Tlr4 (toll-like receptor 4) - Rat Genome Database

Name: Tlr4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Tlr4 (toll-like receptor 4) Rattus norvegicus

Analyze

Symbol:

Tlr4

Name:

toll-like receptor 4

RGD ID:

3870

Description:

Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to lipid; detection of stimulus involved in sensory perception of pain; and response to steroid hormone. Located in cell surface. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; pulpitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4); PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

toll4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TLR4 (toll like receptor 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tlr4 (toll-like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tlr4 (toll like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TLR4 (toll like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TLR4 (toll like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tlr4 (toll like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TLR4 (toll like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TLR4 (toll like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tlr4 (toll like receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TLR4 (toll like receptor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tlr4 (toll-like receptor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tlr4al (toll-like receptor 4a, like)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tlr4bb (toll-like receptor 4b, duplicate b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tlr4ba (toll-like receptor 4b, duplicate a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tl	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)

Allele / Splice:

Tlr4^m1Mcwi Tlr4^em1Geh Tlr4^em5Mcwi

Genetic Models:

WI-Tlr4^em1Geh FHH-Tlr4^m1Mcwi BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4^em5Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	80,145,867 - 80,159,501 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	80,145,826 - 80,159,628 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	82,524,918 - 82,538,532 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	84,342,217 - 84,355,831 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	84,317,856 - 84,331,470 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	82,587,424 - 82,601,056 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	82,587,420 - 82,601,052 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	86,690,670 - 86,704,302 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	83,564,100 - 83,577,735 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	83,569,212 - 83,582,848 (+)	NCBI
Celera	5	79,045,293 - 79,058,928 (+)	NCBI		Celera
RH 3.4 Map	5	643.7	RGD
Cytogenetic Map	5	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acanthamoeba Keratitis (IEP)

acne (ISO)

Acne Conglobata (ISO)

Acute Coronary Syndrome (ISO)

acute kidney failure (IDA,ISO)

Acute Liver Failure (IEP,IMP)

Acute Lung Injury (IEP)

acute necrotizing pancreatitis (IEP)

acute pancreatitis (ISO)

Acute Tubulointerstitial Nephritis (ISO)

Acute-On-Chronic Liver Failure (IEP)

Alcoholic Fatty Liver (ISO)

allergic conjunctivitis (ISO)

allergic contact dermatitis (ISO)

allergic rhinitis (ISO)

Alzheimer's disease (ISO)

ankylosing spondylitis (ISO)

anogenital venereal wart (ISO)

anterior uveitis (ISO)

arteriosclerosis (ISO)

arthritis (ISO)

asthma (ISO)

atherosclerosis (ISO)

atopic dermatitis (ISO)

Bacteremia (ISO)

Bacterial Keratitis (ISO)

bacterial pneumonia (ISO)

Behcet's disease (ISO)

Brain Injuries (IEP,ISO)

brain ischemia (ISO)

breast cancer (ISO)

Bronchial Hyperreactivity (ISO)

carcinoma (ISO)

carotid artery disease (ISO)

carotid stenosis (IDA)

Chemical and Drug Induced Liver Injury (IEP)

cholesteatoma (ISO)

cholesteatoma of middle ear (ISO)

Chronic Hepatitis B (ISO)

Chronic Hepatitis C (ISO)

chronic obstructive pulmonary disease (ISO)

Chronic Pain (ISO)

Chronic Periodontitis (ISO)

colitis (IEP,ISO)

Colorectal Neoplasms (ISO)

contact dermatitis (ISO)

coronary artery disease (ISO)

Crohn's disease (ISO)

cutaneous leishmaniasis (ISO)

cystic echinococcosis (ISO)

cystic fibrosis (ISO)

dermatomyositis (ISO)

diabetes mellitus (ISO)

Diabetic Foot (ISO)

Diabetic Nephropathies (ISO)

diabetic neuropathy (IDA,ISO)

diabetic retinopathy (ISO)

dry eye syndrome (ISO)

Dysbiosis (ISO)

end stage renal disease (ISO)

Endotoxemia (IDA,ISO)

Entamoebiasis (ISO)

Eosinophilia (ISO)

Escherichia Coli Meningitis (ISO)

esophagus adenocarcinoma (ISO)

essential hypertension (ISO)

eumycotic mycetoma (ISO)

exfoliation syndrome (ISO)

Experimental Autoimmune Encephalomyelitis (IEP)

Experimental Autoimmune Neuritis (IEP)

Experimental Autoimmune Uveitis (ISO)

Experimental Diabetes Mellitus (IEP)

Experimental Liver Cirrhosis (IDA,ISO)

extrahepatic cholestasis (ISO)

eye disease (ISO)

familial Mediterranean fever (ISO)

fatty liver disease (ISO)

Fibrosis (ISO)

Fungal Eye Infections (IEP)

Fungal Keratitis (ISO)

genetic disease (ISO)

glomerulonephritis (ISO)

Hearing Loss (ISO)

Hemorrhagic Shock (ISO)

hepatocellular carcinoma (ISO)

hepatorenal syndrome (IEP)

Herpes Simplex Encephalitis (IEP)

herpes simplex virus keratitis (ISO)

Hyperalgesia (IMP,ISO)

hypertension (ISO)

ileitis (IMP,ISO)

Inflammation (ISO)

Insulin Resistance (ISO)

invasive aspergillosis (ISO)

Kawasaki disease (ISO)

keratitis (ISO)

kidney failure (IEP,ISO)

Kidney Reperfusion Injury (IDA,ISO)

learning disability (ISO)

leptospirosis (ISO)

liver cirrhosis (IEP,ISO)

Liver Injury (ISO)

Liver Reperfusion Injury (IEP,ISO)

low tension glaucoma (ISO)

lung adenocarcinoma (ISO)

lung disease (IDA,IEP,ISO)

Lung Injury (ISO)

Lung Neoplasms (ISO)

Lung Reperfusion Injury (IEP)

Lymphatic Metastasis (ISO)

macular degeneration (ISO)

mastitis (IEP)

mastoiditis (ISO)

melanoma (ISO)

membranoproliferative glomerulonephritis (ISO)

meningococcal meningitis (ISO)

multiple sclerosis (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (IDA)

Nasal Polyps (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Neuralgia (IEP)

non-alcoholic fatty liver disease (IEP,ISO)

obesity (IMP,ISO)

Ocular Onchocerciasis (ISO)

Optic Nerve Injuries (ISO)

Oral Lichen Planus (ISO)

otitis media (ISO)

Otitis Media with Effusion (ISO)

Ovarian Neoplasms (ISO)

Pain (IMP)

