Ormdl1 (ORMDL sphingolipid biosynthesis regulator 1)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Ormdl1 (ORMDL sphingolipid biosynthesis regulator 1) Rattus norvegicus

Analyze

Symbol:

Ormdl1

Name:

ORMDL sphingolipid biosynthesis regulator 1

RGD ID:

2300146

Description:

Predicted to enable several functions, including RNA-DNA hybrid ribonuclease activity; nucleotidyltransferase activity; and zinc ion binding activity. Predicted to be involved in ceramide metabolic process; intracellular sphingolipid homeostasis; and sphingolipid biosynthetic process. Predicted to act upstream of or within negative regulation of ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of SPOTS complex. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC100188936; MGC188592; ORM1-like 1; ORM1-like 1 (S. cerevisiae); ORM1-like protein 1; uncharacterized protein LOC100188936

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Alliance Genes

More Info

more info ...

Related Pseudogenes:

Ormdl1-ps4

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	48,243,365 - 48,253,316 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	48,237,572 - 48,253,211 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	56,779,537 - 56,789,480 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	61,902,356 - 61,912,299 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	60,198,344 - 60,208,289 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	53,110,628 - 53,120,454 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	53,111,371 - 53,118,613 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	52,775,064 - 52,784,570 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	45,192,469 - 45,203,142 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	45,909,024 - 45,919,336 (-)	NCBI		Celera
Cytogenetic Map	9	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

immunodeficiency 31B (ISO)

Lynch syndrome (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chlordecone (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fluoranthene (ISO)

folic acid (ISO)

gentamycin (EXP)

indometacin (ISO)

leflunomide (ISO)

mercury dichloride (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ceramide metabolic process (IBA,ISO)

DNA integration (IEA)

intracellular sphingolipid homeostasis (IBA)

motor behavior (ISO)

myelination (ISO)

negative regulation of ceramide biosynthetic process (ISO)

regulation of ceramide biosynthetic process (ISO)

regulation of sphingolipid biosynthetic process (ISO)

RNA phosphodiester bond hydrolysis, endonucleolytic (IEA)

sphingolipid biosynthetic process (IBA)

sphingomyelin biosynthetic process (ISO)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

SPOTS complex (IBA)

Molecular Function

nucleic acid binding (IEA)

nucleotidyltransferase activity (IEA)

protein binding (ISO)

RNA-DNA hybrid ribonuclease activity (IEA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12093374	PMID:12477932	PMID:20182505	PMID:25691431

Genomics

Comparative Map Data

Ormdl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	48,243,365 - 48,253,316 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	48,237,572 - 48,253,211 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	56,779,537 - 56,789,480 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	61,902,356 - 61,912,299 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	60,198,344 - 60,208,289 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	53,110,628 - 53,120,454 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	53,111,371 - 53,118,613 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	52,775,064 - 52,784,570 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	45,192,469 - 45,203,142 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	45,909,024 - 45,919,336 (-)	NCBI		Celera
Cytogenetic Map	9	q22	NCBI

ORMDL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	189,763,859 - 189,784,339 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	189,770,267 - 189,784,364 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	190,628,585 - 190,649,065 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	190,343,295 - 190,355,677 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	190,460,555 - 190,472,938	NCBI
Celera	2	184,229,906 - 184,244,025 (-)	NCBI		Celera
Cytogenetic Map	2	q32.2	NCBI
HuRef	2	182,494,629 - 182,508,748 (-)	NCBI		HuRef
CHM1_1	2	190,640,856 - 190,654,980 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	190,253,126 - 190,273,622 (-)	NCBI		T2T-CHM13v2.0

Ormdl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	53,336,254 - 53,349,404 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	53,336,254 - 53,349,468 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	53,297,095 - 53,310,245 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	53,297,095 - 53,310,309 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	53,353,939 - 53,367,089 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	53,241,658 - 53,254,783 (+)	NCBI		MGSCv36	mm8
Celera	1	53,836,500 - 53,849,637 (+)	NCBI		Celera
Cytogenetic Map	1	C1.1	NCBI

Ormdl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	9,100,516 - 9,113,223 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	9,100,516 - 9,113,230 (+)	NCBI	ChiLan1.0	ChiLan1.0

ORMDL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	194,997,037 - 195,010,516 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	194,996,437 - 195,009,102 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	77,076,432 - 77,090,531 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ORMDL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	509,592 - 521,511 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	511,149 - 522,865 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	1,483,024 - 1,494,763 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	403,411 - 415,148 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	400,745 - 415,141 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	413,833 - 425,569 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	382,316 - 394,032 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	410,296 - 422,040 (-)	NCBI		UU_Cfam_GSD_1.0

