Serpine2 (serpin family E member 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Serpine2 (serpin family E member 2) Rattus norvegicus
Analyze
Symbol: Serpine2
Name: serpin family E member 2
RGD ID: 3748
Description: Exhibits heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including dense core granule biogenesis; embryo implantation; and negative regulation of blood coagulation. Localizes to extracellular space; membrane; and neuronal cell body. Biomarker of brain edema and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2); PARTICIPATES IN fibrinolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Clozapine Regulated Gene; CRG; GDN; Gdnpn1; glia-derived nexin; glia-derived nexin / preotease nexin I; Glia-derived nexin/protease nexin I; peptidase inhibitor 7; PI-7; plasminogen activator inhibitor type 1; Pn-1; protease nexin 1; protease nexin I; protease nexin PN-1; serine (or cysteine) peptidase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 2; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) , member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serpin peptidase inhibitor, clade E, member 2; Spin4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2981,124,746 - 81,188,866 (-)NCBI
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Celera978,614,628 - 78,678,321 (-)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-chloroethanol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dinophysistoxin 1  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (EXP)
Mitotane  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP)
O-methyleugenol  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
progesterone  (EXP)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP)
sarpogrelate  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Arcone R, etal., Biochim Biophys Acta. 2009 Apr;1794(4):602-14. Epub 2008 Dec 24.
2. Bouton MC, etal., Arterioscler Thromb Vasc Biol 2003 Jan 1;23(1):142-7.
3. Bouton MC, etal., Circ Res. 2007 Apr 27;100(8):1174-81. Epub 2007 Mar 22.
4. Erno H and Monard D, Gene Expr 1993;3(2):163-74.
5. Erno H, etal., Mech Dev 1996 Dec;60(2):139-50.
6. Erno H, etal., Mol Cell Neurosci 1996;8(1):28-37.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Giau R, etal., J Neurosci. 2005 Sep 28;25(39):8995-9004.
9. GOA data from the GO Consortium
10. Kim NK, etal., Thromb Res. 2001 Jul 15;103(2):135-42.
11. Kim T and Loh YP, Mol Biol Cell. 2006 Feb;17(2):789-98. Epub 2005 Nov 30.
12. Kury P, etal., Development 1997 Mar;124(6):1251-62.
13. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
14. MGD data from the GO Consortium
15. Mihailescu D, etal., Mech Dev 1999 Jun;84(1-2):55-67.
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Niclou SP, etal., Eur J Neurosci. 1998 May;10(5):1590-607.
18. Nitsch C, etal., Eur J Neurosci. 1993 Mar 1;5(3):292-7.
19. Rao JS, etal., Biochem Biophys Res Commun. 1993 Sep 15;195(2):853-8.
20. RGD automated data pipeline
21. RGD automated import pipeline for gene-chemical interactions
22. Richard B, etal., J Cell Physiol. 2004 Oct;201(1):138-45.
23. Riek-Burchardt M, etal., Neurosci Lett 2002 Aug 30;329(2):181-4.
24. Sommer J, etal., Biochemistry 1987 Oct 6;26(20):6407-10.
25. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Wagner SL, etal., Proc Natl Acad Sci U S A. 1989 Nov;86(21):8284-8.
