Mstn (myostatin) - Rat Genome Database

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Gene: Mstn (myostatin) Rattus norvegicus
Analyze
Symbol: Mstn
Name: myostatin
RGD ID: 3115
Description: Predicted to enable cytokine activity; heparin binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of skeletal muscle tissue growth; response to testosterone; and skeletal muscle atrophy. Located in cytoplasm and extracellular space. Used to study amyotrophic lateral sclerosis. Biomarker of congestive heart failure; hypothyroidism; muscular atrophy; peripheral vascular disease; and uremia. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GDF-8; Gdf8; growth differentiation factor 8; growth/differentiation factor 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mstnem2Mcwi   Mstnem3Mcwi   Mstnem1Mcwi   Mstnem1Cqin  
Genetic Models: SD-Mstnem1Cqin SS-Mstnem2Mcwi SS-Mstnem1Mcwi-/- SS-Mstnem3Mcwi-/- SS-Mstnem1Mcwi SS-Mstnem3Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2948,453,982 - 48,458,809 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)Ensembl
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Celera946,124,738 - 46,129,565 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
extracellular space  (IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Baumann AP, etal., J Musculoskelet Neuronal Interact. 2003 Mar;3(1):8-16.
2. Carneiro I, etal., J Endocrinol Invest. 2008 Sep;31(9):773-8.
3. Ciarmela P, etal., Endocrinology. 2009 Feb;150(2):906-14. Epub 2008 Oct 9.
4. Costelli P, etal., Eur J Clin Invest. 2008 Jul;38(7):531-8.
5. Dasarathy S, etal., Am J Physiol Gastrointest Liver Physiol 2004 Jul 15;.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Gu H, etal., Biochem Biophys Res Commun. 2016 Aug 12;477(1):115-22. doi: 10.1016/j.bbrc.2016.06.030. Epub 2016 Jun 8.
9. Holzbaur EL, etal., Neurobiol Dis. 2006 Sep;23(3):697-707. Epub 2006 Jul 11.
10. Hosoyama T, etal., J Reprod Dev. 2006 Aug;52(4):469-78. Epub 2006 Mar 31.
11. Hosoyama T, etal., Zoolog Sci. 2005 Feb;22(2):229-36.
12. Kawada S and Ishii N, Eur J Appl Physiol. 2009 Jan 6.
13. Lalani R, etal., J Endocrinol. 2000 Dec;167(3):417-28.
14. Lang CH, etal., Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E916-26. Epub 2004 Jan 28.
15. Lang CH, etal., FASEB J. 2001 Aug;15(10):1807-9.
16. Lima SC, etal., Am J Phys Med Rehabil. 2009 Feb;88(2):126-35.
17. Ma K, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E363-71. Epub 2003 Apr 29.
18. Magee TR, etal., J Gene Med. 2006 Sep;8(9):1171-81.
19. Matsakas A, etal., Acta Physiol Scand. 2005 Mar;183(3):299-307.
20. McPherron AC and Lee SJ, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12457-61.
21. Mendias CL, etal., J Physiol. 2015 Apr 15;593(8):2037-52. doi: 10.1113/jphysiol.2014.287144. Epub 2015 Feb 25.
22. Mendler L, etal., J Muscle Res Cell Motil. 2000;21(6):551-63.
23. MGD data from the GO Consortium
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Nishimura T, etal., Biochem Biophys Res Commun. 2007 Oct 5;361(4):896-902. Epub 2007 Jul 30.
26. OMIM Disease Annotation Pipeline
27. Online Mendelian Inheritance in Man, OMIM (TM).
28. RGD automated data pipeline
29. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. RGD automated import pipeline for gene-chemical interactions
31. RGD comprehensive gene curation
32. Rigamonti AE, etal., Horm Metab Res. 2009 Jan;41(1):23-9. Epub 2008 Oct 7.
33. Salehian B, etal., Metabolism. 2006 Sep;55(9):1239-47.
34. Shyu KG, etal., Eur J Clin Invest. 2006 Oct;36(10):713-9.
35. Sun DF, etal., Kidney Int. 2006 Jun 28.
Additional References at PubMed
PMID:9139826   PMID:11459935   PMID:11877467   PMID:12595574   PMID:14517293   PMID:15215484   PMID:16182246   PMID:16450055   PMID:16873457   PMID:16941139   PMID:17395701   PMID:17959844  
PMID:18089396   PMID:18286185   PMID:18422491   PMID:18801898   PMID:19218333   PMID:19357233   PMID:19406121   PMID:19591015   PMID:19644449   PMID:19736304   PMID:19903098   PMID:19959771  
PMID:20002838   PMID:20007454   PMID:20103742   PMID:20191313   PMID:20396675   PMID:20677217   PMID:20801187   PMID:20884321   PMID:21390326   PMID:21539891   PMID:22033906   PMID:22244812  
PMID:22332899   PMID:22464481   PMID:22684687   PMID:22696074   PMID:22854904   PMID:23255067   PMID:23752591   PMID:23829672   PMID:23844238   PMID:24076600   PMID:25575785   PMID:25960249  
PMID:26151859   PMID:26205544   PMID:26342801   PMID:26927339   PMID:27128567   PMID:27625211   PMID:28257634   PMID:28533206   PMID:28539643   PMID:29330193   PMID:30366029   PMID:31054482  
PMID:32173683   PMID:34453705   PMID:34576046  


