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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspd1
Name: heat shock protein family D (Hsp60) member 1
Acc ID: CHEBI:28777
Term: liquiritigenin
Definition: A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.
Chemical ID: MESH:C083152
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspd1multiple interactionsEXP 6480464CTDliquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]

PMID:31589899
Hspd1multiple interactionsISORGD:7338966480464CTDliquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA] liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA] liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA] liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]

PMID:31589899
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