RGD Reference Report - Myocardial heat shock protein 60 expression in insulin-resistant and diabetic rats. - Rat Genome Database

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Myocardial heat shock protein 60 expression in insulin-resistant and diabetic rats.

Authors: Chen, HS  Wu, TE  Juan, CC  Lin, HD 
Citation: Chen HS, etal., J Endocrinol. 2009 Feb;200(2):151-7. doi: 10.1677/JOE-08-0387. Epub 2008 Oct 23.
RGD ID: 10402862
Pubmed: PMID:18948349   (View Abstract at PubMed)
DOI: DOI:10.1677/JOE-08-0387   (Journal Full-text)

Heat shock protein 60 (HSPD1) plays a critical role in myocardial protection. Its reduced expression may lower myocardial protection against ischemic injury in the diabetic state. This study was conducted to investigate the natural course of fructose-fed insulin-resistant rats, define changes in myocardial HSPD1 expression, and determine the effects of thiazolidinedione or anti-hypertensive treatment. Results showed that insulin resistance with hyperinsulinemia and hypertension developed after 6 weeks of fructose feeding. This time-course study also showed that myocardial HSPD1 expression was mildly increased in week 6 (P=0.05) and significantly increased in week 8. Rosiglitazone-treated rats had restored systolic blood pressure (BP) and normalized plasma insulin level during oral glucose tolerance tests, whereas amlodipine-treated rats restored only systolic BP. Both amlodipine and rosiglitazone treatments normalized the abundance of myocardial HSPD1 expression in fructose-fed rats. When these rats received streptozotocin injection and diabetes developed, myocardial HSPD1 expression decreased despite persistent hypertension. In conclusion, this is the first study to report that myocardial HSPD1 expression is increased in high-fructose-fed rats, which may be due to increased BP. Once the high-fructose-fed rats developed diabetes with insulin deficiency, the myocardial HSPD1 expression decreased in spite of persistent hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HSPD1Humanhypertension  ISOHspd1 (Rattus norvegicus) RGD 
Hspd1Rathypertension  IEP  RGD 
Hspd1Mousehypertension  ISOHspd1 (Rattus norvegicus) RGD 
HSPD1HumanInsulin Resistance  ISOHspd1 (Rattus norvegicus) RGD 
Hspd1RatInsulin Resistance  IEP  RGD 
Hspd1MouseInsulin Resistance  ISOHspd1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspd1  (heat shock protein family D (Hsp60) member 1)

Genes (Mus musculus)
Hspd1  (heat shock protein 1 (chaperonin))

Genes (Homo sapiens)
HSPD1  (heat shock protein family D (Hsp60) member 1)


Additional Information