(+)-catechin multiple interactions ISO RGD:737013 6480464 [epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein] CTD PMID:26187476 (+)-epicatechin-3-O-gallate multiple interactions ISO RGD:737013 6480464 [epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein] CTD PMID:26187476 (-)-demecolcine increases expression ISO RGD:737013 6480464 Demecolcine results in increased expression of TLR4 mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:737013 6480464 [epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein], epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR4 protein] CTD PMID:26187476 , PMID:27890776 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:737014 6480464 epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR4 protein] CTD PMID:27890776 (24S)-24-hydroxycholesterol increases expression ISO RGD:737013 6480464 24-hydroxycholesterol results in increased expression of TLR4 mRNA CTD PMID:24802026 (24S)-24-hydroxycholesterol multiple interactions ISO RGD:737013 6480464 [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta more ... CTD PMID:24802026 (25R)-cholest-5-ene-3beta,26-diol increases expression ISO RGD:737013 6480464 27-hydroxycholesterol results in increased expression of TLR4 mRNA CTD PMID:24802026 (25R)-cholest-5-ene-3beta,26-diol multiple interactions ISO RGD:737013 6480464 [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta more ... CTD PMID:24802026 (R)-rosmarinic acid decreases expression EXP 6480464 rosmarinic acid results in decreased expression of TLR4 protein CTD PMID:28789951 (S)-nicotine multiple interactions EXP 6480464 Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 mRNA] CTD PMID:27984197 1,4-dithiothreitol multiple interactions ISO RGD:737014 6480464 Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]], Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 1,4-phenylenediamine increases expression ISO RGD:737013 6480464 4-phenylenediamine results in increased expression of TLR4 mRNA, 4-phenylenediamine results in increased expression of TLR4 protein CTD PMID:31226360 1,4-phenylenediamine multiple interactions ISO RGD:737013 6480464 TLR4 protein promotes the reaction [4-phenylenediamine results in increased phosphorylation of RELA protein] CTD PMID:31226360 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:737014 6480464 TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride] CTD PMID:18725520 1-chloro-2,4,6-trinitrobenzene increases response to substance ISO RGD:737014 6480464 TLR4 protein results in increased susceptibility to Picryl Chloride CTD PMID:18725520 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:737013 6480464 Dinitrochlorobenzene results in increased expression of TLR4 mRNA, Dinitrochlorobenzene results in increased expression of TLR4 protein CTD PMID:31226360 1-chloro-2,4-dinitrobenzene multiple interactions ISO RGD:737013 6480464 TLR4 protein promotes the reaction [Dinitrochlorobenzene results in increased phosphorylation of RELA protein] CTD PMID:31226360 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:737014 6480464 1 more ... CTD PMID:25406165 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of TLR4 mRNA CTD PMID:26496021 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:737013 6480464 bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]] more ... CTD PMID:16317058 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:737014 6480464 [2 more ... CTD PMID:26141388 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:737014 6480464 [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA more ... CTD PMID:21097750 , PMID:21653731 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:737014 6480464 Tetrachlorodibenzodioxin affects the expression of TLR4 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TLR4 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737014 6480464 Tetrachlorodibenzodioxin results in increased expression of TLR4 mRNA CTD PMID:21093581 , PMID:21653731 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:737014 6480464 Trinitrobenzenesulfonic Acid results in increased expression of TLR4, Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein CTD PMID:19597321 more ... 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19002562 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:737014 6480464 lancemaside A inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein], Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of TLR4, Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein CTD PMID:16891783 , PMID:19002562 2,4,6-trinitrobenzenesulfonic acid decreases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of TLR4 mRNA CTD PMID:19998380 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine increases expression EXP 6480464 4-iodo-2, 5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein CTD PMID:30790395 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine multiple interactions EXP 6480464 gastrodin inhibits the reaction [4-iodo-2 more ... CTD PMID:30790395 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID multiple interactions ISO RGD:737014 6480464 Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958 26-hydroxycholesterol multiple interactions ISO RGD:737013 6480464 [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta more ... CTD PMID:24802026 26-hydroxycholesterol increases expression ISO RGD:737013 6480464 27-hydroxycholesterol results in increased expression of TLR4 mRNA CTD PMID:24802026 3,3',4,4',5-pentachlorobiphenyl affects expression ISO RGD:737013 6480464 3 more ... CTD PMID:21703328 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of TLR4 mRNA CTD PMID:28300664 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:737014 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of TLR4 mRNA CTD PMID:26251327 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:737013 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR4 mRNA CTD PMID:28628672 4-hydroxynon-2-enal multiple interactions ISO RGD:737013 6480464 4-hydroxy-2-nonenal inhibits the reaction [TLR4 protein binds to TLR4 protein] CTD PMID:19627980 4-hydroxynon-2-enal decreases activity ISO RGD:737013 6480464 4-hydroxy-2-nonenal results in decreased activity of TLR4 protein CTD PMID:19627980 4-hydroxynon-2-enal multiple interactions ISO RGD:737014 6480464 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]] more ... CTD PMID:19627980 4-hydroxyphenyl retinamide decreases expression ISO RGD:737014 6480464 Fenretinide results in decreased expression of TLR4 mRNA CTD PMID:28973697 7alpha-hydroxycholesterol increases expression ISO RGD:737013 6480464 cholest-5-en-3 beta, 7 alpha-diol results in increased expression of TLR4 mRNA CTD PMID:24802026 7alpha-hydroxycholesterol multiple interactions ISO RGD:737013 6480464 [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta more ... CTD PMID:24802026 acetate ester multiple interactions ISO RGD:737013 6480464 [Lipopolysaccharides results in decreased activity of TLR4 protein] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL1B protein] CTD PMID:25053413 adenosine increases expression ISO RGD:737013 6480464 Adenosine results in increased expression of TLR4 mRNA CTD PMID:21538184 adenosine affects localization ISO RGD:737013 6480464 Adenosine affects the localization of TLR4 protein CTD PMID:21538184 adenosine multiple interactions ISO RGD:737013 6480464 Adenosine promotes the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of TLR4 protein] CTD PMID:21538184 aflatoxin B1 increases expression ISO RGD:737013 6480464 Aflatoxin B1 results in increased expression of TLR4 mRNA CTD PMID:22100608 aflatoxin B1 increases expression ISO RGD:737014 6480464 Aflatoxin B1 results in increased expression of TLR4 mRNA CTD PMID:28789997 aflatoxin B1 decreases expression ISO RGD:737013 6480464 Aflatoxin B1 results in decreased expression of TLR4 mRNA CTD PMID:28943387 aldehydo-D-glucose decreases expression ISO RGD:737013 6480464 Glucose results in decreased expression of TLR4 protein CTD PMID:20200188 aldehydo-D-glucose multiple interactions EXP 6480464 artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of TLR4 protein CTD PMID:30031708 aldehydo-D-glucose multiple interactions ISO RGD:737014 6480464 TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]] more ... CTD PMID:22558381 all-trans-retinoic acid increases expression ISO RGD:737013 6480464 Tretinoin results in increased expression of TLR4 mRNA CTD PMID:21934132 all-trans-retinol increases expression ISO RGD:737013 6480464 Vitamin A results in increased expression of TLR4 mRNA CTD PMID:17033190 alpha-D-galactose multiple interactions ISO RGD:737014 6480464 [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein, scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] CTD PMID:23535186 aluminium hydroxide multiple interactions ISO RGD:737014 6480464 TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]] more ... CTD PMID:22075093 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of TLR4 mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:737013 6480464 Antirheumatic Agents results in decreased expression of TLR4 mRNA CTD PMID:24449571 arachidonic acid multiple interactions EXP 6480464 [Docosahexaenoic Acids co-treated with Arachidonic Acid] affects the expression of TLR4 mRNA, Arachidonic Acid inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of TLR4 mRNA] CTD PMID:17515866 arsane increases expression ISO RGD:737013 6480464 Arsenic results in increased expression of TLR4 mRNA CTD PMID:19945496 , PMID:27838757 arsenic atom increases expression ISO RGD:737013 6480464 Arsenic results in increased expression of TLR4 mRNA CTD PMID:19945496 , PMID:27838757 arsenic(3+) increases expression ISO RGD:737013 6480464 Arsenic results in increased expression of TLR4 mRNA CTD PMID:19945496 , PMID:27838757 arsenite(3-) decreases expression ISO RGD:737014 6480464 arsenite results in decreased expression of TLR4 mRNA CTD PMID:18191166 artesunate multiple interactions EXP 6480464 artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 aspalathin multiple interactions ISO RGD:737013 6480464 aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:25655391 atorvastatin calcium multiple interactions ISO RGD:737013 6480464 [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA more ... CTD PMID:20524934 atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA], Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 protein] CTD PMID:27883937 atorvastatin calcium decreases expression EXP 6480464 Atorvastatin results in decreased expression of TLR4 mRNA, Atorvastatin results in decreased expression of TLR4 protein CTD PMID:27883937 atorvastatin calcium increases