Hspd1 (heat shock protein 1 (chaperonin)) - Rat Genome Database

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Gene: Hspd1 (heat shock protein 1 (chaperonin)) Mus musculus
Symbol: Hspd1
Name: heat shock protein 1 (chaperonin)
RGD ID: 733896
Description: Enables lipopolysaccharide binding activity. Involved in positive regulation of T cell activation. Acts upstream of or within T cell activation; cellular response to interleukin-7; and positive regulation of cytokine production. Located in secretory granule and sperm plasma membrane. Is active in mitochondrion. Is expressed in several structures, including brain; eye; and urinary system. Used to study hereditary spastic paraplegia 13. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; 60kDa; chaperonin 60; CPN60; heat shock 60kDa protein 1 (chaperonin); heat shock protein 60; heat shock protein, 60 kDa; Hsp; HSP-60; HSP-65; Hsp60; mitochondrial matrix protein P1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12608   Gm12667   Gm13806   Gm14465   Gm14786   Gm14907   Gm14935   Gm15789   Gm16123   Gm17101   Gm17192   Gm18611   Gm18634   Gm18682   Gm20567   Gm20586   Gm20596   Gm4803   Gm5268   Gm6757   Gm7570   Gm7724   Gm8408   Gm8684   Gm9655   Gm9700   Hspd1-ps1   Hspd1-ps2   Hspd1-ps3   Hspd1-ps4   Hspd1-ps5  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39155,116,992 - 55,127,402 (-)NCBIGRCm39mm39
GRCm39 Ensembl155,116,994 - 55,127,402 (-)Ensembl
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBImm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
antimycin A  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
captan  (EXP)
carbon nanotube  (EXP,ISO)
chelerythrine  (ISO)
chloroacetic acid  (ISO)
chloropicrin  (ISO)
chromium trinitrate  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cypermethrin  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dicrotophos  (ISO)
dihydroxyacetone  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
drospirenone  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
fenbuconazole  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP)
finasteride  (ISO)
flavone  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
Fusaric acid  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
ginsenoside Re  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indirubin  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (EXP,ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(II) chloride  (ISO)
limonene  (ISO)
lipopolysaccharide  (EXP)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
lovastatin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methanol  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mevinphos  (ISO)
miconazole  (ISO)
minocycline  (ISO)
Mitotane  (ISO)
monocrotaline  (EXP,ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitroprusside  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenytoin  (EXP)
phlorizin  (EXP)
picolinic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
poly(propylene imine) macromolecule  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Propiverine  (ISO)
quartz  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
stavudine  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP,ISO)
tebufenpyrad  (ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (EXP)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
warfarin  (EXP)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adhesion of symbiont to host  (IDA)
apoptotic mitochondrial changes  (IBA,ISO)
B cell activation  (ISO)
B cell proliferation  (ISO)
biological process involved in interaction with symbiont  (ISO)
cellular response to heat  (ISO)
cellular response to interleukin-7  (IDA)
isotype switching to IgG isotypes  (ISO)
mitochondrial unfolded protein response  (IBA)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-alpha production  (IBA,IDA,ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (IBA,ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of T cell activation  (IBA,IDA,ISO)
positive regulation of T cell mediated immune response to tumor cell  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IBA,IDA,IGI,ISO)
protein folding  (IBA)
protein import into mitochondrial intermembrane space  (IBA)
protein refolding  (ISO)
protein stabilization  (ISO)
response to activity  (ISO)
response to ATP  (ISO)
response to cocaine  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to unfolded protein  (ISO)
response to xenobiotic stimulus  (ISO)
T cell activation  (IBA,IDA,IGI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease. Boyd-Kimball D, etal., Neuroscience. 2005;132(2):313-24.
2. Deficiency of chaperonin 60 in Down's syndrome. Bozner P, etal., J Alzheimers Dis. 2002 Dec;4(6):479-86.
3. Heat shock protein 60 in rostral ventrolateral medulla reduces cardiovascular fatality during endotoxaemia in the rat. Chang AY, etal., J Physiol. 2006 Jul 15;574(Pt 2):547-64. Epub 2006 May 4.
4. Myocardial heat shock protein 60 expression in insulin-resistant and diabetic rats. Chen HS, etal., J Endocrinol. 2009 Feb;200(2):151-7. doi: 10.1677/JOE-08-0387. Epub 2008 Oct 23.
5. Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice. Christensen JH, etal., Cell Stress Chaperones. 2010 Nov;15(6):851-63. doi: 10.1007/s12192-010-0194-x.
6. Antibodies to human HSP60 in patients with juvenile chronic arthritis, diabetes mellitus, and cystic fibrosis. de Graeff-Meeder ER, etal., Pediatr Res. 1993 Oct;34(4):424-8.
7. HSP 60 expression in recurrent oral ulcerations of Beh├žet's disease. Deniz E, etal., Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Aug;110(2):196-200. doi: 10.1016/j.tripleo.2010.03.020. Epub 2010 Jun 26.
8. Proteomic analysis of altered protein expression in skeletal muscle of rats in a hypermetabolic state induced by burn sepsis. Duan X, etal., Biochem J. 2006 Jul 1;397(1):149-58.
9. The expression and release of Hsp60 in 6-OHDA induced in vivo and in vitro models of Parkinson's disease. Feng Mj, etal., Neurochem Res. 2013 Oct;38(10):2180-9. doi: 10.1007/s11064-013-1127-8. Epub 2013 Aug 14.
10. Identification of immunodominant autoantigens in rat autoimmune orchitis. Fijak M, etal., J Pathol. 2005 Oct;207(2):127-38.
11. Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60. Hansen JJ, etal., Am J Hum Genet. 2002 May;70(5):1328-32. Epub 2002 Mar 15.
12. Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii. Hisaeda H, etal., Immunology. 1996 Aug;88(4):551-7.
13. Attenuation of mitochondrial unfolded protein response is associated with hepatic dysfunction in septic rats. Huang LJ, etal., Shock. 2012 Dec;38(6):642-8. doi: 10.1097/SHK.0b013e3182734ff9.
14. Autoantibodies to pancreatic hsp60 precede the development of glucose intolerance in patients with cystic fibrosis. Jensen P, etal., J Autoimmun. 2001 Sep;17(2):165-72.
15. Enhanced characterization of serum autoantibody reactivity following HSP 60 immunization in a rat model of experimental autoimmune glaucoma. Joachim SC, etal., Curr Eye Res. 2010 Oct;35(10):900-8. doi: 10.3109/02713683.2010.495829.
16. Role of heat shock protein 60 (HSP60) on paraquat intoxication. Kaetsu A, etal., J Appl Toxicol. 2001 Sep-Oct;21(5):425-30.
17. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
18. Antibodies to human heat shock protein 60, hypertension and dyslipidemia. A study of joint effects on coronary risk. Kervinen H, etal., Atherosclerosis. 2003 Aug;169(2):339-44.
19. Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions. Kim HS, etal., FEBS Lett. 2006 Apr 17;580(9):2311-6. Epub 2006 Mar 24.
20. T-cell reactivity against HSP60 relates to early but not advanced atherosclerosis. Knoflach M, etal., Atherosclerosis. 2006 Oct 26;.
21. High expression of heat shock protein 60 in follicular cells of Hashimoto's thyroiditis. Kotani T, etal., Autoimmunity. 1996;25(1):1-8.
22. Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy. Magen D, etal., Am J Hum Genet. 2008 Jul;83(1):30-42. doi: 10.1016/j.ajhg.2008.05.016. Epub 2008 Jun 19.
23. Late onset motoneuron disorder caused by mitochondrial Hsp60 chaperone deficiency in mice. Magnoni R, etal., Neurobiol Dis. 2013 Jun;54:12-23. doi: 10.1016/j.nbd.2013.02.012. Epub 2013 Mar 4.
24. Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis. Mazzone A, etal., J Am Coll Cardiol. 2004 May 5;43(9):1670-6.
25. MGDs mouse GO annotations MGD data from the GO Consortium
26. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
27. Differential expression of stress response genes in the H-Tx rat model of congenital hydrocephalus. Morgan FW, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):273-90.
28. Induction of heat shock proteins by hyperglycemic cerebral ischemia. Muranyi M, etal., Brain Res Mol Brain Res. 2005 Sep 13;139(1):80-7.
29. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
30. Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney. Oksala NK, etal., Antioxid Redox Signal. 2007 Apr;9(4):497-506.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. A self-hsp60 peptide acts as a partial agonist inducing expression of B7-2 on mycobacterial hsp60-specific T cells: a possible mechanism for inhibitory T cell regulation of adjuvant arthritis? Paul AG, etal., Int Immunol. 2000 Jul;12(7):1041-50.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein. Quintana FJ, etal., Arthritis Rheum. 2004 Nov;50(11):3712-20.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Proteomic analysis of rat heart in ischemia and ischemia-reperfusion using fluorescence two-dimensional difference gel electrophoresis. Sakai J, etal., Proteomics. 2003 Jul;3(7):1318-24.
39. Heat shock proteins expression in brain stem after subarachnoid hemorrhage in rats. Satoh M, etal., Acta Neurochir Suppl. 2003;86:477-82.
40. Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls. Sedlackova L, etal., Scand J Rheumatol. 2011;40(5):354-7. doi: 10.3109/03009742.2011.552522. Epub 2011 Mar 21.
41. Changes in Hsp60 level of the failing heart following acute myocardial infarction and the effect of long-term treatment with trandolapril. Toga W, etal., Biol Pharm Bull. 2007 Jan;30(1):105-10.
42. Subcellular stress response after traumatic brain injury. Truettner JS, etal., J Neurotrauma. 2007 Apr;24(4):599-612.
43. Complement activating antibodies against the human 60 kDa heat shock protein as a new independent family risk factor of coronary heart disease. Veres A, etal., Eur J Clin Invest. 2002 Jun;32(6):405-10.
44. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Vojdani A, etal., Clin Diagn Lab Immunol. 2004 May;11(3):515-24.
45. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. Walls KC, etal., J Biol Chem. 2012 Aug 31;287(36):30317-27. doi: 10.1074/jbc.M112.365890. Epub 2012 Jun 29.
46. Cell stress response in rat chronic small bowel allograft rejection. Wang J, etal., Transplant Proc. 2013 Jul-Aug;45(6):2539-42. doi: 10.1016/j.transproceed.2013.02.120.
47. Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins. Yu HP, etal., J Mol Cell Cardiol. 2006 Jan;40(1):185-94. Epub 2005 Nov 8.
48. Decreased testicular expression of cAMP response element modulator (CREM) in rat with varicocele. Yu JJ and Xu YM, Arch Androl. 2005 Mar-Apr;51(2):93-7.
49. Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats. Zhou J, etal., J Cereb Blood Flow Metab. 2005 Jul;25(7):878-86.
50. Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis. Zhu J, etal., Circulation. 2001 Feb 27;103(8):1071-5.
Additional References at PubMed
PMID:1347942   PMID:1516759   PMID:1707531   PMID:1979012   PMID:2263486   PMID:2406723   PMID:7523108   PMID:8565293   PMID:8824711   PMID:8974842   PMID:9125545   PMID:9867803  
PMID:10349636   PMID:10623794   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11091906   PMID:11449358   PMID:12421990   PMID:12477932   PMID:12748967   PMID:12865426   PMID:12904583  
PMID:12931191   PMID:14610273   PMID:15050156   PMID:15136728   PMID:15166233   PMID:15196922   PMID:15252132   PMID:15339983   PMID:15371451   PMID:15489334   PMID:15546885   PMID:15782199  
PMID:16116071   PMID:16141072   PMID:16141073   PMID:16547598   PMID:16602821   PMID:16708399   PMID:16959573   PMID:17164250   PMID:17324390   PMID:17634366   PMID:17661394   PMID:17923681  
PMID:17967808   PMID:18256040   PMID:18276932   PMID:18307411   PMID:18614015   PMID:18619964   PMID:18799693   PMID:19192108   PMID:19306954   PMID:19423573   PMID:19447897   PMID:19527807  
PMID:19561102   PMID:19647739   PMID:20080761   PMID:20351780   PMID:20501446   PMID:20609438   PMID:20631313   PMID:20633027   PMID:20697350   PMID:21134968   PMID:21266579   PMID:21267068  
PMID:21278135   PMID:21565611   PMID:21589869   PMID:21775438   PMID:21873635   PMID:21874024   PMID:21984432   PMID:22083510   PMID:22282240   PMID:22343714   PMID:22496890   PMID:22673621  
PMID:22794259   PMID:23770722   PMID:23976951   PMID:24084737   PMID:24151936   PMID:24421385   PMID:24449471   PMID:24457600   PMID:24614889   PMID:24922073   PMID:24952961   PMID:25348719  
PMID:25716072   PMID:25737280   PMID:25887709   PMID:26336360   PMID:26477505   PMID:26504810   PMID:26644517   PMID:26767982   PMID:26812922   PMID:27056903   PMID:27106802   PMID:27118120  
PMID:27786175   PMID:28378742   PMID:28609656   PMID:28768200   PMID:29107690   PMID:29459677   PMID:29513653   PMID:29530978   PMID:29581031   PMID:30068389   PMID:30196744   PMID:30224697  
PMID:30333137   PMID:30550785   PMID:30553444   PMID:30562941   PMID:30595499   PMID:30710197   PMID:30713523   PMID:30841425   PMID:31073041   PMID:31162944   PMID:31209364   PMID:31601784  
PMID:32272950   PMID:32325033   PMID:32525278   PMID:32968282   PMID:33441791   PMID:34153520   PMID:34974310   PMID:35009003   PMID:35012549   PMID:35316673   PMID:35496908  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39155,116,992 - 55,127,402 (-)NCBIGRCm39mm39
GRCm39 Ensembl155,116,994 - 55,127,402 (-)Ensembl
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBImm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382197,486,584 - 197,500,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2197,486,584 - 197,516,737 (-)EnsemblGRCh38hg38GRCh38
GRCh372198,351,308 - 198,364,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362198,059,553 - 198,073,243 (-)NCBINCBI36hg18NCBI36
Build 342198,176,815 - 198,190,504NCBI
Celera2192,107,181 - 192,120,871 (-)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2190,203,711 - 190,217,402 (-)NCBIHuRef
CHM1_12198,357,144 - 198,370,838 (-)NCBICHM1_1
T2T-CHM13v2.02197,970,209 - 197,983,875 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2956,579,195 - 56,590,011 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl956,579,201 - 56,589,662 (-)Ensembl
Rnor_6.0961,680,529 - 61,691,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,680,530 - 61,690,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0961,361,745 - 61,372,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,884,193 - 53,895,043 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1953,885,606 - 53,895,580 (-)NCBI
Celera954,060,669 - 54,071,096 (-)NCBICelera
Cytogenetic Map9q31NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554033,063,133 - 3,073,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554033,062,724 - 3,073,419 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12B202,623,497 - 202,637,045 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1377,010,421 - 7,025,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha377,956,566 - 7,967,852 (-)NCBI
ROS_Cfam_1.0376,900,931 - 6,911,990 (-)NCBI
ROS_Cfam_1.0 Ensembl376,900,933 - 6,911,980 (-)Ensembl
UMICH_Zoey_3.1376,899,765 - 6,910,835 (-)NCBI
UNSW_CanFamBas_1.0376,866,679 - 6,877,757 (-)NCBI
UU_Cfam_GSD_1.0376,889,830 - 6,900,900 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303155,150,440 - 155,160,005 (-)NCBI
SpeTri2.0NW_0049365061,678,069 - 1,687,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15101,360,094 - 101,373,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11083,003,266 - 83,017,397 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1083,003,717 - 83,017,363 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040116,426,692 - 116,441,017 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C1.2UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
12879917Shm3_msperm head morphology 3 (mouse)14418690462946882Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:213
Interacting mature miRNAs:230
Transcripts:ENSMUST00000027123, ENSMUST00000127861, ENSMUST00000144077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_001356512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC108391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF607107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY014148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027123   ⟹   ENSMUSP00000027123
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,116,994 - 55,127,183 (-)Ensembl
GRCm38.p6 Ensembl155,077,835 - 55,088,024 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127861   ⟹   ENSMUSP00000119336
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,122,226 - 55,127,402 (-)Ensembl
GRCm38.p6 Ensembl155,083,067 - 55,088,243 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144077   ⟹   ENSMUSP00000122947
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,123,692 - 55,127,402 (-)Ensembl
GRCm38.p6 Ensembl155,084,533 - 55,088,243 (-)Ensembl
RefSeq Acc Id: NM_001356512   ⟹   NP_001343441
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39155,116,992 - 55,127,402 (-)NCBI
GRCm38155,077,833 - 55,088,243 (-)NCBI
RefSeq Acc Id: NM_010477   ⟹   NP_034607
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39155,116,993 - 55,127,091 (-)NCBI
GRCm38155,077,834 - 55,087,932 (-)NCBI
MGSCv37155,134,678 - 55,144,776 (-)RGD
Celera155,597,904 - 55,608,002 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_034607   ⟸   NM_010477
- UniProtKB: P63038 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001343441   ⟸   NM_001356512
RefSeq Acc Id: ENSMUSP00000027123   ⟸   ENSMUST00000027123
RefSeq Acc Id: ENSMUSP00000122947   ⟸   ENSMUST00000144077
RefSeq Acc Id: ENSMUSP00000119336   ⟸   ENSMUST00000127861

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63038-F1-model_v2 AlphaFold P63038 1-573 view protein structure

RGD ID:6873724
Promoter ID:EPDNEW_M313
Type:initiation region
Description:Mus musculus heat shock protein 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38155,087,836 - 55,087,896EPDNEW
RGD ID:6846607
Promoter ID:MM_ACW:884
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2
Mouse AssemblyChrPosition (strand)Source
MGSCv36155,136,581 - 55,137,081 (-)MPROMDB
RGD ID:6846606
Promoter ID:MM_ACW:885
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4
Mouse AssemblyChrPosition (strand)Source
MGSCv36155,138,359 - 55,138,859 (-)MPROMDB
RGD ID:6817900
Promoter ID:MM_KWN:769
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B4,   Spleen
Transcripts:OTTMUST00000051674,   OTTMUST00000051675,   OTTMUST00000051676
Mouse AssemblyChrPosition (strand)Source
MGSCv36155,144,666 - 55,145,877 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96242 AgrOrtholog
Ensembl Genes ENSMUSG00000025980 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000027123 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000119336.2 UniProtKB/TrEMBL
  ENSMUSP00000122947.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027123 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000127861.8 UniProtKB/TrEMBL
  ENSMUST00000144077.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot
InterPro Chaperone_TCP-1 UniProtKB/TrEMBL
  Chaperonin_Cpn60_CS UniProtKB/Swiss-Prot
  Chaprnin_Cpn60 UniProtKB/Swiss-Prot
  Cpn60/TCP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/Swiss-Prot
  GROEL-like_equatorial_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15510 UniProtKB/Swiss-Prot
Pfam Cpn60_TCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspd1 PhenoGen
Superfamily-SCOP SSF48592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52029 UniProtKB/Swiss-Prot
  SSF54849 UniProtKB/Swiss-Prot
TIGRFAMs GroEL UniProtKB/Swiss-Prot
UniProt CH60_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P19226 UniProtKB/Swiss-Prot
  P19227 UniProtKB/Swiss-Prot
  P97602 UniProtKB/Swiss-Prot
  Q3KQP2 UniProtKB/Swiss-Prot
  Q3UIP0 UniProtKB/Swiss-Prot
  Q8C2C7 UniProtKB/Swiss-Prot
  Q8VEF4 UniProtKB/Swiss-Prot