Slc9a4 (solute carrier family 9 member A4) - Rat Genome Database

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Gene: Slc9a4 (solute carrier family 9 member A4) Rattus norvegicus
Analyze
Symbol: Slc9a4
Name: solute carrier family 9 member A4
RGD ID: 3721
Description: Enables sodium:proton antiporter activity. Predicted to be involved in monoatomic cation transmembrane transport; regulation of intracellular pH; and transepithelial ammonium transport. Predicted to act upstream of or within gastric acid secretion and glandular epithelial cell development. Located in basolateral plasma membrane. Orthologous to human SLC9A4 (solute carrier family 9 member A4); INTERACTS WITH 17beta-estradiol; allethrin; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: na(+)/H(+) exchanger 4; NHE-4; Nhe4; sodium/hydrogen exchanger 4; solute carrier family 9 (sodium/hydrogen exchanger) isoform 4; Solute carrier family 9 (sodium/hydrogen exchanger), isoform 4; solute carrier family 9 (sodium/hydrogen exchanger), member 4; solute carrier family 9 member 4; solute carrier family 9, member 4; solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,320,948 - 50,375,336 (+)NCBIGRCr8
mRatBN7.2942,825,334 - 42,879,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,825,064 - 42,879,422 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,327,359 - 51,376,047 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,450,043 - 56,498,733 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,725,727 - 54,774,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,281,821 - 47,334,755 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,281,961 - 47,328,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,965,557 - 47,018,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,725,135 - 39,773,368 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,726,548 - 39,774,782 (+)NCBI
Celera940,568,530 - 40,616,779 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc9a4Rataortic dissection  ISOSLC9A4 (Homo sapiens)8554872ClinVar Annotator: match by term: Ascending aortic dissectionClinVarPMID:34409081
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc9a4RatAcidoses  ISOSLC9A4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20484819

1 to 20 of 38 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc9a4Rat1,2-dimethylhydrazine decreases expressionISOSlc9a4 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of SLC9A4 mRNACTDPMID:22206623
Slc9a4Rat17beta-estradiol decreases expressionISOSlc9a4 (Mus musculus)6480464Estradiol results in decreased expression of SLC9A4 mRNACTDPMID:19484750
Slc9a4Rat17beta-estradiol decreases expressionISOSLC9A4 (Homo sapiens)6480464Estradiol results in decreased expression of SLC9A4 mRNACTDPMID:31614463
Slc9a4Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of SLC9A4 mRNA and Estradiol results in increased expression of SLC9A4 proteinCTDPMID:23509787
Slc9a4Rat3-iodothyronamine affects uptakeISOSLC9A4 (Homo sapiens)6480464SLC9A4 mRNA affects the uptake of 3-iodothyronamineCTDPMID:19074582
Slc9a4Rataflatoxin B1 decreases methylationISOSLC9A4 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of SLC9A4 geneCTDPMID:27153756
Slc9a4RatAflatoxin B2 alpha increases methylationISOSLC9A4 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of SLC9A4 intronCTDPMID:30157460
Slc9a4Ratall-trans-retinoic acid multiple interactionsISOSlc9a4 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of SLC9A4 mRNACTDPMID:36189433
Slc9a4Ratallethrin multiple interactionsEXP 6480464[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of SLC9A4 proteinCTDPMID:34896426
Slc9a4Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SLC9A4 mRNACTDPMID:35163327
Slc9a4Ratammonia affects metabolic processingISOSlc9a4 (Mus musculus)6480464SLC9A4 protein affects the metabolism of AmmoniaCTDPMID:20484819
Slc9a4Ratammonia affects uptakeISOSlc9a4 (Mus musculus)6480464SLC9A4 protein affects the uptake of AmmoniaCTDPMID:20484819
Slc9a4Ratammonia multiple interactionsISOSlc9a4 (Mus musculus)6480464SLC9A4 protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]CTDPMID:20484819
Slc9a4Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of SLC9A4 mRNACTDPMID:16483693
Slc9a4Ratbenzo[a]pyrene increases methylationISOSLC9A4 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of SLC9A4 exonCTDPMID:27901495
Slc9a4RatBenzo[ghi]perylene increases expressionISOSlc9a4 (Mus musculus)64804641 and 12-benzoperylene results in increased expression of SLC9A4 mRNACTDPMID:26377693
Slc9a4Ratbis(2-ethylhexyl) phthalate decreases expressionISOSlc9a4 (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of SLC9A4 mRNACTDPMID:34319233
Slc9a4Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of SLC9A4 mRNACTDPMID:25181051 and PMID:30816183
Slc9a4Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of SLC9A4 geneCTDPMID:28505145
Slc9a4Ratbisphenol A increases expressionISOSlc9a4 (Mus musculus)6480464bisphenol A results in increased expression of SLC9A4 mRNACTDPMID:25594700