expression ISO RGD:737013 6480464 Atorvastatin results in increased expression of TLR4 protein CTD PMID:16387846 auranofin multiple interactions ISO RGD:737014 6480464 Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:17034761 azathioprine increases expression ISO RGD:737014 6480464 Azathioprine results in increased expression of TLR4 mRNA CTD PMID:24184165 baicalin decreases expression EXP 6480464 baicalin results in decreased expression of TLR4 protein CTD PMID:22019745 baicalin multiple interactions EXP 6480464 baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:24312512 benazepril decreases expression ISO RGD:737013 6480464 benazepril results in decreased expression of TLR4 protein CTD PMID:20981132 benzalkonium chloride increases activity ISO RGD:737014 6480464 Benzalkonium Compounds results in increased activity of TLR4 protein CTD PMID:29514330 benzo[a]pyrene increases expression ISO RGD:737014 6480464 Benzo(a)pyrene results in increased expression of TLR4 mRNA CTD PMID:22228805 benzylpenicillin multiple interactions ISO RGD:737014 6480464 [Penicillin G co-treated with Erythromycin] results in increased expression of TLR4 mRNA CTD PMID:27503388 berberine multiple interactions ISO RGD:737014 6480464 Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA] more ... CTD PMID:21963898 , PMID:30240693 Besigomsin multiple interactions ISO RGD:737014 6480464 schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR4 protein] CTD PMID:24211520 bicalutamide multiple interactions ISO RGD:737013 6480464 bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]] CTD PMID:16317058 bis(2-chloroethyl) sulfide increases expression ISO RGD:737014 6480464 Mustard Gas results in increased expression of TLR4 mRNA CTD PMID:18955075 bis(2-ethylhexyl) phthalate increases expression ISO RGD:737013 6480464 Diethylhexyl Phthalate results in increased expression of TLR4 mRNA CTD PMID:31163220 bisdemethoxycurcumin multiple interactions ISO RGD:737013 6480464 [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR4 mRNA, [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR4 mRNA CTD PMID:22029407 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of TLR4 mRNA CTD PMID:26496021 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TLR4 mRNA CTD PMID:25181051 Bisphenol A diglycidyl ether multiple interactions EXP 6480464 2 more ... CTD PMID:24612634 bisphenol F multiple interactions ISO RGD:737013 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR4 mRNA CTD PMID:28628672 bortezomib increases expression ISO RGD:737013 6480464 Bortezomib results in increased expression of TLR4 mRNA CTD PMID:17895889 butyric acid multiple interactions ISO RGD:737014 6480464 Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein] CTD PMID:29751049 cadmium atom decreases expression ISO RGD:737013 6480464 Cadmium results in decreased expression of TLR4 mRNA CTD PMID:24376830 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of TLR4 mRNA CTD PMID:25993096 , PMID:29286200 cadmium dichloride increases expression ISO RGD:737014 6480464 Cadmium Chloride results in increased expression of TLR4 mRNA CTD PMID:26352046 capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of TLR4 protein CTD PMID:22150557 capsaicin multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein] more ... CTD PMID:22150557 carbamazepine increases expression ISO RGD:737014 6480464 Carbamazepine results in increased expression of TLR4 mRNA CTD PMID:22790970 carbon nanotube multiple interactions ISO RGD:737013 6480464 Nanotubes, Carbon promotes the reaction [[K-12 lipopolysaccharide binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL6 protein] more ... CTD PMID:23266719 carbon nanotube increases activity ISO RGD:737013 6480464 Nanotubes, Carbon results in increased activity of TLR4 protein CTD PMID:29348435 carbon nanotube increases expression ISO RGD:737014 6480464 Nanotubes, Carbon results in increased expression of TLR4 mRNA CTD PMID:25554681 casticin decreases expression ISO RGD:737013 6480464 casticin results in decreased expression of TLR4 mRNA CTD PMID:27862857 catalpol multiple interactions ISO RGD:737014 6480464 catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TLR4 mRNA] CTD PMID:23164921 catechin multiple interactions ISO RGD:737013 6480464 [epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein] CTD PMID:26187476 cerium trichloride increases expression ISO RGD:737014 6480464 cerous chloride results in increased expression of TLR4 mRNA, cerous chloride results in increased expression of TLR4 protein CTD PMID:21656643 chitosan decreases expression ISO RGD:737013 6480464 Chitosan results in decreased expression of TLR4 mRNA CTD PMID:21329777 chitosan multiple interactions ISO RGD:737013 6480464 Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA] CTD PMID:21329777 chlorogenic acid multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA], Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein] CTD PMID:23146752 chlorogenic acid multiple interactions ISO RGD:737014 6480464 Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein] CTD PMID:26079055 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of TLR4 CTD PMID:25643018 chlorpyrifos multiple interactions EXP 6480464 Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein], Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:30236991 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of TLR4 protein CTD PMID:26524701 cholesterol multiple interactions EXP 6480464 [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of TLR4 mRNA CTD PMID:26606054 choline multiple interactions ISO RGD:737014 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR4 mRNA more ... CTD PMID:20938992 , PMID:22915297 chromium atom decreases expression ISO RGD:737013 6480464 Chromium results in decreased expression of TLR4 mRNA CTD PMID:21437242 chromium(3+) decreases expression ISO RGD:737013 6480464 Chromium results in decreased expression of TLR4 mRNA CTD PMID:21437242 chrysin multiple interactions ISO RGD:737013 6480464 chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA], chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein] CTD PMID:30016632 chrysin multiple interactions EXP 6480464 chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA] CTD PMID:30500344 cisplatin multiple interactions ISO RGD:737014 6480464 [Cisplatin co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein more ... CTD PMID:21148032 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of TLR4 mRNA CTD PMID:28371137 cisplatin multiple interactions EXP 6480464 Grape Seed Proanthocyanidins inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA] CTD PMID:28371137 cisplatin increases expression ISO RGD:737013 6480464 Cisplatin results in increased expression of TLR4 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:737014 6480464 Cisplatin results in increased expression of TLR4 mRNA, Cisplatin results in increased expression of TLR4 protein CTD PMID:21148032 , PMID:26546572 cobalt dichloride multiple interactions ISO RGD:737013 6480464 cobaltous chloride results in increased activity of [TLR4 protein binds to LY96 protein], TLR4 protein affects the reaction [cobaltous chloride results in increased secretion of CXCL8 protein] CTD PMID:23692033 , PMID:25803856 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of TLR4 mRNA CTD PMID:24386269 copper atom multiple interactions EXP 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA CTD PMID:25813056 copper(0) multiple interactions EXP 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA CTD PMID:25813056 copper(2+) multiple interactions EXP 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA CTD PMID:25813056 copper(II) sulfate multiple interactions ISO RGD:737013 6480464 TLR4 protein inhibits the reaction [Copper Sulfate results in increased secretion of CXCL8 protein] CTD PMID:23692033 corticosterone multiple interactions ISO RGD:737014 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein more ... CTD PMID:29751049 cortisol decreases expression ISO RGD:737013 6480464 Hydrocortisone results in decreased expression of TLR4 mRNA CTD PMID:17033190 crocin-1 multiple interactions EXP 6480464 crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:29409856 curcumin multiple interactions ISO RGD:737014 6480464 Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein], Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:16678799 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA] more ... CTD PMID:19002562 , PMID:22683883 curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of TLR4 mRNA, Curcumin results in decreased expression of TLR4 protein CTD PMID:17965732 cyclosporin A multiple interactions ISO RGD:737014 6480464 ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of TLR4 mRNA] more ... CTD PMID:27585667 cyclosporin A increases expression ISO RGD:737014 6480464 Cyclosporine results in increased expression of TLR4 mRNA, Cyclosporine results in increased expression of TLR4 protein CTD PMID:27585667 D-glucose decreases expression ISO RGD:737013 6480464 Glucose results in decreased expression of TLR4 protein CTD PMID:20200188 D-glucose multiple interactions EXP 6480464 artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 D-glucose increases expression EXP 6480464 Glucose results in increased expression of TLR4 protein CTD PMID:30031708 D-glucose multiple interactions ISO RGD:737014 6480464 TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]] more ... CTD PMID:22558381 DAPT multiple interactions EXP 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TLR4 mRNA] CTD PMID:24223152 daunorubicin decreases response to substance ISO RGD:737014 6480464 TLR4 protein results in decreased susceptibility to Daunorubicin CTD PMID:18789402 dehydroepiandrosterone increases expression EXP 6480464 Dehydroepiandrosterone results in increased expression of TLR4 mRNA, Dehydroepiandrosterone results in increased expression of TLR4 protein CTD PMID:27634381 dehydroepiandrosterone multiple interactions EXP 6480464 Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein] more ... CTD PMID:27634381 desferrioxamine B decreases expression ISO RGD:737013 6480464 Deferoxamine results in decreased expression of TLR4 protein CTD PMID:24170104 dexamethasone increases expression ISO RGD:737013 6480464 Dexamethasone results in increased expression of TLR4 mRNA CTD PMID:19853017 dexamethasone multiple interactions ISO RGD:737013 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR4 mRNA CTD PMID:28628672 dexamethasone multiple interactions ISO RGD:737014 6480464 Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:27568862 dextran sulfate multiple