Painful Neuropathy (ISO)

pancreatitis (IEP,ISO)

perinatal necrotizing enterocolitis (IEP,ISO)

periodontitis (ISO)

Plaque, Atherosclerotic (ISO)

pleural tuberculosis (ISO)

Pneumococcal Meningitis (ISO)

pneumonia (ISO)

pre-eclampsia (ISO)

primary open angle glaucoma (ISO)

Prostatic Neoplasms (ISO)

Pseudomonas Aeruginosa Keratitis (ISO)

psoriasis (ISO)

pulmonary edema (ISO)

pulmonary emphysema (ISO,ISS)

pulmonary fibrosis (ISO)

pulmonary hypertension (ISO)

pulmonary tuberculosis (ISO)

pulpitis (IEP)

renal fibrosis (IMP)

Reperfusion Injury (IEP,ISO)

respiratory allergy (ISO)

Respiratory Sounds (ISO)

respiratory syncytial virus infectious disease (ISO)

Retina Reperfusion Injury (ISO)

Rhinosinusitis (ISO)

sciatic neuropathy (IEP,IMP,ISO)

Seasonal Allergic Rhinitis (ISO)

Sepsis (IEP,ISO)

severe COVID-19 (ISO)

sinusitis (ISO)

Spinal Cord Injuries (ISO)

Spinal Cord Reperfusion Injury (IMP)

sporotrichosis (ISO)

squamous cell carcinoma (ISO)

Stable Angina (ISO)

Stroke (ISO)

Subarachnoid Hemorrhage (IEP)

suppurative otitis media (ISO)

systemic lupus erythematosus (ISO)

temporal arteritis (ISO)

Transplant Rejection (ISO)

tuberculosis (ISO)

tympanosclerosis (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

urinary bladder cancer (ISO)

urinary tract infection (ISO)

uveitis (IEP)

Ventricular Dysfunction, Left (ISO)

Viral Bronchiolitis (ISO)

viral meningitis (ISO)

vitiligo (ISO)

Wallerian Degeneration (ISO)

Weight Loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-epicatechin-3-O-gallate (ISO)

(+)-pilocarpine (EXP)

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(24S)-24-hydroxycholesterol (ISO)

(25R)-cholest-5-ene-3beta,26-diol (ISO)

(S)-nicotine (EXP,ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,4-dithiothreitol (ISO)

1,4-phenylenediamine (ISO)

1-chloro-2,4,6-trinitrobenzene (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2,2-trichloroethanol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP,ISO)

2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine (EXP)

2-amino-2-deoxy-D-galactopyranose (ISO)

26-hydroxycholesterol (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-phenylprop-2-enal (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

7alpha-hydroxycholesterol (ISO)

acetamide (EXP)

acetate ester (ISO)

acetic acid (ISO)

acrolein (ISO)

adenosine (ISO)

aflatoxin B1 (EXP,ISO)

agomelatine (EXP)

aldehydo-D-glucose (EXP,ISO)

all-trans-retinoic acid (ISO)

all-trans-retinol (ISO)

alpha-D-galactose (EXP,ISO)

alpha-pinene (ISO)

aluminium hydroxide (ISO)

ammonium chloride (EXP)

ampicillin (ISO)

anethole (EXP)

antirheumatic drug (ISO)

arachidonic acid (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

artesunate (EXP)

aspalathin (ISO)

astaxanthin (ISO)

atazanavir sulfate (ISO)

atorvastatin calcium (EXP,ISO)

ATP (ISO)

atrazine (ISO)

auranofin (ISO)

azathioprine (ISO)

baicalin (EXP)

benazepril (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

benzylpenicillin (ISO)

berberine (EXP,ISO)

Besigomsin (ISO)

bicalutamide (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisdemethoxycurcumin (ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (EXP)

bisphenol F (ISO)

boldenone (EXP)

bortezomib (EXP,ISO)

bosentan (EXP)

butyric acid (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

calcitriol (EXP)

cannabidiol (ISO)

capsaicin (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

casticin (ISO)

catalpol (ISO)

cerium trichloride (ISO)

CGP 52608 (ISO)

chaetoglobosin A (ISO)

chenodeoxycholic acid (ISO)

chitosan (ISO)

chlorogenic acid (EXP,ISO)

chloroquine (ISO)

chlorothalonil (ISO)

chlorpyrifos (EXP)

cholesterol (EXP)

choline (ISO)

chromium atom (ISO)

chrysin (EXP,ISO)

cirsilineol (ISO)

cisplatin (EXP,ISO)

cobalt dichloride (EXP,ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

corticosterone (ISO)

cortisol (ISO)

crocin-1 (EXP)

cudratricusxanthone A (ISO)

curcumin (EXP,ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

D-glucose (EXP,ISO)

DAPT (EXP)

daunorubicin (ISO)

dehydroepiandrosterone (EXP)

deoxycholic acid (ISO)

deoxynivalenol (ISO)

desferrioxamine B (ISO)

dexamethasone (EXP,ISO)

dextran sulfate (ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dienogest (ISO)

dihydrogen (EXP)

dimethylarsinous acid (ISO)

dioxygen (EXP,ISO)

diprotium (EXP)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

enalapril (ISO)

enalaprilat dihydrate (EXP)

erythromycin A (ISO)

esculetin (ISO)

ethanol (EXP,ISO)

ethion (ISO)

ethyl methanesulfonate (ISO)

eugenol (ISO)

ferric oxide (ISO)

ferroheme b (ISO)

ferulic acid (ISO)

fisetin (ISO)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (EXP)

fructose (EXP,ISO)

furan (EXP)

gadolinium trichloride (EXP)

galactose (EXP,ISO)

gallocatechin (ISO)

gamma-hexachlorocyclohexane (ISO)

ganglioside GM1 (EXP)

Gastrodin (EXP)

geldanamycin (ISO)

genistein (ISO)

genkwanin (ISO)

gentamycin (EXP)

geraniol (ISO)

Ginkgolide A (ISO)

ginsenoside Re (ISO)

glucose (EXP,ISO)

glutathione (ISO)

glyburide (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

glycyrrhetinate (ISO)

glycyrrhetinic acid (ISO)

halothane (ISO)

helenalin (ISO)

heme b (ISO)

hexadecanoic acid (ISO)

hyaluronic acid (ISO)

hydrogen cyanide (ISO)

hydroquinone (ISO)

ifosfamide (ISO)

indometacin (ISO)

indoprofen (ISO)

irinotecan (ISO)

iron(2+) sulfate (anhydrous) (ISO)

isoamylol (ISO)

isoprenaline (EXP,ISO)

ivermectin (ISO)

kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside (ISO)

ketamine (ISO)

Kukoamine B (ISO)

L-1,4-dithiothreitol (ISO)

L-ascorbic acid (ISO)

L-methionine (ISO)

lactulose (EXP)

lead(0) (ISO)

lead(2+) (ISO)

lidocaine (EXP)

linsidomine (ISO)

lipophosphoglycan (ISO)

lipopolysaccharide (EXP,ISO)

liquiritigenin (EXP)

liquiritin (EXP)

lithium chloride (EXP)

LY294002 (ISO)

lycopene (ISO)

magnesium dihydroxide (ISO)

malathion (ISO)

melatonin (EXP,ISO)

melittin (ISO)

melphalan (ISO)

mesalamine (ISO)

metformin (EXP,ISO)

methadone (EXP,ISO)

methamphetamine (EXP,ISO)

methimazole (EXP)

methotrexate (EXP,ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

Methylthiouracil (ISO)

metronidazole (ISO)

monocrotaline (EXP,ISO)

monodansylcadaverine (ISO)

morphine (EXP,ISO)

Morphine-3-glucuronide (EXP,ISO)

Morroniside (ISO)

muramyl dipeptide (ISO)

myrtenol (EXP)

N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide (EXP)

N-acetyl-L-cysteine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (EXP)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

naloxone (ISO)

naproxen (EXP)

nefazodone (ISO)

neomycin (ISO)

nerolidol (EXP)

nickel dichloride (ISO)

nickel sulfate (ISO)

nicorandil (EXP)

nicotine (EXP,ISO)

nitric oxide (ISO)

Nonidet P-40 (ISO)

Nonylphenol (EXP,ISO)

o-anisidine (ISO)

obeticholic acid (ISO)

omeprazole (EXP)

oxaliplatin (ISO)

ozone (EXP,ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

PD 0325901 (ISO)

pelargonidin (ISO)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

perindopril (EXP)

permethrin (ISO)

phenethyl caffeate (ISO)

phenylmercury acetate (ISO)

phenytoin (ISO)

phorbol 13-acetate 12-myristate (ISO)

phosphatidylinositol dimannoside (ISO)

phosphoramide mustard (EXP)

picropodophyllotoxin (ISO)

pipoxolan (ISO)

pirinixic acid (ISO)

platycodin D (EXP)

polymyxin B2 (ISO)

potassium chromate (ISO)

potassium cyanide (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

probenecid (ISO)

procyanidin B1 (ISO)

progesterone (ISO)

propofol (ISO)

puerarin (ISO)

Pyridostigmine bromide (ISO)

quercetin (EXP,ISO)

reactive oxygen species (ISO)

resveratrol (EXP,ISO)

rosmarinic acid (EXP)

S-allylcysteine (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP,ISO)

Salvianolic acid A (ISO)

salvianolic acid B (EXP)

SB 431542 (ISO)

scoparone (ISO)

scopoletin (EXP)

sevoflurane (EXP)

silicon dioxide (ISO)

simvastatin (EXP,ISO)

sodium arsenite (EXP,ISO)

sodium cholate (EXP)

streptozocin (EXP,ISO)

succimer (ISO)

sulfasalazine (ISO)

sulforaphane (ISO)

sulfur dioxide (ISO)

sumatriptan (EXP)

tartrazine (ISO)

tectorigenin (ISO)

telmisartan (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

tetrachloropalladate(2-) (ISO)

thioacetamide (EXP)

thymoquinone (EXP,ISO)

titanium atom (EXP,ISO)

titanium dioxide (ISO)

toluene (ISO)

trans-anethole (EXP)

trichloroethene (ISO)

tropisetron (EXP)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vitamin D (ISO)

Y-27632 (ISO)

zinc atom (EXP)

zinc protoporphyrin (EXP)

zinc(0) (EXP)

zingerone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (ISO)

astrocyte development (IEA,ISO)

B cell proliferation (ISO)

B cell proliferation involved in immune response (IEA,ISO)

cellular response to amyloid-beta (IEA,ISO)

cellular response to lipopolysaccharide (IEP,ISO)

cellular response to lipoteichoic acid (IEA,ISO)

cellular response to mechanical stimulus (IEA,IEP,ISO)

cellular response to oxidised low-density lipoprotein particle stimulus (IEA,ISO)

cellular response to platelet-derived growth factor stimulus (IEA,ISO)

cellular response to retinoic acid (IEP)

cellular response to type II interferon (IEA,ISO)

defense response to Gram-negative bacterium (IBA,IEA,ISO)

detection of lipopolysaccharide (IEA,ISO,ISS)

detection of mechanical stimulus involved in sensory perception of pain (IMP)

detection of temperature stimulus involved in sensory perception of pain (IMP)

ERK1 and ERK2 cascade (IEA,ISO)

gene expression (IEA,ISO)

I-kappaB kinase/NF-kappaB signaling (ISO)

I-kappaB phosphorylation (IEA,ISO)

immunoglobulin mediated immune response (IEP)

inflammatory response (IBA,ISO)

innate immune response-activating signaling pathway (IMP)

intestinal epithelial structure maintenance (IEA,ISO)

JNK cascade (IEA,ISO)

leukotriene metabolic process (IDA)

lipopolysaccharide-mediated signaling pathway (IEA,ISO)

lymphocyte proliferation (ISO)

macrophage activation (IEA,ISO)

MHC class II biosynthetic process (IEA,ISO)

microglia differentiation (IEA,ISO)

microglial cell activation (IDA)

MyD88-dependent toll-like receptor signaling pathway (IEA,ISO)

negative regulation of cold-induced thermogenesis (ISO,ISS)

negative regulation of ERK1 and ERK2 cascade (IEA,ISO)

negative regulation of interleukin-17 production (IEA,ISO)

negative regulation of interleukin-23 production (IEA,ISO)

negative regulation of interleukin-6 production (IEA,ISO)

negative regulation of tumor necrosis factor production (IEA,ISO)

negative regulation of type II interferon production (IEA,ISO)

neurogenesis (ISO)

nitric oxide biosynthetic process (IEA,ISO)

nitric oxide production involved in inflammatory response (IEA,ISO)

nucleotide-binding oligomerization domain containing 1 signaling pathway (IEA,ISO)

nucleotide-binding oligomerization domain containing 2 signaling pathway (IEA,ISO)

phagocytosis (IEA,ISO)

positive regulation of apoptotic process (IMP)

positive regulation of B cell proliferation (IEA,ISO)

positive regulation of cellular response to macrophage colony-stimulating factor stimulus (IEA,ISO)

positive regulation of chemokine (C-X-C motif) ligand 2 production (IEA,ISO)

positive regulation of chemokine production (ISO)

positive regulation of cytokine production involved in inflammatory response (IEA,ISO)

positive regulation of DNA binding (IMP)

