Poglut2 (protein O-glucosyltransferase 2) - Rat Genome Database

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Gene: Poglut2 (protein O-glucosyltransferase 2) Rattus norvegicus
Analyze
Symbol: Poglut2
Name: protein O-glucosyltransferase 2
RGD ID: 1304684
Description: Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in cytosol; endoplasmic reticulum lumen; and nucleoplasm. Predicted to be active in endomembrane system. Orthologous to human POGLUT2 (protein O-glucosyltransferase 2); INTERACTS WITH 17alpha-ethynylestradiol; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KDEL (Lys-Asp-Glu-Leu) containing 1; KDEL motif containing 1; KDEL motif-containing protein 1; Kdelc1; LOC316370; MGC189327
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Poglut2-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,748,484 - 53,801,453 (-)NCBIGRCr8
mRatBN7.2946,256,388 - 46,268,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,256,390 - 46,268,532 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,771,869 - 54,783,977 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,894,669 - 59,906,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0958,174,906 - 58,187,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,872,492 - 50,884,596 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,872,492 - 50,884,596 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,539,453 - 50,551,557 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,194,771 - 43,207,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1943,196,186 - 43,208,615 (-)NCBI
Celera943,960,103 - 43,972,186 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11167020   PMID:12477932   PMID:30127001  


Genomics

Comparative Map Data
Poglut2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,748,484 - 53,801,453 (-)NCBIGRCr8
mRatBN7.2946,256,388 - 46,268,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,256,390 - 46,268,532 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,771,869 - 54,783,977 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,894,669 - 59,906,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0958,174,906 - 58,187,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,872,492 - 50,884,596 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,872,492 - 50,884,596 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,539,453 - 50,551,557 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,194,771 - 43,207,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1943,196,186 - 43,208,615 (-)NCBI
Celera943,960,103 - 43,972,186 (-)NCBICelera
Cytogenetic Map9q22NCBI
POGLUT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,784,281 - 102,798,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,784,281 - 102,799,040 (-)EnsemblGRCh38hg38GRCh38
GRCh3713103,436,631 - 103,451,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,234,632 - 102,249,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413102,234,632 - 102,249,358NCBI
Celera1384,281,120 - 84,295,885 (-)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1384,028,978 - 84,043,745 (-)NCBIHuRef
CHM1_113103,406,079 - 103,420,850 (-)NCBICHM1_1
T2T-CHM13v2.013102,002,466 - 102,017,152 (-)NCBIT2T-CHM13v2.0
Poglut2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,143,060 - 44,158,844 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,145,706 - 44,157,968 (-)EnsemblGRCm39 Ensembl
GRCm38144,106,546 - 44,118,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl144,106,546 - 44,118,808 (-)EnsemblGRCm38mm10GRCm38
MGSCv37144,163,391 - 44,175,618 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36144,051,092 - 44,063,319 (-)NCBIMGSCv36mm8
Celera144,449,999 - 44,462,220 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.54NCBI
Poglut2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,358,542 - 8,374,328 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554048,358,542 - 8,374,216 (+)NCBIChiLan1.0ChiLan1.0
POGLUT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,301,616 - 104,316,338 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113102,971,156 - 102,985,819 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01383,944,645 - 83,959,313 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113103,081,650 - 103,096,378 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13103,081,650 - 103,096,378 (-)Ensemblpanpan1.1panPan2
POGLUT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,274,616 - 52,295,981 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2252,146,466 - 52,372,304 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2252,063,032 - 52,075,652 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,731,044 - 52,743,677 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,731,047 - 52,743,646 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,383,586 - 52,396,199 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,399,690 - 52,412,325 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,440,895 - 52,453,529 (-)NCBIUU_Cfam_GSD_1.0
Poglut2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,666,770 - 187,678,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,273,497 - 8,286,494 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,273,517 - 8,285,384 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POGLUT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,094,223 - 71,110,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11171,095,116 - 71,110,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,386,611 - 78,496,441 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POGLUT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,338,288 - 81,360,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,331,614 - 81,360,706 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604637,875,275 - 37,897,718 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Poglut2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,698,617 - 8,711,241 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247938,698,481 - 8,711,151 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Poglut2
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000016285
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 38 31 2 31 1 1 74 29 35 11 1
Low 3 12 19 10 17 10 7 10 6 6 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000016285   ⟹   ENSRNOP00000016285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,256,390 - 46,268,532 (-)Ensembl
Rnor_6.0 Ensembl950,872,492 - 50,884,596 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109174   ⟹   ENSRNOP00000093048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,256,390 - 46,268,532 (-)Ensembl
RefSeq Acc Id: NM_001277228   ⟹   NP_001264157
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,748,484 - 53,760,588 (-)NCBI
mRatBN7.2946,256,388 - 46,268,492 (-)NCBI
Rnor_6.0950,872,492 - 50,884,596 (-)NCBI
Rnor_5.0950,539,453 - 50,551,557 (-)NCBI
Celera943,960,103 - 43,972,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063267166   ⟹   XP_063123236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,748,486 - 53,801,266 (-)NCBI
RefSeq Acc Id: XM_063267167   ⟹   XP_063123237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,748,486 - 53,801,453 (-)NCBI
RefSeq Acc Id: NP_001264157   ⟸   NM_001277228
- Peptide Label: precursor
- UniProtKB: B5DFA5 (UniProtKB/TrEMBL),   F7FHZ5 (UniProtKB/TrEMBL),   A0A9K3Y6Q7 (UniProtKB/TrEMBL),   A0A8I6AI78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016285   ⟸   ENSRNOT00000016285
RefSeq Acc Id: ENSRNOP00000093048   ⟸   ENSRNOT00000109174
RefSeq Acc Id: XP_063123237   ⟸   XM_063267167
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063123236   ⟸   XM_063267166
- Peptide Label: isoform X1
Protein Domains
Glycosyl transferase CAP10