interactions ISO RGD:737014 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TLR4 mRNA, Lipopolysaccharides inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein] CTD PMID:21359540 , PMID:29950665 dextran sulfate increases expression ISO RGD:737014 6480464 Dextran Sulfate results in increased expression of TLR4 protein CTD PMID:21359540 diallyl trisulfide multiple interactions ISO RGD:737014 6480464 diallyl trisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:25500681 diazinon multiple interactions ISO RGD:737014 6480464 [TLR4 protein mutant form results in increased susceptibility to Diazinon] which results in decreased expression of BDNF mRNA more ... CTD PMID:22428454 diazinon increases response to substance ISO RGD:737014 6480464 TLR4 protein mutant form results in increased susceptibility to Diazinon CTD PMID:22428454 dienogest multiple interactions ISO RGD:737013 6480464 dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 dihydrogen multiple interactions EXP 6480464 Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:30236991 dimethylarsinous acid increases expression ISO RGD:737013 6480464 dimethylarsinous acid results in increased expression of TLR4 mRNA CTD PMID:19945496 dioxygen multiple interactions EXP 6480464 [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TLR4 protein more ... CTD PMID:23082119 more ... dioxygen multiple interactions ISO RGD:737014 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TLR4 mRNA CTD PMID:30529165 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of TLR4 mRNA CTD PMID:23082119 , PMID:24223152 diprotium multiple interactions EXP 6480464 Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:30236991 dorsomorphin multiple interactions ISO RGD:737013 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR4 mRNA CTD PMID:27188386 dorsomorphin multiple interactions ISO RGD:737014 6480464 dorsomorphin inhibits the reaction [A 769662 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]], dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]] CTD PMID:24756886 , PMID:28096963 doxorubicin multiple interactions ISO RGD:737014 6480464 TLR4 protein affects the reaction [Doxorubicin results in decreased expression of GATA4 protein] more ... CTD PMID:18321777 doxorubicin affects response to substance ISO RGD:737014 6480464 TLR4 protein affects the susceptibility to Doxorubicin CTD PMID:18321777 enalapril multiple interactions ISO RGD:737013 6480464 [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA, [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein CTD PMID:20524934 erythromycin A increases expression ISO RGD:737014 6480464 Erythromycin results in increased expression of TLR4 mRNA CTD PMID:27503388 erythromycin A multiple interactions ISO RGD:737014 6480464 [Penicillin G co-treated with Erythromycin] results in increased expression of TLR4 mRNA CTD PMID:27503388 esculetin multiple interactions ISO RGD:737014 6480464 esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA] CTD PMID:27769711 ethanol multiple interactions ISO RGD:737014 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of TLR4 mRNA more ... CTD PMID:16439473 more ... ethanol increases expression EXP 6480464 Ethanol results in increased expression of TLR4 mRNA, Ethanol results in increased expression of TLR4 protein CTD PMID:20861358 more ... ethanol multiple interactions EXP 6480464 ADIPOQ protein inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] more ... CTD PMID:20861358 more ... ethanol increases expression ISO RGD:737014 6480464 Ethanol results in increased expression of TLR4 mRNA CTD PMID:24946281 ethanol increases response to substance ISO RGD:737014 6480464 TLR4 results in increased susceptibility to Ethanol CTD PMID:16439473 ethyl methanesulfonate decreases expression ISO RGD:737013 6480464 Ethyl Methanesulfonate results in decreased expression of TLR4 mRNA CTD PMID:23649840 eugenol increases expression ISO RGD:737013 6480464 Eugenol results in increased expression of TLR4 mRNA CTD PMID:17936526 ferulic acid multiple interactions ISO RGD:737014 6480464 ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA], ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein] CTD PMID:21291945 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of TLR4 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:737014 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR4 mRNA CTD PMID:20938992 formaldehyde multiple interactions EXP 6480464 Formaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:25845602 , PMID:27020608 fructose multiple interactions EXP 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA CTD PMID:25813056 fructose multiple interactions ISO RGD:737014 6480464 [Fructose co-treated with Ethanol] results in increased expression of TLR4 mRNA CTD PMID:26858005 furan increases expression EXP 6480464 furan results in increased expression of TLR4 mRNA CTD PMID:27387713 gadolinium trichloride multiple interactions EXP 6480464 [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein] CTD PMID:25813056 , PMID:26177832 galactose multiple interactions ISO RGD:737014 6480464 [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein, scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] CTD PMID:23535186 gallocatechin multiple interactions ISO RGD:737013 6480464 [epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein], gallocatechol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein] CTD PMID:26187476 ganglioside GM1 decreases expression EXP 6480464 G(M1) Ganglioside results in decreased expression of TLR4 protein CTD PMID:16651628 Gastrodin multiple interactions EXP 6480464 gastrodin inhibits the reaction [4-iodo-2, 5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein] CTD PMID:30790395 geldanamycin increases expression ISO RGD:737013 6480464 geldanamycin results in increased expression of TLR4 mRNA CTD PMID:26705709 genistein decreases expression ISO RGD:737014 6480464 Genistein analog results in decreased expression of TLR4 protein CTD PMID:25447760 geraniol multiple interactions ISO RGD:737014 6480464 geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR4 mRNA], geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR4 protein] CTD PMID:29050341 ginsenoside Re multiple interactions ISO RGD:737014 6480464 ginsenoside Re inhibits the reaction [Lipopolysaccharides binds to TLR4 protein] CTD PMID:22849695 glucose decreases expression ISO RGD:737013 6480464 Glucose results in decreased expression of TLR4 protein CTD PMID:20200188 glucose multiple interactions EXP 6480464 artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 glucose increases expression EXP 6480464 Glucose results in increased expression of TLR4 protein CTD PMID:30031708 glucose multiple interactions ISO RGD:737014 6480464 TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]] more ... CTD PMID:22558381 glutathione decreases expression ISO RGD:737013 6480464 Glutathione results in decreased expression of TLR4 mRNA CTD PMID:22385246 glycyrrhetinic acid multiple interactions ISO RGD:737014 6480464 Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]] CTD PMID:28213090 halothane multiple interactions ISO RGD:737014 6480464 TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein] CTD PMID:21245496 helenalin multiple interactions ISO RGD:737014 6480464 helenalin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:16678799 hexadecanoic acid multiple interactions ISO RGD:737014 6480464 Quercetin inhibits the reaction [Palmitic Acid results in increased expression of TLR4 mRNA] CTD PMID:25614714 hexadecanoic acid increases expression ISO RGD:737014 6480464 Palmitic Acid results in increased expression of TLR4 mRNA CTD PMID:25614714 hyaluronic acid multiple interactions ISO RGD:737013 6480464 [Lipopolysaccharides results in decreased activity of TLR4 protein] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL1B protein] CTD PMID:25053413 hyaluronic acid increases abundance ISO RGD:737013 6480464 TLR4 protein results in increased abundance of Hyaluronic Acid CTD PMID:31226360 hyaluronic acid increases expression ISO RGD:737013 6480464 Hyaluronic Acid metabolite results in increased expression of TLR4 mRNA, Hyaluronic Acid metabolite results in increased expression of TLR4 protein CTD PMID:31226360 hyaluronic acid multiple interactions ISO RGD:737014 6480464 Mn(III) 5 more ... CTD PMID:23692848 hyaluronic acid increases expression ISO RGD:737014 6480464 Hyaluronic Acid metabolite results in increased expression of TLR4 mRNA, Hyaluronic Acid metabolite results in increased expression of TLR4 protein CTD PMID:23692848 hydroquinone multiple interactions ISO RGD:737014 6480464 hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:20054000 ifosfamide increases expression ISO RGD:737013 6480464 Ifosfamide results in increased expression of TLR4 mRNA CTD PMID:25596134 indometacin multiple interactions ISO RGD:737014 6480464 TLR4 protein affects the reaction [Indomethacin results in decreased activity of CYP1A2 protein] more ... CTD PMID:12927920 indometacin multiple interactions ISO RGD:737013 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR4 mRNA CTD PMID:28628672 irinotecan increases expression ISO RGD:737014 6480464 Irinotecan results in increased expression of TLR4 protein CTD PMID:28454924 irinotecan multiple interactions ISO RGD:737014 6480464 Silymarin inhibits the reaction [Irinotecan results in increased expression of TLR4 protein] CTD PMID:28454924 iron(2+) sulfate (anhydrous) multiple interactions ISO RGD:737014 6480464 [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA more ... CTD PMID:23692848 isoamylol multiple interactions ISO RGD:737014 6480464 [Ethanol co-treated with isopentyl alcohol] promotes the reaction [TLR4 results in increased susceptibility to Acetaminophen] CTD PMID:16439473 isoprenaline increases expression ISO RGD:737014 6480464 Isoproterenol results in increased expression of TLR4 mRNA CTD PMID:20003209 isoprenaline multiple interactions EXP 6480464 Metformin inhibits the reaction [Isoproterenol results in increased expression of TLR4 mRNA] CTD PMID:24842192 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of TLR4 mRNA CTD PMID:24842192 ivermectin decreases expression ISO RGD:737013 6480464 Ivermectin results in decreased expression of TLR4 mRNA CTD PMID:28653460 kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside multiple interactions ISO RGD:737013 6480464 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein] CTD PMID:22178603 ketamine multiple interactions ISO RGD:737014 6480464 TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]], TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] CTD PMID:19540866 