positive regulation of DNA-binding transcription factor activity (IMP)

positive regulation of ERK1 and ERK2 cascade (IEA,ISO)

positive regulation of extrinsic apoptotic signaling pathway (IEA,ISO)

positive regulation of gene expression (ISO)

positive regulation of I-kappaB kinase/NF-kappaB signaling (IEA,ISO)

positive regulation of inflammatory response (IEA,ISO)

positive regulation of interferon-alpha production (IEA,ISO)

positive regulation of interferon-beta production (IEA,ISO)

positive regulation of interleukin-1 beta production (IEA,ISO,ISS)

positive regulation of interleukin-1 production (ISO)

positive regulation of interleukin-10 production (IEA,ISO)

positive regulation of interleukin-12 production (IEA,ISO)

positive regulation of interleukin-6 production (IEA,ISO)

positive regulation of interleukin-8 production (IEA,ISO)

positive regulation of JNK cascade (IEA,ISO)

positive regulation of lymphocyte proliferation (ISO)

positive regulation of macrophage activation (IEA,ISO)

positive regulation of macrophage cytokine production (IEA,ISO)

positive regulation of MAP kinase activity (IEA,ISO)

positive regulation of matrix metallopeptidase secretion (IEA,ISO)

positive regulation of MHC class II biosynthetic process (IEA,ISO)

positive regulation of NF-kappaB transcription factor activity (IEA,IMP,ISO)

positive regulation of NIK/NF-kappaB signaling (IEA,ISO)

positive regulation of nitric oxide biosynthetic process (IEA,ISO)

positive regulation of nitric-oxide synthase biosynthetic process (IEA,ISO)

positive regulation of NLRP3 inflammasome complex assembly (IEA,ISO,ISS)

positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway (IEA,ISO)

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (IEA,ISO)

positive regulation of peptidyl-tyrosine phosphorylation (IDA)

positive regulation of platelet activation (IEA,ISO)

positive regulation of reactive oxygen species biosynthetic process (IEA,ISO)

positive regulation of smooth muscle cell migration (IEA,ISO)

positive regulation of smooth muscle cell proliferation (IEA,ISO)

positive regulation of stress-activated MAPK cascade (ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of tumor necrosis factor production (IEA,ISO)

positive regulation of type II interferon production (IEA,ISO)

regulation of dendritic cell cytokine production (IEA,ISO)

regulation of inflammatory response (ISO)

regulation of tumor necrosis factor production (IMP)

response to activity (IEP)

response to bacterium (ISO)

response to ethanol (IMP)

response to fatty acid (IDA)

response to glucocorticoid (IEP)

response to gold nanoparticle (IEP)

response to hypoxia (IEP)

response to insulin (IEP)

response to lipopolysaccharide (IDA,IEP,ISO)

response to oxidative stress (IMP)

response to progesterone (IEP)

response to retinoic acid (IEP)

response to toxic substance (IEP)

skeletal muscle contraction (IEP)

stress-activated MAPK cascade (ISO)

toll-like receptor 4 signaling pathway (IEA,ISO)

toll-like receptor signaling pathway (IBA,IDA,ISO)

TRIF-dependent toll-like receptor signaling pathway (IEA,ISO)

wound healing involved in inflammatory response (IEA,ISO)

Cellular Component

cell surface (IDA,ISO)

cytoplasm (ISO)

early endosome (IEA)

external side of plasma membrane (IEA,ISO)

Golgi apparatus (IEA,ISO)

lipopolysaccharide receptor complex (IEA,ISO,ISS)

perinuclear region of cytoplasm (IEA,ISO)

phagocytic cup (IEA,ISO)

plasma membrane (ISO)

receptor complex (ISO)

ruffle (IEA)

Molecular Function

identical protein binding (IEA,ISO)

lipopolysaccharide binding (IBA,IDA,IEA,ISO)

lipopolysaccharide immune receptor activity (IBA,IEA,ISO,ISS)

NAD(P)+ nucleosidase activity (IEA)

NAD+ nucleotidase, cyclic ADP-ribose generating (IEA)

phosphatidylinositol 3-kinase binding (IPI)

protein binding (IPI,ISO)

protein heterodimerization activity (IEA,ISO)

signaling receptor activity (ISO)

signaling receptor binding (IEA,ISO)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Chagas disease pathway (IEA)

Entamoebiasis pathway (IEA)

influenza A pathway (IEA)

Leishmaniasis pathway (IEA)

malaria pathway (IEA)

measles pathway (IEA)

phagocytosis pathway (IEA)

rheumatoid arthritis pathway (IEA)

titanium dioxide nanoparticle response pathway (ISO)

Toll-like receptor signaling pathway (IDA,IEA,ISO)

toxoplasmosis pathway (IEA)

tuberculosis pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased tumor necrosis factor secretion (IMP)