Ormdl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	148,628,622 - 148,641,164 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936506	8,196,784 - 8,210,584 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936506	8,197,116 - 8,208,712 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ORMDL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	94,359,358 - 94,377,303 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	94,359,784 - 94,377,331 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	105,397,162 - 105,414,708 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ORMDL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	75,291,320 - 75,305,412 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	75,287,780 - 75,305,001 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	124,175,553 - 124,189,636 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Ormdl1
105 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	131
Count of miRNA genes:	112
Interacting mature miRNAs:	116
Transcripts:	ENSRNOT00000065581
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
11353947	Bp392	Blood pressure QTL 392			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	7283252	52283252	Rat
9589133	Insul26	Insulin level QTL 26	17.96	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	9	8952560	53952560	Rat
7411609	Foco16	Food consumption QTL 16	25.6	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	8952560	53952560	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	22133322	49968732	Rat
7207805	Bmd88	Bone mineral density QTL 88	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	9	23754024	58157242	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	23754024	61381613	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
6903937	Bp356	Blood pressure QTL 356		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	47902208	52283252	Rat

Markers in Region

AI547482

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	48,248,925 - 48,249,110 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	53,116,189 - 53,116,373	NCBI	Rnor6.0
Rnor_5.0	9	52,780,625 - 52,780,809	UniSTS	Rnor5.0
RGSC_v3.4	9	45,198,304 - 45,198,488	UniSTS	RGSC3.4
Celera	9	45,914,860 - 45,915,044	UniSTS
RH 3.4 Map	7	636.49	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	16	27	12	19	12			41	22	34	10
Low		27	30	29		29	8	11	33	13	7	1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000065581 ⟹ ENSRNOP00000061507

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	48,237,572 - 48,253,197 (-)	Ensembl
Rnor_6.0 Ensembl	9	53,111,371 - 53,118,613 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102001 ⟹ ENSRNOP00000083666

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	48,243,405 - 48,253,197 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102245 ⟹ ENSRNOP00000084742

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	48,242,511 - 48,253,211 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102919 ⟹ ENSRNOP00000091138

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	48,242,511 - 48,251,526 (-)	Ensembl

RefSeq Acc Id:

NM_001134704 ⟹ NP_001128176

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	48,243,365 - 48,253,196 (-)	NCBI
Rnor_6.0	9	53,110,628 - 53,120,454 (-)	NCBI
Rnor_5.0	9	52,775,064 - 52,784,570 (-)	NCBI
RGSC_v3.4	9	45,192,469 - 45,203,142 (-)	RGD
Celera	9	45,909,024 - 45,919,336 (-)	RGD

Sequence:

show sequence

CGGGATTTGTCCTGTAACCTGCCAGGAGCTGGCGGCCGAGCAGACATGAATGTTGGAGTTGCCC
ACAGTGAGGTAAACCCCAATACTCGTGTAATGAATAGCCGTGGTATGTGGCTGACATATGCTTT
GGGAGTTGGCCTGCTTCACATTGTATTTCTCAGCATCCCCTTCTGCAGTGTTCCTGTTGCCTGG
ACCTTAACAAACATAATACATAATCTGGTGTCCCCGCGTATTCTTGCTGGCGAGGTCGCGCAGG
ACATTTGGTGCCGAGAACCCGGGACGCCACACCATCGCCAGGCGCTGACAGAGGAGGTCCTCCG
TCCGCAGAGAGAATCCAAAAAGCTGCAGGACGCGGGAAGAAGACAACCCATTCTGGCTACCGGA
ACGACTGACACGGAGAATTCTGACGCCTAAAAATGACTCCTGGATGGATCCCTCGGAAACTACC
TCTAGCCCTCACACTGCCTCTTTGGATTTGGATTCCTAGTACTTCAAAGAATGAGTGGGGGTGG
CTCTGTTTGGTGCAGCCCTATGCTGTGGATTAGTGTTCATGCTATGGTTGGTTTGCAAACTCAG
ATCTCAACAGAAACGTGACAAGGCCGTTATCACTCAAGCACTTGTGGCCATTGAACAAGGGGCC
TCCCCTAAAATTTGGTTATCTATCTTCAAAAATTAGTCGGTATCTGAGTTCTCTGCTCTTGCAC
CCCATGGATCTGTGGATCCATTGCACTGGGATGAGAGAGACTTAATGATTCTTTGATCAGCCCT
TCTACATCGCTGAGGTTTCCTCATTGCACGCGATAGGGTGATCATGATTTCCCCACTAACTCAT
TTTCTGGCTGGCCTCTTTTTAGAGTTCGCCCTAGGTCATTTAACAGTTACTGTCACACAGCACT
GCGGTATCCAGAGACGGGCAACTTTCCTCATGCACAGACCAATCTAAGACACGGGGCCCAGTGG
CGATAGGGTTACCCTTCGACGGATAAGGCTGTGACATAGAGGAACGACCTAAGACAGGAGCCAC
AGCAGATGGACGTAACTGCAGGGACCTAGACCAGCCTAGACAATAATTTTTTGTTATTAATAAA
ATAATAAGGGGGAGATGTAGAGGGCTGCAATAACATTCGCCACCACAAGATGGCGCTGGCTTCC
ACTGCGCCCCACGTGGAAGGCCGAGATAGCTTTGCCATTACAAGATGGCGCTGGCCTCCGCCGC
GCCAGCTGACTTCCTTTCAGGAAGTTAACTGTGTGCGAATGTGCAAGAGTGCCTTTGTGCCAGG
TCTTTGCGCACTCCGGGGCGTGCCTAATGAGATCATGGGTAAGCGACCAATCAGGTGTGGATGC
GCCGCGCTAGGGTGTATATAAGCCGTGCCATGCCGGTGCTCCTGGCCTCTCTTTAAGATTCAAT
AAACGTTTTAGCTGCAGTAAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039082897 ⟹ XP_038938825

