Igfbp2 (insulin-like growth factor binding protein 2) - Rat Genome Database

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Gene: Igfbp2 (insulin-like growth factor binding protein 2) Rattus norvegicus
Analyze
Symbol: Igfbp2
Name: insulin-like growth factor binding protein 2
RGD ID: 2873
Description: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BRL-BP; IBP-2; IGF-binding protein 2; IGFBP-2; ILGFBPA; insulin-like growth factor-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,864,811 - 81,892,179 (+)NCBIGRCr8
mRatBN7.2974,415,574 - 74,442,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,415,546 - 74,442,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx982,870,444 - 82,897,811 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0987,999,330 - 88,026,694 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0986,386,056 - 86,413,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0980,118,029 - 80,144,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,118,029 - 80,144,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,888,642 - 79,915,196 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4971,966,877 - 71,994,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1972,113,854 - 72,141,188 (+)NCBI
Celera972,008,814 - 72,036,115 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bicalutamide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cocaine  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP)
fenpyroximate  (ISO)
fentin chloride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
griseofulvin  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lycopene  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
omeprazole  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rotenone  (EXP,ISO)
RU 58668  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium tungstate  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc oxide  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protective role of retinoic acid from antiproliferative action of TNF-alpha on lung epithelial cells. Besnard V, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L863-71.
2. Insulin-like growth factor binding protein-2 expression is decreased by lithium. Bezchlibnyk YB, etal., Neuroreport. 2006 Jun 26;17(9):897-901.
3. Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors. Brown AL, etal., J Biol Chem 1989 Mar 25;264(9):5148-54.
4. Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats. Cardona-Gomez GP, etal., J Neurobiol. 2000 Jun 5;43(3):269-81.
5. Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls. Cha DM, etal., Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7038-44. doi: 10.1167/iovs.13-12730.
6. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
7. The regulation of IGFs and IGFBPs by prolactin in primary culture of fetal rat hepatocytes is influenced by maternal malnutrition. El Khattabi I, etal., Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E835-42. Epub 2006 May 23.
8. Neonatal isolation changes the expression of IGF-IR and IGFBP-2 in the hippocampus in response to adulthood restraint stress. Erabi K, etal., Int J Neuropsychopharmacol. 2007 Jun;10(3):369-81. Epub 2006 Jul 19.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells. Gordon PV, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G79-87. Epub 2005 Feb 10.
12. Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome. Heald AH, etal., Exp Clin Endocrinol Diabetes. 2006 Jul;114(7):371-6.
13. Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. Holmin S, etal., Growth Horm IGF Res 2001 Dec;11(6):399-406.
14. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Jin K, etal., Ann Neurol. 2001 Jul;50(1):93-103.
15. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
16. Perinatal growth disturbance in the spontaneously hypertensive rat. Lewis RM, etal., Pediatr Res. 1997 Dec;42(6):758-64.
17. A low molecular weight insulin-like growth factor binding protein from rat: cDNA cloning and tissue distribution of its messenger RNA. Margot JB, etal., Mol Endocrinol 1989 Jul;3(7):1053-60.
18. Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat. Martin MA, etal., Endocrinology. 2005 Mar;146(3):1364-71. Epub 2004 Dec 2.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
21. Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells. Mottola C, etal., J Biol Chem. 1986 Aug 25;261(24):11180-8.
22. Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia: a possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation. Narasaraju TA, etal., J Cell Biochem. 2006 Apr 1;97(5):984-98.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Potentiating role of IGFBP-2 on IGF-II-stimulated alkaline phosphatase activity in differentiating osteoblasts. Palermo C, etal., Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E648-57. Epub 2003 Dec 9.
25. Influence of hypothyroidism on circulating concentrations and liver expression of IGF-binding proteins mRNA from neonatal and adult rats. Ramos S, etal., J Endocrinol. 2002 Feb;172(2):363-73.
26. Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism. Rasmussen MH, etal., Obesity (Silver Spring). 2007 Apr;15(4):879-86.
27. In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes. Reijnders CM, etal., Calcif Tissue Int. 2007 Feb;80(2):137-43. Epub 2007 Feb 3.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Altered IGF-I and IGFBPs in senescent male and female rats. Severgnini S, etal., J Gerontol A Biol Sci Med Sci. 1999 Mar;54(3):B111-5.
32. Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. Shimasaki S, etal., J Biol Chem 1991 Jun 5;266(16):10646-53.
33. Identification of a novel binding protein for insulin-like growth factors in adult rat serum. Shimonaka M, etal., Biochem Biophys Res Commun. 1989 Nov 30;165(1):189-95.
34. Insulin-Like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy. Shynlova O, etal., Biol Reprod. 2006 Nov 22;.
35. Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat. Shynlova O, etal., Biol Reprod. 2007 Apr;76(4):571-8. Epub 2006 Nov 22.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors. Wang JF, etal., Biochem Biophys Res Commun. 1988 Dec 15;157(2):718-26.
38. IGF-binding protein-2 protects against the development of obesity and insulin resistance. Wheatcroft SB, etal., Diabetes. 2007 Feb;56(2):285-94.
39. Gene expression profiling of the effects of castration and estrogen treatment in the rat uterus. Wu X, etal., Biol Reprod. 2003 Oct;69(4):1308-17. Epub 2003 Jun 11.
40. Growth factors and proliferation of cultured rat gingival cells in response to cyclosporin A. Yoshida T, etal., J Periodontal Res. 2005 Feb;40(1):11-9.
Additional References at PubMed
PMID:7510770   PMID:7679139   PMID:10601973   PMID:12477932   PMID:12902319   PMID:15248291   PMID:15694994   PMID:16055936   PMID:16131350   PMID:18549709   PMID:18563800   PMID:18946176  
PMID:19081843   PMID:23376485   PMID:23533145   PMID:24006456   PMID:24352370  


Genomics

Comparative Map Data
Igfbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,864,811 - 81,892,179 (+)NCBIGRCr8
mRatBN7.2974,415,574 - 74,442,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,415,546 - 74,442,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx982,870,444 - 82,897,811 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0987,999,330 - 88,026,694 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0986,386,056 - 86,413,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0980,118,029 - 80,144,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,118,029 - 80,144,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,888,642 - 79,915,196 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4971,966,877 - 71,994,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1972,113,854 - 72,141,188 (+)NCBI
Celera972,008,814 - 72,036,115 (+)NCBICelera
Cytogenetic Map9q33NCBI
IGFBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,632,828 - 216,664,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,632,828 - 216,664,436 (+)EnsemblGRCh38hg38GRCh38
GRCh372217,497,551 - 217,529,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,206,372 - 217,237,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 342217,323,632 - 217,354,665NCBI
Celera2211,266,003 - 211,297,047 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2209,352,529 - 209,383,563 (+)NCBIHuRef
CHM1_12217,504,294 - 217,535,337 (+)NCBICHM1_1
T2T-CHM13v2.02217,115,243 - 217,146,861 (+)NCBIT2T-CHM13v2.0
Igfbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,863,650 - 72,891,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,863,662 - 72,891,633 (+)EnsemblGRCm39 Ensembl
GRCm38172,824,480 - 72,852,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,824,503 - 72,852,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37172,871,078 - 72,899,048 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36172,756,390 - 72,785,681 (+)NCBIMGSCv36mm8
Celera173,392,679 - 73,420,660 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.94NCBI
Igfbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,557,194 - 16,584,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545316,556,873 - 16,584,737 (-)NCBIChiLan1.0ChiLan1.0
IGFBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213119,259,714 - 119,292,783 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B119,276,573 - 119,307,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,893,724 - 103,925,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,498,392 - 222,527,302 (+)NCBIpanpan1.1PanPan1.1panPan2
IGFBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,553,227 - 23,569,321 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,559,501 - 23,569,312 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3724,374,276 - 24,397,898 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03723,573,472 - 23,597,135 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,573,472 - 23,596,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,456,971 - 23,480,636 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03723,417,432 - 23,433,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03723,436,098 - 23,452,395 (+)NCBIUU_Cfam_GSD_1.0
Igfbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,929,066 - 171,954,100 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936586672,091 - 696,692 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936586671,760 - 696,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,822,047 - 118,850,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115118,822,092 - 118,850,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IGFBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110102,469,611 - 102,503,229 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10102,469,669 - 102,503,276 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604096,906,056 - 96,936,013 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248238,460,553 - 8,486,495 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248238,460,968 - 8,486,495 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Igfbp2
172 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:108
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000023068
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat

Markers in Region
RH130162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,442,629 - 74,442,832 (+)MAPPERmRatBN7.2
Rnor_6.0980,144,489 - 80,144,691NCBIRnor6.0
Rnor_5.0979,914,881 - 79,915,083UniSTSRnor5.0
RGSC_v3.4971,993,896 - 71,994,098UniSTSRGSC3.4
Celera972,035,800 - 72,036,002UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 14 14 14
Medium 18 12 165 109 109 250 105 145 53
Low 3 107 48 24 61 24 24 26 10 24
Below cutoff 15 19

Sequence


Ensembl Acc Id: ENSRNOT00000023068   ⟹   ENSRNOP00000023068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl974,415,546 - 74,442,937 (+)Ensembl
Rnor_6.0 Ensembl980,118,029 - 80,144,789 (+)Ensembl
RefSeq Acc Id: NM_013122   ⟹   NP_037254
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8981,864,811 - 81,892,179 (+)NCBI
mRatBN7.2974,415,574 - 74,442,945 (+)NCBI
Rnor_6.0980,118,029 - 80,144,804 (+)NCBI
Rnor_5.0979,888,642 - 79,915,196 (+)NCBI
RGSC_v3.4971,966,877 - 71,994,211 (+)RGD
Celera972,008,814 - 72,036,115 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266738   ⟹   XP_063122808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8981,865,763 - 81,892,179 (+)NCBI
RefSeq Acc Id: NP_037254   ⟸   NM_013122
- Peptide Label: precursor
- UniProtKB: Q569C7 (UniProtKB/Swiss-Prot),   P12843 (UniProtKB/Swiss-Prot),   A6JVQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023068   ⟸   ENSRNOT00000023068
RefSeq Acc Id: XP_063122808   ⟸   XM_063266738
- Peptide Label: isoform X1
- UniProtKB: Q6LDF9 (UniProtKB/TrEMBL),   A6JVQ7 (UniProtKB/TrEMBL)
Protein Domains
IGFBP N-terminal   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12843-F1-model_v2 AlphaFold P12843 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696739
Promoter ID:EPDNEW_R7264
Type:initiation region
Name:Igfbp2_1
Description:insulin-like growth factor binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0980,118,011 - 80,118,071EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2873 AgrOrtholog
BioCyc Gene G2FUF-27191 BioCyc
Ensembl Genes ENSRNOG00000016957 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00065008583 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023068.4 UniProtKB/Swiss-Prot
  ENSRNOT00065013641 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7308779 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25662 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108749 IMAGE-MGC_LOAD
NCBI Gene 25662 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igfbp2 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBPFAMILY2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016957 RatGTEx
  ENSRNOG00065008583 RatGTEx
SMART SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Growth factor receptor domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216909
UniProt A6JVQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JVQ7 ENTREZGENE, UniProtKB/TrEMBL
  A6JVQ8_RAT UniProtKB/TrEMBL
  IBP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q569C7 ENTREZGENE
  Q6LDF9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q569C7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igfbp2  Insulin-like growth factor binding protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, kidney, intestine, and lung 729148
gene_regulation expression is upregulated by NMDA receptor-mediated depolarization in astrocytes 729220