1 to 20 of 38 rows

Biological Process
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc9a4Ratgastric acid secretion acts_upstream_of_or_withinISOSlc9a4 (Mus musculus)1624291MGI:3579458 PMID:15684419RGDPMID:15684419
Slc9a4Ratgastric acid secretion acts_upstream_of_or_withinIEAUniProtKB:Q8BUE1 and ensembl:ENSMUSP000000272331600115GO_REF:0000107EnsemblGO_REF:0000107
Slc9a4Ratglandular epithelial cell development acts_upstream_of_or_withinISOSlc9a4 (Mus musculus)1624291MGI:3579458 PMID:15684419RGDPMID:15684419
Slc9a4Ratglandular epithelial cell development acts_upstream_of_or_withinIEAUniProtKB:Q8BUE1 and ensembl:ENSMUSP000000272331600115GO_REF:0000107EnsemblGO_REF:0000107
Slc9a4Ratmonoatomic cation transport involved_inIEAInterPro:IPR006153 and InterPro:IPR0184221600115GO_REF:0000002InterProGO_REF:0000002
Slc9a4Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Slc9a4Ratpotassium ion transmembrane transport involved_inIBAMGI:2679732 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc9a4Ratproton transmembrane transport involved_inIEAInterPro:IPR006153 and InterPro:IPR0184221600115GO_REF:0000002InterProGO_REF:0000002
Slc9a4Ratregulation of intracellular pH involved_inIBAFB:FBgn0040297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc9a4Ratregulation of pH involved_inIEAInterPro:IPR001953 and InterPro:IPR0047091600115GO_REF:0000002InterProGO_REF:0000002
Slc9a4Ratsodium ion import across plasma membrane involved_inIBAPANTHER:PTN008493947 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc9a4Ratsodium ion transmembrane transport involved_inIEAGO:00153851600115GO_REF:0000108GOCGO_REF:0000108
Slc9a4Ratsodium ion transport involved_inIEAInterPro:IPR001953 and InterPro:IPR0047091600115GO_REF:0000002InterProGO_REF:0000002
Slc9a4Ratsodium ion transport involved_inIEAUniProtKB-KW:KW-07391600115GO_REF:0000043UniProtGO_REF:0000043
Slc9a4Rattransepithelial ammonium transport involved_inISOSlc9a4 (Mus musculus)1624291 PMID:20484819RGDPMID:20484819
Slc9a4Rattransepithelial ammonium transport involved_inISSUniProtKB:Q8BUE11600115GO_REF:0000024UniProtGO_REF:0000024
Slc9a4Rattransepithelial ammonium transport involved_inIEAUniProtKB:Q8BUE1 and ensembl:ENSMUSP000000272331600115GO_REF:0000107EnsemblGO_REF:0000107
Slc9a4Rattransmembrane transport involved_inIEAInterPro:IPR004709 and InterPro:IPR0061531600115GO_REF:0000002InterProGO_REF:0000002
1 to 18 of 18 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc9a4Ratapical plasma membrane located_inIEAUniProtKB-SubCell:SL-00151600115GO_REF:0000044UniProtGO_REF:0000044
Slc9a4Ratbasolateral plasma membrane located_inIDA 329955551PMID:11553518UniProt 
Slc9a4Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Slc9a4Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Slc9a4Ratmembrane located_inIEAInterPro:IPR001953 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Slc9a4Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Slc9a4Ratplasma membrane is_active_inIBAFB:FBgn0040297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc9a4Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Slc9a4Ratzymogen granule membrane located_inIEAUniProtKB-SubCell:SL-05491600115GO_REF:0000044UniProtGO_REF:0000044
1 to 9 of 9 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc9a4Ratantiporter activity enablesIEAInterPro:IPR0061531600115GO_REF:0000002InterProGO_REF:0000002
Slc9a4Ratantiporter activity enablesIEAUniProtKB-KW:KW-00501600115GO_REF:0000043UniProtGO_REF:0000043
Slc9a4Ratpotassium:proton antiporter activity enablesIBAMGI:2443511 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc9a4Ratsodium:proton antiporter activity enablesIEAInterPro:IPR001953 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Slc9a4Ratsodium:proton antiporter activity enablesIBAMGI:102462 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc9a4Ratsodium:proton antiporter activity enablesIDA 329955540PMID:8944646UniProt 


#
Reference Title
Reference Citation
1. Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus. Bookstein C, etal., Am J Physiol. 1996 Nov;271(5 Pt 1):C1629-38. doi: 10.1152/ajpcell.1996.271.5.C1629.
2. Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs. Chambrey R, etal., Am J Physiol Renal Physiol. 2001 Oct;281(4):F707-17. doi: 10.1152/ajprenal.2001.281.4.F707.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. Orlowski J, etal., J Biol Chem 1992 May 5;267(13):9331-9.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:15684419   PMID:22049213   PMID:23509787   PMID:26078707  