27. Wu H, etal., J Neurol Sci. 2008 Jul 15;270(1-2):172-83. Epub 2008 Apr 28.
Additional References at PubMed
PMID:1298926   PMID:1554734   PMID:1691280   PMID:1939253   PMID:2037625   PMID:2337608   PMID:3279057   PMID:3997857   PMID:8889548   PMID:9169529   PMID:9757068   PMID:11248026  
PMID:12947022   PMID:15354176   PMID:15509762   PMID:16941024   PMID:17409116   PMID:17409231   PMID:18398001   PMID:19249338   PMID:19855083   PMID:20819545   PMID:20942929   PMID:22206666  
PMID:23106098   PMID:24006456   PMID:24769233  


Genomics

Comparative Map Data
Serpine2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2981,124,746 - 81,188,866 (-)NCBI
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Celera978,614,628 - 78,678,321 (-)NCBICelera
Cytogenetic Map9q34NCBI
SERPINE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2223,975,045 - 224,039,318 (-)EnsemblGRCh38hg38GRCh38
GRCh382223,975,045 - 224,039,286 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,839,762 - 224,904,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,548,118 - 224,612,237 (-)NCBINCBI36hg18NCBI36
Build 342224,665,383 - 224,729,498NCBI
Celera2218,605,681 - 218,669,944 (-)NCBI
Cytogenetic Map2q36.1NCBI
HuRef2216,691,512 - 216,755,073 (-)NCBIHuRef
CHM1_12224,846,268 - 224,910,507 (-)NCBICHM1_1
Serpine2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,772,038 - 79,836,382 (-)NCBIGRCm39mm39
GRCm39 Ensembl179,771,914 - 79,838,897 (-)Ensembl
GRCm38179,794,317 - 79,858,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,794,197 - 79,861,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37179,790,896 - 79,855,240 (-)NCBIGRCm37mm9NCBIm37
MGSCv36179,673,221 - 79,737,660 (-)NCBImm8
Celera179,823,073 - 79,887,353 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.97NCBI
Serpine2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,027,104 - 10,076,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,049,822 - 10,076,155 (+)NCBIChiLan1.0ChiLan1.0
SERPINE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B229,797,659 - 229,854,027 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B229,797,655 - 229,861,040 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B111,221,317 - 111,285,491 (-)NCBIMhudiblu_PPA_v0panPan3
SERPINE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13729,699,551 - 29,750,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3729,700,024 - 29,724,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3730,534,229 - 30,591,635 (-)NCBI
ROS_Cfam_1.03729,723,835 - 29,781,464 (-)NCBI
UMICH_Zoey_3.13729,633,656 - 29,691,135 (-)NCBI
UNSW_CanFamBas_1.03729,569,650 - 29,627,098 (-)NCBI
UU_Cfam_GSD_1.03729,584,772 - 29,642,251 (-)NCBI
Serpine2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,299,482 - 179,325,465 (-)NCBI
SpeTri2.0NW_0049365695,642,328 - 5,668,278 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,747,294 - 125,816,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115125,748,383 - 125,777,788 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,183,910 - 139,249,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110109,921,619 - 109,988,137 (-)NCBI
ChlSab1.1 Ensembl10109,921,598 - 109,987,513 (-)Ensembl
Vero_WHO_p1.0NW_02366604089,416,611 - 89,482,995 (+)NCBI
Serpine2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248231,261,458 - 1,326,261 (+)NCBI

Position Markers
AU047411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,189,752 - 81,189,924 (+)MAPPER
Rnor_6.0985,627,032 - 85,627,201NCBIRnor6.0
Rnor_5.0985,376,489 - 85,376,658UniSTSRnor5.0
RGSC_v3.4979,167,267 - 79,167,436UniSTSRGSC3.4
Celera978,679,252 - 78,679,421UniSTS
Cytogenetic Map9q34UniSTS
RH140749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,124,865 - 81,124,999 (+)MAPPER
mRatBN7.26140,485,411 - 140,485,545 (-)MAPPER
mRatBN7.2981,124,865 - 81,124,999 (-)MAPPER
mRatBN7.26140,485,411 - 140,485,545 (+)MAPPER
Rnor_6.0985,560,972 - 85,561,105NCBIRnor6.0
Rnor_6.06147,447,365 - 147,447,498NCBIRnor6.0
Rnor_5.0985,312,260 - 85,312,393UniSTSRnor5.0
Rnor_5.06156,356,829 - 156,356,962UniSTSRnor5.0
RGSC_v3.46146,869,648 - 146,869,781UniSTSRGSC3.4
RGSC_v3.4979,091,534 - 79,091,667UniSTSRGSC3.4
Celera978,614,746 - 78,614,879UniSTS
Celera6138,128,445 - 138,128,578UniSTS
Cytogenetic Map9q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92748615588333183Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)94126103490024806Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94657976991579769Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94657976991579769Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94724896594124663Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)966757444112943287Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96745166499920892Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96745166499920892Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)970241351115241351Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)970942881115942881Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)981411073119983851Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)98368615398164303Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)983686153111609081Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000020919