L-1,4-dithiothreitol multiple interactions ISO RGD:737014 6480464 Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]], Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 L-ascorbic acid multiple interactions ISO RGD:737014 6480464 [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA more ... CTD PMID:23692848 L-methionine multiple interactions ISO RGD:737014 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR4 mRNA more ... CTD PMID:20938992 , PMID:22915297 lactulose multiple interactions EXP 6480464 Lactulose inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein] CTD PMID:30450033 linsidomine multiple interactions ISO RGD:737014 6480464 TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein], TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein] CTD PMID:29175419 lipophosphoglycan multiple interactions ISO RGD:737013 6480464 [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] more ... CTD PMID:15910421 lipophosphoglycan multiple interactions ISO RGD:737014 6480464 lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein CTD PMID:15910421 lipophosphoglycan increases response to substance ISO RGD:737014 6480464 TLR4 protein results in increased susceptibility to lipopeptidophosphoglycan CTD PMID:15910421 lipopolysaccharide decreases activity ISO RGD:737013 6480464 Lipopolysaccharides results in decreased activity of TLR4 protein CTD PMID:25053413 lipopolysaccharide affects localization EXP 6480464 Lipopolysaccharides affects the localization of TLR4 protein CTD PMID:29375565 lipopolysaccharide increases response to substance ISO RGD:737013 6480464 TLR4 protein results in increased susceptibility to Lipopolysaccharides CTD PMID:21383675 lipopolysaccharide affects response to substance ISO RGD:737013 6480464 TLR4 protein mutant form affects the susceptibility to Lipopolysaccharides CTD PMID:10835634 lipopolysaccharide increases expression ISO RGD:737013 6480464 Lipopolysaccharides results in increased expression of TLR4 mRNA, Lipopolysaccharides results in increased expression of TLR4 protein CTD PMID:16317058 more ... lipopolysaccharide increases activity ISO RGD:737013 6480464 Lipopolysaccharides results in increased activity of TLR4 protein CTD PMID:10835634 more ... lipopolysaccharide decreases expression ISO RGD:737013 6480464 Lipopolysaccharides results in decreased expression of TLR4 mRNA, Lipopolysaccharides results in decreased expression of TLR4 protein CTD PMID:12176910 more ... lipopolysaccharide affects binding ISO RGD:737013 6480464 Lipopolysaccharides binds to TLR4 protein CTD PMID:22180778 lipopolysaccharide multiple interactions ISO RGD:737013 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] more ... CTD PMID:12574384 more ... lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of TLR4 mRNA, Lipopolysaccharides results in increased expression of TLR4 protein CTD PMID:12575980 more ... lipopolysaccharide decreases expression EXP 6480464 Lipopolysaccharides results in decreased expression of TLR4 protein CTD PMID:16651628 lipopolysaccharide decreases response to substance ISO RGD:737014 6480464 TLR4 results in decreased susceptibility to Lipopolysaccharides analog CTD PMID:22039958 lipopolysaccharide increases response to substance ISO RGD:737014 6480464 TLR4 protein results in increased susceptibility to Lipopolysaccharides CTD PMID:23000425 lipopolysaccharide affects response to substance ISO RGD:737014 6480464 TLR4 protein affects the susceptibility to Lipopolysaccharides CTD PMID:11581577 lipopolysaccharide increases localization ISO RGD:737014 6480464 Lipopolysaccharides results in increased localization of TLR4 protein CTD PMID:21276822 lipopolysaccharide increases expression ISO RGD:737014 6480464 Lipopolysaccharides results in increased expression of TLR4 mRNA, Lipopolysaccharides results in increased expression of TLR4 protein CTD PMID:15665042 more ... lipopolysaccharide increases activity ISO RGD:737014 6480464 Lipopolysaccharides results in increased activity of TLR4 protein CTD PMID:12848851 more ... lipopolysaccharide decreases expression ISO RGD:737014 6480464 Lipopolysaccharides results in decreased expression of TLR4 mRNA, Lipopolysaccharides results in decreased expression of TLR4 protein CTD PMID:16651628 , PMID:25896969 lipopolysaccharide multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with sodium bisulfide] results in increased expression of TLR4 mRNA more ... CTD PMID:17504260 more ... lipopolysaccharide affects binding ISO RGD:737014 6480464 Lipopolysaccharides binds to TLR4 protein CTD PMID:16678799 more ... lipopolysaccharide multiple interactions ISO RGD:737014 6480464 2 more ... CTD PMID:11123339 more ... LY294002 multiple interactions ISO RGD:737014 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:25171655 lycopene multiple interactions ISO RGD:737013 6480464 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein], lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:22429818 magnesium dihydroxide multiple interactions ISO RGD:737014 6480464 TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]] more ... CTD PMID:22075093 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 mRNA] more ... CTD PMID:27413111 , PMID:28238930 melphalan decreases expression ISO RGD:737013 6480464 Melphalan results in decreased expression of TLR4 mRNA CTD PMID:22363485 metformin multiple interactions EXP 6480464 Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein] more ... CTD PMID:24842192 , PMID:27634381 metformin multiple interactions ISO RGD:737013 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of TLR4 mRNA CTD PMID:29309887 methadone affects binding ISO RGD:737013 6480464 Methadone binds to TLR4 protein CTD PMID:20178837 methadone increases expression EXP 6480464 Methadone results in increased expression of TLR4 mRNA, Methadone results in increased expression of TLR4 protein CTD PMID:20178837 methadone affects response to substance EXP 6480464 Methadone affects the susceptibility to TLR4 protein CTD PMID:20178837 methadone multiple interactions ISO RGD:737013 6480464 Naloxone affects the reaction [Methadone binds to TLR4 protein] CTD PMID:20178837 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of TLR4 protein CTD PMID:30450033 methamphetamine multiple interactions EXP 6480464 Lactulose inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein] CTD PMID:30450033 methimazole multiple interactions EXP 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein] CTD PMID:26177832 methotrexate affects expression ISO RGD:737014 6480464 Methotrexate affects the expression of TLR4 mRNA CTD PMID:18502557 methotrexate decreases expression ISO RGD:737013 6480464 Methotrexate results in decreased expression of TLR4 mRNA CTD PMID:17400583 methyl methanesulfonate decreases expression ISO RGD:737013 6480464 Methyl Methanesulfonate results in decreased expression of TLR4 mRNA CTD PMID:23649840 Methylthiouracil multiple interactions ISO RGD:737013 6480464 Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:26298005 morphine affects binding ISO RGD:737013 6480464 Morphine binds to TLR4 protein CTD PMID:20178837 morphine increases expression ISO RGD:737014 6480464 Morphine results in increased expression of TLR4 protein CTD PMID:24756886 morphine multiple interactions ISO RGD:737014 6480464 dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]], Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein] CTD PMID:24756886 morphine increases expression EXP 6480464 Morphine results in increased expression of TLR4 protein CTD PMID:20178837 morphine affects response to substance EXP 6480464 Morphine affects the susceptibility to TLR4 protein CTD PMID:20178837 morphine multiple interactions ISO RGD:737013 6480464 Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 Morphine-3-glucuronide multiple interactions ISO RGD:737013 6480464 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [morphine-3-glucuronide results in increased activity of TLR4 protein], Lipopolysaccharides inhibits the reaction [morphine-3-glucuronide results in increased activity of TLR4 protein] CTD PMID:19833175 Morphine-3-glucuronide increases activity ISO RGD:737013 6480464 morphine-3-glucuronide results in increased activity of TLR4 protein CTD PMID:19833175 Morphine-3-glucuronide increases expression EXP 6480464 morphine-3-glucuronide results in increased expression of TLR4 mRNA CTD PMID:19833175 muramyl dipeptide increases activity ISO RGD:737013 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR4 protein CTD PMID:15905553 muramyl dipeptide increases response to substance ISO RGD:737014 6480464 TLR4 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog CTD PMID:15905553 muramyl dipeptide increases activity ISO RGD:737014 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR4 protein CTD PMID:15905553 N-acetyl-L-cysteine multiple interactions ISO RGD:737014 6480464 Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]] more ... CTD PMID:19627980 , PMID:28495615 N-acetyl-L-cysteine decreases expression ISO RGD:737013 6480464 Acetylcysteine results in decreased expression of TLR4 mRNA CTD PMID:22385246 N-methyl-4-phenylpyridinium increases expression ISO RGD:737014 6480464 1-Methyl-4-phenylpyridinium results in increased expression of TLR4 mRNA, 1-Methyl-4-phenylpyridinium results in increased expression of TLR4 protein CTD PMID:26881113 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:737014 6480464 TLR4 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein] more ... CTD PMID:26881113 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of TLR4 mRNA CTD PMID:15120970 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of TLR4 mRNA CTD PMID:25380136 naloxone multiple interactions ISO RGD:737013 6480464 Naloxone affects the reaction [Methadone binds to TLR4 protein], Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 naproxen multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of TLR4 protein] CTD PMID:22150557 nickel dichloride multiple interactions ISO RGD:737013 6480464 chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA] more ... CTD PMID:23692033 more ... nickel dichloride increases expression ISO RGD:737013 6480464 nickel chloride results in increased expression of TLR4 mRNA, nickel chloride results in increased expression of TLR4 protein CTD PMID:30016632 nickel dichloride multiple interactions ISO RGD:737014 6480464 TLR4 mutant form inhibits the reaction [nickel chloride results in increased expression of TSLP protein] CTD PMID:24670797 nickel dichloride increases expression ISO RGD:737014 6480464 nickel chloride results in increased expression of TLR4 mRNA CTD PMID:24670797 nickel sulfate increases expression