HSPD1 (heat shock protein family D (Hsp60) member 1) - Rat Genome Database

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Gene: HSPD1 (heat shock protein family D (Hsp60) member 1) Canis lupus familiaris
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Symbol: HSPD1
Name: heat shock protein family D (Hsp60) member 1
RGD ID: 12436414
Description: ENCODES a protein that exhibits apolipoprotein A-I binding (ortholog); apolipoprotein binding (ortholog); chaperone binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); adhesion of symbiont to host (ortholog); apoptotic mitochondrial changes (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); adenocarcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cell surface (ortholog); clathrin-coated pit (ortholog); coated vesicle (ortholog); INTERACTS WITH 7,9-dihydro-1H-purine-2,6,8(3H)-trione; clofibrate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,010,421 - 7,025,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha377,956,566 - 7,967,852 (-)NCBI
ROS_Cfam_1.0376,900,931 - 6,911,990 (-)NCBI
ROS_Cfam_1.0 Ensembl376,900,933 - 6,911,980 (-)Ensembl
UMICH_Zoey_3.1376,899,765 - 6,910,835 (-)NCBI
UNSW_CanFamBas_1.0376,866,679 - 6,877,757 (-)NCBI
UU_Cfam_GSD_1.0376,889,830 - 6,900,900 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adhesion of symbiont to host  (ISO)
apoptotic mitochondrial changes  (ISO)
B cell activation  (ISO)
B cell proliferation  (ISO)
biological process involved in interaction with symbiont  (ISO)
cellular response to heat  (ISO)
cellular response to interleukin-7  (IEA,ISO)
isotype switching to IgG isotypes  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of T cell activation  (IEA)
positive regulation of T cell mediated immune response to tumor cell  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IEA,ISO)
protein folding  (IEA)
protein refolding  (IEA)
protein stabilization  (ISO)
response to activity  (ISO)
response to ATP  (ISO)
response to cocaine  (ISO)
response to cold  (ISS)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to unfolded protein  (ISO)
response to xenobiotic stimulus  (ISO)
T cell activation  (IEA,ISO)

References
Additional References at PubMed
PMID:18241025  


Genomics

Comparative Map Data
HSPD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,010,421 - 7,025,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha377,956,566 - 7,967,852 (-)NCBI
ROS_Cfam_1.0376,900,931 - 6,911,990 (-)NCBI
ROS_Cfam_1.0 Ensembl376,900,933 - 6,911,980 (-)Ensembl
UMICH_Zoey_3.1376,899,765 - 6,910,835 (-)NCBI
UNSW_CanFamBas_1.0376,866,679 - 6,877,757 (-)NCBI
UU_Cfam_GSD_1.0376,889,830 - 6,900,900 (-)NCBI
HSPD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382197,486,584 - 197,500,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2197,486,584 - 197,516,737 (-)EnsemblGRCh38hg38GRCh38
GRCh372198,351,308 - 198,364,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362198,059,553 - 198,073,243 (-)NCBINCBI36hg18NCBI36
Build 342198,176,815 - 198,190,504NCBI
Celera2192,107,181 - 192,120,871 (-)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2190,203,711 - 190,217,402 (-)NCBIHuRef
CHM1_12198,357,144 - 198,370,838 (-)NCBICHM1_1
T2T-CHM13v2.02197,970,209 - 197,983,875 (-)NCBI
Hspd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,116,992 - 55,127,402 (-)NCBIGRCm39mm39
GRCm39 Ensembl155,116,994 - 55,127,402 (-)Ensembl
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBImm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
Hspd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2956,579,195 - 56,590,011 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl956,579,201 - 56,589,662 (-)Ensembl
Rnor_6.0961,680,529 - 61,691,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,680,530 - 61,690,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0961,361,745 - 61,372,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,884,193 - 53,895,043 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1953,885,606 - 53,895,580 (-)NCBI
Celera954,060,669 - 54,071,096 (-)NCBICelera
Cytogenetic Map9q31NCBI
Hspd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,063,133 - 3,073,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554033,062,724 - 3,073,419 (+)NCBIChiLan1.0ChiLan1.0
HSPD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B202,623,497 - 202,637,045 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBIMhudiblu_PPA_v0panPan3
Hspd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303155,150,440 - 155,160,005 (-)NCBI
SpeTri2.0NW_0049365061,678,069 - 1,687,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,360,094 - 101,373,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11083,003,266 - 83,017,397 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1083,003,717 - 83,017,363 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040116,426,692 - 116,441,017 (+)NCBIVero_WHO_p1.0
Hspd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 5 5 21 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005640496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005640497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005640498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014111036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038447492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038447493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038463568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038585251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038585252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00845047733   ⟹   ENSCAFP00845037453
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl376,900,933 - 6,911,980 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845047787   ⟹   ENSCAFP00845037497
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl376,900,934 - 6,911,753 (-)Ensembl
RefSeq Acc Id: XM_005640498   ⟹   XP_005640555
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1377,010,421 - 7,021,604 (-)NCBI
Dog10K_Boxer_Tasha377,956,566 - 7,967,852 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038447492   ⟹   XP_038303420
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0376,900,931 - 6,911,756 (-)NCBI
RefSeq Acc Id: XM_038447493   ⟹   XP_038303421
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0376,900,931 - 6,911,990 (-)NCBI
RefSeq Acc Id: XM_038463568   ⟹   XP_038319496
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha377,956,566 - 7,967,618 (-)NCBI
RefSeq Acc Id: XM_038521555   ⟹   XP_038377483
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1376,899,765 - 6,910,598 (-)NCBI
RefSeq Acc Id: XM_038521556   ⟹   XP_038377484
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1376,899,765 - 6,910,835 (-)NCBI
RefSeq Acc Id: XM_038585251   ⟹   XP_038441179
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0376,889,830 - 6,900,663 (-)NCBI
RefSeq Acc Id: XM_038585252   ⟹   XP_038441180
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0376,889,830 - 6,900,900 (-)NCBI
RefSeq Acc Id: XM_038649657   ⟹   XP_038505585
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0376,866,679 - 6,877,521 (-)NCBI
RefSeq Acc Id: XM_038649658   ⟹   XP_038505586
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0376,866,679 - 6,877,757 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005640555   ⟸   XM_005640498
- UniProtKB: E2QUU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038377484   ⟸   XM_038521556
RefSeq Acc Id: XP_038377483   ⟸   XM_038521555
RefSeq Acc Id: XP_038505586   ⟸   XM_038649658
RefSeq Acc Id: XP_038505585   ⟸   XM_038649657
RefSeq Acc Id: XP_038303421   ⟸   XM_038447493
RefSeq Acc Id: XP_038303420   ⟸   XM_038447492
RefSeq Acc Id: XP_038319496   ⟸   XM_038463568
RefSeq Acc Id: XP_038441180   ⟸   XM_038585252
RefSeq Acc Id: XP_038441179   ⟸   XM_038585251
RefSeq Acc Id: ENSCAFP00845037453   ⟸   ENSCAFT00845047733
RefSeq Acc Id: ENSCAFP00845037497   ⟸   ENSCAFT00845047787

Promoters
RGD ID:13689108
Promoter ID:EPDNEW_C7177
Type:initiation region
Name:HSPD1_1
Description:heat shock protein family D member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1377,020,351 - 7,020,411EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
37 7022565 7022566 G A snv Chinese indigenous dogs (LJ10)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00030009163 UniProtKB/TrEMBL
  ENSCAFG00040021521 UniProtKB/TrEMBL
  ENSCAFG00845027075 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030014824.1 UniProtKB/TrEMBL
  ENSCAFP00040034890 UniProtKB/TrEMBL
  ENSCAFP00845037453 ENTREZGENE
  ENSCAFP00845037453.1 UniProtKB/TrEMBL
  ENSCAFP00845037497 ENTREZGENE
  ENSCAFP00845037497.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030016962.1 UniProtKB/TrEMBL
  ENSCAFT00040039974 UniProtKB/TrEMBL
  ENSCAFT00845047733 ENTREZGENE
  ENSCAFT00845047733.1 UniProtKB/TrEMBL
  ENSCAFT00845047787 ENTREZGENE
  ENSCAFT00845047787.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
InterPro Chaperonin_Cpn60_CS UniProtKB/TrEMBL
  Chaprnin_Cpn60 UniProtKB/TrEMBL
  Cpn60/TCP-1 UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/TrEMBL
  GROEL-like_equatorial_sf UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/TrEMBL
NCBI Gene HSPD1 ENTREZGENE
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
PRINTS CHAPERONIN60 UniProtKB/TrEMBL
PROSITE CHAPERONINS_CPN60 UniProtKB/TrEMBL
Superfamily-SCOP SSF48592 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
TIGRFAMs GroEL UniProtKB/TrEMBL
UniProt A0A8C0TC09_CANLF UniProtKB/TrEMBL
  A0A8I3PXL2_CANLF UniProtKB/TrEMBL
  A0A8I3Q1N0_CANLF UniProtKB/TrEMBL
  CH60_CANLF UniProtKB/Swiss-Prot
  E2QUU5 ENTREZGENE
  P49818 ENTREZGENE