RGD Reference Report - The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoter. - Rat Genome Database

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The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoter.

Authors: Ryan, MT  Herd, SM  Sberna, G  Samuel, MM  Hoogenraad, NJ  Hoj, PB 
Citation: Ryan MT, etal., Gene 1997 Sep 1;196(1-2):9-17.
RGD ID: 633052
Pubmed: PMID:9322735   (View Abstract at PubMed)

Chaperonins are a class of stress-inducible molecular chaperones involved in protein folding. We report the cloning, sequencing and characterisation of the rat mitochondrial chaperonin 60 and chaperonin 10 genes. The two genes are arranged in a head-to-head configuration and together comprise 14 kb and contain 14 introns. The genes are linked together by a region of approximately 280 bp, which constitutes a bidirectional promoter and includes a common heat-shock element. Insertion of the shared promoter region between two reporter genes is sufficient to drive their expression under both constitutive and heat-shock conditions. The arrangement of the mammalian chaperonin genes suggests the potential to provide the coordinated regulation of their products in a manner that is mechanistically distinct from, yet conceptually similar to, that employed by the bacterial chaperonin (groE) operon.

Objects referenced in this article
Gene Hspd1 heat shock protein family D (Hsp60) member 1 Rattus norvegicus
Gene Hspe1 heat shock protein family E (Hsp10) member 1 Rattus norvegicus

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