ISO RGD:737014 6480464 nickel sulfate results in increased expression of TLR4 protein CTD PMID:26607348 nickel sulfate multiple interactions ISO RGD:737013 6480464 TLR4 protein affects the reaction [nickel sulfate results in increased expression of EBI3 mRNA], TLR4 protein affects the reaction [nickel sulfate results in increased expression of IL27 mRNA] CTD PMID:30421605 nickel sulfate multiple interactions ISO RGD:737014 6480464 puerarin inhibits the reaction [nickel sulfate results in increased expression of TLR4 protein] CTD PMID:26607348 nicotine multiple interactions EXP 6480464 Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 mRNA] CTD PMID:27984197 nitric oxide multiple interactions ISO RGD:737014 6480464 TLR4 gene mutant form inhibits the reaction [Fungal Polysaccharides results in increased abundance of Nitric Oxide] more ... CTD PMID:22687552 , PMID:23246459 Nonidet P-40 decreases expression ISO RGD:737013 6480464 Nonidet P-40 results in decreased expression of TLR4 mRNA CTD PMID:26552463 Nonylphenol decreases expression ISO RGD:737014 6480464 nonylphenol analog results in decreased expression of TLR4 mRNA CTD PMID:25242005 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of TLR4 protein CTD PMID:30481583 o-anisidine affects expression ISO RGD:737013 6480464 2-anisidine affects the expression of TLR4 mRNA CTD PMID:28089782 oxaliplatin decreases response to substance ISO RGD:737014 6480464 TLR4 protein results in decreased susceptibility to oxaliplatin CTD PMID:18789402 ozone multiple interactions ISO RGD:737014 6480464 [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR4 mRNA more ... CTD PMID:11159012 more ... ozone affects response to substance ISO RGD:737014 6480464 TLR4 protein affects the susceptibility to Ozone CTD PMID:22300504 ozone increases expression ISO RGD:737014 6480464 Ozone results in increased expression of TLR4 mRNA CTD PMID:11159012 more ... ozone increases response to substance ISO RGD:737014 6480464 TLR4 protein results in increased susceptibility to Ozone, TLR4 results in increased susceptibility to Ozone CTD PMID:11159012 , PMID:21543283 ozone decreases response to substance ISO RGD:737014 6480464 TLR4 gene mutant form results in decreased susceptibility to Ozone, TLR4 protein mutant form results in decreased susceptibility to Ozone CTD PMID:11159012 , PMID:17626835 ozone decreases expression ISO RGD:737014 6480464 Ozone results in decreased expression of TLR4 mRNA mutant form CTD PMID:11159012 paclitaxel multiple interactions ISO RGD:737014 6480464 TLR4 protein affects the reaction [Paclitaxel results in increased expression of CXCL10 mRNA] more ... CTD PMID:11123339 , PMID:28242239 paclitaxel multiple interactions ISO RGD:737013 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of TLR4 mRNA CTD PMID:29309887 paclitaxel affects response to substance ISO RGD:737014 6480464 TLR4 protein affects the susceptibility to Paclitaxel CTD PMID:11581577 paracetamol affects expression ISO RGD:737014 6480464 Acetaminophen affects the expression of TLR4 mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:737013 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of TLR4 mRNA CTD PMID:31059760 paracetamol increases expression ISO RGD:737014 6480464 Acetaminophen results in increased expression of TLR4 protein CTD PMID:26079055 paracetamol increases response to substance ISO RGD:737014 6480464 TLR4 results in increased susceptibility to Acetaminophen CTD PMID:16439473 paracetamol multiple interactions ISO RGD:737014 6480464 [Ethanol co-treated with isopentyl alcohol] promotes the reaction [TLR4 results in increased susceptibility to Acetaminophen], Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein] CTD PMID:16439473 , PMID:26079055 paraquat multiple interactions ISO RGD:737014 6480464 epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR4 protein] more ... CTD PMID:23969119 more ... paraquat increases expression EXP 6480464 Paraquat results in increased expression of TLR4 mRNA, Paraquat results in increased expression of TLR4 protein CTD PMID:27883937 paraquat multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA], Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 protein] CTD PMID:27883937 paraquat multiple interactions ISO RGD:737013 6480464 epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR4 protein], ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Paraquat results in increased expression of TLR4 protein] CTD PMID:27890776 paraquat increases expression ISO RGD:737013 6480464 Paraquat results in increased expression of TLR4 protein CTD PMID:27890776 paraquat increases response to substance ISO RGD:737014 6480464 TLR4 results in increased susceptibility to Paraquat CTD PMID:23969119 paraquat increases expression ISO RGD:737014 6480464 Paraquat results in increased expression of TLR4 mRNA, Paraquat results in increased expression of TLR4 protein CTD PMID:23969119 more ... PD 0325901 decreases expression ISO RGD:737013 6480464 PD 0325901 results in decreased expression of TLR4 mRNA CTD PMID:25119042 PD 0325901 multiple interactions ISO RGD:737013 6480464 [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TLR4 mRNA CTD PMID:25119042 pelargonidin multiple interactions ISO RGD:737013 6480464 pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:30753810 permethrin multiple interactions ISO RGD:737014 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein more ... CTD PMID:29751049 phenylmercury acetate increases expression ISO RGD:737013 6480464 Phenylmercuric Acetate results in increased expression of TLR4 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:737013 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR4 mRNA CTD PMID:27188386 phenytoin decreases expression ISO RGD:737014 6480464 Phenytoin results in decreased expression of TLR4 mRNA CTD PMID:23986454 phenytoin multiple interactions ISO RGD:737014 6480464 [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA CTD PMID:23986454 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:737013 6480464 [epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein] more ... CTD PMID:23680697 , PMID:26187476 phorbol 13-acetate 12-myristate increases expression ISO RGD:737013 6480464 Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein CTD PMID:26187476 , PMID:28720485 phosphatidylinositol dimannoside multiple interactions ISO RGD:737014 6480464 TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 phosphoramide mustard increases expression EXP 6480464 phosphoramide mustard results in increased expression of TLR4 mRNA CTD PMID:27888070 picropodophyllotoxin multiple interactions ISO RGD:737014 6480464 [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA], picropodophyllin inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA] CTD PMID:21371294 pirinixic acid decreases expression ISO RGD:737014 6480464 pirinixic acid results in decreased expression of TLR4 mRNA CTD PMID:16985257 platycodin D multiple interactions EXP 6480464 platycodin D inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA], platycodin D inhibits the reaction [Lipopolysaccharides affects the localization of TLR4 protein] CTD PMID:28852734 , PMID:29375565 polymyxin B1 multiple interactions ISO RGD:737013 6480464 Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 polymyxin B2 multiple interactions ISO RGD:737013 6480464 Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 potassium chromate decreases expression ISO RGD:737013 6480464 potassium chromate(VI) results in decreased expression of TLR4 mRNA CTD PMID:22714537 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of TLR4 mRNA CTD PMID:19162173 probenecid multiple interactions ISO RGD:737014 6480464 1 more ... CTD PMID:25406165 progesterone multiple interactions ISO RGD:737013 6480464 [Proteoglycans co-treated with Progesterone] inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein], Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 , PMID:22314502 progesterone increases expression ISO RGD:737013 6480464 Progesterone results in increased expression of TLR4 mRNA, Progesterone results in increased expression of TLR4 protein CTD PMID:17701593 , PMID:20864642 propofol multiple interactions ISO RGD:737014 6480464 Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] more ... CTD PMID:19433076 puerarin multiple interactions ISO RGD:737014 6480464 puerarin inhibits the reaction [nickel sulfate results in increased expression of TLR4 protein] CTD PMID:26607348 Pyridostigmine bromide multiple interactions ISO RGD:737014 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein more ... CTD PMID:29751049 quercetin multiple interactions ISO RGD:737013 6480464 Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of TLR4 mRNA] more ... CTD PMID:24802026 more ... quercetin increases expression ISO RGD:737013 6480464 Quercetin results in increased expression of TLR4 mRNA CTD PMID:21632981 quercetin multiple interactions ISO RGD:737014 6480464 Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TLR4 protein] more ... CTD PMID:22915297 more ... quercetin decreases expression ISO RGD:737013 6480464 Quercetin results in decreased expression of TLR4 mRNA, Quercetin results in decreased expression of TLR4 protein CTD PMID:20828867 , PMID:27279714 quercetin multiple interactions EXP 6480464 Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein], Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA] CTD PMID:27634381 reactive oxygen species multiple interactions ISO RGD:737014 6480464 [TLR4 protein affects the abundance of Reactive Oxygen Species] affects the reaction [Fungal Polysaccharides results in increased secretion of TNF protein] more ... CTD PMID:19735705 , PMID:24447977 reactive oxygen species affects abundance ISO RGD:737014 6480464 TLR4 protein affects the abundance of Reactive Oxygen Species CTD PMID:24447977 resveratrol decreases expression ISO RGD:737013 6480464 resveratrol results in decreased expression of TLR4, resveratrol results in decreased expression of TLR4 protein CTD PMID:22251620 , PMID:24170104 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of TLR4 mRNA, resveratrol results in decreased expression of TLR4 protein CTD PMID:22246136 , PMID:26936125 resveratrol affects response to substance ISO RGD:737013 6480464 TLR4 protein affects the susceptibility to resveratrol CTD PMID:24758933 resveratrol decreases activity ISO RGD:737013 6480464 resveratrol results in decreased activity of TLR4 protein CTD PMID:24758933 resveratrol multiple interactions ISO RGD:737013 6480464 [resveratrol co-treated with [Lipopolysaccharides binds to and results in increased activity of TLR4 protein]] results in decreased secretion