Tlr4 (toll-like receptor 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tlr4 (toll-like receptor 4) Rattus norvegicus
Analyze
Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 3870
Description: Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; immune response-regulating signaling pathway; and response to steroid hormone. Located in cell surface and cytoplasm. Colocalizes with membrane raft. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; pulpitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetes mellitus (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4); PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tlr4m1Mcwi   Tlr4em1Geh   Tlr4em5Mcwi  
Genetic Models: WI-Tlr4em1Geh BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi FHH-Tlr4m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)Ensembl
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (IEP)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IDA,ISO)
Acute Liver Failure  (IEP,IMP)
Acute Lung Injury  (IEP)
acute necrotizing pancreatitis  (IEP)
acute pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
Acute-On-Chronic Liver Failure  (IEP)
age related macular degeneration 10  (ISO)
Alcoholic Fatty Liver  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
Angina, Stable  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (IDA)
Chemical and Drug Induced Liver Injury  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IEP,ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (IDA,ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA,ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
esophagus adenocarcinoma  (ISO)
eumycotic mycetoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IDA,ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Fungal Eye Infections  (IEP)
Fungal Keratitis  (ISO)
glomerulonephritis  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (IEP)
Herpes Simplex Encephalitis  (IEP)
herpes simplex virus keratitis  (ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (ISO)
ileitis  (IMP,ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (ISO)
kidney failure  (IEP,ISO)
Kidney Reperfusion Injury  (IDA,ISO)
learning disability  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (IEP,ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
low tension glaucoma  (ISO)
lung disease  (IDA,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (IEP)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (IEP)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Meningitis, Escherichia Coli  (ISO)
meningococcal meningitis  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (IEP)
non-alcoholic fatty liver disease  (IEP,ISO)
obesity  (IMP,ISO)
Onchocerciasis, Ocular  (ISO)
Optic Nerve Injuries  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (IMP)
Painful Neuropathy  (ISO)
pancreatitis  (IEP,ISO)
perinatal necrotizing enterocolitis  (IEP,ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO,ISS)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pulpitis  (IEP)
renal fibrosis  (IMP)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,IMP,ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP,ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (IMP)
sporotrichosis  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (IEP)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
uveitis  (IEP)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
viral meningitis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7alpha-hydroxycholesterol  (ISO)
acetamide  (EXP)
acetate ester  (ISO)
acetic acid  (ISO)
acrolein  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (EXP)
aspalathin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
baicalin  (EXP)
benazepril  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
Besigomsin  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boldenone  (EXP)
bortezomib  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
catalpol  (ISO)
cerium trichloride  (ISO)
chaetoglobosin A  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (ISO)
chrysin  (EXP,ISO)
cirsilineol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
crocin-1  (EXP)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DAPT  (EXP)
daunorubicin  (ISO)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dienogest  (ISO)
dihydrogen  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethion  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
galactose  (EXP,ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
ganglioside GM1  (EXP)
Gastrodin  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
halothane  (ISO)
helenalin  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoamylol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketamine  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactulose  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
linsidomine  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithium chloride  (EXP)
LY294002  (ISO)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malathion  (ISO)
melatonin  (EXP)
melittin  (ISO)
melphalan  (ISO)
metformin  (EXP,ISO)
methadone  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
Methylthiouracil  (ISO)
monocrotaline  (EXP,ISO)
monodansylcadaverine  (ISO)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (EXP,ISO)
muramyl dipeptide  (ISO)
myrtenol  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
naproxen  (EXP)
nefazodone  (ISO)
nerolidol  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotine  (EXP)
nitric oxide  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
omeprazole  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pelargonidin  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
permethrin  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol dimannoside  (ISO)
phosphoramide mustard  (EXP)
picropodophyllotoxin  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probenecid  (ISO)
progesterone  (ISO)
propofol  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (EXP)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP)
SB 431542  (ISO)
scoparone  (ISO)
scopoletin  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (EXP)
tartrazine  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachloropalladate(2-)  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP,ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA,ISO)
astrocyte development  (IEA,ISO)
B cell proliferation  (ISO)
B cell proliferation involved in immune response  (IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to interferon-gamma  (IEA,ISO)
cellular response to lipopolysaccharide  (IEP,ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,IEP,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to retinoic acid  (IEP)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (IBA,IEA,ISO)
detection of lipopolysaccharide  (IEA,ISO,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
ERK1 and ERK2 cascade  (IEA,ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
I-kappaB phosphorylation  (IEA,ISO)
immunoglobulin mediated immune response  (IEP)
inflammatory response  (IBA,IEP,ISO)
innate immune response-activating signal transduction  (IMP)
intestinal epithelial structure maintenance  (IEA,ISO)
JNK cascade  (IEA,ISO)
leukotriene metabolic process  (IDA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lymphocyte proliferation  (ISO)
macrophage activation  (IEA,ISO)
MHC class II biosynthetic process  (IEA,ISO)
microglial cell activation  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of interferon-gamma production  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-23 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
nitric oxide biosynthetic process  (IEA,ISO)
nitric oxide production involved in inflammatory response  (IEA,ISO)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
phagocytosis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA binding  (IMP)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
positive regulation of inflammatory response  (IEA,IMP,ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interferon-gamma production  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of interleukin-1 production  (ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of macrophage activation  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of matrix metallopeptidase secretion  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA,IMP,ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
positive regulation of oxidative stress-induced neuron death  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
regulation of dendritic cell cytokine production  (IEA,ISO)
regulation of inflammatory response  (ISO)
regulation of sensory perception of pain  (IMP)
regulation of tumor necrosis factor production  (IMP)
response to activity  (IEP)
response to bacterium  (ISO)
response to ethanol  (IMP)
response to fatty acid  (IDA)
response to glucocorticoid  (IEP)
response to gold nanoparticle  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IDA,IEP,ISO)
response to morphine  (IEP)
response to oxidative stress  (IMP)
response to progesterone  (IEP)
response to retinoic acid  (IEP)
response to toxic substance  (IEP)
skeletal muscle contraction  (IEP)
stress-activated MAPK cascade  (ISO)
toll-like receptor 4 signaling pathway  (IEA,ISO)
toll-like receptor signaling pathway  (IBA,IDA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA,ISO)
wound healing involved in inflammatory response  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Abel B, etal., J Immunol. 2002 Sep 15;169(6):3155-62.
2. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Algandaby MM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):419-28. doi: 10.1007/s00210-016-1210-1. Epub 2016 Jan 26.
4. Ali I, etal., Ann Thorac Surg. 2012 Jan;93(1):282-8. doi: 10.1016/j.athoracsur.2011.08.074. Epub 2011 Nov 23.
5. Alpay HC, etal., Auris Nasus Larynx. 2010 Feb;37(1):29-32. doi: 10.1016/j.anl.2009.03.001. Epub 2009 Apr 26.
6. Alvarez-Rodriguez L, etal., Rheumatology (Oxford). 2011 Sep;50(9):1562-8. doi: 10.1093/rheumatology/ker168. Epub 2011 May 17.
7. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
8. Assassi S, etal., J Rheumatol. 2011 Jan;38(1):87-98. doi: 10.3899/jrheum.100469. Epub 2010 Oct 15.
9. Aumeunier A, etal., PLoS One. 2010 Jul 7;5(7):e11484.
10. Awomoyi AA, etal., J Immunol. 2007 Sep 1;179(5):3171-7.
11. Bagarolli RA, etal., J Diabetes Complications. 2009 Apr 21.
12. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
13. Ben Dhifallah I, etal., Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S58-62.
14. Ben-Ari Z, etal., Cell Physiol Biochem. 2012;30(2):489-98. doi: 10.1159/000341432. Epub 2012 Jul 13.
15. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
16. Bettoni I, etal., Glia. 2008 Sep;56(12):1312-9. doi: 10.1002/glia.20699.
17. Blanco AM, etal., J Immunol. 2005 Nov 15;175(10):6893-9.
18. Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76.
19. Bonini S, etal., Ophthalmology. 2005 Sep;112(9):1528; discussion 1548-9.
20. Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
21. Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131.
22. Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31.
23. Buraczynska M, etal., Hum Immunol. 2009 Feb;70(2):121-4. Epub 2009 Jan 7.
24. Canale-Zambrano JC, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G381-90. Epub 2010 Jun 3.
25. Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
26. Casale TB, etal., Ann Allergy Asthma Immunol. 2006 Oct;97(4):454-6.
27. Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24.
28. Chang JH, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1711-7.
29. Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.
30. Chen C, etal., Shock. 2009 May;31(5):486-92.
31. Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74.
32. Chen W, etal., Mol Vis. 2009;15:619-28. Epub 2009 Mar 30.
33. Chen X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1584-8.
34. Cho HJ, etal., Ann Allergy Asthma Immunol. 2011 Jul;107(1):57-64. doi: 10.1016/j.anai.2011.04.003. Epub 2011 May 19.
35. Cho Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5614-8. doi: 10.1167/iovs.09-3688. Epub 2009 Jul 23.
36. Chung SH, etal., Clin Exp Immunol. 2011 May;164(2):275-81. doi: 10.1111/j.1365-2249.2011.04368.x. Epub 2011 Mar 10.
37. Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14.
38. Cundy T, etal., Hum Mol Genet. 2002 Sep 1;11(18):2119-27.
39. Deng YN and Zhou WB, Neuroimmunomodulation. 2007;14(6):337-43. Epub 2008 Apr 23.
40. Deng ZB, etal., Diabetes. 2009 Aug 12.
41. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
42. Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20.
43. Ding N, etal., Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.
44. Du T, etal., Clin Chim Acta. 2009 Apr;402(1-2):133-8. Epub 2009 Jan 11.
45. Du T, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):208-14. Epub 2008 Nov 17.
46. Dvoriantchikova G, etal., Mol Vis. 2010 Sep 30;16:1907-12.
47. Ehsan N, etal., Tumour Biol. 2013 Apr;34(2):1053-9. doi: 10.1007/s13277-013-0645-y. Epub 2013 Jan 22.
48. Ekman AK, etal., Int Arch Allergy Immunol. 2012;159(1):6-14. doi: 10.1159/000335196. Epub 2012 Apr 27.
49. Enquobahrie DA, etal., Am J Cardiol. 2008 Jun 15;101(12):1683-8. Epub 2008 Apr 9.
50. Etokebe GE, etal., Genet Test Mol Biomarkers. 2009 Dec;13(6):729-34. doi: 10.1089/gtmb.2009.0045.
51. Fageras Bottcher M, etal., J Allergy Clin Immunol. 2004 Sep;114(3):561-7.
52. Fan J, etal., J Immunol 2002 May 15;168(10):5252-9.
53. Ferguson C, etal., Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.
54. Forte A, etal., Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8.
55. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
56. Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5.
57. Fuertes E, etal., J Allergy Clin Immunol. 2013 Aug;132(2):342-52.e2. doi: 10.1016/j.jaci.2013.03.007. Epub 2013 Apr 30.