Genomics

Comparative Map Data
Mstn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2948,453,982 - 48,458,809 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)Ensembl
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Celera946,124,738 - 46,129,565 (-)NCBICelera
Cytogenetic Map9q22NCBI
MSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,055,700 - 190,062,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2190,055,700 - 190,062,729 (-)EnsemblGRCh38hg38GRCh38
GRCh372190,920,426 - 190,927,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,628,671 - 190,635,700 (-)NCBINCBI36hg18NCBI36
Build 342190,745,932 - 190,752,961NCBI
Celera2184,515,357 - 184,522,386 (-)NCBI
Cytogenetic Map2q32.2NCBI
HuRef2182,780,433 - 182,787,462 (-)NCBIHuRef
CHM1_12190,926,378 - 190,933,407 (-)NCBICHM1_1
T2T-CHM13v2.02190,545,060 - 190,552,089 (-)NCBI
Mstn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,100,799 - 53,107,238 (+)NCBIGRCm39mm39
GRCm39 Ensembl153,100,799 - 53,107,238 (+)Ensembl
GRCm38153,061,640 - 53,068,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,061,640 - 53,068,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv37153,118,507 - 53,124,923 (+)NCBIGRCm37mm9NCBIm37
MGSCv36153,006,208 - 53,012,624 (+)NCBImm8
Celera153,601,512 - 53,607,928 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Mstn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,914,482 - 8,923,465 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,914,505 - 8,921,190 (+)NCBIChiLan1.0ChiLan1.0
MSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B195,283,903 - 195,290,922 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B195,283,903 - 195,290,922 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B77,364,927 - 77,452,426 (-)NCBIMhudiblu_PPA_v0panPan3
MSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137729,172 - 734,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37729,172 - 734,362 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha371,685,007 - 1,690,090 (-)NCBI
ROS_Cfam_1.037623,197 - 628,235 (-)NCBI
ROS_Cfam_1.0 Ensembl37621,860 - 628,368 (-)Ensembl
UMICH_Zoey_3.137633,617 - 638,697 (-)NCBI
UNSW_CanFamBas_1.037601,655 - 606,733 (-)NCBI
UU_Cfam_GSD_1.037629,871 - 634,951 (-)NCBI
Mstn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,842,726 - 148,849,304 (-)NCBI
SpeTri2.0NW_0049365067,988,879 - 7,996,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,620,269 - 94,628,546 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11594,623,526 - 94,628,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,734,309 - 105,739,223 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,564,816 - 75,570,956 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,565,152 - 75,570,528 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040123,900,932 - 123,908,109 (+)NCBIVero_WHO_p1.0
Mstn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,892,938 - 5,899,473 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248545,893,051 - 5,899,380 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
GDF8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,454,110 - 48,454,300 (+)MAPPERmRatBN7.2
Rnor_6.0953,311,106 - 53,311,295NCBIRnor6.0
Rnor_5.0952,977,500 - 52,977,689UniSTSRnor5.0
RGSC_v3.4945,426,960 - 45,427,149UniSTSRGSC3.4
Celera946,124,867 - 46,125,056UniSTS
Cytogenetic Map9q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
6903937Bp356Blood pressure QTL 3560.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94790220852283252Rat


Genetic Models
This gene Mstn is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:149
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000038093
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 8 1 6
Low 15 6 14 2 3 44 18 10 2 2
Below cutoff 3 28 10 8 5 8 24 12 10 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038093   ⟹   ENSRNOP00000038159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)Ensembl
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)Ensembl
RefSeq Acc Id: NM_019151   ⟹   NP_062024
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2948,453,982 - 48,458,809 (-)NCBI
Rnor_6.0953,310,977 - 53,315,804 (-)NCBI
Rnor_5.0952,977,371 - 52,982,198 (-)NCBI
RGSC_v3.4945,426,831 - 45,431,658 (-)RGD
Celera946,124,738 - 46,129,565 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062024 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB86691 (Get FASTA)   NCBI Sequence Viewer  
  EDL99109 (Get FASTA)   NCBI Sequence Viewer  
  O35312 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062024   ⟸   NM_019151
- Peptide Label: precursor
- UniProtKB: O35312 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038159   ⟸   ENSRNOT00000038093

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35312-F1-model_v2 AlphaFold O35312 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 53315642 53315643 C T snv LEW/Crl (RGD), LEW/NCrlBR (RGD), SR/JrHsd (RGD), SHR/NHsd (RGD)
9 53315644 53315645 A T snv LEW/NCrlBR (RGD), SHR/NHsd (RGD), SR/JrHsd (RGD), LEW/Crl (RGD)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 52982036 52982037 C T snv SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 45431496 45431497 C T snv ACI/EurMcwi (MCW), SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3115 AgrOrtholog
BioCyc Gene G2FUF-27623 BioCyc
Ensembl Genes ENSRNOG00000021294 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000038159 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038093 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  GDF_8 UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:29152 UniProtKB/Swiss-Prot
NCBI Gene 29152 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  PTHR11848:SF150 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Mstn PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt GDF8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Mstn  myostatin  Gdf8  growth differentiation factor 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gdf8  growth differentiation factor 8       Name updated 70584 APPROVED
2002-02-27 Gdf8  growth differentiation factor 8      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may contribute to cirrhosis-associated skeletal muscle atrophy by causing impairment of satellite cell proliferation 1302208
gene_function positive regulator of satellite cell function 1302208
gene_mutations_overexpression overexpression leads to skeletal muscle atrophy 1302208
gene_physical_interaction binds to receptor activinR2b 1302208