of IL10 protein more ... CTD PMID:24035785 , PMID:26497626 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TLR4 protein] more ... CTD PMID:27064547 resveratrol decreases expression ISO RGD:737014 6480464 resveratrol results in decreased expression of TLR4 protein CTD PMID:24818579 resveratrol multiple interactions ISO RGD:737014 6480464 dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]] more ... CTD PMID:22118570 more ... rosmarinic acid decreases expression EXP 6480464 rosmarinic acid results in decreased expression of TLR4 protein CTD PMID:28789951 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:737014 6480464 [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA CTD PMID:23986454 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein] CTD PMID:26177832 salvianolic acid B multiple interactions EXP 6480464 salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA], salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:22101700 SB 431542 multiple interactions ISO RGD:737013 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR4 mRNA CTD PMID:27188386 Scoparone multiple interactions ISO RGD:737014 6480464 scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] CTD PMID:23535186 scopoletin multiple interactions EXP 6480464 Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] CTD PMID:26115886 silicon dioxide increases expression ISO RGD:737013 6480464 Silicon Dioxide analog results in increased expression of TLR4 mRNA CTD PMID:25895662 silicon dioxide decreases expression ISO RGD:737014 6480464 Silicon Dioxide results in decreased expression of TLR4 mRNA CTD PMID:19073995 simvastatin increases expression ISO RGD:737013 6480464 Simvastatin results in increased expression of TLR4 protein CTD PMID:16387846 simvastatin multiple interactions ISO RGD:737013 6480464 Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:16443229 simvastatin decreases expression EXP 6480464 Simvastatin results in decreased expression of TLR4 mRNA, Simvastatin results in decreased expression of TLR4 protein CTD PMID:19166837 sodium arsenite increases expression ISO RGD:737014 6480464 sodium arsenite results in increased expression of TLR4 mRNA CTD PMID:21134390 sodium cholate multiple interactions EXP 6480464 [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of TLR4 mRNA CTD PMID:26606054 streptozocin multiple interactions ISO RGD:737013 6480464 TNF protein inhibits the reaction [Streptozocin results in increased expression of TLR4 mRNA] CTD PMID:20446767 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of TLR4 protein CTD PMID:29409856 streptozocin multiple interactions ISO RGD:737014 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA, esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA] CTD PMID:27769711 streptozocin multiple interactions EXP 6480464 crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:29409856 streptozocin increases expression ISO RGD:737014 6480464 Streptozocin results in increased expression of TLR4 mRNA CTD PMID:20446767 succimer multiple interactions ISO RGD:737014 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TLR4 mRNA CTD PMID:21641980 sulfasalazine multiple interactions ISO RGD:737014 6480464 Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958 sulforaphane increases expression ISO RGD:737013 6480464 sulforafan results in increased expression of TLR4 mRNA CTD PMID:26833863 sumatriptan multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TLR4 protein] CTD PMID:22150557 telmisartan multiple interactions ISO RGD:737013 6480464 [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA, [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein CTD PMID:20524934 tert-butyl hydroperoxide multiple interactions ISO RGD:737013 6480464 1-(3 more ... CTD PMID:28063877 , PMID:29111459 tetrachloromethane increases expression ISO RGD:737014 6480464 Carbon Tetrachloride results in increased expression of TLR4 mRNA, Carbon Tetrachloride results in increased expression of TLR4 protein CTD PMID:21291945 more ... tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of TLR4 mRNA, Carbon Tetrachloride results in increased expression of TLR4 protein CTD PMID:17504260 more ... tetrachloromethane multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA] more ... CTD PMID:17504260 more ... tetrachloromethane affects expression ISO RGD:737014 6480464 Carbon Tetrachloride affects the expression of TLR4 mRNA CTD PMID:17484886 tetrachloromethane multiple interactions ISO RGD:737014 6480464 2-cyano-3 more ... CTD PMID:21291945 more ... tetrachloropalladate(2-) multiple interactions ISO RGD:737013 6480464 TLR4 protein affects the reaction [tetrachloropalladium results in increased secretion of CXCL8 protein] CTD PMID:23692033 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of TLR4 mRNA CTD PMID:30500344 thioacetamide multiple interactions EXP 6480464 chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA] CTD PMID:30500344 Tiapride hydrochloride multiple interactions EXP 6480464 Tiapride Hydrochloride inhibits the reaction [4-iodo-2, 5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein] CTD PMID:30790395 titanium atom multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Titanium] results in decreased expression of TLR4 mRNA CTD PMID:21308757 titanium atom increases expression ISO RGD:737014 6480464 Titanium results in increased expression of TLR4 mRNA CTD PMID:20682337 titanium dioxide multiple interactions ISO RGD:737014 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TLR4 mRNA CTD PMID:29950665 toluene increases expression ISO RGD:737014 6480464 Toluene results in increased expression of TLR4 mRNA CTD PMID:21381054 valproic acid decreases methylation ISO RGD:737013 6480464 Valproic Acid results in decreased methylation of TLR4 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:737013 6480464 Valproic Acid results in increased expression of TLR4 mRNA CTD PMID:28001369 valproic acid decreases expression ISO RGD:737013 6480464 Valproic Acid results in decreased expression of TLR4 mRNA CTD PMID:23179753 , PMID:25716160 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of TLR4 mRNA CTD PMID:18629315 vitamin D decreases expression ISO RGD:737013 6480464 Vitamin D results in decreased expression of TLR4 mRNA, Vitamin D results in decreased expression of TLR4 protein CTD PMID:23281135 vitamin D multiple interactions ISO RGD:737014 6480464 Vitamin D inhibits the reaction [Dust results in increased expression of TLR4 mRNA] CTD PMID:23281135 zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of TLR4 mRNA CTD PMID:19111725 , PMID:22689922 zinc oxide multiple interactions ISO RGD:737014 6480464 [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR4 protein, Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR4 mRNA] CTD PMID:25127755 zinc protoporphyrin multiple interactions EXP 6480464 zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein] CTD PMID:25780291 zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of TLR4 mRNA CTD PMID:19111725 , PMID:22689922 zingerone multiple interactions ISO RGD:737014 6480464 zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:29289488
Biological Process activation of innate immune response ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:3530402 , PMID:15661922) RGD MGI:MGI:3530402 , PMID:15661922 activation of MAPK activity ISO RGD:737014 1624291 (MGI:MGI:4421230, PMID:20051628) RGD MGI:MGI:4421230 , PMID:20051628 activation of MAPK activity IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 astrocyte development ISO RGD:737014 1624291 (MGI:MGI:5440388, PMID:22577135) RGD MGI:MGI:5440388 , PMID:22577135 astrocyte development IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 B cell proliferation involved in immune response ISO RGD:737014 1624291 (MGI:MGI:1860539, PMID:10880523) RGD MGI:MGI:1860539 , PMID:10880523 B cell proliferation involved in immune response IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to amyloid-beta ISO RGD:737013 1624291 UniProtKB:P16671 , UniProtKB:Q9Y2C9 (PMID:20037584) RGD PMID:20037584 cellular response to amyloid-beta IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to interferon-gamma ISO RGD:737013 1624291 (PMID:11672593) RGD PMID:11672593 cellular response to interferon-gamma IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to lipopolysaccharide IEP 7777075 RGD cellular response to lipopolysaccharide ISO RGD:737013 1624291 RNAcentral:URS000026261D_9606 (PMID:11432859), (PMID:30321456) RGD PMID:11432859 , PMID:30321456 cellular response to lipopolysaccharide ISO RGD:737014 1624291 MGI:MGI:1860755 (MGI:MGI:1860539 more ... RGD MGI:MGI:1860539 more ... cellular response to lipoteichoic acid ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:2178646 , PMID:10549626) RGD MGI:MGI:2178646 , PMID:10549626 cellular response to lipoteichoic acid IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to mechanical stimulus IEP 4144075 RGD cellular response to mechanical stimulus IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to mechanical stimulus ISO RGD:737013 1624291 (PMID:19593445) RGD PMID:19593445 cellular response to oxidised low-density lipoprotein particle stimulus IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to oxidised low-density lipoprotein particle stimulus ISO RGD:737014 1624291 UniProtKB:Q9Y2C9 (MGI:MGI:4438693 , PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 cellular response to retinoic acid IEP 7777075 RGD defense response to bacterium ISO RGD:737013 1624291 RNAcentral:URS000026261D_9606 (PMID:30321456) RGD PMID:30321456 defense response to Gram-negative bacterium ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:3530402 , PMID:15661922) RGD MGI:MGI:3530402 , PMID:15661922 defense response to Gram-negative bacterium IBA MGI:MGI:96824 , PANTHER:PTN000687406 13792537 PMID:21873635 GO_Central defense response to Gram-negative bacterium IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 detection of lipopolysaccharide ISO RGD:737013 1624291 (PMID:19252480) RGD PMID:19252480 detection of lipopolysaccharide IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 detection of lipopolysaccharide ISO RGD:737014 1624291 (MGI:MGI:5913054, PMID:28098138) RGD MGI:MGI:5913054 , PMID:28098138 detection of lipopolysaccharide IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 detection of lipopolysaccharide ISS UniProtKB:O00206 1600115 GO_REF:0000024 UniProt GO_REF:0000024 detection of mechanical stimulus involved in sensory perception of pain IMP 12910551 RGD detection of temperature stimulus involved in sensory perception of pain IMP 12910551 RGD I-kappaB phosphorylation ISO RGD:737013 1624291 (PMID:19740627) RGD PMID:19740627 I-kappaB phosphorylation IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 I-kappaB phosphorylation IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 I-kappaB phosphorylation ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:3835701 , PMID:18820689) RGD MGI:MGI:3835701 , PMID:18820689 immunoglobulin mediated immune response IEP 2312508 RGD inflammatory response IEP 1624166 RGD inflammatory response IBA PANTHER:PTN000687652 more ... 