58. Gagro A, etal., Clin Exp Immunol. 2004 Feb;135(2):267-72.
59. Gao Q, etal., Am J Transplant. 2010 Jul;10(7):1588-96. doi: 10.1111/j.1600-6143.2010.03151.x.
60. Gao Y and Guo ZP, Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40(4):655-7.
61. Garantziotis S, etal., Am J Respir Crit Care Med. 2010 Apr 1;181(7):666-75. Epub 2009 Dec 10.
62. Garcia-Rodriguez S, etal., J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50.
63. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
64. Genuneit J, etal., Clin Exp Allergy. 2009 Dec;39(12):1875-88.
65. Gilmour PS, etal., Inhal Toxicol. 2004;16 Suppl 1:5-18.
66. GOA data from the GO Consortium
67. Grech I, etal., J Eur Acad Dermatol Venereol. 2012 Dec;26(12):1538-43. doi: 10.1111/j.1468-3083.2011.04338.x. Epub 2011 Nov 16.
68. Gu B, etal., Int Immunopharmacol. 2010 Jul;10(7):799-805. doi: 10.1016/j.intimp.2010.04.022. Epub 2010 May 10.
69. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
70. Halfhide CP, etal., Thorax. 2009 Sep;64(9):798-805. Epub 2009 Jun 3.
71. Hammad H, etal., Nat Med. 2009 Apr;15(4):410-6. Epub 2009 Mar 29.
72. Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
73. Hazeki K, etal., Eur J Immunol 2003 Mar;33(3):740-7.
74. He D, etal., Int Immunopharmacol. 2016 Jun;35:201-209. doi: 10.1016/j.intimp.2016.03.032. Epub 2016 Apr 16.
75. He Z, etal., Respir Res. 2009 Dec 18;10:126.
76. Heimesaat MM, etal., Gut. 2007 Jul;56(7):941-8. Epub 2007 Jan 25.
77. Hirai H, etal., Int J Pediatr Otorhinolaryngol. 2013 May;77(5):674-6. doi: 10.1016/j.ijporl.2013.01.010. Epub 2013 Feb 4.
78. Hochhauser E, etal., PLoS One. 2013 Aug 15;8(8):e73041. doi: 10.1371/journal.pone.0073041. eCollection 2013.
79. Holloway JW, etal., Pharmacogenet Genomics. 2005 Jan;15(1):15-21.
80. Horie Y, etal., Rheumatology (Oxford). 2009 Jun;48(6):638-42. doi: 10.1093/rheumatology/kep077. Epub 2009 Apr 24.
81. Hsieh YY, etal., Int J Biol Sci. 2009;5(1):74-81. Epub 2009 Jan 9.
82. Hu J, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2087-94. doi: 10.1167/iovs.07-1237. Epub 2008 Dec 13.
83. Hu ZJ, et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Jan;21(1):40-3.
84. Hua J, etal., J Gastroenterol Hepatol. 2007 Jun;22(6):862-9. doi: 10.1111/j.1440-1746.2007.04896.x. Epub 2007 May 17.
85. Huang D, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Nov;21(11):644-7.
86. Huang X, etal., Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4910-6.
87. Hussein YM, etal., Cell Immunol. 2012;274(1-2):34-8. doi: 10.1016/j.cellimm.2012.02.006. Epub 2012 Feb 17.
88. Hutchinson MR, etal., Brain Behav Immun. 2008 Nov;22(8):1178-89. doi: 10.1016/j.bbi.2008.05.004. Epub 2008 Jul 2.
89. Hutchinson MR, etal., Eur J Neurosci. 2008 Jul;28(1):20-9.
90. Illig T, etal., Diabetes. 2003 Nov;52(11):2861-4.
91. Impellizzeri D, etal., Immunobiology. 2015 Sep;220(9):1039-49. doi: 10.1016/j.imbio.2015.05.013. Epub 2015 May 11.
92. Inokuchi S, etal., Alcohol Clin Exp Res. 2011 Aug;35(8):1509-18. doi: 10.1111/j.1530-0277.2011.01487.x. Epub 2011 Apr 4.
93. Jesic S, etal., Ann Otol Rhinol Laryngol. 2014 Apr 1.
94. Jeyaseelan S, etal., Infect Immun. 2005 Mar;73(3):1754-63.
95. Jia L, etal., Mol Metab. 2018 Aug;14:121-129. doi: 10.1016/j.molmet.2018.05.015. Epub 2018 May 23.
96. Jiang W, etal., Transplant Proc. 2011 Jun;43(5):1462-7.
97. Jiang ZC, etal., Tumour Biol. 2014 Dec;35(12):12345-52. doi: 10.1007/s13277-014-2547-z. Epub 2014 Sep 2.
98. Jie Zhao, etal., Innate Immun. 2009 Jun;15(3):155-68.
99. Jilling T, etal., J Immunol. 2006 Sep 1;177(5):3273-82.
100. Jin X, etal., Cornea. 2007 Aug;26(7):847-52.
101. Jin X, etal., Curr Eye Res. 2008 Apr;33(4):319-24. doi: 10.1080/02713680802008238.
102. Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
103. Jing K and Sun M, Zhongguo Dang Dai Er Ke Za Zhi. 2011 Dec;13(12):985-8.
104. Jou I, etal., Am J Pathol. 2006 May;168(5):1619-30.
105. Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18.
106. Karaca N, etal., J Eur Acad Dermatol Venereol. 2013 Jan;27(1):e85-90. doi: 10.1111/j.1468-3083.2012.04514.x. Epub 2012 Mar 16.
107. Katsargyris A, etal., Expert Opin Ther Targets. 2010 Jan;14(1):1-10. doi: 10.1517/14728220903401294.
108. Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7.
109. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
110. Kim K, etal., Clin Nutr. 2013 Oct;32(5):855-62. doi: 10.1016/j.clnu.2012.11.026. Epub 2013 Jan 23.
111. Kim YM, etal., Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):921-7.
112. Kirino Y, etal., Arthritis Res Ther. 2008;10(1):R16. doi: 10.1186/ar2367. Epub 2008 Jan 31.
113. Kitazawa T, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e494-8. Epub 2007 Dec 7.
114. Kitazawa T, etal., J Gastroenterol Hepatol. 2009 Jun;24(6):1089-94. Epub 2009 Feb 15.
115. Kitazawa T, etal., J Gastroenterol Hepatol. 2010 May;25(5):1009-12. doi: 10.1111/j.1440-1746.2009.06145.x.
116. Knapp S, etal., Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
117. Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20.
