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Gene: Dlst (dihydrolipoamide S-succinyltransferase) Rattus norvegicus
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Symbol: Dlst
Name: dihydrolipoamide S-succinyltransferase
Description: Exhibits chaperone binding activity; dihydrolipoyllysine-residue succinyltransferase activity; and heat shock protein binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Localizes to the mitochondrion; oxoglutarate dehydrogenase complex; and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; citric acid cycle pathway; fumaric aciduria pathway; INTERACTS WITH 2,2,2-tetramine; 2,4,6-trinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-oxoglutarate dehydrogenase complex component E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2; E2K; MGC95077; OGDC-E2
Orthologs:
Homo sapiens (human) : DLST (dihydrolipoamide S-succinyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Dlst (dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlst (dihydrolipoamide S-succinyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLST (dihydrolipoamide S-succinyltransferase)
Canis lupus familiaris (dog) : DLST (dihydrolipoamide S-succinyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlst (dihydrolipoamide S-succinyltransferase)
Sus scrofa (pig) : DLST (dihydrolipoamide S-succinyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06108,936,534 - 108,961,322 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,936,664 - 108,959,803 (+)Ensembl
Rnor_5.06116,595,654 - 116,620,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,156,751 - 109,180,537 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16109,160,220 - 109,183,992 (+)NCBI
Celera6102,581,378 - 102,605,253 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Dlst
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1359615
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.