13792537 PMID:21873635 GO_Central innate immune response IEA UniProtKB-KW:KW-0399 1600115 GO_REF:0000037 UniProt GO_REF:0000037 innate immune response-activating signal transduction IMP 2312509 RGD interferon-gamma production ISO RGD:737014 1624291 MGI:MGI:1270861 (MGI:MGI:2148358 , PMID:11489994) RGD MGI:MGI:2148358 , PMID:11489994 interferon-gamma production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-1 beta secretion IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-1 beta secretion ISS UniProtKB:Q9QUK6 1600115 GO_REF:0000024 UniProt GO_REF:0000024 interleukin-1 beta secretion ISO RGD:737014 1624291 (MGI:MGI:5546292, PMID:23812099) RGD MGI:MGI:5546292 , PMID:23812099 intestinal epithelial structure maintenance ISO RGD:737014 1624291 (MGI:MGI:4421230, PMID:20051628) RGD MGI:MGI:4421230 , PMID:20051628 intestinal epithelial structure maintenance IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 leukotriene metabolic process IDA 7241098 RGD lipopolysaccharide-mediated signaling pathway NOT ISO RGD:737013 1624291 (PMID:10880523) RGD PMID:10880523 lipopolysaccharide-mediated signaling pathway IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 lipopolysaccharide-mediated signaling pathway IEA GO:0001875 1600115 GO_REF:0000108 GOC GO_REF:0000108 lipopolysaccharide-mediated signaling pathway ISO RGD:737014 1624291 MGI:MGI:1194924 more ... RGD MGI:MGI:1860539 more ... lipopolysaccharide-mediated signaling pathway IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 lipopolysaccharide-mediated signaling pathway ISO RGD:737014 1624291 MGI:MGI:1194924 more ... RGD MGI:MGI:1860539 , PMID:10880523 lipopolysaccharide-mediated signaling pathway ISO RGD:737013 1624291 UniProtKB:O95711 , UniProtKB:Q9Y6Y9 (PMID:10880523) RGD PMID:10880523 macrophage activation ISO RGD:737013 1624291 (PMID:10835634) RGD PMID:10835634 macrophage activation IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 microglial cell activation IDA 1643119 RGD MyD88-dependent toll-like receptor signaling pathway IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 MyD88-dependent toll-like receptor signaling pathway ISO RGD:737014 1624291 UniProtKB:Q9EPW9 (MGI:MGI:4438693 , PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 negative regulation of cold-induced thermogenesis ISS UniProtKB:Q9QUK6 13673848 PMID:26370079 YuBioLab negative regulation of cold-induced thermogenesis ISO RGD:737014 1624291 (MGI:MGI:6101064, PMID:26370079) RGD MGI:MGI:6101064 , PMID:26370079 negative regulation of ERK1 and ERK2 cascade ISO RGD:737014 1624291 (MGI:MGI:4421230, PMID:20051628) RGD MGI:MGI:4421230 , PMID:20051628 negative regulation of ERK1 and ERK2 cascade IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of interferon-gamma production ISO RGD:737014 1624291 (MGI:MGI:4421230, PMID:20051628) RGD MGI:MGI:4421230 , PMID:20051628 negative regulation of interferon-gamma production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of interleukin-17 production ISO RGD:737014 1624291 (MGI:MGI:3773594 more ... RGD MGI:MGI:3773594 more ... negative regulation of interleukin-17 production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of interleukin-23 production ISO RGD:737014 1624291 (MGI:MGI:3773594, PMID:18203139) RGD MGI:MGI:3773594 , PMID:18203139 negative regulation of interleukin-23 production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of interleukin-6 production ISO RGD:737014 1624291 (MGI:MGI:3773594 more ... RGD MGI:MGI:3773594 more ... negative regulation of interleukin-6 production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of tumor necrosis factor production ISO RGD:737014 1624291 (MGI:MGI:4421230, PMID:20051628) RGD MGI:MGI:4421230 , PMID:20051628 negative regulation of tumor necrosis factor production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 nitric oxide production involved in inflammatory response ISO RGD:737014 1624291 MGI:MGI:1857718 (MGI:MGI:1351361 , PMID:10623794) RGD MGI:MGI:1351361 , PMID:10623794 nitric oxide production involved in inflammatory response IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 phagocytosis ISO RGD:737013 1624291 (PMID:30883606) RGD PMID:30883606 phagocytosis IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of apoptotic process IMP 1598594 RGD positive regulation of B cell proliferation ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:2178646 , PMID:10549626) RGD MGI:MGI:2178646 , PMID:10549626 positive regulation of B cell proliferation IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cellular response to macrophage colony-stimulating factor stimulus ISO RGD:737013 1624291 (PMID:11672593) RGD PMID:11672593 positive regulation of cellular response to macrophage colony-stimulating factor stimulus IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of chemokine (C-C motif) ligand 2 secretion IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of chemokine (C-C motif) ligand 2 secretion ISO RGD:737013 1624291 (PMID:21329689) RGD PMID:21329689 positive regulation of chemokine production ISO RGD:737013 1624291 (PMID:19740627) RGD PMID:19740627 positive regulation of chemokine production ISO RGD:737014 1624291 (MGI:MGI:4456948, PMID:15356140) RGD MGI:MGI:4456948 , PMID:15356140 positive regulation of cytokine production involved in inflammatory response IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cytokine production involved in inflammatory response ISO RGD:737013 1624291 (PMID:30321456) RGD PMID:30321456 positive regulation of cytokine production involved in inflammatory response IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cytokine production involved in inflammatory response ISO RGD:737014 1624291 UniProtKB:Q9Y2C9 (MGI:MGI:4438693 , PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 positive regulation of DNA binding IMP 1598594 RGD positive regulation of DNA-binding transcription factor activity IMP 1598594 RGD positive regulation of ERK1 and ERK2 cascade ISO RGD:737014 1624291 (MGI:MGI:3775161, PMID:18261938) RGD MGI:MGI:3775161 , PMID:18261938 positive regulation of ERK1 and ERK2 cascade IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:737013 1624291 (PMID:23817958) RGD PMID:23817958 positive regulation of gene expression ISO RGD:737014 1624291 UniProtKB:P05067:PRO_0000000092 more ... RGD MGI:MGI:4438693 , PMID:20037584 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:737014 1624291 (MGI:MGI:3607973 more ... RGD MGI:MGI:3607973 more ... positive regulation of I-kappaB kinase/NF-kappaB signaling IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of inflammatory response IMP 1598593 RGD positive regulation of inflammatory response ISO RGD:737013 1624291 (PMID:21329689) RGD PMID:21329689 positive regulation of inflammatory response ISO RGD:737014 1624291 UniProtKB:O00206 (MGI:MGI:4438693 , PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 positive regulation of interferon-alpha production ISO RGD:737014 1624291 (MGI:MGI:4456948, PMID:15356140) RGD MGI:MGI:4456948 , PMID:15356140 positive regulation of interferon-alpha production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interferon-beta biosynthetic process ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:3530402 , PMID:15661922) RGD MGI:MGI:3530402 , PMID:15661922 positive regulation of interferon-beta biosynthetic process IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interferon-beta production ISO RGD:737014 1624291 (MGI:MGI:4456948, PMID:15356140) RGD MGI:MGI:4456948 , PMID:15356140 positive regulation of interferon-gamma production ISO RGD:737014 1624291 (MGI:MGI:3773594, PMID:18203139) RGD MGI:MGI:3773594 , PMID:18203139 positive regulation of interferon-gamma production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interleukin-1 beta secretion ISO RGD:737013 1624291 (PMID:11432859) RGD PMID:11432859 positive regulation of interleukin-1 beta secretion IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interleukin-1 production ISO RGD:737014 1624291 (MGI:MGI:4456948, PMID:15356140) RGD MGI:MGI:4456948 , PMID:15356140 positive regulation of interleukin-10 production ISO RGD:737014 1624291 (MGI:MGI:4456948 more ... RGD MGI:MGI:4456948 more ... positive regulation of interleukin-10 production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interleukin-12 biosynthetic process ISO RGD:737013 1624291 (PMID:15027902) RGD PMID:15027902 positive regulation of interleukin-12 biosynthetic process IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interleukin-12 production ISO RGD:737014 1624291 (MGI:MGI:4456948, PMID:15356140) RGD MGI:MGI:4456948 , PMID:15356140 positive regulation of interleukin-12 production ISO RGD:737014 1624291 (MGI:MGI:4456948 more ... RGD MGI:MGI:4456948 more ... positive regulation of interleukin-6 production ISO RGD:737014 1624291 MGI:MGI:1860755 more ... RGD MGI:MGI:2178646 more ... positive regulation of interleukin-6 production ISO RGD:737013 1624291 (PMID:19740627), (PMID:30321456) RGD PMID:19740627 , PMID:30321456 positive regulation of interleukin-6 production ISO RGD:737014 1624291 MGI:MGI:1860755 more ... RGD MGI:MGI:2178646 more ... positive regulation of interleukin-6 secretion IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interleukin-6 secretion ISO RGD:737013 1624291 (PMID:21329689) RGD PMID:21329689 positive regulation of interleukin-8 biosynthetic process ISO RGD:737013 1624291 (PMID:17951129) RGD PMID:17951129 positive regulation of interleukin-8 biosynthetic process IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interleukin-8 production ISO RGD:737013 1624291 (PMID:19740627) RGD PMID:19740627 positive regulation of interleukin-8 secretion IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interleukin-8 secretion ISO RGD:737013 1624291 (PMID:21329689) RGD PMID:21329689 positive regulation of JNK cascade ISO RGD:737014 1624291 MGI:MGI:1346877 (MGI:MGI:3607973 more ... RGD MGI:MGI:3607973 more ... positive regulation of JNK cascade IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of keratinocyte proliferation IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of keratinocyte proliferation ISO RGD:737013 1624291 (PMID:27641447) RGD PMID:27641447 positive regulation