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 30 25 7 25 8 11 74 31 32 9 8
Low 1 27 16 12 16 4 9 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ007480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY780673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ199747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF110312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV726078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020919   ⟹   ENSRNOP00000020919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077331   ⟹   ENSRNOP00000072257
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl985,560,892 - 85,617,954 (-)Ensembl
RefSeq Acc Id: NM_019197   ⟹   NP_062070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2981,124,746 - 81,188,816 (-)NCBI
Rnor_6.0985,560,852 - 85,626,094 (-)NCBI
Rnor_5.0985,312,140 - 85,375,577 (-)NCBI
RGSC_v3.4979,091,414 - 79,166,330 (-)RGD
Celera978,614,628 - 78,678,321 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245162   ⟹   XP_006245224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2981,124,842 - 81,188,866 (-)NCBI
Rnor_6.0985,560,987 - 85,626,141 (-)NCBI
Rnor_5.0985,312,140 - 85,375,577 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767212   ⟹   XP_008765434
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0985,560,987 - 85,597,444 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596304   ⟹   XP_017451793
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0985,560,987 - 85,629,410 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083112   ⟹   XP_038939040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2981,124,842 - 81,188,842 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062070   ⟸   NM_019197
- Peptide Label: precursor
- UniProtKB: P07092 (UniProtKB/Swiss-Prot),   G3V7Z4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245224   ⟸   XM_006245162
- Peptide Label: isoform X1
- UniProtKB: G3V7Z4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765434   ⟸   XM_008767212
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017451793   ⟸   XM_017596304
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000072257   ⟸   ENSRNOT00000077331
RefSeq Acc Id: ENSRNOP00000020919   ⟸   ENSRNOT00000020919
RefSeq Acc Id: XP_038939040   ⟸   XM_039083112
- Peptide Label: isoform X1
Protein Domains
SERPIN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696794
Promoter ID:EPDNEW_R7318
Type:single initiation site
Name:Serpine2_1
Description:serpin family E member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0985,626,107 - 85,626,167EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3748 AgrOrtholog
Ensembl Genes ENSRNOG00000015461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020919 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072257 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020919 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000077331 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29366 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpine2 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228852
UniProt G3V7Z4 ENTREZGENE, UniProtKB/TrEMBL
  GDN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpine2  serpin family E member 2  Serpine2  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serpine2  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Serpine2  serpin peptidase inhibitor, clade E, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serpine2  serpin peptidase inhibitor, clade E, member 2  Serpine2  serine (or cysteine) peptidase inhibitor, clade E, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Serpine2  serine (or cysteine) peptidase inhibitor, clade E, member 2  Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-05-03 Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2   Gdnpn1  serine (or cysteine) proteinase inhibitor, clade E, member 2   Data Merged 737654 APPROVED
2003-04-09 Gdnpn1  serine (or cysteine) proteinase inhibitor, clade E, member 2     Glia-derived nexin/protease nexin I  Name updated 629478 APPROVED
2002-06-10 Gdnpn1  Glia-derived nexin/protease nexin I      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2       Name updated 70584 APPROVED
2001-11-02 Serpine2  serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) , member 2      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript promoter contains five SP1 consensus sites, four consensus sites for the MyoD1 transcription factor, and one binding site for the transcription factors NGFI-A, NGFI-C, Krox-20, and Wilms tumor factor 632811