References

References - curated

#	Reference Title	Reference Citation
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10.	Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children.	Awomoyi AA, etal., J Immunol. 2007 Sep 1;179(5):3171-7.
11.	Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes.	Bagarolli RA, etal., J Diabetes Complications. 2009 Apr 21.
12.	TLR4 links podocytes with the innate immune system to mediate glomerular injury.	Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
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15.	Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis.	Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
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17.	Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes.	Blanco AM, etal., J Immunol. 2005 Nov 15;175(10):6893-9.
18.	Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury.	Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76.
19.	Expression of Toll-like receptors in healthy and allergic conjunctiva.	Bonini S, etal., Ophthalmology. 2005 Sep;112(9):1528; discussion 1548-9.
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21.	MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages.	Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131.
22.	TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis.	Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31.
23.	Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes.	Buraczynska M, etal., Hum Immunol. 2009 Feb;70(2):121-4. Epub 2009 Jan 7.
24.	Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice.	Canale-Zambrano JC, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G381-90. Epub 2010 Jun 3.
25.	Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.	Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
26.	Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis.	Casale TB, etal., Ann Allergy Asthma Immunol. 2006 Oct;97(4):454-6.
27.	TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis.	Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24.
28.	Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis.	Chang JH, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1711-7.
29.	TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans.	Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.
30.	Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation.	Chen C, etal., Shock. 2009 May;31(5):486-92.
31.	Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion.	Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74.
32.	Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis.	Chen W, etal., Mol Vis. 2009;15:619-28. Epub 2009 Mar 30.
33.	[Effect of electro-acupuncture on hepatic Toll-like receptor 4 and nuclear factor κB expressions in rats with non-alcoholic fatty liver disease].	Chen X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1584-8.
34.	Effect of Toll-like receptor 4 gene polymorphisms on work-related respiratory symptoms and sensitization to wheat flour in bakery workers.	Cho HJ, etal., Ann Allergy Asthma Immunol. 2011 Jul;107(1):57-64. doi: 10.1016/j.anai.2011.04.003. Epub 2011 May 19.
35.	Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples.	Cho Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5614-8. doi: 10.1167/iovs.09-3688. Epub 2009 Jul 23.
36.	Toll-like receptor 4 signalling attenuates experimental allergic conjunctivitis.	Chung SH, etal., Clin Exp Immunol. 2011 May;164(2):275-81. doi: 10.1111/j.1365-2249.2011.04368.x. Epub 2011 Mar 10.
37.	Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis.	Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14.
38.	A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype.	Cundy T, etal., Hum Mol Genet. 2002 Sep 1;11(18):2119-27.
39.	Expression of TLR4 and TLR9 mRNA in Lewis rats with experimental allergic neuritis.	Deng YN and Zhou WB, Neuroimmunomodulation. 2007;14(6):337-43. Epub 2008 Apr 23.
40.	Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance.	Deng ZB, etal., Diabetes. 2009 Aug 12.
41.	Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration.	Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
42.	Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state.	Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20.
43.	Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.	Ding N, etal., Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.
44.	Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes.	Du T, etal., Clin Chim Acta. 2009 Apr;402(1-2):133-8. Epub 2009 Jan 11.
45.	Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM.	Du T, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):208-14. Epub 2008 Nov 17.
46.	Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury.	Dvoriantchikova G, etal., Mol Vis. 2010 Sep 30;16:1907-12.
47.	Significant correlation of TLR4 expression with the clinicopathological features of invasive ductal carcinoma of the breast.	Ehsan N, etal., Tumour Biol. 2013 Apr;34(2):1053-9. doi: 10.1007/s13277-013-0645-y. Epub 2013 Jan 22.
48.	Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis.	Ekman AK, etal., Int Arch Allergy Immunol. 2012;159(1):6-14. doi: 10.1159/000335196. Epub 2012 Apr 27.
49.	Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke.	Enquobahrie DA, etal., Am J Cardiol. 2008 Jun 15;101(12):1683-8. Epub 2008 Apr 9.
50.	Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer.	Etokebe GE, etal., Genet Test Mol Biomarkers. 2009 Dec;13(6):729-34. doi: 10.1089/gtmb.2009.0045.
51.	A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children.	Fageras Bottcher M, etal., J Allergy Clin Immunol. 2004 Sep;114(3):561-7.
52.	Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide.	Fan J, etal., J Immunol 2002 May 15;168(10):5252-9.
53.	Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation.	Ferguson C, etal., Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.
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55.	Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis.	Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
56.	Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats.	Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5.
57.	Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study.	Fuertes E, etal., J Allergy Clin Immunol. 2013 Aug;132(2):342-52.e2. doi: 10.1016/j.jaci.2013.03.007. Epub 2013 Apr 30.
58.	Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis.	Gagro A, etal., Clin Exp Immunol. 2004 Feb;135(2):267-72.
59.	TLR4 mediates early graft failure after intraportal islet transplantation.	Gao Q, etal., Am J Transplant. 2010 Jul;10(7):1588-96. doi: 10.1111/j.1600-6143.2010.03151.x.
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61.	TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation.	Garantziotis S, etal., Am J Respir Crit Care Med. 2010 Apr 1;181(7):666-75. Epub 2009 Dec 10.
62.	Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis.	Garcia-Rodriguez S, etal., J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50.
63.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
64.	A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.	Genuneit J, etal., Clin Exp Allergy. 2009 Dec;39(12):1875-88.
65.	Hypertensive rats are susceptible to TLR4-mediated signaling following exposure to combustion source particulate matter.	Gilmour PS, etal., Inhal Toxicol. 2004;16 Suppl 1:5-18.
66.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
67.	Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata.	Grech I, etal., J Eur Acad Dermatol Venereol. 2012 Dec;26(12):1538-43. doi: 10.1111/j.1468-3083.2011.04338.x. Epub 2011 Nov 16.
68.	Retinoic acid attenuates lipopolysaccharide-induced inflammatory responses by suppressing TLR4/NF-kappaB expression in rat mammary tissue.	Gu B, etal., Int Immunopharmacol. 2010 Jul;10(7):799-805. doi: 10.1016/j.intimp.2010.04.022. Epub 2010 May 10.
69.	Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.	Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