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	48,243,882 - 48,253,316 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128176	(Get FASTA)	NCBI Sequence Viewer
	XP_038938825	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66795	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001128176 ⟸ NM_001134704
- UniProtKB:	E9PSZ0 (UniProtKB/TrEMBL), A0A8I5ZW96 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVFLSIPFCSVPVAWTLTNIIHNLVSPRIL AGEVAQDIWCREPGTPHHRQALTEEVLRPQRESKKLQDAGRRQPILATGTTDTENSDA hide sequence

RefSeq Acc Id:

ENSRNOP00000061507 ⟸ ENSRNOT00000065581

RefSeq Acc Id:	XP_038938825 ⟸ XM_039082897
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000084742 ⟸ ENSRNOT00000102245

RefSeq Acc Id:

ENSRNOP00000083666 ⟸ ENSRNOT00000102001

RefSeq Acc Id:

ENSRNOP00000091138 ⟸ ENSRNOT00000102919

Protein Domains

Integrase catalytic Integrase-type RNase H type-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PSZ0-F1-model_v2	AlphaFold	E9PSZ0	1-122	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2300146	AgrOrtholog
BioCyc Gene	G2FUF-27627	BioCyc
Ensembl Genes	ENSRNOG00000042961	Ensembl
	ENSRNOG00000064999	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000061507.2	UniProtKB/TrEMBL
	ENSRNOP00000083666	ENTREZGENE
	ENSRNOP00000083666.1	UniProtKB/TrEMBL
	ENSRNOP00000084742.1	UniProtKB/TrEMBL
	ENSRNOP00000091138.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065581.2	UniProtKB/TrEMBL
	ENSRNOT00000102001	ENTREZGENE
	ENSRNOT00000102001.1	UniProtKB/TrEMBL
	ENSRNOT00000102245.1	UniProtKB/TrEMBL
	ENSRNOT00000102919.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.200	UniProtKB/TrEMBL
	2.30.30.10	UniProtKB/TrEMBL
	3.30.420.10	UniProtKB/TrEMBL
InterPro	Integrase-like_N	UniProtKB/TrEMBL
	Integrase_C_dom_sf_retrovir	UniProtKB/TrEMBL
	Integrase_C_retrovir	UniProtKB/TrEMBL
	Integrase_cat-core	UniProtKB/TrEMBL
	Integrase_Zn-bd_dom_N	UniProtKB/TrEMBL
	ORMDL	UniProtKB/TrEMBL
	RNaseH-like_sf	UniProtKB/TrEMBL
	RNaseH_domain	UniProtKB/TrEMBL
	RNaseH_sf	UniProtKB/TrEMBL
KEGG Report	rno:100188936	UniProtKB/TrEMBL
NCBI Gene	100188936	ENTREZGENE
PANTHER	ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN	UniProtKB/TrEMBL
	INTEGRASE-RELATED	UniProtKB/TrEMBL
	PTHR12665	UniProtKB/TrEMBL
	PTHR12665:SF12	UniProtKB/TrEMBL
Pfam	IN_DBD_C	UniProtKB/TrEMBL
	Integrase_Zn	UniProtKB/TrEMBL
	ORMDL	UniProtKB/TrEMBL
	RNase_H	UniProtKB/TrEMBL
	rve	UniProtKB/TrEMBL
PhenoGen	Ormdl1	PhenoGen
PROSITE	INTEGRASE	UniProtKB/TrEMBL
	INTEGRASE_DBD	UniProtKB/TrEMBL
	RNASE_H	UniProtKB/TrEMBL
	ZF_INTEGRASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46919	UniProtKB/TrEMBL
	SSF50122	UniProtKB/TrEMBL
	SSF53098	UniProtKB/TrEMBL
UniProt	A0A8I5ZW96	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GC53_RAT	UniProtKB/TrEMBL
	E9PSZ0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-06-25	Ormdl1	ORMDL sphingolipid biosynthesis regulator 1	Ormdl1	ORM1-like 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-06	LOC100188936				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar