Gene: Tlr4 (toll-like receptor 4) Rattus norvegicus
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Symbol: Tlr4
Name: toll-like receptor 4
Description: ENCODES a protein that exhibits lipopolysaccharide binding; phosphatidylinositol 3-kinase binding; identical protein binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to retinoic acid; PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; ASSOCIATED WITH decreased tumor necrosis factor secretion; ASSOCIATED WITH Acanthamoeba Keratitis; acute kidney failure; Acute Liver Failure; FOUND IN cell surface; cytoplasm; membrane raft; INTERACTS WITH (R)-rosmarinic acid; (S)-nicotine; 17beta-estradiol
AGR Description: Exhibits lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity; involved in several processes, including cellular response to lipid, detection of stimulus involved in sensory perception, and regulation of defense response; localizes to the cell surface and cytoplasm; colocalizes with the membrane raft; used to study several diseases, including acute kidney failure, carotid stenosis, ileitis, lung disease, and neuropathy (multiple); biomarker of several diseases, including colitis, kidney failure (multiple), lung disease, mastitis, and nonalcoholic fatty liver disease; orthologous to human TLR4 (toll like receptor 4).
Merged Description: Exhibits lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity; involved in several processes, including cellular response to lipid, detection of stimulus involved in sensory perception, and regulation of defense response; localizes to the cell surface and cytoplasm; colocalizes with the membrane raft; used to study several diseases, including acute kidney failure, carotid stenosis, ileitis, lung disease, and neuropathy (multiple); biomarker of several diseases, including colitis, kidney failure (multiple), lung disease, mastitis, and nonalcoholic fatty liver disease; orthologous to human TLR4 (toll like receptor 4); PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; INTERACTS WITH (R)-rosmarinic acid; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: toll4
Orthologs:
Homo sapiens (human) : TLR4 (toll like receptor 4)  HGNC  Alliance
Mus musculus (house mouse) : Tlr4 (toll-like receptor 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr4 (toll like receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR4 (toll like receptor 4)
Canis lupus familiaris (dog) : TLR4 (toll like receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr4 (toll like receptor 4)
Sus scrofa (pig) : TLR4 (toll like receptor 4)
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Allele / Splice: Tlr4m1Mcwi   Tlr4em1Geh   Tlr4em5Mcwi  
Genetic Models: WI-Tlr4em1Geh BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi FHH-Tlr4m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
Cytogenetic Map5q24NCBI
RH 3.4 Map5643.7RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)