118. Kolek MJ, etal., Am Heart J. 2004 Dec;148(6):1034-40.
119. Koreck A, etal., Dermatology. 2006;213(3):267-9.
120. Kuang X, etal., Eur J Pharmacol. 2012 Feb 15;676(1-3):51-6. doi: 10.1016/j.ejphar.2011.11.037. Epub 2011 Dec 7.
121. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
122. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
123. Kwok YH, etal., PLoS One. 2013 Oct 30;8(10):e77799. doi: 10.1371/journal.pone.0077799. eCollection 2013.
124. Laflamme N and Rivest S, FASEB J. 2001 Jan;15(1):155-163.
125. Lartigue A, etal., J Immunol. 2009 Nov 15;183(10):6207-16. doi: 10.4049/jimmunol.0803219. Epub 2009 Oct 19.
126. Lauriello M, etal., Int J Otolaryngol. 2012;2012:925164. doi: 10.1155/2012/925164. Epub 2012 Apr 10.
127. Leal SM Jr, etal., PLoS Pathog. 2010 Jul 1;6:e1000976. doi: 10.1371/journal.ppat.1000976.
128. Leichtle A, etal., Innate Immun. 2009 Aug;15(4):205-15. doi: 10.1177/1753425909103170. Epub 2009 Jul 8.
129. Levchenko LIu, etal., Tsitol Genet. 2013 May-Jun;47(3):46-53.
130. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
131. Li DQ, etal., J Allergy Clin Immunol. 2011 Dec;128(6):1318-1325.e2. doi: 10.1016/j.jaci.2011.06.041. Epub 2011 Aug 6.
132. Li H, etal., Anesthesiology. 2010 Sep;113(3):619-29.
133. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
134. Li X, etal., Inflamm Res. 2013 Jul;62(7):703-9. doi: 10.1007/s00011-013-0624-1. Epub 2013 Apr 17.
135. Li X, etal., Toxicol Lett. 2016 Nov 2;261:1-12. doi: 10.1016/j.toxlet.2016.09.002. Epub 2016 Sep 4.
136. Li XQ, etal., PLoS One. 2016 Oct 19;11(10):e0163807. doi: 10.1371/journal.pone.0163807. eCollection 2016.
137. Liao P, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R599-607. Epub 2009 Dec 9.
138. Lim SW, etal., Transplantation. 2005 Sep 15;80(5):691-9.
139. Lin M, etal., J Am Soc Nephrol. 2012 Jan;23(1):86-102. doi: 10.1681/ASN.2010111210. Epub 2011 Oct 21.
140. Liu A, etal., Histochem Cell Biol. 2011 May;135(5):443-52. doi: 10.1007/s00418-011-0802-6. Epub 2011 Mar 24.
141. Liu L, etal., Clin Res Hepatol Gastroenterol. 2016 Nov;40(5):575-583. doi: 10.1016/j.clinre.2016.02.008. Epub 2016 Apr 6.
