HSPD1 (heat shock protein family D (Hsp60) member 1) - Rat Genome Database
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Gene: HSPD1 (heat shock protein family D (Hsp60) member 1) Sus scrofa
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Symbol: HSPD1
Name: heat shock protein family D (Hsp60) member 1
RGD ID: 14202796
Description: ENCODES a protein that exhibits apolipoprotein A-I binding (ortholog); apolipoprotein binding (ortholog); chaperone binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); adhesion of symbiont to host (ortholog); apoptotic mitochondrial changes (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); adenocarcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cell surface (ortholog); clathrin-coated pit (ortholog); coated vesicle (ortholog); INTERACTS WITH chloroquine; ochratoxin A
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 60 kDa heat shock protein, mitochondrial; heat shock 60 kDa protein 1; HSP60; mitochondrial heat shock 60 kDa protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,360,094 - 101,373,527 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adhesion of symbiont to host  (ISO)
apoptotic mitochondrial changes  (ISO)
B cell activation  (ISO)
B cell proliferation  (ISO)
biological process involved in interaction with symbiont  (ISO)
cellular response to heat  (ISO)
cellular response to interleukin-7  (IEA,ISO)
isotype switching to IgG isotypes  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interferon-gamma production  (IEA,ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of T cell activation  (IEA,ISO)
positive regulation of T cell mediated immune response to tumor cell  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
protein refolding  (IEA)
protein stabilization  (ISO)
response to activity  (ISO)
response to ATP  (ISO)
response to cocaine  (ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to unfolded protein  (ISO)
T cell activation  (IEA,ISO)

References
Additional References at PubMed
PMID:14681463   PMID:18548335   PMID:26427351   PMID:29208924  


Genomics

Comparative Map Data
HSPD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,360,094 - 101,373,527 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2197,486,584 - 197,516,737 (-)EnsemblGRCh38hg38GRCh38
GRCh382197,486,584 - 197,500,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372198,351,308 - 198,364,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362198,059,553 - 198,073,243 (-)NCBINCBI36hg18NCBI36
Build 342198,176,815 - 198,190,504NCBI
Celera2192,107,181 - 192,120,871 (-)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2190,203,711 - 190,217,402 (-)NCBIHuRef
CHM1_12198,357,144 - 198,370,838 (-)NCBICHM1_1
Hspd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,116,992 - 55,127,402 (-)NCBIGRCm39mm39
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBImm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
Hspd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2956,579,195 - 56,590,011 (-)NCBI
Rnor_6.0 Ensembl961,680,530 - 61,690,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0961,680,529 - 61,691,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0961,361,745 - 61,372,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,884,193 - 53,895,043 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1953,885,606 - 53,895,580 (-)NCBI
Celera954,060,669 - 54,071,096 (-)NCBICelera
Cytogenetic Map9q31NCBI
Hspd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,063,133 - 3,073,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554033,062,724 - 3,073,419 (+)NCBIChiLan1.0ChiLan1.0
HSPD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B202,623,497 - 202,637,045 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBIMhudiblu_PPA_v0panPan3
HSPD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,010,421 - 7,025,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hspd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365061,678,069 - 1,687,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPD1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11083,003,266 - 83,017,397 (-)NCBI
ChlSab1.1 Ensembl1083,003,717 - 83,017,363 (-)Ensembl
Hspd1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000064449   ⟹   ENSSSCP00000047456
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15101,360,094 - 101,373,527 (-)Ensembl
RefSeq Acc Id: NM_001254716   ⟹   NP_001241645
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001241645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV40980 (Get FASTA)   NCBI Sequence Viewer  
  AET99216 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001241645   ⟸   NM_001254716
- UniProtKB: G9F6X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047456   ⟸   ENSSSCT00000064449


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016077 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000047456 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000064449 UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
InterPro Chaperonin_Cpn60_CS UniProtKB/TrEMBL
  Chaprnin_Cpn60 UniProtKB/TrEMBL
  Cpn60/TCP-1 UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/TrEMBL
  GROEL-like_equatorial_sf UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/TrEMBL
KEGG Report ssc:492279 UniProtKB/TrEMBL
NCBI Gene HSPD1 ENTREZGENE
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
PRINTS CHAPERONIN60 UniProtKB/TrEMBL
PROSITE CHAPERONINS_CPN60 UniProtKB/TrEMBL
Superfamily-SCOP SSF48592 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
TIGRFAMs GroEL UniProtKB/TrEMBL
UniProt A0A287ATN8_PIG UniProtKB/TrEMBL
  G9F6X6 ENTREZGENE, UniProtKB/TrEMBL