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Gene: Hspd1 (heat shock protein 1 (chaperonin)) Mus musculus
Symbol: Hspd1
Name: heat shock protein 1 (chaperonin)
Description: Exhibits lipopolysaccharide binding activity. Involved in several processes, including cellular response to interleukin-7; positive regulation of T cell activation; and positive regulation of cytokine production. Localizes to mitochondrion; plasma membrane; and secretory granule. Used to study hereditary spastic paraplegia 13. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Is expressed in several structures, including brain; eye; and urinary system. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1); PARTICIPATES IN tuberculosis pathway; type 1 diabetes mellitus pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; 60kDa; chaperonin 60; CPN60; heat shock 60kDa protein 1 (chaperonin); heat shock protein 60; heat shock protein, 60 kDa; HSP-60; HSP-65; Hsp60; mitochondrial matrix protein P1
Homo sapiens (human) : HSPD1 (heat shock protein family D (Hsp60) member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspd1 (heat shock protein family D (Hsp60) member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspd1 (heat shock protein family D (Hsp60) member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Canis lupus familiaris (dog) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspd1 (heat shock protein family D (Hsp60) member 1)
Sus scrofa (pig) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Chlorocebus sabaeus (African green monkey) : HSPD1 (heat shock protein family D (Hsp60) member 1)
Heterocephalus glaber (naked mole-rat) : Hspd1 (heat shock protein family D (Hsp60) member 1)
more info ...
Related Pseudogenes: Gm12608   Gm12667   Gm13806   Gm14465   Gm14786   Gm14907   Gm14935   Gm15789   Gm16123   Gm17101   Gm17192   Gm18611   Gm18634   Gm18682   Gm20567   Gm20586   Gm20596   Gm4803   Gm5268   Gm6757   Gm7570   Gm7724   Gm8408   Gm8684   Gm9655   Gm9700   Hspd1-ps1   Hspd1-ps2   Hspd1-ps3   Hspd1-ps4   Hspd1-ps5  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBImm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hspd1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733896
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.