Ogdh (oxoglutarate dehydrogenase) - Rat Genome Database

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Gene: Ogdh (oxoglutarate dehydrogenase) Rattus norvegicus
Analyze
Symbol: Ogdh
Name: oxoglutarate dehydrogenase
RGD ID: 1561359
Description: Enables heat shock protein binding activity; oxoglutarate dehydrogenase (succinyl-transferring) activity; and protein-folding chaperone binding activity. Involved in 2-oxoglutarate metabolic process; nucleoside phosphate metabolic process; and tricarboxylic acid cycle. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in oxoglutarate dehydrogenase deficiency. Orthologous to human OGDH (oxoglutarate dehydrogenase); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-nicotine; 1,1'-azobis(N,N-dimethylformamide).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-oxoglutarate dehydrogenase complex component E1; 2-oxoglutarate dehydrogenase E1 component, mitochondrial; 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase, mitochondrial-like; alpha-ketoglutarate dehydrogenase; alpha-KGDH-E1; E1o; LOC103693780; LOC360975; OGDC-E1; OGDH-E1; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); oxoglutarate dehydrogenase (lipoamide); similar to oxoglutarate dehydrogenase (lipoamide); thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ogdhem1Yuyi  
Genetic Models: SD-Ogdhem1Yuyi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,363,949 - 85,431,405 (+)NCBIGRCr8
mRatBN7.21481,150,021 - 81,217,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,150,091 - 81,217,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,551,494 - 85,617,817 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,791,580 - 86,857,903 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,240,905 - 83,307,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,414,924 - 86,481,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,414,949 - 86,613,327 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01487,376,110 - 87,442,862 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,022,994 - 87,090,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1480,033,036 - 80,099,636 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (EXP,ISO)
aluminium(0)  (EXP,ISO)
amiodarone  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (EXP)
inulin  (ISO)
iodide salt  (EXP)
isoniazide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kahweol  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
myrtenal  (EXP)
N(4)-hydroxycytidine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP,ISO)
omeprazole  (EXP)
oxybenzone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-allylcysteine  (EXP)
silicon dioxide  (ISO)
sinapic acid  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrial membrane  (ISS)
mitochondrion  (IBA,IEA,ISO)
nucleus  (IEA,ISO,ISS)
oxoglutarate dehydrogenase complex  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Andersson U, etal., Biochem Biophys Res Commun. 1998 Aug 19;249(2):512-6.
2. Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death. Bruschi SA, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13413-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex. Ono K, etal., J Biochem. 1987 Jan;101(1):19-27.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The alpha-ketoglutarate dehydrogenase complex. Sheu KF and Blass JP, Ann N Y Acad Sci. 1999;893:61-78.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:14651853   PMID:15356189   PMID:15489334   PMID:16025302   PMID:16901643   PMID:17322295   PMID:18614015   PMID:18783430   PMID:19723099   PMID:24495017   PMID:24515115   PMID:26316108  
PMID:26936970   PMID:28601082   PMID:29211711   PMID:32024885  


Genomics

Comparative Map Data
Ogdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,363,949 - 85,431,405 (+)NCBIGRCr8
mRatBN7.21481,150,021 - 81,217,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,150,091 - 81,217,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,551,494 - 85,617,817 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,791,580 - 86,857,903 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,240,905 - 83,307,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,414,924 - 86,481,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,414,949 - 86,613,327 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01487,376,110 - 87,442,862 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,022,994 - 87,090,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1480,033,036 - 80,099,636 (+)NCBICelera
Cytogenetic Map14q21NCBI
OGDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,606,627 - 44,709,066 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,606,572 - 44,709,066 (+)EnsemblGRCh38hg38GRCh38
GRCh37744,646,226 - 44,748,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,612,696 - 44,715,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 34744,419,410 - 44,521,908NCBI
Celera744,744,966 - 44,847,513 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,530,268 - 44,633,659 (+)NCBIHuRef
