Dlst (dihydrolipoamide S-succinyltransferase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dlst (dihydrolipoamide S-succinyltransferase) Rattus norvegicus
Analyze
Symbol: Dlst
Name: dihydrolipoamide S-succinyltransferase
RGD ID: 1359615
Description: Enables dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; citric acid cycle pathway; fumaric aciduria pathway; INTERACTS WITH 2,2,2-tetramine; 2,4,6-trinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-oxoglutarate dehydrogenase complex component E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2; E2K; MGC95077; OGDC-E2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,489,576 - 110,512,841 (+)NCBIGRCr8
mRatBN7.26104,758,511 - 104,783,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,758,631 - 104,783,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,927,983 - 104,951,140 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,227,149 - 105,250,302 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,596,515 - 104,619,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,936,534 - 108,961,322 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,936,664 - 108,959,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,595,654 - 116,620,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,156,751 - 109,180,537 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,160,220 - 109,183,992 (+)NCBI
Celera6102,581,378 - 102,605,253 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
Cuprizon  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
hypochlorous acid  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lovastatin  (ISO)
maneb  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
minocycline  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
sarin  (EXP)
sodium arsenite  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
thapsigargin  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
warfarin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death. Bruschi SA, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13413-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle. Matuda S, etal., Biochem Biophys Res Commun 1997 Dec 8;241(1):151-6.
4. Isolation and sequence analysis of the rat dihydrolipoamide succinyltransferase gene. Nakano K, etal., DNA Seq 2002 Dec;13(6):363-7.
5. Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex. Ono K, etal., J Biochem. 1987 Jan;101(1):19-27.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The alpha-ketoglutarate dehydrogenase complex. Sheu KF and Blass JP, Ann N Y Acad Sci. 1999;893:61-78.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1918017   PMID:8889548   PMID:10806400   PMID:15489334   PMID:17634366   PMID:18614015   PMID:19819302   PMID:19946888   PMID:20833797   PMID:21630459   PMID:23376485   PMID:26316108  
PMID:29211711   PMID:29476059   PMID:30929736   PMID:35352799  


Genomics

Comparative Map Data
Dlst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,489,576 - 110,512,841 (+)NCBIGRCr8
mRatBN7.26104,758,511 - 104,783,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,758,631 - 104,783,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,927,983 - 104,951,140 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,227,149 - 105,250,302 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,596,515 - 104,619,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,936,534 - 108,961,322 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,936,664 - 108,959,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,595,654 - 116,620,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,156,751 - 109,180,537 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,160,220 - 109,183,992 (+)NCBI
Celera6102,581,378 - 102,605,253 (+)NCBICelera
Cytogenetic Map6q31NCBI
DLST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,881,916 - 74,903,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,881,891 - 74,903,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,348,619 - 75,370,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,418,372 - 74,440,199 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,418,371 - 74,440,196NCBI
Celera1455,386,967 - 55,408,821 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,516,596 - 55,538,452 (+)NCBIHuRef
CHM1_11475,287,750 - 75,309,620 (+)NCBICHM1_1
T2T-CHM13v2.01469,091,016 - 69,112,843 (+)NCBIT2T-CHM13v2.0
Dlst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,157,597 - 85,180,865 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,157,607 - 85,181,619 (+)EnsemblGRCm39 Ensembl
GRCm381285,110,822 - 85,134,091 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,110,833 - 85,134,845 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,451,783 - 86,475,041 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,999,999 - 86,023,189 (+)NCBIMGSCv36mm8
Celera1286,568,081 - 86,591,232 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.55NCBI
Dlst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523661,738 - 680,802 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523660,413 - 680,878 (-)NCBIChiLan1.0ChiLan1.0
DLST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,963,959 - 75,986,536 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,180,451 - 75,205,720 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,433,358 - 55,455,876 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,278,128 - 74,300,133 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,278,128 - 74,300,133 (+)Ensemblpanpan1.1panPan2
DLST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,003,730 - 48,025,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,002,211 - 48,024,999 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,687,937 - 47,709,198 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,231,361 - 48,252,635 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,230,731 - 48,252,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,902,283 - 47,923,535 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,923,602 - 47,944,852 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,321,863 - 48,343,131 (+)NCBIUU_Cfam_GSD_1.0
Dlst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,007,904 - 28,030,206 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,038,985 - 4,061,087 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,038,985 - 4,061,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,091,124 - 98,111,572 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,091,161 - 98,111,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,935,074 - 103,955,180 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,098,270 - 52,121,560 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,098,349 - 52,120,121 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,330,079 - 40,352,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,803,344 - 26,825,272 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,802,902 - 26,824,632 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlst
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:140
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000007298
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat

Markers in Region
RH127785  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,781,457 - 104,781,677 (+)MAPPERmRatBN7.2
Rnor_6.06108,959,484 - 108,959,703NCBIRnor6.0
Rnor_5.06116,597,273 - 116,597,492UniSTSRnor5.0
RGSC_v3.46109,180,218 - 109,180,437UniSTSRGSC3.4
Celera6102,604,934 - 102,605,153UniSTS
RH 3.4 Map6732.09UniSTS
Cytogenetic Map6q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001006981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB075013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB504752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB504753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC114701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB807447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK355938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK845707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000007298   ⟹   ENSRNOP00000007298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,758,631 - 104,781,774 (+)Ensembl
Rnor_6.0 Ensembl6108,936,664 - 108,959,803 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095379   ⟹   ENSRNOP00000089733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,758,684 - 104,783,296 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116362   ⟹   ENSRNOP00000077611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,758,632 - 104,781,767 (+)Ensembl
RefSeq Acc Id: NM_001006981   ⟹   NP_001006982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,489,706 - 110,512,841 (+)NCBI
mRatBN7.26104,758,641 - 104,781,777 (+)NCBI
Rnor_6.06108,936,664 - 108,959,803 (+)NCBI
Rnor_5.06116,595,654 - 116,620,427 (-)NCBI
RGSC_v3.46109,156,751 - 109,180,537 (+)RGD
Celera6102,581,378 - 102,605,253 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240306   ⟹   XP_006240368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,489,576 - 110,512,841 (+)NCBI
mRatBN7.26104,758,511 - 104,783,296 (+)NCBI
Rnor_6.06108,936,534 - 108,961,322 (+)NCBI
Rnor_5.06116,595,654 - 116,620,427 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764756   ⟹   XP_008762978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,489,699 - 110,512,841 (+)NCBI
mRatBN7.26104,758,661 - 104,781,777 (+)NCBI
Rnor_6.06108,936,684 - 108,959,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112045   ⟹   XP_038967973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,489,713 - 110,512,841 (+)NCBI
mRatBN7.26104,758,662 - 104,781,777 (+)NCBI
RefSeq Acc Id: NP_001006982   ⟸   NM_001006981
- UniProtKB: Q5XI35 (UniProtKB/Swiss-Prot),   Q01205 (UniProtKB/Swiss-Prot),   G3V6P2 (UniProtKB/TrEMBL),   A6JE02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240368   ⟸   XM_006240306
- Peptide Label: isoform X1
- UniProtKB: Q8CJG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762978   ⟸   XM_008764756
- Peptide Label: isoform X3
- UniProtKB: D0VYQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007298   ⟸   ENSRNOT00000007298
RefSeq Acc Id: XP_038967973   ⟸   XM_039112045
- Peptide Label: isoform X2
- UniProtKB: Q5XI35 (UniProtKB/Swiss-Prot),   Q01205 (UniProtKB/Swiss-Prot),   Q8CJG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077611   ⟸   ENSRNOT00000116362
RefSeq Acc Id: ENSRNOP00000089733   ⟸   ENSRNOT00000095379
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01205-F1-model_v2 AlphaFold Q01205 1-454 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694735
Promoter ID:EPDNEW_R5260
Type:initiation region
Name:Dlst_1
Description:dihydrolipoamide S-succinyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06108,936,668 - 108,936,728EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359615 AgrOrtholog
BioCyc Gene G2FUF-36796 BioCyc
Ensembl Genes ENSRNOG00000005061 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007298 ENTREZGENE
  ENSRNOT00000007298.5 UniProtKB/TrEMBL
  ENSRNOT00000095379.1 UniProtKB/TrEMBL
  ENSRNOT00000116362.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125734 IMAGE-MGC_LOAD
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2-oxoacid_DH_actylTfrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SucB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299201 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95077 IMAGE-MGC_LOAD
NCBI Gene 299201 ENTREZGENE
PANTHER DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 2-oxoacid_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlst PhenoGen
PROSITE BIOTINYL_LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005061 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XWB5_RAT UniProtKB/TrEMBL
  A0A8I6ACB9_RAT UniProtKB/TrEMBL
  A6JE02 ENTREZGENE, UniProtKB/TrEMBL
  A6JE03_RAT UniProtKB/TrEMBL
  A6JE04_RAT UniProtKB/TrEMBL
  D0VYQ0 ENTREZGENE, UniProtKB/TrEMBL
  G3V6P2 ENTREZGENE, UniProtKB/TrEMBL
  ODO2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XI35 ENTREZGENE
  Q8CJG5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q5XI35 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Dlst  dihydrolipoamide S-succinyltransferase  Dlst  dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dlst  dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Dlst  dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)      Symbol and Name status set to provisional 70820 PROVISIONAL