Ppp1r14bl (protein phosphatase 1, regulatory inhibitor subunit 14B like) - Rat Genome Database

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Gene: Ppp1r14bl (protein phosphatase 1, regulatory inhibitor subunit 14B like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ppp1r14bl (Ensembl: RGD1309049)
Name: protein phosphatase 1, regulatory inhibitor subunit 14B like (Ensembl:similar to RIKEN cDNA 4933415F23)
RGD ID: 1309049
Description: Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm. Orthologous to human PPP1R14B (protein phosphatase 1 regulatory inhibitor subunit 14B).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC301306; LOC301306; RGD1309049; similar to RIKEN cDNA 4933415F23; uncharacterized protein LOC301306
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8933,027,512 - 33,029,145 (-)NCBIGRCr8
mRatBN7.2925,531,165 - 25,532,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl925,530,869 - 25,532,807 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx934,034,219 - 34,035,874 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0939,157,344 - 39,159,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0937,462,296 - 37,463,951 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0929,336,288 - 29,337,922 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl929,336,290 - 29,337,922 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0928,174,028 - 28,175,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4921,934,169 - 21,935,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1921,935,584 - 21,937,216 (-)NCBI
Celera923,079,698 - 23,081,353 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Ppp1r14bl
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000018896
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 2 4 19 20 21 12 5 12 1 32 13 16 3 29 9

Sequence


Ensembl Acc Id: ENSRNOT00000018896   ⟹   ENSRNOP00000018896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl925,530,869 - 25,532,807 (-)Ensembl
Rnor_6.0 Ensembl929,336,290 - 29,337,922 (-)Ensembl
RefSeq Acc Id: NM_001013956   ⟹   NP_001013978
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8933,027,512 - 33,029,145 (-)NCBI
mRatBN7.2925,531,165 - 25,532,798 (-)NCBI
Rnor_6.0929,336,288 - 29,337,922 (-)NCBI
Rnor_5.0928,174,028 - 28,175,662 (-)NCBI
RGSC_v3.4921,934,169 - 21,935,802 (-)RGD
Celera923,079,698 - 23,081,353 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013978 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82106 (Get FASTA)   NCBI Sequence Viewer  
  EDM18630 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018896.3
RefSeq Acc Id: NP_001013978   ⟸   NM_001013956
- UniProtKB: Q641W6 (UniProtKB/TrEMBL),   A6JJA3 (UniProtKB/TrEMBL),   F7EYB6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018896   ⟸   ENSRNOT00000018896

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641W6-F1-model_v2 AlphaFold Q641W6 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696578
Promoter ID:EPDNEW_R7103
Type:multiple initiation site
Name:RGD1309049_1
Description:similar to RIKEN cDNA 4933415F23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0929,337,921 - 29,337,981EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309049 AgrOrtholog
BioCyc Gene G2FUF-27990 BioCyc
Ensembl Genes ENSRNOG00000014123 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018896.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.220 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134835 IMAGE-MGC_LOAD
InterPro CPI-17_sf UniProtKB/TrEMBL
  PP1_inhibitor UniProtKB/TrEMBL
KEGG Report rno:301306 UniProtKB/TrEMBL
MGC_CLONE MGC:95304 IMAGE-MGC_LOAD
NCBI Gene 301306 ENTREZGENE
PANTHER 4933415F23RIK PROTEIN UniProtKB/TrEMBL
  PP1_inhibitor UniProtKB/TrEMBL
Pfam PP1_inhibitor UniProtKB/TrEMBL
PhenoGen Ppp1r14bl PhenoGen
RatGTEx ENSRNOG00000014123 RatGTEx
Superfamily-SCOP PP1_inhibitor UniProtKB/TrEMBL
UniProt A6JJA3 ENTREZGENE, UniProtKB/TrEMBL
  F7EYB6 ENTREZGENE, UniProtKB/TrEMBL
  Q641W6 ENTREZGENE
UniProt Secondary Q641W6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ppp1r14bl  protein phosphatase 1, regulatory inhibitor subunit 14B like  RGD1309049  similar to RIKEN cDNA 4933415F23  Symbol and Name Changed 1299863 APPROVED
2005-12-06 RGD1309049  similar to RIKEN cDNA 4933415F23  RGD1309049_predicted  similar to RIKEN cDNA 4933415F23 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309049_predicted  similar to RIKEN cDNA 4933415F23 (predicted)  LOC301306_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC301306_predicted  similar to RIKEN cDNA 4933415F23 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL