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Gene: Dlst (dihydrolipoamide S-succinyltransferase) Rattus norvegicus

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Symbol:

Dlst

Name:

dihydrolipoamide S-succinyltransferase

RGD ID:

1359615

Description:

Enables heat shock protein binding activity and protein-folding chaperone binding activity. Involved in 2-oxoglutarate metabolic process. Located in mitochondrion and sarcolemma. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; citric acid cycle pathway; fumaric aciduria pathway; INTERACTS WITH 2,2,2-tetramine; 2,4,6-trinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

2-oxoglutarate dehydrogenase complex component E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2; E2K; MGC95077; OGDC-E2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DLST (dihydrolipoamide S-succinyltransferase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dlst (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dlst (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DLST (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DLST (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dlst (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DLST (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DLST (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dlst (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dlst (dihydrolipoamide S-succinyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HEBP2 (heme binding protein 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DLST (dihydrolipoamide S-succinyltransferase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dlst (dihydrolipoamide S-succinyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dlst (dihydrolipoamide S-succinyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	KGD2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5214	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dlst-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dlst	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dlst	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	110,489,576 - 110,512,841 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	110,489,392 - 110,514,357 (+)	Ensembl				GRCr8
mRatBN7.2	6	104,758,511 - 104,783,296 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	104,758,631 - 104,783,296 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	104,927,983 - 104,951,140 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	105,227,149 - 105,250,302 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	104,596,515 - 104,619,669 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	108,936,534 - 108,961,322 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	108,936,664 - 108,959,803 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	116,595,654 - 116,620,427 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	109,156,751 - 109,180,537 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	102,581,378 - 102,605,253 (+)	NCBI		Celera
RGSC_v3.1	6	109,160,220 - 109,183,992 (+)	NCBI
Cytogenetic Map	6	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Hereditary Paraganglioma-Pheochromocytoma Syndromes (ISO)

oxoglutarate dehydrogenase deficiency (ISO)

paraganglioma (ISO)

Paragangliomas 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2,2-tetramine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,4,6-trinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

all-trans-retinoic acid (ISO)

allethrin (EXP)

amitrole (EXP)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

butanal (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

clofibrate (EXP,ISO)

clozapine (ISO)

Cuprizon (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

decabromodiphenyl ether (ISO)

doxorubicin (ISO)

ethanol (EXP,ISO)

fenthion (ISO)

fenvalerate (EXP)

flutamide (EXP)

furfural (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

hypochlorous acid (ISO)

isoniazide (ISO)

isotretinoin (ISO)

ivermectin (ISO)

lamivudine (ISO)

lovastatin (ISO)

maneb (ISO)

methamphetamine (EXP)

methidathion (ISO)

methimazole (EXP)

minocycline (ISO)

oxybenzone (EXP)

ozone (EXP)

paraquat (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

pyrethrins (EXP)

resveratrol (ISO)

sarin (EXP)

sodium arsenite (EXP,ISO)

sodium chloride (ISO)

streptozocin (EXP)

sulfadimethoxine (EXP)

thapsigargin (EXP)

thiram (ISO)

triphenyl phosphate (ISO)

trovafloxacin (EXP)

tunicamycin (ISO)

valproic acid (EXP,ISO)

vitamin E (ISO)

warfarin (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2-oxoglutarate decarboxylation to succinyl-CoA (ISO)

2-oxoglutarate metabolic process (IDA,ISO)

carboxylic acid metabolic process (IEA)

L-lysine catabolic process to acetyl-CoA via saccharopine (IEA)

succinyl-CoA metabolic process (ISO,ISS)

tricarboxylic acid cycle (IBA,IEA,ISO,ISS)

Cellular Component

cytosol (ISO)

mitochondrial matrix (IEA)

mitochondrion (IBA,IDA,ISO)

nucleoplasm (ISO)

nucleus (IEA,ISO,ISS)

oxoadipate dehydrogenase complex (ISO)

oxoglutarate dehydrogenase complex (IDA,IEA,ISO)

sarcolemma (IDA)

Molecular Function

acyltransferase activity (IEA,ISO)

dihydrolipoyllysine-residue succinyltransferase activity (IBA,IEA,ISO)

heat shock protein binding (IPI)

protein binding (ISO)

protein-folding chaperone binding (IPI)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

2-aminoadipic 2-oxoadipic aciduria pathway (ISO)

citric acid cycle pathway (IEA,ISO)

fumaric aciduria pathway (ISO)

glutaric aciduria type I pathway (ISO)

hyperlysinemia pathway (ISO)

lysine degradation pathway (IEA,ISO)

mitochondrial complex II deficiency pathway (ISO)

pyruvate dehydrogenase E2 deficiency pathway (ISO)

pyruvate dehydrogenase E3 deficiency pathway (ISO)

saccharopinuria pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death.	Bruschi SA, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13413-8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle.	Matuda S, etal., Biochem Biophys Res Commun 1997 Dec 8;241(1):151-6.
4.	Isolation and sequence analysis of the rat dihydrolipoamide succinyltransferase gene.	Nakano K, etal., DNA Seq 2002 Dec;13(6):363-7.
5.	Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex.	Ono K, etal., J Biochem. 1987 Jan;101(1):19-27.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	The alpha-ketoglutarate dehydrogenase complex.	Sheu KF and Blass JP, Ann N Y Acad Sci. 1999;893:61-78.
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:1918017	PMID:8889548	PMID:10806400	PMID:15489334	PMID:17634366	PMID:18614015	PMID:19819302	PMID:19946888	PMID:20833797	PMID:21630459	PMID:23376485	PMID:26316108
PMID:29211711	PMID:29476059	PMID:30929736	PMID:35352799