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFA5-F1-model_v2 AlphaFold B5DFA5 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696645
Promoter ID:EPDNEW_R7169
Type:initiation region
Name:Kdelc1_1
Description:KDEL motif containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0950,884,587 - 50,884,647EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304684 AgrOrtholog
BioCyc Gene G2FUF-27654 BioCyc
Ensembl Genes ENSRNOG00000011740 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016285.7 UniProtKB/TrEMBL
  ENSRNOT00000109174.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126740 IMAGE-MGC_LOAD
InterPro Filamin UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  LipoPS_modifying UniProtKB/TrEMBL
KEGG Report rno:316370 UniProtKB/TrEMBL
MGC_CLONE MGC:95095 IMAGE-MGC_LOAD
NCBI Gene 316370 ENTREZGENE
PANTHER KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED UniProtKB/TrEMBL
  PROTEIN O-GLUCOSYLTRANSFERASE 2 UniProtKB/TrEMBL
Pfam Filamin UniProtKB/TrEMBL
  Glyco_transf_90 UniProtKB/TrEMBL
PhenoGen Poglut2 PhenoGen
PROSITE FILAMIN_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011740 RatGTEx
SMART CAP10 UniProtKB/TrEMBL
  IG_FLMN UniProtKB/TrEMBL
Superfamily-SCOP Ig_E-set UniProtKB/TrEMBL
UniProt A0A8I6AI78 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y6Q7 ENTREZGENE, UniProtKB/TrEMBL
  A6INS4_RAT UniProtKB/TrEMBL
  B5DFA5 ENTREZGENE, UniProtKB/TrEMBL
  F7FHZ5 ENTREZGENE
UniProt Secondary F7FHZ5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Poglut2  protein O-glucosyltransferase 2  Kdelc1  KDEL motif containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-16 Kdelc1  KDEL motif containing 1  Kdelc1  KDEL (Lys-Asp-Glu-Leu) containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Kdelc1  KDEL (Lys-Asp-Glu-Leu) containing 1  Kdelc1_predicted  KDEL (Lys-Asp-Glu-Leu) containing 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Kdelc1_predicted  KDEL (Lys-Asp-Glu-Leu) containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED