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Gene: Tlr4 (toll-like receptor 4) Rattus norvegicus
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Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 3870
Description: Exhibits lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to lipid; detection of stimulus involved in sensory perception of pain; and response to steroid hormone. Localizes to cell surface and cytoplasm. Colocalizes with membrane raft. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); mastitis; perinatal necrotizing enterocolitis; pulpitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4); PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: toll4
Orthologs:
Homo sapiens (human) : TLR4 (toll like receptor 4)  HGNC  Alliance
Mus musculus (house mouse) : Tlr4 (toll-like receptor 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr4 (toll like receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR4 (toll like receptor 4)
Canis lupus familiaris (dog) : TLR4 (toll like receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr4 (toll like receptor 4)
Sus scrofa (pig) : TLR4 (toll like receptor 4)
Chlorocebus sabaeus (African green monkey) : TLR4 (toll like receptor 4)
Heterocephalus glaber (naked mole-rat) : Tlr4 (toll like receptor 4)
more info ...
Allele / Splice: Tlr4m1Mcwi   Tlr4em1Geh   Tlr4em5Mcwi  
Genetic Models: WI-Tlr4em1Geh BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi FHH-Tlr4m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
Cytogenetic Map5q24NCBI
RH 3.4 Map5643.7RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

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