Genomics

Comparative Map Data

Dlst
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	110,489,576 - 110,512,841 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	110,489,392 - 110,514,357 (+)	Ensembl				GRCr8
mRatBN7.2	6	104,758,511 - 104,783,296 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	104,758,631 - 104,783,296 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	104,927,983 - 104,951,140 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	105,227,149 - 105,250,302 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	104,596,515 - 104,619,669 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	108,936,534 - 108,961,322 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	108,936,664 - 108,959,803 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	116,595,654 - 116,620,427 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	109,156,751 - 109,180,537 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	102,581,378 - 102,605,253 (+)	NCBI		Celera
RGSC_v3.1	6	109,160,220 - 109,183,992 (+)	NCBI
Cytogenetic Map	6	q31	NCBI

DLST
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	74,881,916 - 74,903,743 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	74,881,891 - 74,903,966 (+)	Ensembl			hg38	GRCh38
GRCh37	14	75,348,619 - 75,370,446 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	74,418,372 - 74,440,199 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	74,418,371 - 74,440,196	NCBI
Celera	14	55,386,967 - 55,408,821 (+)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	55,516,596 - 55,538,452 (+)	NCBI		HuRef
CHM1_1	14	75,287,750 - 75,309,620 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	69,091,016 - 69,112,843 (+)	NCBI		T2T-CHM13v2.0

Dlst
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	85,157,597 - 85,180,865 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	85,157,607 - 85,181,619 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	85,110,822 - 85,134,091 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	85,110,833 - 85,134,845 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	86,451,783 - 86,475,041 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	85,999,999 - 86,023,189 (+)	NCBI		MGSCv36	mm8
Celera	12	86,568,081 - 86,591,232 (+)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	39.55	NCBI

Dlst
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955523	661,738 - 680,802 (-)	Ensembl
ChiLan1.0	NW_004955523	660,413 - 680,878 (-)	NCBI	ChiLan1.0	ChiLan1.0

DLST
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	75,963,959 - 75,986,536 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	75,180,451 - 75,205,720 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	55,433,358 - 55,455,876 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	74,278,128 - 74,300,133 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	74,278,128 - 74,300,133 (+)	Ensembl			panPan2	panpan1.1

DLST
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	48,003,730 - 48,025,001 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	48,002,211 - 48,024,999 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	47,687,937 - 47,709,198 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	48,231,361 - 48,252,635 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	48,230,731 - 48,252,633 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	47,902,283 - 47,923,535 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	47,923,602 - 47,944,852 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	48,321,863 - 48,343,131 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dlst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	28,007,904 - 28,030,206 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	4,038,985 - 4,061,087 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	4,038,985 - 4,061,071 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DLST
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	98,091,124 - 98,111,572 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	98,091,161 - 98,111,267 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	103,935,074 - 103,955,180 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DLST
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	52,098,270 - 52,121,560 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	52,098,349 - 52,120,121 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	40,330,079 - 40,352,940 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dlst
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	26,803,344 - 26,825,272 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624734	26,802,902 - 26,824,632 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dlst
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	99,218,979 - 99,243,735 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dlst
115 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	207
Count of miRNA genes:	140
Interacting mature miRNAs:	167
Transcripts:	ENSRNOT00000007298
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	71278722	116278722	Rat
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	78204640	123204640	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	76937178	121937178	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	86494122	112380234	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	99708426	112483760	Rat

Markers in Region

RH127785

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	104,781,457 - 104,781,677 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	108,959,484 - 108,959,703	NCBI	Rnor6.0
Rnor_5.0	6	116,597,273 - 116,597,492	UniSTS	Rnor5.0
RGSC_v3.4	6	109,180,218 - 109,180,437	UniSTS	RGSC3.4
Celera	6	102,604,934 - 102,605,153	UniSTS
RH 3.4 Map	6	732.09	UniSTS
Cytogenetic Map	6	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001006981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB075013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB504752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB504753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC114701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB807447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK355938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK845707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D90401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007298 ⟹ ENSRNOP00000007298

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	110,489,692 - 110,514,357 (+)	Ensembl
mRatBN7.2 Ensembl	6	104,758,631 - 104,781,774 (+)	Ensembl
Rnor_6.0 Ensembl	6	108,936,664 - 108,959,803 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095379 ⟹ ENSRNOP00000089733

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	110,489,749 - 110,514,357 (+)	Ensembl
mRatBN7.2 Ensembl	6	104,758,684 - 104,783,296 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116362 ⟹ ENSRNOP00000077611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	110,489,692 - 110,514,357 (+)	Ensembl
mRatBN7.2 Ensembl	6	104,758,632 - 104,781,767 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142994 ⟹ ENSRNOP00000109609