of lymphocyte proliferation ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:3640248 , PMID:10607756) RGD MGI:MGI:3640248 , PMID:10607756 positive regulation of macrophage activation IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of macrophage activation ISO RGD:737014 1624291 UniProtKB:Q9Y2C9 (MGI:MGI:4438693 , PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 positive regulation of macrophage cytokine production ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:2178646 , PMID:10549626) RGD MGI:MGI:2178646 , PMID:10549626 positive regulation of macrophage cytokine production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of matrix metallopeptidase secretion IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of matrix metallopeptidase secretion ISO RGD:737013 1624291 (PMID:21329689) RGD PMID:21329689 positive regulation of MHC class II biosynthetic process ISO RGD:737014 1624291 MGI:MGI:1860885 (MGI:MGI:2178646 , PMID:10549626) RGD MGI:MGI:2178646 , PMID:10549626 positive regulation of MHC class II biosynthetic process IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of NF-kappaB transcription factor activity IMP 1598593 RGD positive regulation of NF-kappaB transcription factor activity IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of NF-kappaB transcription factor activity ISO RGD:737013 1624291 UniProtKB:P05067:PRO_0000000092 more ... RGD PMID:12594207 , PMID:20037584 positive regulation of NIK/NF-kappaB signaling ISO RGD:737013 1624291 (PMID:19740627) RGD PMID:19740627 positive regulation of NIK/NF-kappaB signaling IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of nitric oxide biosynthetic process ISO RGD:737014 1624291 MGI:MGI:1860885 more ... RGD MGI:MGI:2178646 more ... positive regulation of nitric oxide biosynthetic process IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of nitric-oxide synthase biosynthetic process ISO RGD:737014 1624291 (MGI:MGI:4456948, PMID:15356140) RGD MGI:MGI:4456948 , PMID:15356140 positive regulation of nitric-oxide synthase biosynthetic process IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of NLRP3 inflammasome complex assembly IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of NLRP3 inflammasome complex assembly ISS UniProtKB:Q9QUK6 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of NLRP3 inflammasome complex assembly ISO RGD:737014 1624291 (MGI:MGI:5546292, PMID:23812099) RGD MGI:MGI:5546292 , PMID:23812099 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway ISO RGD:737014 1624291 (MGI:MGI:3775161, PMID:18261938) RGD MGI:MGI:3775161 , PMID:18261938 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO RGD:737014 1624291 (MGI:MGI:3775161, PMID:18261938) RGD MGI:MGI:3775161 , PMID:18261938 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of oxidative stress-induced neuron death IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of oxidative stress-induced neuron death ISO RGD:737014 1624291 UniProtKB:P05067:PRO_0000000092 (MGI:MGI:4438693 , PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 positive regulation of peptidyl-tyrosine phosphorylation IDA 634467 RGD positive regulation of platelet activation ISO RGD:737014 1624291 (MGI:MGI:3838274, PMID:16514062) RGD MGI:MGI:3838274 , PMID:16514062 positive regulation of platelet activation IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of reactive oxygen species biosynthetic process ISO RGD:737014 1624291 (MGI:MGI:4438693, PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 positive regulation of stress-activated MAPK cascade ISO RGD:737014 1624291 (MGI:MGI:3775161, PMID:18261938) RGD MGI:MGI:3775161 , PMID:18261938 positive regulation of transcription by RNA polymerase II ISO RGD:737014 1624291 (MGI:MGI:4456948, PMID:15356140) RGD MGI:MGI:4456948 , PMID:15356140 positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of tumor necrosis factor biosynthetic process ISO RGD:737013 1624291 (PMID:17951129) RGD PMID:17951129 positive regulation of tumor necrosis factor biosynthetic process IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of tumor necrosis factor production ISO RGD:737014 1624291 MGI:MGI:1857718 more ... RGD MGI:MGI:1351361 more ... positive regulation of tumor necrosis factor production ISO RGD:737013 1624291 (PMID:30321456) RGD PMID:30321456 regulation of dendritic cell cytokine production ISO RGD:737014 1624291 (MGI:MGI:3828894, PMID:19047410) RGD MGI:MGI:3828894 , PMID:19047410 regulation of dendritic cell cytokine production IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of inflammatory response ISO RGD:737014 1624291 (MGI:MGI:3773594, PMID:18203139) RGD MGI:MGI:3773594 , PMID:18203139 regulation of sensory perception of pain IMP 4144073 RGD regulation of tumor necrosis factor secretion IMP 12910488 RGD response to activity IEP 4144074 ; 4144081 RGD response to bacterium ISO RGD:737014 1624291 (MGI:MGI:3608578, PMID:11294571) RGD MGI:MGI:3608578 , PMID:11294571 response to ethanol IMP 1598594 RGD response to fatty acid IDA 2312510 RGD response to glucocorticoid IEP 8693609 RGD response to gold nanoparticle IEP 7815044 RGD response to hypoxia IEP 2312731 RGD response to insulin IEP 2312491 RGD response to lipopolysaccharide IEP 1620770 RGD response to lipopolysaccharide ISO RGD:737014 1624291 MGI:MGI:1270861 more ... RGD MGI:MGI:1336850 more ... response to lipopolysaccharide ISO RGD:737013 1624291 (PMID:12594207) RGD PMID:12594207 response to lipopolysaccharide IDA 1643119 E. coli K12 LPS RGD response to morphine IEP 7777128 RGD response to oxidative stress IMP 1598585 RGD response to progesterone IEP 2312713 RGD response to retinoic acid IEP 7777075 RGD response to toxic substance IEP 2312731 RGD skeletal muscle contraction IEP 4144081 RGD toll-like receptor 4 signaling pathway IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 toll-like receptor 4 signaling pathway ISO RGD:737014 1624291 (MGI:MGI:5913054, PMID:28098138) RGD MGI:MGI:5913054 , PMID:28098138 toll-like receptor signaling pathway IDA 1643119 RGD toll-like receptor signaling pathway IBA PANTHER:PTN000687652 more ... 13792537 PMID:21873635 GO_Central TRIF-dependent toll-like receptor signaling pathway IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 TRIF-dependent toll-like receptor signaling pathway ISO RGD:737014 1624291 UniProtKB:Q9EPW9 (MGI:MGI:4438693 , PMID:20037584) RGD MGI:MGI:4438693 , PMID:20037584 Cellular Component cell surface IDA 1598585 RGD cell surface ISO RGD:737013 1624291 (PMID:25204797) RGD PMID:25204797 cytoplasm IDA 1598585 RGD cytoplasm ISO RGD:737013 1624291 UniProtKB:P16671 , UniProtKB:Q9Y2C9 (PMID:19740627), (PMID:20037584) RGD PMID:19740627 , PMID:20037584 early endosome IEA UniProtKB-SubCell:SL-0094 1600115 GO_REF:0000039 UniProt GO_REF:0000039 external side of plasma membrane ISO RGD:737013 1624291 (PMID:16514062) RGD PMID:16514062 external side of plasma membrane IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 Golgi apparatus ISO RGD:737013 1624291 RGD GO_REF:0000052 integral component of plasma membrane TAS 625648 RGD integral component of plasma membrane IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of plasma membrane IBA PANTHER:PTN000687652 , UniProtKB:O00206 13792537 PMID:21873635 GO_Central integral component of plasma membrane ISO RGD:737013 1624291 (PMID:15027902) RGD PMID:15027902 intrinsic component of plasma membrane ISO RGD:737013 1624291 (PMID:11274165) RGD PMID:11274165 lipopolysaccharide receptor complex ISO RGD:737013 1624291 (PMID:11274165), (PMID:19252480) RGD PMID:11274165 , PMID:19252480 lipopolysaccharide receptor complex IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 lipopolysaccharide receptor complex ISS UniProtKB:O00206 1600115 GO_REF:0000024 UniProt GO_REF:0000024 membrane raft colocalizes_with IDA 1598585 RGD perinuclear region of cytoplasm ISO RGD:737013 1624291 (PMID:15027902) RGD PMID:15027902 perinuclear region of cytoplasm IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 phagocytic cup ISO RGD:737013 1624291 (PMID:30883606) RGD PMID:30883606 phagocytic cup IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane ISO RGD:737014 1624291 (MGI:MGI:6244743, PMID:28096568) RGD MGI:MGI:6244743 , PMID:28096568 plasma membrane ISO RGD:737013 1624291 (PMID:16338228), (PMID:19740627) RGD GO_REF:0000052 more ... receptor complex ISO RGD:737013 1624291 UniProtKB:P16671 , UniProtKB:Q9Y2C9 (PMID:20037584) RGD PMID:20037584 receptor complex ISO RGD:737014 1624291 (MGI:MGI:5913054, PMID:28098138) RGD MGI:MGI:5913054 , PMID:28098138 Molecular Function identical protein binding ISO RGD:737013 1624291 UniProtKB:O00206 (PMID:23059983), (PMID:23155421) RGD PMID:23059983 , PMID:23155421 identical protein binding IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 lipopolysaccharide binding IDA 1643119 E. coli K12 LPS RGD lipopolysaccharide binding IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 lipopolysaccharide binding IBA PANTHER:PTN000687407 more ... 13792537 PMID:21873635 GO_Central lipopolysaccharide binding ISO RGD:737013 1624291 (PMID:16514062) RGD PMID:16514062 lipopolysaccharide receptor activity ISO RGD:737013 1624291 (PMID:19252480) RGD PMID:19252480 lipopolysaccharide receptor activity IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 lipopolysaccharide receptor activity IBA PANTHER:PTN000687407 , UniProtKB:O00206 13792537 PMID:21873635 GO_Central lipopolysaccharide receptor activity ISO RGD:737014 1624291 (MGI:MGI:5913054, PMID:28098138) RGD MGI:MGI:5913054 , PMID:28098138 lipopolysaccharide receptor activity IEA UniProtKB:Q9QUK6 , ensembl:ENSMUSP000000457701600115 GO_REF:0000107 Ensembl GO_REF:0000107 lipopolysaccharide receptor activity ISS UniProtKB:O00206 1600115 GO_REF:0000024 UniProt GO_REF:0000024 phosphatidylinositol 3-kinase binding IPI RGD:3329 1302746 RGD protein binding IPI RGD:735043 1302746 RGD protein binding ISO RGD:737014 1624291 UniProtKB:E9Q4P1 more ... RGD MGI:MGI:3763315 more ... protein binding ISO RGD:737014 1624291 UniProtKB:E9Q4P1 more ... RGD MGI:MGI:3763315 more ... protein binding ISO RGD:737013 1624291 UniProtKB:O15389 more ... RGD PMID:11441107 more ... protein binding IPI RGD:61306 10402845 RGD protein heterodimerization activity ISO RGD:737013 1624291 UniProtKB:Q9Y2C9 (PMID:20037584) RGD PMID:20037584 protein heterodimerization activity IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107 signaling receptor activity TAS 625648 RGD signaling receptor binding ISO RGD:737013 1624291 UniProtKB:P16671 , UniProtKB:Q9Y2C9 (PMID:20037584) RGD PMID:20037584 signaling receptor binding IEA UniProtKB:O00206 , ensembl:ENSP000003630891600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
