Serpine2 (serpin family E member 2) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Serpine2 (serpin family E member 2) Rattus norvegicus
Analyze
Symbol: Serpine2
Name: serpin family E member 2
RGD ID: 3748
Description: Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including dense core granule biogenesis; embryo implantation; and negative regulation of blood coagulation. Located in extracellular space and neuronal cell body. Biomarker of brain edema and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2); PARTICIPATES IN fibrinolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Clozapine Regulated Gene; CRG; GDN; Gdnpn1; glia-derived nexin; glia-derived nexin / preotease nexin I; Glia-derived nexin/protease nexin I; peptidase inhibitor 7; PI-7; plasminogen activator inhibitor type 1; Pn-1; protease nexin 1; protease nexin I; protease nexin PN-1; serine (or cysteine) peptidase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 2; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) , member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serpin peptidase inhibitor, clade E, member 2; Spin4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2981,124,746 - 81,188,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,124,804 - 81,188,826 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx989,554,492 - 89,618,567 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0994,683,384 - 94,747,462 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0993,065,906 - 93,129,981 (-)NCBIRnor_WKY
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Celera978,614,628 - 78,678,321 (-)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-chloroethanol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dinophysistoxin 1  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (EXP)
Mitotane  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
progesterone  (EXP)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (ISO)
cell differentiation  (IEA)
cerebellar granular layer morphogenesis  (IEA,ISO)
dense core granule biogenesis  (IDA)
detection of mechanical stimulus involved in sensory perception  (IEA,ISO)
embryo implantation  (IEP)
innervation  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
mating plug formation  (IEA,ISO)
negative regulation of blood coagulation  (IDA,ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of endopeptidase activity  (IBA)
negative regulation of peptidase activity  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISO)
negative regulation of plasminogen activation  (IBA,IEA,ISO)
negative regulation of platelet activation  (ISO)
negative regulation of platelet aggregation  (IEA,ISO)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of proteolysis  (IDA,ISO)
negative regulation of smoothened signaling pathway  (IEA,ISO)
negative regulation of sodium ion transport  (IEA,ISO)
platelet activation  (IEA,ISO)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of neuron projection development  (IDA)
protein catabolic process  (IEA,ISO)
regulation of synaptic transmission, glutamatergic  (IEA,ISO)
regulation of timing of cell differentiation  (IEA,ISO)
response to wounding  (ISO)
secretion by cell  (IEA,ISO)
secretory granule organization  (IDA,IEA,ISO)
seminal vesicle epithelium development  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Conformational and biochemical characterization of a biologically active rat recombinant Protease Nexin-1 expressed in E. coli. Arcone R, etal., Biochim Biophys Acta. 2009 Apr;1794(4):602-14. Epub 2008 Dec 24.
2. The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats. Bouton MC, etal., Arterioscler Thromb Vasc Biol 2003 Jan 1;23(1):142-7.
3. Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Bouton MC, etal., Circ Res. 2007 Apr 27;100(8):1174-81. Epub 2007 Mar 22.
4. Molecular organization of the rat glia-derived nexin/protease nexin-1 promoter. Erno H and Monard D, Gene Expr 1993;3(2):163-74.
5. A Krox binding site regulates protease nexin-1 promoter activity in embryonic heart, cartilage and parts of the nervous system. Erno H, etal., Mech Dev 1996 Dec;60(2):139-50.
6. Excitotoxic brain lesion modifies binding to a USF binding site acting as a negative regulatory element in the Protease nexin-1 promoter. Erno H, etal., Mol Cell Neurosci 1996;8(1):28-37.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Constitutive secretion of protease nexin-1 by glial cells and its regulation by G-protein-coupled receptors. Giau R, etal., J Neurosci. 2005 Sep 28;25(39):8995-9004.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Increased expression and localization of a serine protease inhibitor, protease nexin-1 (PN-1), in the ovary and uterus during implantation in rat. Kim NK, etal., Thromb Res. 2001 Jul 15;103(2):135-42.
11. Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Kim T and Loh YP, Mol Biol Cell. 2006 Feb;17(2):789-98. Epub 2005 Nov 30.
12. Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells. Kury P, etal., Development 1997 Mar;124(6):1251-62.
13. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. An octamer-binding site is crucial for the activity of an enhancer active at the embryonic met-/mesencephalic junction. Mihailescu D, etal., Mech Dev 1999 Jun;84(1-2):55-67.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion. Niclou SP, etal., Eur J Neurosci. 1998 May;10(5):1590-607.
18. The glia-derived protease nexin 1 persists for over 1 year in rat brain areas selectively lesioned by transient global ischaemia. Nitsch C, etal., Eur J Neurosci. 1993 Mar 1;5(3):292-7.
