Hspd1 (heat shock protein family D (Hsp60) member 1) - Rat Genome Database

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Gene: Hspd1 (heat shock protein family D (Hsp60) member 1) Heterocephalus glaber
Analyze
Symbol: Hspd1
Name: heat shock protein family D (Hsp60) member 1
RGD ID: 18914228
Description: ENCODES a protein that exhibits apolipoprotein A-I binding (ortholog); apolipoprotein binding (ortholog); cysteine-type endopeptidase activator activity (ortholog); INVOLVED IN adhesion of symbiont to host (ortholog); apoptotic mitochondrial changes (ortholog); B cell activation (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); adenocarcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cell surface (ortholog); clathrin-coated pit (ortholog); coated vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 60 kDa heat shock protein, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Animal Toxoplasmosis  (ISO)
aphthous stomatitis  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
autosomal recessive nonsyndromic deafness 9  (ISO)
Calcification of Aortic Valve  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Orchitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Death  (ISO)
genetic disease  (ISO)
glucose intolerance  (ISO)
Hashimoto Disease  (ISO)
Hemorrhage  (ISO)
hereditary spastic paraplegia  (ISO)
hereditary spastic paraplegia 10  (ISO)
hereditary spastic paraplegia 13  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hydrocephalus  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypomyelinating leukodystrophy 4  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
juvenile rheumatoid arthritis  (ISO)
low tension glaucoma  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neurodevelopmental Disorders  (ISO)
Oral Ulcer  (ISO)
paraplegia  (ISO)
Parkinson's disease  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
varicocele  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adhesion of symbiont to host  (ISO)
apoptotic mitochondrial changes  (ISO)
B cell activation  (ISO)
B cell proliferation  (ISO)
cellular response to heat  (ISO)
cellular response to interleukin-7  (ISO)
isotype switching to IgG isotypes  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of execution phase of apoptosis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of T cell activation  (ISO)
positive regulation of T cell mediated immune response to tumor cell  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (ISO)
protein refolding  (IEA)
protein stabilization  (ISO)
response to activity  (ISO)
response to ATP  (ISO)
response to cocaine  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to resveratrol  (ISO)
response to unfolded protein  (ISO)
response to xenobiotic stimulus  (ISO)
T cell activation  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hspd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HSPD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382197,486,584 - 197,500,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2197,486,584 - 197,516,737 (-)EnsemblGRCh38hg38GRCh38
GRCh372198,351,308 - 198,364,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362198,059,553 - 198,073,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 342198,176,815 - 198,190,504NCBI
Celera2192,107,181 - 192,120,871 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2190,203,711 - 190,217,402 (-)NCBIHuRef
CHM1_12198,357,144 - 198,370,838 (-)NCBICHM1_1
T2T-CHM13v2.02197,970,209 - 197,983,875 (-)NCBIT2T-CHM13v2.0
Hspd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,116,992 - 55,127,402 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,116,994 - 55,127,402 (-)EnsemblGRCm39 Ensembl
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBIMGSCv36mm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
cM Map128.01NCBI
Hspd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8964,073,610 - 64,084,332 (-)NCBIGRCr8
mRatBN7.2956,579,195 - 56,590,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl956,579,201 - 56,589,662 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx965,088,118 - 65,098,576 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0970,204,015 - 70,214,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0968,503,767 - 68,514,191 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0961,680,529 - 61,691,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,680,530 - 61,690,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0961,361,745 - 61,372,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,884,193 - 53,895,043 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1953,885,606 - 53,895,580 (-)NCBI
Celera954,060,669 - 54,071,096 (-)NCBICelera
Cytogenetic Map9q31NCBI
Hspd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,063,133 - 3,073,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554033,062,724 - 3,073,419 (+)NCBIChiLan1.0ChiLan1.0
HSPD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213100,100,280 - 100,114,129 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B100,115,490 - 100,129,121 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B202,623,497 - 202,637,045 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensemblpanpan1.1panPan2
HSPD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,010,421 - 7,025,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha377,956,566 - 7,967,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0376,900,931 - 6,911,990 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl376,900,933 - 6,911,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1376,899,765 - 6,910,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0376,866,679 - 6,877,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0376,889,830 - 6,900,900 (-)NCBIUU_Cfam_GSD_1.0
Hspd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303155,150,440 - 155,160,005 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365061,678,069 - 1,687,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,360,094 - 101,373,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11083,003,266 - 83,017,397 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1083,003,717 - 83,017,363 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040116,426,692 - 116,441,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_004871701   ⟹   XP_004871758
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBI
RefSeq Acc Id: XM_021249799   ⟹   XP_021105458
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248892,737,244 - 2,746,333 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004871758 (Get FASTA)   NCBI Sequence Viewer  
  XP_021105458 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011049
RefSeq Acc Id: XP_004871758   ⟸   XM_004871701
- UniProtKB: A0AAX6SAG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105458   ⟸   XM_021249799
- UniProtKB: A0AAX6SAG1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007927 ENTREZGENE
Ensembl Transcript ENSHGLT00000011173 ENTREZGENE
NCBI Gene Hspd1 ENTREZGENE
UniProt A0AAX6SAG1 ENTREZGENE, UniProtKB/TrEMBL