70.	Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis.	Halfhide CP, etal., Thorax. 2009 Sep;64(9):798-805. Epub 2009 Jun 3.
71.	House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells.	Hammad H, etal., Nat Med. 2009 Apr;15(4):410-6. Epub 2009 Mar 29.
72.	Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.	Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
73.	Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.	Hazeki K, etal., Eur J Immunol 2003 Mar;33(3):740-7.
74.	Resveratrol preconditioning protects hepatocytes against hepatic ischemia reperfusion injury via Toll-like receptor 4/nuclear factor-κB signaling pathway in vitro and in vivo.	He D, etal., Int Immunopharmacol. 2016 Jun;35:201-209. doi: 10.1016/j.intimp.2016.03.032. Epub 2016 Apr 16.
75.	Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study.	He Z, etal., Respir Res. 2009 Dec 18;10:126.
76.	Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli.	Heimesaat MM, etal., Gut. 2007 Jul;56(7):941-8. Epub 2007 Jan 25.
77.	Expression of toll-like receptors in chronic otitis media and cholesteatoma.	Hirai H, etal., Int J Pediatr Otorhinolaryngol. 2013 May;77(5):674-6. doi: 10.1016/j.ijporl.2013.01.010. Epub 2013 Feb 4.
78.	Bone marrow and nonbone marrow Toll like receptor 4 regulate acute hepatic injury induced by endotoxemia.	Hochhauser E, etal., PLoS One. 2013 Aug 15;8(8):e73041. doi: 10.1371/journal.pone.0073041. eCollection 2013.
79.	Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction.	Holloway JW, etal., Pharmacogenet Genomics. 2005 Jan;15(1):15-21.
80.	Association of TLR4 polymorphisms with Behcet's disease in a Korean population.	Horie Y, etal., Rheumatology (Oxford). 2009 Jun;48(6):638-42. doi: 10.1093/rheumatology/kep077. Epub 2009 Apr 24.
81.	STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma.	Hsieh YY, etal., Int J Biol Sci. 2009;5(1):74-81. Epub 2009 Jan 9.
82.	Potential role of macrophages in experimental keratomycosis.	Hu J, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2087-94. doi: 10.1167/iovs.07-1237. Epub 2008 Dec 13.
83.	[Changes in adrenal cortex function and protective effect of dexamethasone in septic rats during early phases].	Hu ZJ, et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Jan;21(1):40-3.
84.	Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury.	Hua J, etal., J Gastroenterol Hepatol. 2007 Jun;22(6):862-9. doi: 10.1111/j.1440-1746.2007.04896.x. Epub 2007 May 17.
85.	[The role of expression of Toll-like receptor 2 and Toll-like receptor 4 in hyperoxia-induced acute lung injury in rat]	Huang D, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Nov;21(11):644-7.
86.	TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis.	Huang X, etal., Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4910-6.
87.	Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis.	Hussein YM, etal., Cell Immunol. 2012;274(1-2):34-8. doi: 10.1016/j.cellimm.2012.02.006. Epub 2012 Feb 17.
88.	Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.	Hutchinson MR, etal., Brain Behav Immun. 2008 Nov;22(8):1178-89. doi: 10.1016/j.bbi.2008.05.004. Epub 2008 Jul 2.
89.	Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).	Hutchinson MR, etal., Eur J Neurosci. 2008 Jul;28(1):20-9.
90.	The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome.	Illig T, etal., Diabetes. 2003 Nov;52(11):2861-4.
91.	Role of Toll like receptor 4 signaling pathway in the secondary damage induced by experimental spinal cord injury.	Impellizzeri D, etal., Immunobiology. 2015 Sep;220(9):1039-49. doi: 10.1016/j.imbio.2015.05.013. Epub 2015 May 11.
92.	Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice.	Inokuchi S, etal., Alcohol Clin Exp Res. 2011 Aug;35(8):1509-18. doi: 10.1111/j.1530-0277.2011.01487.x. Epub 2011 Apr 4.
93.	Expression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Study.	Jesic S, etal., Ann Otol Rhinol Laryngol. 2014 Apr 1.
94.	Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.	Jeyaseelan S, etal., Infect Immun. 2005 Mar;73(3):1754-63.
95.	Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.	Jia L, etal., Mol Metab. 2018 Aug;14:121-129. doi: 10.1016/j.molmet.2018.05.015. Epub 2018 May 23.
96.	Inhibition of Toll-like receptor 4 with vasoactive intestinal peptide attenuates liver ischemia-reperfusion injury.	Jiang W, etal., Transplant Proc. 2011 Jun;43(5):1462-7.
97.	A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population.	Jiang ZC, etal., Tumour Biol. 2014 Dec;35(12):12345-52. doi: 10.1007/s13277-014-2547-z. Epub 2014 Sep 2.
98.	Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis.	Jie Zhao, etal., Innate Immun. 2009 Jun;15(3):155-68.
99.	The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis.	Jilling T, etal., J Immunol. 2006 Sep 1;177(5):3273-82.
100.	Expression of toll-like receptors in the healthy and herpes simplex virus-infected cornea.	Jin X, etal., Cornea. 2007 Aug;26(7):847-52.
101.	Expression of toll-like receptors in the Fusarium solani infected cornea.	Jin X, etal., Curr Eye Res. 2008 Apr;33(4):319-24. doi: 10.1080/02713680802008238.
102.	The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection.	Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
103.	[Effects of intestinal trefoil factor on Toll-like receptors 2 and 4 expression in intestinal tissue in young rats with endotoxemia].	Jing K and Sun M, Zhongguo Dang Dai Er Ke Za Zhi. 2011 Dec;13(12):985-8.
104.	Gangliosides trigger inflammatory responses via TLR4 in brain glia.	Jou I, etal., Am J Pathol. 2006 May;168(5):1619-30.
105.	Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis.	Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18.
106.	TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients.	Karaca N, etal., J Eur Acad Dermatol Venereol. 2013 Jan;27(1):e85-90. doi: 10.1111/j.1468-3083.2012.04514.x. Epub 2012 Mar 16.
107.	Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques.	Katsargyris A, etal., Expert Opin Ther Targets. 2010 Jan;14(1):1-10. doi: 10.1517/14728220903401294.
108.	Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma.	Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7.
109.	Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis.	Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
110.	Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts.	Kim K, etal., Clin Nutr. 2013 Oct;32(5):855-62. doi: 10.1016/j.clnu.2012.11.026. Epub 2013 Jan 23.
111.	Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia?	Kim YM, etal., Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):921-7.
112.	Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease.	Kirino Y, etal., Arthritis Res Ther. 2008;10(1):R16. doi: 10.1186/ar2367. Epub 2008 Jan 31.
113.	Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure.	Kitazawa T, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e494-8. Epub 2007 Dec 7.
114.	Therapeutic approach to regulate innate immune response by Toll-like receptor 4 antagonist E5564 in rats with D-galactosamine-induced acute severe liver injury.	Kitazawa T, etal., J Gastroenterol Hepatol. 2009 Jun;24(6):1089-94. Epub 2009 Feb 15.
115.	Salvage effect of E5564, Toll-like receptor 4 antagonist on d-galactosamine and lipopolysaccharide-induced acute liver failure in rats.	Kitazawa T, etal., J Gastroenterol Hepatol. 2010 May;25(5):1009-12. doi: 10.1111/j.1440-1746.2009.06145.x.
116.	Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia.	Knapp S, etal., Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
117.	Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation.	Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20.
118.	Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes.	Kolek MJ, etal., Am Heart J. 2004 Dec;148(6):1034-40.
119.	TLR2 and TLR4 polymorphisms are not associated with acne vulgaris.	Koreck A, etal., Dermatology. 2006;213(3):267-9.
120.	Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats.	Kuang X, etal., Eur J Pharmacol. 2012 Feb 15;676(1-3):51-6. doi: 10.1016/j.ejphar.2011.11.037. Epub 2011 Dec 7.
