI
ChlSab1.1 Ensembl	10	83,003,717 - 83,017,363 (-)	Ensembl

Hspd1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624889	2,736,727 - 2,746,333 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013512058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01001746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01001747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01032751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01032752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000016987 ⟹ ENSCLAP00000016823

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955403	3,063,133 - 3,067,309 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000016988 ⟹ ENSCLAP00000016824

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955403	3,063,503 - 3,073,419 (+)	Ensembl

RefSeq Acc Id:

XM_013512058 ⟹ XP_013367512

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955403	3,062,724 - 3,073,419 (+)	NCBI

Sequence:

show sequence

GGTGGCCGGAGAGCGCAGTGTCCACAGGCCGCACGCGGCGCGGCAGGAGGGGGCGGGGCTCGCG
CACGGCGCAGGCAGATTGCCGGGCCGGGGGCGGGCCCGGGGCGGCGCCGGCGCGCACGCGGGGC
CGCGGCGAGGGCGGGGACTCGCGCTCATTGCCGCGCGCGCTCCGCGTTCCGACCTCACTCGCCG
CTGAAGGCCTTCCTCACCGCGTGAGCTCTCGCCGCCGCCCCGCAGAAATGCTCCGGCTACCCGC
GGTCCTCCGCCAGGCGAGGCCAGTGTCCCGGGCTCTGGCCCCGCACCTCACTCGGGCTTATGCC
AAAGACGTGAAATTCGGTGCGGATGCCCGCGCCCTCATGCTTCAGGGGGTAGACCTCCTGGCTG
ATGCCGTCGCCGTTACAATGGGGCCAAAGGGAAGAACAGTGATTATTGAACAGAGTTGGGGAAG
TCCCAAAGTAACTAAAGATGGTGTGACTGTTGCAAAGTCAATTGATTTAAAGGACAAATACAAA
AATATTGGGGCAAAACTTGTTCAAGATGTTGCCAACAACACAAATGAAGAGGCAGGGGATGGCA
CCACCACTGCAACTGTCCTGGCACGCTCCATTGCCAAGGAAGGCTTCGAGAAGATCAGCAAAGG
CGCAAACCCCGTGGAAATCAGAAGAGGTGTGATGTTAGCTGTTGATGCTGTGATTGCTGAACTT
AAGAAACAGTCCAAACCTGTGACAACCCCTGAAGAAATTGCTCAGGTTGCTACGATTTCTGCAA
ATGGAGACAAAGAAATTGGCAACATCATATCAGACGCCATGAAGAAGGTCGGCAGGAAGGGTGT
CATCACAGTGAAGGATGGAAAAACCTTAAATGATGAGTTGGAAATTATTGAAGGCATGAAGTTT
GATCGAGGATATATTTCTCCGTACTTTATTAACACTTCAAAAGGCCAGAAGTGTGAATTCCAGG
ATGCCTATGTTCTACTGAGCGAGAAGAAAATCTCTAGCGTCCAGACCATTGTACCCGCTCTTGA
AATTGCCAATGCTCACCGAAAGCCCTTGGTCATAATTGCTGAGGATGTTGACGGAGAAGCTCTC
AGTACCCTGGTTTTAAACAGGCTAAAGGTTGGTCTTCAAGTTGTTGCAGTCAAAGCTCCAGGGT
TTGGTGACAACAGGAAGAACCAGCTGAAAGACATGGCTATTGCTACTGGCGGTGCGGTGTTTGG
AGAAGAGGGGTTGACCCTAAATCTTGAAGATGTTCAGCCCCATGACTTAGGAAAAGTTGGAGAG
GTTATTGTAACCAAAGATGATGCCATGCTTTTGAAAGGCAAAGGTGACAAAGCACAAATTGAAA
AACGTATTCAAGAAATCACTGAGCAATTAGAAATCACAACCAGTGAATATGAGAAGGAGAAACT
AAATGAGCGGCTGGCGAAGCTTTCGGATGGAGTGGCTGTGCTGAAGGTTGGTGGGACAAGTGAC
GTTGAGGTGAATGAAAAGAAAGACAGAGTCACAGATGCTCTCAATGCTACGAGGGCAGCTGTGG
AAGAAGGCATTGTGCTAGGTGGTGGGTGTGCCTTGCTTCGGTGCATTCCCGCCCTGGATGCCTT
AACTCCTGCTAATGAAGATCAAAAAATTGGTATAGAAATTATTAAAAGAACACTGAAAATCCCT
GCAATGACCATTGCTAAGAATGCAGGTGTGGAAGGATCTTTGATAGTTGAGAAAATCTTGCAGA
GCTCCTCTGAAGTTGGCTATGACGCTATGCTTGGAGATTTTGTGAATATGGTAGAGAAAGGAAT
CATTGATCCAACAAAGGTTGTAAGAACTGCTCTGCTGGATGCTGCAGGGGTGGCTTCTCTGTTA
ACAACAGCAGAAGTTGTGGTCACAGAAATCCCTAAGGAGGAGAAGGACCCTGCCATGGGAGCCA
TGGGTGGGATGGGTGGCGGAATGGGCGGTGGAATGTTCTAGCCTAGAAAGCGCATGGCCCTCAC
TCATGAACTGTGACAGGAAGCGCCACGCAGGGTCCTCCCCAATAACTTTGGAGATTTCAGATGA
AGGGAATGAAGAGAAGGCTGCTGATGTAAGGAAATCACGTGCCCACCATTGCTGGTTTCAGTTA
CCATACATGTAAATGGTTTACCGCTGTCATTGTCCATGCCTACAGATAATTTATTTTGTATTTT
TGAATACAAAAACATTTGTACATTCCTGAAACTGGGTGCCAGAGCCACGTAGCAGTGTACTGCT
TTCAACTTAAATCACGGAGGCATTTCTACTACTATTCTGTTACAGTCAGGATTCTAGTGCTTGC
CATCACAGACGAGAAGTCAGAAACAGCCTTTCTGTGGAGAGGAAGAATAATTGTGTACAAAGTA
GAGAAGATCAATTATGTGACAACCTTTGTGTAATAAAAATCTGTTTAAAGTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013367512	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_013367512 ⟸ XM_013512058

- Sequence:

show sequence

MLRLPAVLRQARPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVII
EQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGF
EKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKK
VGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQT
IVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIAT
GGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEITEQLEITTSE
YEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCI
PALDALTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVN
MVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPAMGAMGGMGGGMGGGMF

hide sequence

RefSeq Acc Id:

ENSCLAP00000016823 ⟸ ENSCLAT00000016987

RefSeq Acc Id:

ENSCLAP00000016824 ⟸ ENSCLAT00000016988

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011541	Ensembl, ENTREZGENE
Ensembl Protein	ENSCLAP00000016824	ENTREZGENE
Ensembl Transcript	ENSCLAT00000016988	ENTREZGENE
NCBI Gene	Hspd1	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Hspd1	heat shock protein family D (Hsp60) member 1		heat shock 60kDa protein 1 (chaperonin)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM