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Gene: Mstn (myostatin) Rattus norvegicus
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Symbol: Mstn
Name: myostatin
Description: Predicted to have heparin binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of skeletal muscle tissue growth; response to testosterone; and skeletal muscle atrophy. Localizes to the cytoplasm and extracellular space. Used to study amyotrophic lateral sclerosis. Biomarker of congestive heart failure; hypothyroidism; muscular atrophy; peripheral vascular disease; and uremia. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin); INTERACTS WITH 17beta-estradiol 3-benzoate; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GDF-8; Gdf8; growth differentiation factor 8; growth/differentiation factor 8
Orthologs:
Homo sapiens (human) : MSTN (myostatin)  HGNC  Alliance
Mus musculus (house mouse) : Mstn (myostatin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mstn (myostatin)
Pan paniscus (bonobo/pygmy chimpanzee) : MSTN (myostatin)
Canis lupus familiaris (dog) : MSTN (myostatin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mstn (myostatin)
Sus scrofa (pig) : MSTN (myostatin)
more info ...
Allele / Splice: Mstnem2Mcwi   Mstnem3Mcwi   Mstnem1Mcwi  
Genetic Models: SS-Mstnem1Mcwi SS-Mstnem2Mcwi SS-Mstnem3Mcwi-/- SS-Mstnem1Mcwi-/- SS-Mstnem3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Celera946,124,738 - 46,129,565 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mstn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3115
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.