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	110,489,392 - 110,514,357 (+)	Ensembl

RefSeq Acc Id:

NM_001006981 ⟹ NP_001006982

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,489,706 - 110,512,841 (+)	NCBI
mRatBN7.2	6	104,758,641 - 104,781,777 (+)	NCBI
Rnor_6.0	6	108,936,664 - 108,959,803 (+)	NCBI
Rnor_5.0	6	116,595,654 - 116,620,427 (-)	NCBI
RGSC_v3.4	6	109,156,751 - 109,180,537 (+)	RGD
Celera	6	102,581,378 - 102,605,253 (+)	RGD

Sequence:

show sequence

CTATATCCGGTGTCCGCCCGCCCTCCATCCCGCTGGCTCCGCGATGCTGTCCCGGTCCCGCTGC
GTGTCCCGGGCGTTCAGCCGCTCGCTTTCTGCCTTCCAGAAGGGGAACTGCCCTCTAGGGAGAC
GTTCCCTGCCTGGGGTCTCCTTATGTCAGGGACCAGGTTACCCTGACAGCAGGAAGATGGTCAT
TAACAACAGTAGCGTCTTCAGTGTTCGCTTCTTCCAAACCACGGCAGTGTGCAAGAATGATGTG
ATTACAGTCCAGACCCCAGCGTTTGCAGAGTCTGTCACAGAGGGAGATGTCAGGTGGGAGAAAG
CTGTTGGAGATGCAGTTGCAGAAGATGAAGTGGTGTGTGAGATTGAGACAGACAAGACTTCTGT
GCAGGTTCCATCACCAGCAAATGGCATCATTGAAGCTCTTTTGGTACCCGATGGGGGCAAAGTT
GAAGGAGGAACTCCTCTATTCACACTCAGGAAAACCGGTGCTGCTCCTGCTAAGGCCAAACCAG
CTGAAGCCCCTGCTACAGCCCACAAAGCAGCGCCTGAAGCACCGGCGGCCCCTCCTCCTCCTGT
AGCACCAGTGCCCACTCAGATGCCACCTGTGCCCTCACCCTCACAACCTCCTTCTAGCAAACCA
GTGTCTGCAATAAAACCCACTGCTGCCCCTCCACTGGCTGAGGCGGGAGCTGCTAAAGGCCTGC
GCTCAGAACATCGGGAAAAGATGAACAGGATGCGGCAGCGCATCGCCCAGCGTCTGAAGGAAGC
CCAGAACACCTGCGCAATGCTGACGACGTTCAATGAGGTTGACATGAGTAACATACAAGAGATG
AGAGCTCGGCACAAAGATGCTTTCCTGAAAAAACATAACCTGAAATTAGGCTTCATGTCGGCAT
TTGTGAAGGCCTCAGCATTCGCCTTGCAGGAGCAGCCTGTAGTAAACGCAGTGATTGATGACGC
AACCAAGGAGGTGGTGTACAGAGATTATATTGACATCAGTGTCGCAGTTGCTACCCCAAGGGGT
CTCGTGGTTCCTGTCATCAGGAATGTGGAAACTATGAATTATGCAGATATTGAACGGACCATTA
ATGAACTAGGAGAGAAGGCCCGGAAGAATGAACTTGCCATCGAAGACATGGATGGGGGCACCTT
CACCATCAGCAATGGAGGAGTTTTCGGCTCACTTTTCGGAACACCCATTATCAACCCGCCTCAG
TCTGCCATTCTGGGCATGCATGGCATCTTCGACAGGCCTGTGGCTGTGGGGGGCAAGGTGGAAG
TCCGACCTATGATGTATGTAGCCCTGACCTACGACCACCGGCTGATTGATGGCAGAGAGGCTGT
GACTTTCCTCCGAAAAATCAAGGCAGCAGTAGAAGATCCACGAGTCCTCCTCCTAGACCTTTAG
GAGGAAGCCACACACCCTACCTACTGATCATGCAGGAACTGAAAAACCAGTCTTCTCCCCGACC
CTCCTCAGTCCCAGGTTAACCTGAGGGCAGGCAGGCACTACCATTGGCCTCGAGCAAGGACTCC
AGGGCACTACGTAACCAGCTTTCATGGGTCTTTTTTAGTGTTCCTTCTAGGCTCTTCCTCTCTC
CGTGTGACTCTTACCTTCTGCTCTCTTGGGCCTGAGCGAGAGAGAGAGAGAGAGAGAGAGAGAG
AGAGAGAGAGAGAGCCCTGTGGATGCCCATCAATAGTCCTGCCTTTATTCCAGTCCTCTACAAA
GACACCTTTGCTTCTCTCCAGTAACAGTATGCTATAGGGATACCACCAGGGACCATGTGATTGA
GTTTCTGTCTTTGGAAAGTGTTCTCCAAAGATGCCTAGGGGGAAGCTTTGCCTCCGGGGCTCAA
AGCAGCCTCTGTCGCAGCTGTTCTTGGTCTCACTTGATGCCCCCTGTGTGGGGTATTGAACATA
GGCAAAGCAGGGCACCCTCATCCTAACCTGTCAGCGGCTTCAAGGTGCCTCTCTACCTCTGACA
GGAAGCACAGGCTGGAGGATTTAGGGATAGGCACAATTGTGCTGGGTCCCTGAGGCTACCTGTT
GTAGTCACAGATGGGAGTTGAAACTTGGCTTGCCTTTACAGGCTCCATTGTATGCTGGCACTGG
GAAGATTCATGTTGTCATAACTACGTACAACTGTTGTCCATCATACCAACCCTTTCCAGCTTCT
AGGAATCATTCTAGGACGGTGTTCTCACGTAAAGCAGATTTTAGCATATCATGGCAGTGGGACA
GCCTGGTGAACGGACTGTTCTCACCAGATCAGGCTGATGAGAGCTTTTAAATTCAAGGTGGTAC
GAGCATGTGCTGGGAAGGGCTGTTCTCTCCCTTCCTGGGATGTGGCCTGTGGGGAGCAAGGCCT
TGGTTCCTCTGGTGAAGGACACAGATAAGGGGAGGATGGACTGTGGCGGGAACCAGCCTCAGGA
GTTAGGAGAGTGAAGAGATAATGACGTCATCGCTACACTCACCCTTCAGGGGTAGGTGGTAGTT
AGAATATTTTTGAAGCATGGTGAAATGTAATTAACTGGTTATGAAAGCTCCTAGCCCTTGTGTC
CTTCACTGAGCCTGAGACTGCTGACAGCTGACATGGGGCCATTAGTGCTGAATGCCCTTTTTTC
TTGTAATCCAAGACTTGCTGGGGGGAGGGGAAGAGGTCAGTATTGAGTGCCTGCAACATCTGCT
ACTATAGCTATACCATTCAGAACTTGTAATGAAAATATTTAAAGAGACTGATTTTGAATGAAAA
TTAAAGGGCAAATGTTCTCAAACAGGGAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006240306 ⟹ XP_006240368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,489,576 - 110,512,841 (+)	NCBI
mRatBN7.2	6	104,758,511 - 104,783,296 (+)	NCBI
Rnor_6.0	6	108,936,534 - 108,961,322 (+)	NCBI
Rnor_5.0	6	116,595,654 - 116,620,427 (-)	NCBI