121.	Pathogen recognition by the innate immune system.	Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
122.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
123.	TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers.	Kwok YH, etal., PLoS One. 2013 Oct 30;8(10):e77799. doi: 10.1371/journal.pone.0077799. eCollection 2013.
124.	Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components.	Laflamme N and Rivest S, FASEB J. 2001 Jan;15(1):155-163.
125.	Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus.	Lartigue A, etal., J Immunol. 2009 Nov 15;183(10):6207-16. doi: 10.4049/jimmunol.0803219. Epub 2009 Oct 19.
126.	TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis.	Lauriello M, etal., Int J Otolaryngol. 2012;2012:925164. doi: 10.1155/2012/925164. Epub 2012 Apr 10.
127.	Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis.	Leal SM Jr, etal., PLoS Pathog. 2010 Jul 1;6:e1000976. doi: 10.1371/journal.ppat.1000976.
128.	TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media.	Leichtle A, etal., Innate Immun. 2009 Aug;15(4):205-15. doi: 10.1177/1753425909103170. Epub 2009 Jul 8.
129.	[Polymorphism 896A/G of TLR4 gene rather than 1196C/T and 2258G/A of TLR2 gene determines severe and complicated course of atopic dermatitis in children].	Levchenko LIu, etal., Tsitol Genet. 2013 May-Jun;47(3):46-53.
130.	Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection.	Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
131.	Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways.	Li DQ, etal., J Allergy Clin Immunol. 2011 Dec;128(6):1318-1325.e2. doi: 10.1016/j.jaci.2011.06.041. Epub 2011 Aug 6.
132.	Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice.	Li H, etal., Anesthesiology. 2010 Sep;113(3):619-29.
133.	[Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice].	Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
134.	Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats.	Li X, etal., Inflamm Res. 2013 Jul;62(7):703-9. doi: 10.1007/s00011-013-0624-1. Epub 2013 Apr 17.
135.	Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways.	Li X, etal., Toxicol Lett. 2016 Nov 2;261:1-12. doi: 10.1016/j.toxlet.2016.09.002. Epub 2016 Sep 4.
136.	Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord.	Li XQ, etal., PLoS One. 2016 Oct 19;11(10):e0163807. doi: 10.1371/journal.pone.0163807. eCollection 2016.
137.	Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-alpha.	Liao P, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R599-607. Epub 2009 Dec 9.
138.	Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells.	Lim SW, etal., Transplantation. 2005 Sep 15;80(5):691-9.
139.	Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy.	Lin M, etal., J Am Soc Nephrol. 2012 Jan;23(1):86-102. doi: 10.1681/ASN.2010111210. Epub 2011 Oct 21.
140.	HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat.	Liu A, etal., Histochem Cell Biol. 2011 May;135(5):443-52. doi: 10.1007/s00418-011-0802-6. Epub 2011 Mar 24.
141.	Changes in gut toll-like receptor-4 and nod-like receptor family pyrin domain containing-3 innate pathways in liver cirrhosis rats with bacterial translocation.	Liu L, etal., Clin Res Hepatol Gastroenterol. 2016 Nov;40(5):575-583. doi: 10.1016/j.clinre.2016.02.008. Epub 2016 Apr 6.
142.	Tibia tumor-induced cancer pain involves spinal p38 mitogen-activated protein kinase activation via TLR4-dependent mechanisms.	Liu S, etal., Brain Res. 2010 Jul 30;1346:213-23. Epub 2010 May 15.
143.	Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis.	Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
144.	[Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats]	Lu ZQ, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):138-41.
145.	Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis.	Lubbad A, etal., Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11.
146.	Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma.	Lun SW, etal., J Clin Immunol. 2009 May;29(3):330-42. Epub 2008 Dec 6.
147.	Evaluation of importance of Toll-like receptor 4 in acute Streptococcus pneumoniae sinusitis in mice.	Luxameechanporn T, etal., Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):1001-6.
148.	Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage.	Ma CX, etal., Chin Med J (Engl). 2009 Jul 5;122(13):1575-81.
149.	The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4.	Maldonado-Bernal C, etal., Parasite Immunol. 2005 Apr;27(4):127-37.
150.	Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles.	Mano SS, etal., Int J Mol Sci. 2013 Jun 26;14(7):13154-70. doi: 10.3390/ijms140713154.
151.	Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity.	Martin SF, etal., J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.
152.	Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcal alpha-toxin.	Maslinska D, etal., Folia Neuropathol. 2004;42(3):125-32.
153.	Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease.	Meguro A, etal., Ann Rheum Dis. 2008 May;67(5):725-7. doi: 10.1136/ard.2007.079871.
154.	Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome.	Methe H, etal., Circulation. 2005 May 24;111(20):2654-61. Epub 2005 May 9.
155.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
156.	Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.	Milanski M, etal., J Neurosci. 2009 Jan 14;29(2):359-70.
157.	In situ TLR2 and TLR4 expression in a murine model of mycetoma caused by Nocardia brasiliensis.	Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
158.	Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma.	Minmin S, etal., PLoS One. 2011 Apr 29;6(4):e19466. doi: 10.1371/journal.pone.0019466.
159.	Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease.	Minoretti P, etal., Neurosci Lett. 2006 Jan 2;391(3):147-9. Epub 2005 Sep 12.
160.	Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse.	Mohammad MK, etal., Int Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25.
161.	Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.	Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
162.	Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and severity of pulmonary tuberculosis in the Asian Indian population.	Najmi N, etal., Tissue Antigens. 2010 Aug;76(2):102-9. Epub 2010 Apr 8.
163.	Involvement of innate immunity in the pathogenesis of intestinal Behcet's disease.	Nara K, etal., Clin Exp Immunol. 2008 May;152(2):245-51. doi: 10.1111/j.1365-2249.2008.03626.x. Epub 2008 Mar 10.
164.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
165.	Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation.	Ohara K, etal., J Neuroinflammation. 2013 Nov 23;10:139. doi: 10.1186/1742-2094-10-139.
166.	Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress.	Okla M, etal., J Biol Chem. 2015 Oct 30;290(44):26476-90. doi: 10.1074/jbc.M115.677724. Epub 2015 Sep 14.
167.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
168.	Association between toll-like receptor 4 gene polymorphism and biopsy-proven giant cell arteritis.	Palomino-Morales R, etal., J Rheumatol. 2009 Jul;36(7):1501-6. doi: 10.3899/jrheum.081286. Epub 2009 Jun 16.
169.	[Expression of toll-like receptors on CD14+ monocytes from patients with chronic obstructive pulmonary disease and smokers]	Pan MM, etal., Zhonghua Yi Xue Za Zhi. 2008 Aug 5;88(30):2103-7.
170.	Myeloid differentiation 2 as a therapeutic target of inflammatory disorders.	Park SH, etal., Pharmacol Ther. 2012 Mar;133(3):291-8. doi: 10.1016/j.pharmthera.2011.11.001. Epub 2011 Nov 19.
171.	Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis.	Pasternak BA, etal., Inflamm Bowel Dis. 2010 May;16(5):856-69. doi: 10.1002/ibd.21132.
172.	Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance.	Paulus SC, etal., Clin Immunol. 2007 Jun;123(3):252-7. Epub 2007 Apr 20.
173.	Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice.	Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
174.	Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis.	Peng Y, etal., Surgery. 2008 May;143(5):679-85. doi: 10.1016/j.surg.2008.01.005.