142. Liu S, etal., Brain Res. 2010 Jul 30;1346:213-23. Epub 2010 May 15.
143. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
144. Lu ZQ, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):138-41.
145. Lubbad A, etal., Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11.
146. Lun SW, etal., J Clin Immunol. 2009 May;29(3):330-42. Epub 2008 Dec 6.
147. Luxameechanporn T, etal., Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):1001-6.
148. Ma CX, etal., Chin Med J (Engl). 2009 Jul 5;122(13):1575-81.
149. Maldonado-Bernal C, etal., Parasite Immunol. 2005 Apr;27(4):127-37.
150. Mano SS, etal., Int J Mol Sci. 2013 Jun 26;14(7):13154-70. doi: 10.3390/ijms140713154.
151. Martin SF, etal., J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.
152. Maslinska D, etal., Folia Neuropathol. 2004;42(3):125-32.
153. Meguro A, etal., Ann Rheum Dis. 2008 May;67(5):725-7. doi: 10.1136/ard.2007.079871.
154. Methe H, etal., Circulation. 2005 May 24;111(20):2654-61. Epub 2005 May 9.
155. MGD data from the GO Consortium
156. Milanski M, etal., J Neurosci. 2009 Jan 14;29(2):359-70.
157. Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
158. Minmin S, etal., PLoS One. 2011 Apr 29;6(4):e19466. doi: 10.1371/journal.pone.0019466.
159. Minoretti P, etal., Neurosci Lett. 2006 Jan 2;391(3):147-9. Epub 2005 Sep 12.
160. Mohammad MK, etal., Int Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25.
161. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
162. Najmi N, etal., Tissue Antigens. 2010 Aug;76(2):102-9. Epub 2010 Apr 8.
163. Nara K, etal., Clin Exp Immunol. 2008 May;152(2):245-51. doi: 10.1111/j.1365-2249.2008.03626.x. Epub 2008 Mar 10.
164. NCBI rat LocusLink and RefSeq merged data July 26, 2002
165. Ohara K, etal., J Neuroinflammation. 2013 Nov 23;10:139. doi: 10.1186/1742-2094-10-139.
166. Okla M, etal., J Biol Chem. 2015 Oct 30;290(44):26476-90. doi: 10.1074/jbc.M115.677724. Epub 2015 Sep 14.
167. OMIM Disease Annotation Pipeline
168. Palomino-Morales R, etal., J Rheumatol. 2009 Jul;36(7):1501-6. doi: 10.3899/jrheum.081286. Epub 2009 Jun 16.
169. Pan MM, etal., Zhonghua Yi Xue Za Zhi. 2008 Aug 5;88(30):2103-7.
170. Park SH, etal., Pharmacol Ther. 2012 Mar;133(3):291-8. doi: 10.1016/j.pharmthera.2011.11.001. Epub 2011 Nov 19.
171. Pasternak BA, etal., Inflamm Bowel Dis. 2010 May;16(5):856-69. doi: 10.1002/ibd.21132.
172. Paulus SC, etal., Clin Immunol. 2007 Jun;123(3):252-7. Epub 2007 Apr 20.
173. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
174. Peng Y, etal., Surgery. 2008 May;143(5):679-85. doi: 10.1016/j.surg.2008.01.005.
175. Pereira DV, etal., Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8036-41. doi: 10.1167/iovs.12-10743.
176. Pietrzak A, etal., Mediators Inflamm. 2011;2011:427473. doi: 10.1155/2011/427473. Epub 2011 May 2.
177. Pipeline to import KEGG annotations from KEGG into RGD
178. Poggi M, etal., Diabetologia. 2007 Apr 11;.
179. Powers KA, etal., J Exp Med. 2006 Aug 7;203(8):1951-61. Epub 2006 Jul 17.
180. Prabha C, etal., Immunol Lett. 2008 Apr 15;117(1):26-34. Epub 2007 Dec 3.
181. Puthothu B, etal., Dis Markers. 2006;22(5-6):303-8.
182. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
183. Reismann P, etal., J Neurol. 2004 Jul;251(7):853-8.
184. Ren MY and Wu XY, Parasite Immunol. 2011 Jan;33(1):25-33. doi: 10.1111/j.1365-3024.2010.01247.x.
185. Reyna SM, etal., Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.
186. RGD automated data pipeline
187. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
188. RGD automated import pipeline for gene-chemical interactions
189. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
190. Rosas-Taraco AG, etal., J Infect Dis. 2007 Dec 1;196(11):1698-706. Epub 2007 Oct 25.
191. Rudofsky G Jr, etal., Diabetes Care. 2004 Jan;27(1):179-83.
192. Rusai K, etal., Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4.
193. Sackesen C, etal., Allergy. 2005 Dec;60(12):1485-92.
194. Sadik NA, etal., Arch Virol. 2015 Sep;160(9):2181-95. doi: 10.1007/s00705-015-2493-0. Epub 2015 Jun 23.
195. Saint Andre Av, etal., Science. 2002 Mar 8;295(5561):1892-5.
196. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
197. Saraswathy S, etal., Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3680-6. doi: 10.1167/iovs.09-4575. Epub 2010 Mar 5.
198. Sassa MF, etal., Immunology. 2009 Oct;128(2):301-9. doi: 10.1111/j.1365-2567.2009.03118.x.
199. Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
200. Schmidt M, etal., Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15.
201. Senthilselvan A, etal., Ann Allergy Asthma Immunol. 2008 May;100(5):463-8.
202. Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17.
203. Shan JY, etal., Parasite Immunol. 2011 Dec;33(12):692-6. doi: 10.1111/j.1365-3024.2011.01335.x.
204. Sharif R, etal., Gut. 2009 Jun;58(6):813-9. Epub 2009 Feb 6.
205. Shi H, etal., J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.
206. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
207. Shimamoto A, etal., Ann Thorac Surg. 2006 Dec;82(6):2017-23.
208. Shirai Y, etal., J Gastroenterol Hepatol. 2013 Apr;28(4):723-30. doi: 10.1111/jgh.12112.
209. Shyu KG, etal., J Biomed Sci. 2010 Mar 5;17:15.
210. Si Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;47(5):388-93.
211. Silva MA, etal., Inflamm Bowel Dis. 2008 May;14(5):632-44.
212. Singh K, etal., Biomed Res Int. 2013;2013:318686. doi: 10.1155/2013/318686. Epub 2013 Jul 11.
213. Siponen M, etal., J Oral Pathol Med. 2012 Nov;41(10):741-7. doi: 10.1111/j.1600-0714.2012.01169.x. Epub 2012 Jun 5.
214. Speletas M, etal., Clin Dev Immunol. 2009;2009:260286. Epub 2010 Feb 15.
215. Speletas M, etal., Hum Immunol. 2009 Sep;70(9):750-3. doi: 10.1016/j.humimm.2009.05.004. Epub 2009 May 13.
216. Sturges NC, etal., Pediatr Pulmonol. 2010 Sep;45(9):883-9.
217. Suh W, etal., Mol Vis. 2011;17:2343-8. Epub 2011 Aug 31.
218. Summers SA, etal., Kidney Int. 2010 Sep 15.
219. Sun Y, etal., Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
220. Sun Y, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1511-6. doi: 10.1167/iovs.09-4237. Epub 2009 Oct 29.
221. Takano Y, etal., Am J Ophthalmol. 2012 Nov;154(5):825-832.e1. doi: 10.1016/j.ajo.2012.03.050. Epub 2012 Jul 24.
222. Takeuchi A, etal., Int Immunopharmacol. 2009 Dec;9(13-14):1562-7. doi: 10.1016/j.intimp.2009.09.012. Epub 2009 Sep 27.
223. Tanga FY, etal., Neurochem Int 2004 Jul-Aug;45(2-3):397-407.
224. Tanga FY, etal., Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5856-61. Epub 2005 Apr 4.
225. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
226. Testro AG, etal., J Hepatol. 2010 Feb;52(2):199-205. doi: 10.1016/j.jhep.2009.11.006. Epub 2009 Dec 16.
227. Theodoropoulos GE, etal., Breast. 2012 Aug;21(4):534-8. doi: 10.1016/j.breast.2012.04.001. Epub 2012 May 2.
228. Tian J, etal., Cardiovasc Res. 2013 Jun 1;98(3):391-401. doi: 10.1093/cvr/cvt047. Epub 2013 Feb 27.
229. Tittarelli A, etal., Cancer Immunol Immunother. 2012 Nov;61(11):2067-77. doi: 10.1007/s00262-012-1268-7. Epub 2012 May 3.
230. Tu CT, etal., Food Chem Toxicol. 2012 Sep;50(9):3343-51. doi: 10.1016/j.fct.2012.05.050. Epub 2012 Jun 7.
231. Tullos NA, etal., Curr Eye Res. 2013 Oct;38(10):1036-48. doi: 10.3109/02713683.2013.804094. Epub 2013 Jul 10.
232. Tuon FF, etal., J Dermatol Sci. 2010 Jul;59(1):55-7. doi: 10.1016/j.jdermsci.2010.04.009. Epub 2010 May 20.
233. Vainas T, etal., J Vasc Surg. 2006 Aug;44(2):326-32.
234. van Well GT, etal., PLoS One. 2012;7(5):e35837. doi: 10.1371/journal.pone.0035837. Epub 2012 May 25.
235. van Well GT, etal., PLoS One. 2013 May 14;8(5):e64252. doi: 10.1371/journal.pone.0064252. Print 2013.
236. Velez DR, etal., Hum Genet. 2009 Nov;126(5):643-53. Epub 2009 Jul 3.
237. Viriyakosol S, etal., Infect Immun. 2006 Feb;74(2):887-95.
238. Wang CS and Dong Z, Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Aug;38(4):243-6.
239. Wang GB, etal., Zhonghua Er Ke Za Zhi. 2008 Jan;46(1):49-54.
240. Wang J, etal., Mol Vis. 2011 Jan 18;17:170-6.
241. Wang N, etal., Curr Eye Res. 2014 Jan;39(1):47-52. doi: 10.3109/02713683.2013.827212. Epub 2013 Sep 27.
242. Wang S, etal., Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28.
243. Wieland CW, etal., Eur Respir J. 2010 Jul 22.
244. Wolfs TG, etal., J Immunol. 2002 Feb 1;168(3):1286-93.
245. Wu FX, etal., Int J Med Sci. 2010 Aug 2;7(5):251-9.
246. Wu HS, etal., Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):609-13.
247. Wu R, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Mar;25(3):201-3.
248. Wu YW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2009 Feb;32(2):111-4.
249. Xia Y, etal., Brain Res. 2006 Jun 20;1095(1):85-95. Epub 2006 May 12.
250. Xu J, etal., J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):140-6.
251. Yan CG, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Dec;19(12):731-4.
252. Yan JE, etal., Neurosci Lett. 2012 Sep 20;526(1):54-8. doi: 10.1016/j.neulet.2012.08.012. Epub 2012 Aug 15.
253. Yang CX, etal., Tissue Antigens. 2013 Apr;81(4):221-6. doi: 10.1111/tan.12096.
254. Yang IA, etal., Atherosclerosis. 2003 Sep;170(1):187-90.
255. Yao XM, etal., Hepatol Res. 2009 Mar 10.
256. Yao YM, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Nov;15(11):646-50.
257. Ye D, etal., Gut. 2012 Jul;61(7):1058-67. doi: 10.1136/gutjnl-2011-300269. Epub 2012 Jan 17.
258. Yin Y, etal., Cell Physiol Biochem. 2017;42(2):469-479. doi: 10.1159/000477594. Epub 2017 Jun 5.
259. Young KC, etal., Exp Lung Res. 2010 Mar;36(2):111-9.
260. Yu M, etal., Croat Med J. 2006 Dec;47(6):825-31.
261. Yuan FF, etal., Immunol Cell Biol. 2008 Mar-Apr;86(3):268-70. Epub 2008 Jan 8.
262. Zager RA, etal., Am J Physiol Renal Physiol. 2006 Sep;291(3):F546-56. Epub 2006 Apr 25.
263. Zanchi NE, etal., Eur J Appl Physiol. 2010 Aug;109(6):1095-102. Epub 2010 Apr 6.
264. Zanotti G, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L52-63. Epub 2009 Apr 17.
265. Zareparsi S, etal., Hum Mol Genet. 2005 Jun 1;14(11):1449-55. Epub 2005 Apr 13.
266. Zee RY, etal., Stroke. 2005 Jan;36(1):154-7. Epub 2004 Dec 2.
267. Zhang L, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Mar;18(3):161-4.
268. Zhang Q, etal., Acta Otolaryngol. 2013 Feb;133(2):165-73. doi: 10.3109/00016489.2012.717713. Epub 2012 Nov 19.
269. Zhang X, etal., J Clin Invest. 2006 Nov;116(11):3050-9. Epub 2006 Oct 19.
270. Zhao H, etal., J Immunol. 2010 May 1;184(9):5308-14. Epub 2010 Mar 31.
271. Zheng XY, etal., Chin J Integr Med. 2012 Dec;18(12):918-24. doi: 10.1007/s11655-012-1295-1. Epub 2012 Dec 13.
272. Zheng Z, etal., Brain Res. 2012 Dec 13;1489:90-7. doi: 10.1016/j.brainres.2012.10.014. Epub 2012 Oct 24.
273. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
274. Zhu W, etal., Inflamm Res. 2011 Oct;60(10):937-45. doi: 10.1007/s00011-011-0354-1. Epub 2011 Jun 21.
Additional References at PubMed
PMID:10229796   PMID:10430608   PMID:10549626   PMID:10607756   PMID:10623794   PMID:10835634   PMID:10880523   PMID:11274165   PMID:11294571   PMID:11432859   PMID:11489994   PMID:11672593  
PMID:12055258   PMID:12594207   PMID:12824464   PMID:14599981   PMID:14691481   PMID:15027902   PMID:15334694   PMID:15356140   PMID:15661922   PMID:15712600   PMID:15737196   PMID:15793310  
PMID:15841051   PMID:15935092   PMID:16260493   PMID:16338228   PMID:16386178   PMID:16489656   PMID:16514062   PMID:16522744   PMID:16543639   PMID:16870940   PMID:16879219   PMID:16954392  
PMID:17417665   PMID:17446308   PMID:17512285   PMID:17553348   PMID:17560208   PMID:17565820   PMID:17634395   PMID:17896797   PMID:17951129   PMID:17971865   PMID:17974996   PMID:18203139  
PMID:18204298   PMID:18261938   PMID:18343629   PMID:18397856   PMID:18476595   PMID:18592153   PMID:18677579   PMID:18756515   PMID:18787027   PMID:18820689   PMID:19034968   PMID:19047410  
PMID:19115402   PMID:19201895   PMID:19215923   PMID:19252480   PMID:19375882   PMID:19454685   PMID:19584052   PMID:19593445   PMID:19625374   PMID:19695174   PMID:19705455   PMID:19726014  
PMID:19734906   PMID:19740627   PMID:19824106   PMID:19852543   PMID:20016926   PMID:20021788   PMID:20037584   PMID:20043889   PMID:20051628   PMID:20107953   PMID:20113783   PMID:20127518  
PMID:20130368   PMID:20143470   PMID:20150961   PMID:20302880   PMID:20332628   PMID:20441697   PMID:20534845   PMID:20586888   PMID:20646617   PMID:20649597   PMID:20652722   PMID:20654065  
PMID:20665543   PMID:20670634   PMID:20717659   PMID:20945364   PMID:21109260   PMID:21151968   PMID:21186609   PMID:21227038   PMID:21248757   PMID:21329689   PMID:21343866   PMID:21368176  
PMID:21434346   PMID:21490391   PMID:21503675   PMID:21515354   PMID:21543208   PMID:21570752   PMID:21609717   PMID:21659958   PMID:21675862   PMID:21699766   PMID:21772666   PMID:21870333  
PMID:21878382   PMID:22002480   PMID:22053929   PMID:22067617   PMID:22086008   PMID:22097716   PMID:22207578   PMID:22233532   PMID:22246136   PMID:22288937   PMID:22381760   PMID:22392144  
PMID:22422608   PMID:22496605   PMID:22523073   PMID:22564590   PMID:22577135   PMID:22590866   PMID:22735756   PMID:22737905   PMID:22837686   PMID:22850250   PMID:22870324   PMID:22927965  
PMID:22957757   PMID:23040781   PMID:23050932   PMID:23059983   PMID:23082119   PMID:23116637   PMID:23141143   PMID:23146752   PMID:23155421   PMID:23165960   PMID:23171961   PMID:23280522  
PMID:23295061   PMID:23388509   PMID:23402995   PMID:23423259   PMID:23426570   PMID:23428594   PMID:23534838   PMID:23559285   PMID:23568774   PMID:23574173   PMID:23628899   PMID:23645013  
PMID:23656243   PMID:23691208   PMID:23790335   PMID:23791745   PMID:23812099   PMID:23817958   PMID:23840067   PMID:23844137   PMID:23861108   PMID:23874864   PMID:23884833   PMID:23970162  
PMID:23973554   PMID:23973924   PMID:23982744   PMID:24091496   PMID:24111943   PMID:24142717   PMID:24167596   PMID:24214856   PMID:24223475   PMID:24261962   PMID:24298017   PMID:24324707  
PMID:24423688   PMID:24428851   PMID:24429329   PMID:24472280   PMID:24499354   PMID:24573569   PMID:24582748   PMID:24587659   PMID:24601788   PMID:24612634   PMID:24660535   PMID:24667851  
PMID:24680857   PMID:24717912   PMID:24729619   PMID:24740015   PMID:24751148   PMID:24751828   PMID:24840167   PMID:24842692   PMID:24846408   PMID:24937603   PMID:25089018   PMID:25093580  
PMID:25103966   PMID:25106729   PMID:25108428   PMID:25169970   PMID:25171787   PMID:25204797   PMID:25223904   PMID:25318877   PMID:25342286   PMID:25343247   PMID:25359392   PMID:25400741  
PMID:25404055   PMID:25446875   PMID:25448126   PMID:25459886   PMID:25465639   PMID:25497689   PMID:25498891   PMID:25530127   PMID:25545945   PMID:25567426   PMID:25592618   PMID:25600901  
PMID:25619390   PMID:25652858   PMID:25695672   PMID:25732086   PMID:25738964   PMID:25772012   PMID:25780291   PMID:25783987   PMID:25810567   PMID:25811788   PMID:25821307   PMID:25826492  
PMID:25853857   PMID:25880347   PMID:25895164   PMID:25931256   PMID:25978623   PMID:25979559   PMID:25986658   PMID:26033363   PMID:26056446   PMID:26065826   PMID:26085359   PMID:26116862  
PMID:26119193   PMID:26229403   PMID:26279421   PMID:26290459   PMID:26312770   PMID:26390417   PMID:26434622   PMID:26436391   PMID:26465095   PMID:26477505   PMID:26510582   PMID:26556957  
PMID:26585410   PMID:26617842   PMID:26637556   PMID:26657742   PMID:26699475   PMID:26707779   PMID:26744383   PMID:26770978   PMID:26802935   PMID:26806574   PMID:26859874   PMID:26895894  
PMID:26899371   PMID:26962463   PMID:26966782   PMID:27031871   PMID:27057550   PMID:27107073   PMID:27107801   PMID:27187237   PMID:27193049   PMID:27279424   PMID:27318790   PMID:27412936  
PMID:27413256   PMID:27431018   PMID:27494109   PMID:27506813   PMID:27519154   PMID:27538408   PMID:27539497   PMID:27590301   PMID:27665434   PMID:27681173   PMID:27714571   PMID:27756052  
PMID:27776340   PMID:27916733   PMID:27922677   PMID:27956802   PMID:27981756   PMID:27986929   PMID:28033732   PMID:28096568   PMID:28098138   PMID:28272417   PMID:28291959   PMID:28306133  
PMID:28359050   PMID:28410596   PMID:28412141   PMID:28432060   PMID:28525945   PMID:28542370   PMID:28547529   PMID:28623271   PMID:28690033   PMID:28692063   PMID:28692940   PMID:28714001  
PMID:28753906   PMID:28771774   PMID:28808786   PMID:28827130   PMID:28855278   PMID:28946139   PMID:28978536   PMID:29039447   PMID:29113143   PMID:29115455   PMID:29142263   PMID:29157986  
PMID:29193143   PMID:29215742   PMID:29222622   PMID:29281615   PMID:29304519   PMID:29309503   PMID:29359143   PMID:29488614   PMID:29508184   PMID:29510084   PMID:29511370   PMID:29524303  
PMID:29532872   PMID:29536648   PMID:29589070   PMID:29627845   PMID:29656686   PMID:29682548   PMID:29749502   PMID:29845266   PMID:29845292   PMID:29907783   PMID:29940584   PMID:29944647  
PMID:30031930   PMID:30032721   PMID:30046125   PMID:30143913   PMID:30195636   PMID:30221655   PMID:30292407   PMID:30293084   PMID:30321456   PMID:30541949   PMID:30610955   PMID:30718548  
PMID:30793463   PMID:30883606   PMID:30901719   PMID:30953818   PMID:30978539   PMID:30980393   PMID:31002842   PMID:31096078   PMID:31173204   PMID:31220774   PMID:31256136   PMID:31288981  
PMID:31318049   PMID:31376096   PMID:31391320   PMID:31432123   PMID:31444671   PMID:31595494   PMID:31598849   PMID:31678414   PMID:31781182   PMID:31801411   PMID:31939007   PMID:31998444  
PMID:32003057   PMID:32031699   PMID:32084554   PMID:32124969   PMID:32160960   PMID:32214070   PMID:32240615   PMID:32259563   PMID:32270948   PMID:32396274   PMID:32667865   PMID:32777313  
PMID:32865657   PMID:32926510   PMID:33039977   PMID:33081813   PMID:33098506   PMID:33159115   PMID:33181267   PMID:33236160   PMID:33287126   PMID:33290148   PMID:33378037   PMID:33381567  
PMID:33383282   PMID:33583793   PMID:33629321   PMID:33629328   PMID:33730389   PMID:33744886   PMID:33855084   PMID:33900898   PMID:33909363   PMID:33962830   PMID:34032546   PMID:34051593  
PMID:34112866   PMID:34142718   PMID:34260072   PMID:34296787   PMID:34343528   PMID:34369678   PMID:34411492   PMID:34491653   PMID:34507068   PMID:34610358   PMID:34610452   PMID:34676874  
PMID:34719837   PMID:34734089   PMID:34780278   PMID:34929310   PMID:34955133   PMID:34964444   PMID:35070875   PMID:35163308   PMID:35217365  


Genomics

Comparative Map Data
Tlr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)Ensembl
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
TLR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9117,704,175 - 117,724,735 (+)EnsemblGRCh38hg38GRCh38
GRCh379120,466,681 - 120,487,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBINCBI36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBI
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
Tlr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBImm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
Tlr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBIChiLan1.0ChiLan1.0
TLR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19117,180,250 - 117,193,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9117,180,550 - 117,190,711 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0988,827,495 - 88,840,458 (+)NCBIMhudiblu_PPA_v0panPan3
TLR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11171,356,390 - 71,367,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBI
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBI
ROS_Cfam_1.0 Ensembl1172,483,210 - 72,494,579 (+)Ensembl
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBI
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBI
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBI
Tlr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947186,750,688 - 186,763,650 (+)NCBI
SpeTri2.0NW_0049364876,519,140 - 6,532,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,044,610 - 258,059,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,044,610 - 258,054,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21289,775,816 - 289,785,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11221,873,762 - 21,885,562 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1221,871,773 - 21,885,515 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603521,002,852 - 21,019,229 (+)NCBIVero_WHO_p1.0
Tlr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476017,596,516 - 17,608,955 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
PMC289161P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2580,158,544 - 80,158,848 (+)MAPPERmRatBN7.2
Rnor_6.0582,600,100 - 82,600,403NCBIRnor6.0
Rnor_5.0586,703,346 - 86,703,649UniSTSRnor5.0
RGSC_v3.4583,576,779 - 83,577,082UniSTSRGSC3.4
Celera579,057,972 - 79,058,275UniSTS
Cytogenetic Map5q24UniSTS
Tlr4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2580,158,060 - 80,158,238 (+)MAPPERmRatBN7.2
Rnor_6.0582,599,616 - 82,599,793NCBIRnor6.0
Rnor_5.0586,702,862 - 86,703,039UniSTSRnor5.0
RGSC_v3.4583,576,295 - 83,576,472UniSTSRGSC3.4
Celera579,057,488 - 79,057,665UniSTS
RH 3.4 Map5643.7UniSTS
Cytogenetic Map5q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598845Mcs14Mammary carcinoma susceptibility QTL 140.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57636977680813390Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat


Genetic Models
This gene Tlr4 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:65
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000014020
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9