Sequence:

show sequence

GCGCTGGGACCGCTAATGATACTAGCCCGGCTCACCACCCGCCACCCAACACGGTTAGTGGTTC
ACTCCGAACACCCCTCGCTGCTTGGCTGGTGCTGCGGCCGGCCTCACTTCCGGTTGTTGCCGGG
CCCTATATCCGGTGTCCGCCCGCCCTCCATCCCGCTGGCTCCGCGATGCTGTCCCGGTCCCGCT
GCGTGTCCCGGGCGTTCAGCCGCTCGCTTTCTGCCTTCCAGAAGCATTAACAACAGTAGCGTCT
TCAGTGTTCGCTTCTTCCAAACCACGGCAGTGTGCAAGAATGATGTGATTACAGTCCAGACCCC
AGCGTTTGCAGAGTCTGTCACAGAGGGAGATGTCAGGTGGGAGAAAGCTGTTGGAGATGCAGTT
GCAGAAGATGAAGTGGTGTGTGAGATTGAGACAGACAAGACTTCTGTGCAGGTTCCATCACCAG
CAAATGGCATCATTGAAGCTCTTTTGGTACCCGATGGGGGCAAAGTTGAAGGAGGAACTCCTCT
ATTCACACTCAGGAAAACCGGTGCTGCTCCTGCTAAGGCCAAACCAGCTGAAGCCCCTGCTACA
GCCCACAAAGCAGCGCCTGAAGCACCGGCGGCCCCTCCTCCTCCTGTAGCACCAGTGCCCACTC
AGATGCCACCTGTGCCCTCACCCTCACAACCTCCTTCTAGCAAACCAGTGTCTGCAATAAAACC
CACTGCTGCCCCTCCACTGGCTGAGGCGGGAGCTGCTAAAGGCCTGCGCTCAGAACATCGGGAA
AAGATGAACAGGATGCGGCAGCGCATCGCCCAGCGTCTGAAGGAAGCCCAGAACACCTGCGCAA
TGCTGACGACGTTCAATGAGGTTGACATGAGTAACATACAAGAGATGAGAGCTCGGCACAAAGA
TGCTTTCCTGAAAAAACATAACCTGAAATTAGGCTTCATGTCGGCATTTGTGAAGGCCTCAGCA
TTCGCCTTGCAGGAGCAGCCTGTAGTAAACGCAGTGATTGATGACGCAACCAAGGAGGTGGTGT
ACAGAGATTATATTGACATCAGTGTCGCAGTTGCTACCCCAAGGGGTCTCGTGGTTCCTGTCAT
CAGGAATGTGGAAACTATGAATTATGCAGATATTGAACGGACCATTAATGAACTAGGAGAGAAG
GCCCGGAAGAATGAACTTGCCATCGAAGACATGGATGGGGGCACCTTCACCATCAGCAATGGAG
GAGTTTTCGGCTCACTTTTCGGAACACCCATTATCAACCCGCCTCAGTCTGCCATTCTGGGCAT
GCATGGCATCTTCGACAGGCCTGTGGCTGTGGGGGGCAAGGTGGAAGTCCGACCTATGATGTAT
GTAGCCCTGACCTACGACCACCGGCTGATTGATGGCAGAGAGGCTGTGACTTTCCTCCGAAAAA
TCAAGGCAGCAGTAGAAGATCCACGAGTCCTCCTCCTAGACCTTTAGGAGGAAGCCACACACCC
TACCTACTGATCATGCAGGAACTGAAAAACCAGTCTTCTCCCCGACCCTCCTCAGTCCCAGGTT
AACCTGAGGGCAGGCAGGCACTACCATTGGCCTCGAGCAAGGACTCCAGGGCACTACGTAACCA
GCTTTCATGGGTCTTTTTTAGTGTTCCTTCTAGGCTCTTCCTCTCTCCGTGTGACTCTTACCTT
CTGCTCTCTTGGGCCTGAGCGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGCCC
TGTGGATGCCCATCAATAGTCCTGCCTTTATTCCAGTCCTCTACAAAGACACCTTTGCTTCTCT
CCAGTAACAGTATGCTATAGGGATACCACCAGGGACCATGTGATTGAGTTTCTGTCTTTGGAAA
GTGTTCTCCAAAGATGCCTAGGGGGAAGCTTTGCCTCCGGGGCTCAAAGCAGCCTCTGTCGCAG
CTGTTCTTGGTCTCACTTGATGCCCCCTGTGTGGGGTATTGAACATAGGCAAAGCAGGGCACCC
TCATCCTAACCTGTCAGCGGCTTCAAGGTGCCTCTCTACCTCTGACAGGAAGCACAGGCTGGAG
GATTTAGGGATAGGCACAATTGTGCTGGGTCCCTGAGGCTACCTGTTGTAGTCACAGATGGGAG
TTGAAACTTGGCTTGCCTTTACAGGCTCCATTGTATGCTGGCACTGGGAAGATTCATGTTGTCA
TAACTACGTACAACTGTTGTCCATCATACCAACCCTTTCCAGCTTCTAGGAATCATTCTAGGAC
GGTGTTCTCACGTAAAGCAGATTTTAGCATATCATGGCAGTGGGACAGCCTGGTGAACGGACTG
TTCTCACCAGATCAGGCTGATGAGAGCTTTTAAATTCAAGGTGGTACGAGCATGTGCTGGGAAG
GGCTGTTCTCTCCCTTCCTGGGATGTGGCCTGTGGGGAGCAAGGCCTTGGTTCCTCTGGTGAAG
GACACAGATAAGGGGAGGATGGACTGTGGCGGGAACCAGCCTCAGGAGTTAGGAGAGTGAAGAG
ATAATGACGTCATCGCTACACTCACCCTTCAGGGGTAGGTGGTAGTTAGAATATTTTTGAAGCA
TGGTGAAATGTAATTAACTGGTTATGAAAGCTCCTAGCCCTTGTGTCCTTCACTGAGCCTGAGA
CTGCTGACAGCTGACATGGGGCCATTAGTGCTGAATGCCCTTTTTTCTTGTAATCCAAGACTTG
CTGGGGGGAGGGGAAGAGGTCAGTATTGAGTGCCTGCAACATCTGCTACTATAGCTATACCATT
CAGAACTTGTAATGAAAATATTTAAAGAGACTGATTTTGAATGAAAATTAAAGGGCAAATGTTC
TCAAACAGGGCTCCAGGGTCTGTGGTCCTTTTGACCCTTGAGTCTGTACAGCCCCCGTCATTGT
TGGCAACCACAATGTCATTACTTTATCCTGCGTTGACTGTCCTGGTGGAACCCAGGATATCTTT
GTGTATTCTTGTCTCTGAGCAGCACACCAGGCCCCCAGCCAGCCAGGAGAACCCACTGTCTCAG
TACCCTGGGTTCTTTTCAGGGAGCCCGTGACCCTGACAAGCCAACTCCTGAACAGAAAGTGTGG
CTCCTACCTATTGAAGCCCCTTCAAGACACCAAGGGCAGTTTCTCTTTGAAGGGCTTACATAAT
TTCCTAGATAAAGTGGGGAGGCATGAACACTCCTAATACCATTTGGACTTGGTTGCCACATATG
CACCATTATAACCACATCTGGCTATAATGAAGTGAGGGGTCGTCTCCTAGGAGCAGTAGTAGTA
TTTGAGGAGCAATGGACAGGACAGGGTTGGTCACCAACCCAGAATCTCCCCAATGGATAGGCAG
GATGGAGCAAGAGGCTTAGGCACAGCCTTGCTTTCCCACACATCTGCTGACCGTTTGCAGAGGG
GCCCTCCCTCTGGTGGCATGTCCCAGGAAGAAATGAGGTCCTTGAGCAATTGCAGCTGGTAGGT
GGGTTCATGAATTATGTATCTGGTCTAGTGTTTGATATGTTACAAGTTTTAAATTTTTCTACCA
GATTCCTGGAGTTAGCTGCCCTAGTGTATTGAAAGGCCATCCATAAGCCCTGTCAGGACCAGGA
CCATGGTATTCCAAACGTATGGCTCGGCTGAGTGCCAGACGTACAGTGTATTGGCAGGGCAAGC
CTGGAAGGGACATGTACTCTGTAAAGCAGTGGCCAAAGTTGCCTGGCATTATGGGTTACCACAG
AAGGAACCTACACTTGTGAGCCAGCTCTGCCAGGTTCTAAGCTAACCTCCCAAGAACCTCTCTT
CTCAGGAGAATCTTCCATGAGCTGACTGCAGATTATGTGCTCCTCAGGCACCATGACCAGTTGA
GGTGTCTGTCTCCTTCCTCCCTTTTTTCTGAGGCTGTTCTCAGGCTGCTTCCTTGTAGGCACTG
TATTGATGCAAAGATGCCACAGAAGGATTAGGCTTTATTAGAGGGTAGACAAACCCTAGGCACT
TCGAGGGCCAGCGCACTCGTGGGCACGCATGCACGCACGCATGCACGCACGCACAATCTAGGGA
TTGGTCAAGGGAAGTTTTGCTGCACGCGCACGCCCCAGTGACTGGGCAAGCCCTCAAACCCAGG
CTGTCTTTGGAGATAACCTCTTCCTTCAGAGACCAGAAATGCCTGTCTGAAGGCACTGGGTAAA
ACTGGTCCCTGTGCTCTGTGGTATCTCATTCTAAGTCAGCAGGCAGTGAAGCAAACAGATGCTC
ATACCAAAATGCACAGTGGGAAAAAACAAACGCCTGAGAACCAACTGCTGGTCCTGTGGAGCAA
GCTCTTCTGACATAGGAGAGCCAGCCAGAGAATAAAGCACTTTATTCTGTTTCCAAA

hide sequence

RefSeq Acc Id:

XM_008764756 ⟹ XP_008762978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,489,699 - 110,512,841 (+)	NCBI
mRatBN7.2	6	104,758,661 - 104,781,777 (+)	NCBI
Rnor_6.0	6	108,936,684 - 108,959,803 (+)	NCBI

Sequence:

show sequence

CCCTCCATCCCGCTGGCTCCGCGATGCTGTCCCGGTCCCGCTGCGTGTCCCGGGCGTTCAGCCG
CTCGCTTTCTGCCTTCCAGAAGGGGAACTGCCCTCTAGGGAGACGTTCCCTGCCTGCATTAACA
ACAGTAGCGTCTTCAGTGTTCGCTTCTTCCAAACCACGGCAGTGTGCAAGAATGATGTGATTAC
AGTCCAGACCCCAGCGTTTGCAGAGTCTGTCACAGAGGGAGATGTCAGGTGGGAGAAAGCTGTT
GGAGATGCAGTTGCAGAAGATGAAGTGGTGTGTGAGATTGAGACAGACAAGACTTCTGTGCAGG
TTCCATCACCAGCAAATGGCATCATTGAAGCTCTTTTGGTACCCGATGGGGGCAAAGTTGAAGG
AGGAACTCCTCTATTCACACTCAGGAAAACCGGTGCTGCTCCTGCTAAGGCCAAACCAGCTGAA
GCCCCTGCTACAGCCCACAAAGCAGCGCCTGAAGCACCGGCGGCCCCTCCTCCTCCTGTAGCAC
CAGTGCCCACTCAGATGCCACCTGTGCCCTCACCCTCACAACCTCCTTCTAGCAAACCAGTGTC
TGCAATAAAACCCACTGCTGCCCCTCCACTGGCTGAGGCGGGAGCTGCTAAAGGCCTGCGCTCA
GAACATCGGGAAAAGATGAACAGGATGCGGCAGCGCATCGCCCAGCGTCTGAAGGAAGCCCAGA
ACACCTGCGCAATGCTGACGACGTTCAATGAGGTTGACATGAGTAACATACAAGAGATGAGAGC
TCGGCACAAAGATGCTTTCCTGAAAAAACATAACCTGAAATTAGGCTTCATGTCGGCATTTGTG
AAGGCCTCAGCATTCGCCTTGCAGGAGCAGCCTGTAGTAAACGCAGTGATTGATGACGCAACCA
AGGAGGTGGTGTACAGAGATTATATTGACATCAGTGTCGCAGTTGCTACCCCAAGGGGTCTCGT
GGTTCCTGTCATCAGGAATGTGGAAACTATGAATTATGCAGATATTGAACGGACCATTAATGAA
CTAGGAGAGAAGGCCCGGAAGAATGAACTTGCCATCGAAGACATGGATGGGGGCACCTTCACCA
TCAGCAATGGAGGAGTTTTCGGCTCACTTTTCGGAACACCCATTATCAACCCGCCTCAGTCTGC
CATTCTGGGCATGCATGGCATCTTCGACAGGCCTGTGGCTGTGGGGGGCAAGGTGGAAGTCCGA
CCTATGATGTATGTAGCCCTGACCTACGACCACCGGCTGATTGATGGCAGAGAGGCTGTGACTT
TCCTCCGAAAAATCAAGGCAGCAGTAGAAGATCCACGAGTCCTCCTCCTAGACCTTTAGGAGGA
AGCCACACACCCTACCTACTGATCATGCAGGAACTGAAAAACCAGTCTTCTCCCCGACCCTCCT
CAGTCCCAGGTTAACCTGAGGGCAGGCAGGCACTACCATTGGCCTCGAGCAAGGACTCCAGGGC
ACTACGTAACCAGCTTTCATGGGTCTTTTTTAGTGTTCCTTCTAGGCTCTTCCTCTCTCCGTGT
GACTCTTACCTTCTGCTCTCTTGGGCCTGAGCGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA
GAGAGAGAGCCCTGTGGATGCCCATCAATAGTCCTGCCTTTATTCCAGTCCTCTACAAAGACAC
CTTTGCTTCTCTCCAGTAACAGTATGCTATAGGGATACCACCAGGGACCATGTGATTGAGTTTC