19. Decreased levels of glia-derived nexin/protease nexin I in irradiated rat spinal cord in vivo. Rao JS, etal., Biochem Biophys Res Commun. 1993 Sep 15;195(2):853-8.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Protease nexin-1: a cellular serpin down-regulated by thrombin in rat aortic smooth muscle cells. Richard B, etal., J Cell Physiol. 2004 Oct;201(1):138-45.
23. Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors. Riek-Burchardt M, etal., Neurosci Lett 2002 Aug 30;329(2):181-4.
24. cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily. Sommer J, etal., Biochemistry 1987 Oct 6;26(20):6407-10.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Wagner SL, etal., Proc Natl Acad Sci U S A. 1989 Nov;86(21):8284-8.
27. The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage. Wu H, etal., J Neurol Sci. 2008 Jul 15;270(1-2):172-83. Epub 2008 Apr 28.
Additional References at PubMed
PMID:1298926   PMID:1554734   PMID:1691280   PMID:1939253   PMID:2037625   PMID:2337608   PMID:3279057   PMID:3997857   PMID:8889548   PMID:9169529   PMID:9757068   PMID:11248026  
PMID:12947022   PMID:15354176   PMID:15509762   PMID:16941024   PMID:17409116   PMID:17409231   PMID:18398001   PMID:19249338   PMID:19855083   PMID:20819545   PMID:20942929   PMID:22206666  
PMID:23106098   PMID:24006456   PMID:24769233  


Genomics

Comparative Map Data
Serpine2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2981,124,746 - 81,188,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,124,804 - 81,188,826 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx989,554,492 - 89,618,567 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0994,683,384 - 94,747,462 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0993,065,906 - 93,129,981 (-)NCBIRnor_WKY
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Celera978,614,628 - 78,678,321 (-)NCBICelera
Cytogenetic Map9q34NCBI
SERPINE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,975,045 - 224,039,286 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2223,975,045 - 224,039,318 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,839,762 - 224,904,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,548,118 - 224,612,237 (-)NCBINCBI36Build 36hg18NCBI36
Build 342224,665,383 - 224,729,498NCBI
Celera2218,605,681 - 218,669,944 (-)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2216,691,512 - 216,755,073 (-)NCBIHuRef
CHM1_12224,846,268 - 224,910,507 (-)NCBICHM1_1
T2T-CHM13v2.02224,458,312 - 224,522,521 (-)NCBIT2T-CHM13v2.0
Serpine2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,772,038 - 79,836,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,771,914 - 79,838,897 (-)EnsemblGRCm39 Ensembl
GRCm38179,794,317 - 79,858,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,794,197 - 79,861,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37179,790,896 - 79,855,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36179,673,221 - 79,737,660 (-)NCBIMGSCv36mm8
Celera179,823,073 - 79,887,353 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.97NCBI
Serpine2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,027,104 - 10,076,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,049,822 - 10,076,155 (+)NCBIChiLan1.0ChiLan1.0
SERPINE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B126,610,192 - 126,636,992 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,221,317 - 111,285,491 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B229,797,659 - 229,854,027 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B229,797,655 - 229,861,040 (-)Ensemblpanpan1.1panPan2
SERPINE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13729,699,551 - 29,750,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3729,700,024 - 29,724,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3730,534,229 - 30,591,635 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03729,723,835 - 29,781,464 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13729,633,656 - 29,691,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03729,569,650 - 29,627,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03729,584,772 - 29,642,251 (-)NCBIUU_Cfam_GSD_1.0
Serpine2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,299,482 - 179,325,465 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365695,642,264 - 5,668,323 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365695,642,328 - 5,668,278 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,748,394 - 125,816,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115125,748,383 - 125,777,788 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,183,910 - 139,249,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110109,921,619 - 109,988,137 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10109,921,598 - 109,987,513 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604089,416,611 - 89,482,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpine2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248231,261,406 - 1,326,917 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248231,261,458 - 1,326,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpine2
569 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000020919
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat

Markers in Region
AU047411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,189,752 - 81,189,924 (+)MAPPERmRatBN7.2
Rnor_6.0985,627,032 - 85,627,201NCBIRnor6.0
Rnor_5.0985,376,489 - 85,376,658UniSTSRnor5.0
RGSC_v3.4979,167,267 - 79,167,436UniSTSRGSC3.4
Celera978,679,252 - 78,679,421UniSTS
Cytogenetic Map9q34UniSTS
RH140749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,124,865 - 81,124,999 (+)MAPPERmRatBN7.2
mRatBN7.26140,485,411 - 140,485,545 (-)MAPPERmRatBN7.2
mRatBN7.2981,124,865 - 81,124,999 (-)MAPPERmRatBN7.2
mRatBN7.26140,485,411 - 140,485,545 (+)MAPPERmRatBN7.2
Rnor_6.0985,560,972 - 85,561,105NCBIRnor6.0
Rnor_6.06147,447,365 - 147,447,498NCBIRnor6.0
Rnor_5.0985,312,260 - 85,312,393UniSTSRnor5.0
Rnor_5.06156,356,829 - 156,356,962UniSTSRnor5.0
RGSC_v3.46146,869,648 - 146,869,781UniSTSRGSC3.4
RGSC_v3.4979,091,534 - 79,091,667UniSTSRGSC3.4
Celera978,614,746 - 78,614,879UniSTS
Celera6138,128,445 - 138,128,578UniSTS
Cytogenetic Map9q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 30 25 7 25 8 11 74 31 32 9 8
Low 1 27 16 12 16 4 9 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ007480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY780673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ199747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF110312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV726078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020919   ⟹   ENSRNOP00000020919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl981,126,320 - 81,188,826 (-)Ensembl
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077331   ⟹   ENSRNOP00000072257
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl981,124,804 - 81,188,826 (-)Ensembl
Rnor_6.0 Ensembl985,560,892 - 85,617,954 (-)Ensembl
RefSeq Acc Id: NM_019197   ⟹   NP_062070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2981,124,746 - 81,188,816 (-)NCBI
Rnor_6.0985,560,852 - 85,626,094 (-)NCBI
Rnor_5.0985,312,140 - 85,375,577 (-)NCBI
RGSC_v3.4979,091,414 - 79,166,330 (-)RGD
Celera978,614,628 - 78,678,321 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245162   ⟹   XP_006245224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2981,124,842 - 81,188,866 (-)NCBI
Rnor_6.0985,560,987 - 85,626,141 (-)NCBI
Rnor_5.0985,312,140 - 85,375,577 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083112   ⟹   XP_038939040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2981,124,842 - 81,188,842 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062070   ⟸   NM_019197
- Peptide Label: precursor
- UniProtKB: P07092 (UniProtKB/Swiss-Prot),   G3V7Z4 (UniProtKB/TrEMBL),   A0A0G2K2I7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245224   ⟸   XM_006245162
- Peptide Label: isoform X1
- UniProtKB: G3V7Z4 (UniProtKB/TrEMBL),   A0A0G2K2I7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072257   ⟸   ENSRNOT00000077331
RefSeq Acc Id: ENSRNOP00000020919   ⟸   ENSRNOT00000020919
RefSeq Acc Id: XP_038939040   ⟸   XM_039083112
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2I7 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07092-F1-model_v2 AlphaFold P07092 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696794
Promoter ID:EPDNEW_R7318
Type:single initiation site
Name:Serpine2_1
Description:serpin family E member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0985,626,107 - 85,626,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3748 AgrOrtholog
BioCyc Gene G2FUF-27006 BioCyc
Ensembl Genes ENSRNOG00000015461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020919.6 UniProtKB/TrEMBL
  ENSRNOP00000072257 ENTREZGENE
  ENSRNOP00000072257.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020919.8 UniProtKB/TrEMBL
  ENSRNOT00000077331 ENTREZGENE
  ENSRNOT00000077331.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpins superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29366 ENTREZGENE
PANTHER GLIA-DERIVED NEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpine2 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228852
UniProt A0A0G2K2I7 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Z4 ENTREZGENE, UniProtKB/TrEMBL
  GDN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpine2  serpin family E member 2  Serpine2  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serpine2  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Serpine2  serpin peptidase inhibitor, clade E, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serpine2  serpin peptidase inhibitor, clade E, member 2  Serpine2  serine (or cysteine) peptidase inhibitor, clade E, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Serpine2  serine (or cysteine) peptidase inhibitor, clade E, member 2  Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-05-03 Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2   Gdnpn1  serine (or cysteine) proteinase inhibitor, clade E, member 2   Data Merged 737654 APPROVED
2003-04-09 Gdnpn1  serine (or cysteine) proteinase inhibitor, clade E, member 2     Glia-derived nexin/protease nexin I  Name updated 629478 APPROVED
2002-06-10 Gdnpn1  Glia-derived nexin/protease nexin I      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Serpine2  serine (or cysteine) proteinase inhibitor, clade E, member 2       Name updated 70584 APPROVED
2001-11-02 Serpine2  serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) , member 2      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript promoter contains five SP1 consensus sites, four consensus sites for the MyoD1 transcription factor, and one binding site for the transcription factors NGFI-A, NGFI-C, Krox-20, and Wilms tumor factor 632811