CHM1_1744,650,491 - 44,752,987 (+)NCBICHM1_1
T2T-CHM13v2.0744,766,778 - 44,869,231 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,685,639 - 44,788,190 (+)NCBI
Ogdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,241,597 - 6,309,094 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,241,633 - 6,306,642 (+)EnsemblGRCm39 Ensembl
GRCm38116,291,597 - 6,359,094 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,291,633 - 6,356,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,191,600 - 6,259,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,191,600 - 6,268,605 (+)NCBIMGSCv36mm8
Celera116,773,507 - 6,842,010 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.94NCBI
Ogdh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,415,589 - 7,485,515 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,416,343 - 7,484,889 (-)NCBIChiLan1.0ChiLan1.0
OGDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,519,160 - 49,621,977 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,843,898 - 97,946,715 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,321,559 - 45,422,515 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,390,679 - 45,492,000 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,409,148 - 45,491,636 (+)Ensemblpanpan1.1panPan2
OGDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,363,764 - 2,432,958 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,428,589 - 14,497,803 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,428,589 - 14,497,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,059,830 - 14,129,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,040,718 - 14,109,906 (-)NCBIUU_Cfam_GSD_1.0
Ogdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,295,062 - 100,372,678 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,506,154 - 19,583,364 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,506,845 - 19,584,411 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,609,418 - 50,684,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,609,415 - 50,684,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,497,953 - 55,588,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OGDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12113,975,825 - 14,070,216 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2113,973,845 - 14,070,731 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,465,981 - 8,560,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ogdh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,482,314 - 7,549,417 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,481,719 - 7,549,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ogdh
407 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:91
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000057199
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
D14Rat20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21481,204,751 - 81,204,906 (+)MAPPERmRatBN7.2
Rnor_6.01486,468,309 - 86,468,463NCBIRnor6.0
Rnor_6.01486,601,370 - 86,601,524NCBIRnor6.0
Rnor_5.01487,430,137 - 87,430,291UniSTSRnor5.0
RGSC_v3.41487,078,650 - 87,079,096RGDRGSC3.4
RGSC_v3.41487,078,921 - 87,079,075UniSTSRGSC3.4
RGSC_v3.11487,098,066 - 87,098,220RGD
Celera1480,087,790 - 80,087,944UniSTS
RH 3.4 Map14584.8RGD
RH 3.4 Map14584.8UniSTS
RH 2.0 Map14716.2RGD
SHRSP x BN Map1444.91RGD
Cytogenetic Map14q21UniSTS
RH133330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21481,217,185 - 81,217,370 (+)MAPPERmRatBN7.2
Rnor_6.01486,613,801 - 86,613,985NCBIRnor6.0
Rnor_6.01486,480,741 - 86,480,925NCBIRnor6.0
Rnor_5.01487,442,569 - 87,442,753UniSTSRnor5.0
RGSC_v3.41487,091,353 - 87,091,537UniSTSRGSC3.4
Celera1480,100,221 - 80,100,405UniSTS
RH 3.4 Map14582.5UniSTS
Cytogenetic Map14q21UniSTS
BF387217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21481,170,945 - 81,171,116 (+)MAPPERmRatBN7.2
Rnor_6.01486,435,231 - 86,435,401NCBIRnor6.0
Rnor_5.01487,397,059 - 87,397,229UniSTSRnor5.0
RGSC_v3.41487,043,964 - 87,044,134UniSTSRGSC3.4
Celera1480,053,820 - 80,053,990UniSTS
RH 3.4 Map14578.0UniSTS
Cytogenetic Map14q21UniSTS
RH135290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21481,157,499 - 81,157,705 (+)MAPPERmRatBN7.2
Rnor_6.01486,421,714 - 86,421,919NCBIRnor6.0
Rnor_5.01487,383,542 - 87,383,747UniSTSRnor5.0
RGSC_v3.41487,030,611 - 87,030,816UniSTSRGSC3.4
Celera1480,040,436 - 80,040,641UniSTS
RH 3.4 Map14576.1UniSTS
Cytogenetic Map14q21UniSTS
MARC_4335-4336:996679558:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21481,215,864 - 81,216,450 (+)MAPPERmRatBN7.2
Rnor_6.01486,612,480 - 86,613,065NCBIRnor6.0
Rnor_6.01486,479,420 - 86,480,005NCBIRnor6.0
Rnor_5.01487,441,248 - 87,441,833UniSTSRnor5.0
RGSC_v3.41487,090,032 - 87,090,617UniSTSRGSC3.4
Celera1480,098,900 - 80,099,485UniSTS
Cytogenetic Map14q21UniSTS


Genetic Models
This gene Ogdh is modified in the following models/strains:
SD-Ogdhem1Yuyi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 31 34 30 18 6 18 6 58 24 19 10 19 12

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001017461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000057199   ⟹   ENSRNOP00000054026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,150,091 - 81,217,479 (+)Ensembl
Rnor_6.0 Ensembl1486,414,976 - 86,480,156 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083394   ⟹   ENSRNOP00000068674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,150,091 - 81,217,479 (+)Ensembl
Rnor_6.0 Ensembl1486,414,949 - 86,613,327 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095078   ⟹   ENSRNOP00000086308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,150,091 - 81,217,479 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101150   ⟹   ENSRNOP00000091120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,150,091 - 81,217,479 (+)Ensembl
RefSeq Acc Id: NM_001017461   ⟹   NP_001017461
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,364,031 - 85,430,527 (+)NCBI
mRatBN7.21481,150,101 - 81,216,601 (+)NCBI
Rnor_6.01486,414,976 - 86,480,156 (+)NCBI
Rnor_5.01487,376,110 - 87,442,862 (+)NCBI
RGSC_v3.41487,022,994 - 87,090,768 (+)RGD
Celera1480,033,036 - 80,099,636 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251446   ⟹   XP_006251508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,364,019 - 85,431,405 (+)NCBI
mRatBN7.21481,150,116 - 81,217,479 (+)NCBI
Rnor_6.01486,414,937 - 86,481,903 (+)NCBI
Rnor_5.01487,376,110 - 87,442,862 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251448   ⟹   XP_006251510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,949 - 85,431,405 (+)NCBI
mRatBN7.21481,150,021 - 81,217,479 (+)NCBI
Rnor_6.01486,414,924 - 86,481,903 (+)NCBI
Rnor_5.01487,376,110 - 87,442,862 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092218   ⟹   XP_038948146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,949 - 85,431,405 (+)NCBI
mRatBN7.21481,150,021 - 81,217,479 (+)NCBI
RefSeq Acc Id: XM_039092219   ⟹   XP_038948147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
mRatBN7.21481,150,438 - 81,217,479 (+)NCBI
RefSeq Acc Id: XM_039092220   ⟹   XP_038948148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,364,027 - 85,431,405 (+)NCBI
mRatBN7.21481,150,114 - 81,217,479 (+)NCBI
RefSeq Acc Id: XM_039092222   ⟹   XP_038948150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,949 - 85,431,405 (+)NCBI
mRatBN7.21481,150,021 - 81,217,479 (+)NCBI
RefSeq Acc Id: XM_063273392   ⟹   XP_063129462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
RefSeq Acc Id: XM_063273393   ⟹   XP_063129463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
RefSeq Acc Id: XM_063273394   ⟹   XP_063129464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
RefSeq Acc Id: XM_063273395   ⟹   XP_063129465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
RefSeq Acc Id: XM_063273396   ⟹   XP_063129466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
RefSeq Acc Id: XM_063273397   ⟹   XP_063129467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,364,061 - 85,431,405 (+)NCBI
RefSeq Acc Id: XM_063273398   ⟹   XP_063129468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
RefSeq Acc Id: XM_063273399   ⟹   XP_063129469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,363,966 - 85,431,405 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001017461 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251508 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251510 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948146 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948147 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948148 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948150 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129462 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129463 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129464 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129465 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129466 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129467 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129468 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129469 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83811 (Get FASTA)   NCBI Sequence Viewer  
  EDM00340 (Get FASTA)   NCBI Sequence Viewer  
  EDM00341 (Get FASTA)   NCBI Sequence Viewer  
  EDM00342 (Get FASTA)   NCBI Sequence Viewer  
  EDM00343 (Get FASTA)   NCBI Sequence Viewer  
  EDM00344 (Get FASTA)   NCBI Sequence Viewer  
  EDM00345 (Get FASTA)   NCBI Sequence Viewer  
  EDM00346 (Get FASTA)   NCBI Sequence Viewer  
  EDM00347 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054026.2
  ENSRNOP00000068674.2
  ENSRNOP00000086308.1
  ENSRNOP00000091120.1
GenBank Protein Q5XI78 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001017461   ⟸   NM_001017461
- Peptide Label: precursor
- UniProtKB: Q5XI78 (UniProtKB/Swiss-Prot),   A6IKS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251510   ⟸   XM_006251448
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251508   ⟸   XM_006251446
- Peptide Label: isoform X3
- UniProtKB: Q5XI78 (UniProtKB/Swiss-Prot),   A6IKS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054026   ⟸   ENSRNOT00000057199
Ensembl Acc Id: ENSRNOP00000068674   ⟸   ENSRNOT00000083394
RefSeq Acc Id: XP_038948150   ⟸   XM_039092222
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1Y1 (UniProtKB/TrEMBL),   A6IKS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948146   ⟸   XM_039092218
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R156 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948148   ⟸   XM_039092220
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R156 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948147   ⟸   XM_039092219
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R156 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091120   ⟸   ENSRNOT00000101150
Ensembl Acc Id: ENSRNOP00000086308   ⟸   ENSRNOT00000095078
RefSeq Acc Id: XP_063129466   ⟸   XM_063273396
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1Y1 (UniProtKB/TrEMBL),   A6IKS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129464   ⟸   XM_063273394
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129462   ⟸   XM_063273392
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R156 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129469   ⟸   XM_063273399
- Peptide Label: isoform X3
- UniProtKB: Q5XI78 (UniProtKB/Swiss-Prot),   A6IKS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129463   ⟸   XM_063273393
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1Y1 (UniProtKB/TrEMBL),   A6IKS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129465   ⟸   XM_063273395
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129468   ⟸   XM_063273398
- Peptide Label: isoform X3
- UniProtKB: Q5XI78 (UniProtKB/Swiss-Prot),   A6IKS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129467   ⟸   XM_063273397
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1Y1 (UniProtKB/TrEMBL),   A6IKS6 (UniProtKB/TrEMBL)
Protein Domains
Transketolase-like pyrimidine-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI78-F1-model_v2 AlphaFold Q5XI78 1-1023 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699472
Promoter ID:EPDNEW_R9996
Type:initiation region
Name:LOC103693780_1
Description:2-oxoglutarate dehydrogenase, mitochondrial-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,415,001 - 86,415,061EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561359 AgrOrtholog
BioCyc Gene G2FUF-15094 BioCyc
BioCyc Pathway LYSINE-DEG1-PWY [L-lysine degradation XI (mammalian)] BioCyc
  PWY-5084 [2-oxoglutarate decarboxylation to succinyl-CoA] BioCyc
  PWY-5652 [2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA] BioCyc
  PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
BioCyc Pathway Image LYSINE-DEG1-PWY BioCyc
  PWY-5084 BioCyc
  PWY-5652 BioCyc
  PWY-5690 BioCyc
Ensembl Genes ENSRNOG00000005130 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057199.5 UniProtKB/Swiss-Prot
  ENSRNOT00000083394.2 UniProtKB/TrEMBL
  ENSRNOT00000095078.1 UniProtKB/TrEMBL
  ENSRNOT00000101150.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.12470 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP helical domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110182 IMAGE-MGC_LOAD
InterPro 2-oxogl_dehyd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2oxoglutarate_DH_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KGD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KGD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360975 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94869 IMAGE-MGC_LOAD
NCBI Gene 360975 ENTREZGENE
PANTHER 2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 2-oxogl_dehyd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxoGdeHyase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ogdh PhenoGen
PIRSF Oxoglu_dh_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005130 RatGTEx
SMART Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A1Y1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF05 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R156 ENTREZGENE, UniProtKB/TrEMBL
  A6IKS6 ENTREZGENE, UniProtKB/TrEMBL
  A6IKS7 ENTREZGENE, UniProtKB/TrEMBL
  ODO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ogdh  oxoglutarate dehydrogenase  LOC103693780  2-oxoglutarate dehydrogenase, mitochondrial-like  Data merged from RGD:9122992 737654 PROVISIONAL
2016-03-22 Ogdh  oxoglutarate dehydrogenase  Ogdh  oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103693780  2-oxoglutarate dehydrogenase, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Ogdh  oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)  Ogdh  oxoglutarate dehydrogenase (lipoamide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ogdh  oxoglutarate dehydrogenase (lipoamide)  LOC360975  similar to oxoglutarate dehydrogenase (lipoamide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC360975  similar to oxoglutarate dehydrogenase (lipoamide)      Symbol and Name status set to provisional 70820 PROVISIONAL