TGTCTTTGGAAAGTGTTCTCCAAAGATGCCTAGGGGGAAGCTTTGCCTCCGGGGCTCAAAGCAG
CCTCTGTCGCAGCTGTTCTTGGTCTCACTTGATGCCCCCTGTGTGGGGTATTGAACATAGGCAA
AGCAGGGCACCCTCATCCTAACCTGTCAGCGGCTTCAAGGTGCCTCTCTACCTCTGACAGGAAG
CACAGGCTGGAGGATTTAGGGATAGGCACAATTGTGCTGGGTCCCTGAGGCTACCTGTTGTAGT
CACAGATGGGAGTTGAAACTTGGCTTGCCTTTACAGGCTCCATTGTATGCTGGCACTGGGAAGA
TTCATGTTGTCATAACTACGTACAACTGTTGTCCATCATACCAACCCTTTCCAGCTTCTAGGAA
TCATTCTAGGACGGTGTTCTCACGTAAAGCAGATTTTAGCATATCATGGCAGTGGGACAGCCTG
GTGAACGGACTGTTCTCACCAGATCAGGCTGATGAGAGCTTTTAAATTCAAGGTGGTACGAGCA
TGTGCTGGGAAGGGCTGTTCTCTCCCTTCCTGGGATGTGGCCTGTGGGGAGCAAGGCCTTGGTT
CCTCTGGTGAAGGACACAGATAAGGGGAGGATGGACTGTGGCGGGAACCAGCCTCAGGAGTTAG
GAGAGTGAAGAGATAATGACGTCATCGCTACACTCACCCTTCAGGGGTAGGTGGTAGTTAGAAT
ATTTTTGAAGCATGGTGAAATGTAATTAACTGGTTATGAAAGCTCCTAGCCCTTGTGTCCTTCA
CTGAGCCTGAGACTGCTGACAGCTGACATGGGGCCATTAGTGCTGAATGCCCTTTTTTCTTGTA
ATCCAAGACTTGCTGGGGGGAGGGGAAGAGGTCAGTATTGAGTGCCTGCAACATCTGCTACTAT
AGCTATACCATTCAGAACTTGTAATGAAAATATTTAAAGAGACTGATTTTGAATGAAAATTAAA
GGGCAAATGTTCTCAAACAGGG

hide sequence

RefSeq Acc Id:

XM_039112045 ⟹ XP_038967973

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,489,713 - 110,512,841 (+)	NCBI
mRatBN7.2	6	104,758,662 - 104,781,777 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001006982	(Get FASTA)	NCBI Sequence Viewer
	XP_006240368	(Get FASTA)	NCBI Sequence Viewer
	XP_008762978	(Get FASTA)	NCBI Sequence Viewer
	XP_038967973	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83858	(Get FASTA)	NCBI Sequence Viewer
	BAA14397	(Get FASTA)	NCBI Sequence Viewer
	BAC11910	(Get FASTA)	NCBI Sequence Viewer
	BAI49953	(Get FASTA)	NCBI Sequence Viewer
	EDL81544	(Get FASTA)	NCBI Sequence Viewer
	EDL81545	(Get FASTA)	NCBI Sequence Viewer
	EDL81546	(Get FASTA)	NCBI Sequence Viewer
	EDL81547	(Get FASTA)	NCBI Sequence Viewer
	EDL81548	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007298
	ENSRNOP00000109609
GenBank Protein	Q01205	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001006982 ⟸ NM_001006981

- UniProtKB:

Q5XI35 (UniProtKB/Swiss-Prot), Q01205 (UniProtKB/Swiss-Prot), G3V6P2 (UniProtKB/TrEMBL), A6JE02 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPDSRKMVINNSSVFSVRFFQTT
AVCKNDVITVQTPAFAESVTEGDVRWEKAVGDAVAEDEVVCEIETDKTSVQVPSPANGIIEALL
VPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPATAHKAAPEAPAAPPPPVAPVPTQMPPVPSPS
QPPSSKPVSAIKPTAAPPLAEAGAAKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEVD
MSNIQEMRARHKDAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDATKEVVYRDYIDISV
AVATPRGLVVPVIRNVETMNYADIERTINELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGT
PIINPPQSAILGMHGIFDRPVAVGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPR
VLLLDL

hide sequence

RefSeq Acc Id:	XP_006240368 ⟸ XM_006240306
- Peptide Label:	isoform X1
- UniProtKB:	Q8CJG5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MILARLTTRHPTRLVVHSEHPSLLGWCCGRPHFRLLPGPISGVRPPSIPLAPRCCPGPAACPGR SAARFLPSRSINNSSVFSVRFFQTTAVCKNDVITVQTPAFAESVTEGDVRWEKAVGDAVAEDEV VCEIETDKTSVQVPSPANGIIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPATAHKAA PEAPAAPPPPVAPVPTQMPPVPSPSQPPSSKPVSAIKPTAAPPLAEAGAAKGLRSEHREKMNRM RQRIAQRLKEAQNTCAMLTTFNEVDMSNIQEMRARHKDAFLKKHNLKLGFMSAFVKASAFALQE QPVVNAVIDDATKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYADIERTINELGEKARKNE LAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAVGGKVEVRPMMYVALTY DHRLIDGREAVTFLRKIKAAVEDPRVLLLDL hide sequence

RefSeq Acc Id:	XP_008762978 ⟸ XM_008764756
- Peptide Label:	isoform X3
- UniProtKB:	D0VYQ0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPPVPSPSQPPSSKPVSAIKPTAAPPLAEAGAAKGLRSEHREKMNRMRQRIAQRLKEAQNTCAM LTTFNEVDMSNIQEMRARHKDAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDATKEVVY RDYIDISVAVATPRGLVVPVIRNVETMNYADIERTINELGEKARKNELAIEDMDGGTFTISNGG VFGSLFGTPIINPPQSAILGMHGIFDRPVAVGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKI KAAVEDPRVLLLDL hide sequence

Ensembl Acc Id:

ENSRNOP00000007298 ⟸ ENSRNOT00000007298

RefSeq Acc Id:	XP_038967973 ⟸ XM_039112045
- Peptide Label:	isoform X2
- UniProtKB:	Q5XI35 (UniProtKB/Swiss-Prot), Q01205 (UniProtKB/Swiss-Prot), Q8CJG5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000077611 ⟸ ENSRNOT00000116362

Ensembl Acc Id:

ENSRNOP00000089733 ⟸ ENSRNOT00000095379

Ensembl Acc Id:

ENSRNOP00000109609 ⟸ ENSRNOT00000142994

Protein Domains

2-oxoacid dehydrogenase acyltransferase catalytic Lipoyl-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q01205-F1-model_v2	AlphaFold	Q01205	1-454	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694735

Promoter ID:

EPDNEW_R5260

Type:

initiation region

Name:

Dlst_1

Description:

dihydrolipoamide S-succinyltransferase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	108,936,668 - 108,936,728	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359615	AgrOrtholog
BioCyc Gene	G2FUF-36796	BioCyc
Ensembl Genes	ENSRNOG00000005061	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000007298	ENTREZGENE
	ENSRNOT00000142994	ENTREZGENE
Gene3D-CATH	2.40.50.100	UniProtKB/Swiss-Prot
	3.30.559.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7125734	IMAGE-MGC_LOAD
InterPro	2-oxoA_DH_lipoyl-BS	UniProtKB/Swiss-Prot
	2-oxoacid_dehydrogenase	UniProtKB/Swiss-Prot
	2-oxoacid_DH_actylTfrase	UniProtKB/Swiss-Prot
	Biotin_lipoyl	UniProtKB/Swiss-Prot
	CAT-like_dom_sf	UniProtKB/Swiss-Prot
	Single_hybrid_motif	UniProtKB/Swiss-Prot
	SucB	UniProtKB/Swiss-Prot
KEGG Report	rno:299201	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95077	IMAGE-MGC_LOAD
NCBI Gene	299201	ENTREZGENE
PANTHER	DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED	UniProtKB/Swiss-Prot
Pfam	2-oxoacid_dh	UniProtKB/Swiss-Prot
	Biotin_lipoyl	UniProtKB/Swiss-Prot
PhenoGen	Dlst	PhenoGen
PROSITE	BIOTINYL_LIPOYL	UniProtKB/Swiss-Prot
	LIPOYL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005061	RatGTEx
Superfamily-SCOP	CoA-dependent acyltransferases	UniProtKB/Swiss-Prot
	SSF51230	UniProtKB/Swiss-Prot
UniProt	A0A8I5XWB5_RAT	UniProtKB/TrEMBL
	A0A8I6ACB9_RAT	UniProtKB/TrEMBL
	A0ABK0M337_RAT	UniProtKB/TrEMBL
	A6JE02	ENTREZGENE, UniProtKB/TrEMBL
	A6JE03_RAT	UniProtKB/TrEMBL
	A6JE04_RAT	UniProtKB/TrEMBL
	D0VYQ0	ENTREZGENE, UniProtKB/TrEMBL
	G3V6P2	ENTREZGENE, UniProtKB/TrEMBL
	ODO2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5XI35	ENTREZGENE
	Q8CJG5	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	Q5XI35	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-29	Dlst	dihydrolipoamide S-succinyltransferase	Dlst	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Dlst	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Dlst	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)