175.	Effects of gold nanoparticles on endotoxin-induced uveitis in rats.	Pereira DV, etal., Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8036-41. doi: 10.1167/iovs.12-10743.
176.	Surface TLR2 and TLR4 expression on mature rat mast cells can be affected by some bacterial components and proinflammatory cytokines.	Pietrzak A, etal., Mediators Inflamm. 2011;2011:427473. doi: 10.1155/2011/427473. Epub 2011 May 2.
177.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
178.	C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet.	Poggi M, etal., Diabetologia. 2007 Apr 11;.
179.	Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages.	Powers KA, etal., J Exp Med. 2006 Aug 7;203(8):1951-61. Epub 2006 Jul 17.
180.	TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid.	Prabha C, etal., Immunol Lett. 2008 Apr 15;117(1):26-34. Epub 2007 Dec 3.
181.	TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease.	Puthothu B, etal., Dis Markers. 2006;22(5-6):303-8.
182.	Toll-like receptor expression and activation in mice with experimental dry eye.	Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
183.	Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia.	Reismann P, etal., J Neurol. 2004 Jul;251(7):853-8.
184.	Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis.	Ren MY and Wu XY, Parasite Immunol. 2011 Jan;33(1):25-33. doi: 10.1111/j.1365-3024.2010.01247.x.
185.	Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.	Reyna SM, etal., Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.
186.	GOA pipeline	RGD automated data pipeline
187.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
188.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
189.	Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis.	Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
190.	CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis.	Rosas-Taraco AG, etal., J Infect Dis. 2007 Dec 1;196(11):1698-706. Epub 2007 Oct 25.
191.	Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.	Rudofsky G Jr, etal., Diabetes Care. 2004 Jan;27(1):179-83.
192.	Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury.	Rusai K, etal., Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4.
193.	The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma.	Sackesen C, etal., Allergy. 2005 Dec;60(12):1485-92.
194.	Single-nucleotide polymorphism of Toll-like receptor 4 and interleukin-10 in response to interferon-based therapy in Egyptian chronic hepatitis C patients.	Sadik NA, etal., Arch Virol. 2015 Sep;160(9):2181-95. doi: 10.1007/s00705-015-2493-0. Epub 2015 Jun 23.
195.	The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness.	Saint Andre Av, etal., Science. 2002 Mar 8;295(5561):1892-5.
196.	Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis.	Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
197.	The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis.	Saraswathy S, etal., Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3680-6. doi: 10.1167/iovs.09-4575. Epub 2010 Mar 5.
198.	Response of macrophage Toll-like receptor 4 to a Sporothrix schenckii lipid extract during experimental sporotrichosis.	Sassa MF, etal., Immunology. 2009 Oct;128(2):301-9. doi: 10.1111/j.1365-2567.2009.03118.x.
199.	Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis.	Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
200.	Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.	Schmidt M, etal., Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15.
201.	Association of polymorphisms of toll-like receptor 4 with a reduced prevalence of hay fever and atopy.	Senthilselvan A, etal., Ann Allergy Asthma Immunol. 2008 May;100(5):463-8.
202.	Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression.	Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17.
203.	TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10.	Shan JY, etal., Parasite Immunol. 2011 Dec;33(12):692-6. doi: 10.1111/j.1365-3024.2011.01335.x.
204.	Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice.	Sharif R, etal., Gut. 2009 Jun;58(6):813-9. Epub 2009 Feb 6.
205.	TLR4 links innate immunity and fatty acid-induced insulin resistance.	Shi H, etal., J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.
206.	Mechanistic investigation of immunosuppression in patients with condyloma acuminata.	Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
207.	Toll-like receptor 4 mediates lung ischemia-reperfusion injury.	Shimamoto A, etal., Ann Thorac Surg. 2006 Dec;82(6):2017-23.
208.	Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis.	Shirai Y, etal., J Gastroenterol Hepatol. 2013 Apr;28(4):723-30. doi: 10.1111/jgh.12112.
209.	Cyclic stretch enhances the expression of toll-like receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-kappaB pathway.	Shyu KG, etal., J Biomed Sci. 2010 Mar 5;17:15.
210.	[Differential expression of toll-like receptors in chronic suppurative otitis media and cholesteatoma].	Si Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;47(5):388-93.
211.	Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage.	Silva MA, etal., Inflamm Bowel Dis. 2008 May;14(5):632-44.
212.	Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients.	Singh K, etal., Biomed Res Int. 2013;2013:318686. doi: 10.1155/2013/318686. Epub 2013 Jul 11.
213.	TLR4 and TLR9 are induced in oral lichen planus.	Siponen M, etal., J Oral Pathol Med. 2012 Nov;41(10):741-7. doi: 10.1111/j.1600-0714.2012.01169.x. Epub 2012 Jun 5.
214.	Association of TLR4-T399I polymorphism with chronic obstructive pulmonary disease in smokers.	Speletas M, etal., Clin Dev Immunol. 2009;2009:260286. Epub 2010 Feb 15.
215.	TLR2 and TLR4 polymorphisms in familial Mediterranean fever.	Speletas M, etal., Hum Immunol. 2009 Sep;70(9):750-3. doi: 10.1016/j.humimm.2009.05.004. Epub 2009 May 13.
216.	Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4.	Sturges NC, etal., Pediatr Pulmonol. 2010 Sep;45(9):883-9.
217.	Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population.	Suh W, etal., Mol Vis. 2011;17:2343-8. Epub 2011 Aug 31.
218.	Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis.	Summers SA, etal., Kidney Int. 2010 Sep 15.
219.	Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis.	Sun Y, etal., Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
220.	A murine model of contact lens-associated fusarium keratitis.	Sun Y, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1511-6. doi: 10.1167/iovs.09-4237. Epub 2009 Oct 29.
221.	Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma.	Takano Y, etal., Am J Ophthalmol. 2012 Nov;154(5):825-832.e1. doi: 10.1016/j.ajo.2012.03.050. Epub 2012 Jul 24.
222.	Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4.	Takeuchi A, etal., Int Immunopharmacol. 2009 Dec;9(13-14):1562-7. doi: 10.1016/j.intimp.2009.09.012. Epub 2009 Sep 27.
223.	Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain.	Tanga FY, etal., Neurochem Int 2004 Jul-Aug;45(2-3):397-407.
224.	The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.	Tanga FY, etal., Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5856-61. Epub 2005 Apr 4.
225.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
226.	Effects of antibiotics on expression and function of Toll-like receptors 2 and 4 on mononuclear cells in patients with advanced cirrhosis.	Testro AG, etal., J Hepatol. 2010 Feb;52(2):199-205. doi: 10.1016/j.jhep.2009.11.006. Epub 2009 Dec 16.
227.	Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development.	Theodoropoulos GE, etal., Breast. 2012 Aug;21(4):534-8. doi: 10.1016/j.breast.2012.04.001. Epub 2012 May 2.
228.	Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes.	Tian J, etal., Cardiovasc Res. 2013 Jun 1;98(3):391-401. doi: 10.1093/cvr/cvt047. Epub 2013 Feb 27.
229.	Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients.	Tittarelli A, etal., Cancer Immunol Immunother. 2012 Nov;61(11):2067-77. doi: 10.1007/s00262-012-1268-7. Epub 2012 May 3.
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