Slc9a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,320,948 - 50,375,336 (+)NCBIGRCr8
mRatBN7.2942,825,334 - 42,879,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,825,064 - 42,879,422 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,327,359 - 51,376,047 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,450,043 - 56,498,733 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,725,727 - 54,774,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,281,821 - 47,334,755 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,281,961 - 47,328,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,965,557 - 47,018,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,725,135 - 39,773,368 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,726,548 - 39,774,782 (+)NCBI
Celera940,568,530 - 40,616,779 (+)NCBICelera
Cytogenetic Map9q22NCBI
SLC9A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,473,226 - 102,533,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,473,226 - 102,533,972 (+)EnsemblGRCh38hg38GRCh38
GRCh372103,089,685 - 103,150,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,456,194 - 102,516,863 (+)NCBINCBI36Build 36hg18NCBI36
Celera297,290,912 - 97,351,604 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef296,854,147 - 96,914,821 (+)NCBIHuRef
CHM1_12103,094,074 - 103,154,769 (+)NCBICHM1_1
T2T-CHM13v2.02102,932,202 - 102,992,943 (+)NCBIT2T-CHM13v2.0
Slc9a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,619,146 - 40,670,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,619,241 - 40,669,885 (+)EnsemblGRCm39 Ensembl
GRCm38140,579,986 - 40,630,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,580,081 - 40,630,725 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,637,072 - 40,687,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,524,747 - 40,574,199 (+)NCBIMGSCv36mm8
Celera140,395,812 - 40,446,178 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.51NCBI
Slc9a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554707,936,532 - 7,984,777 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554707,936,677 - 7,989,946 (+)NCBIChiLan1.0ChiLan1.0
SLC9A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,165,483 - 25,228,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A25,168,248 - 25,231,359 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A99,280,738 - 99,341,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A103,566,298 - 103,626,975 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,566,128 - 103,626,975 (+)Ensemblpanpan1.1panPan2
SLC9A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,492,031 - 40,560,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,492,613 - 40,560,472 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,413,457 - 40,486,515 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,358,013 - 41,426,831 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,358,399 - 41,426,351 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,068,471 - 41,141,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,349,102 - 41,422,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,541,819 - 41,614,694 (-)NCBIUU_Cfam_GSD_1.0
Slc9a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629289,943,031 - 89,999,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367131,134,059 - 1,186,145 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367131,134,059 - 1,186,145 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,687,642 - 51,749,636 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1351,686,001 - 51,749,996 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,166,243 - 54,230,077 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,136,179 - 6,197,632 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,137,368 - 6,195,786 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041173,819,885 - 173,879,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,972,904 - 7,024,665 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247496,972,364 - 7,025,929 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Slc9a4
511 total Variants

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:43
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000065234
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 31 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat

1 to 10 of 31 rows
D9Rat124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2942,864,924 - 42,865,057 (+)MAPPERmRatBN7.2
Rnor_6.0947,319,756 - 47,319,888NCBIRnor6.0
Rnor_5.0947,004,007 - 47,004,139UniSTSRnor5.0
RGSC_v3.4939,764,582 - 39,764,715RGDRGSC3.4
RGSC_v3.4939,764,583 - 39,764,715UniSTSRGSC3.4
RGSC_v3.1939,765,996 - 39,766,129RGD
Celera940,608,076 - 40,608,208UniSTS
SHRSP x BN Map937.7198UniSTS
SHRSP x BN Map937.7198RGD
Cytogenetic Map9q21UniSTS
D9Mco26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2942,831,017 - 42,831,226 (+)MAPPERmRatBN7.2
Rnor_6.0947,287,912 - 47,288,120NCBIRnor6.0
Rnor_5.0946,972,136 - 46,972,344UniSTSRnor5.0
RGSC_v3.4939,731,087 - 39,731,295UniSTSRGSC3.4
Celera940,574,481 - 40,574,689UniSTS
Cytogenetic Map9q21UniSTS




alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 9 75 20 24 5 2 5 6 76 12 66 45 41 19



Ensembl Acc Id: ENSRNOT00000065234   ⟹   ENSRNOP00000059258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,825,064 - 42,879,422 (+)Ensembl
Rnor_6.0 Ensembl947,281,961 - 47,328,839 (+)Ensembl
RefSeq Acc Id: NM_001413317   ⟹   NP_001400246
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,320,948 - 50,375,336 (+)NCBI
mRatBN7.2942,825,334 - 42,879,729 (+)NCBI
Protein RefSeqs NP_001400246 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41703 (Get FASTA)   NCBI Sequence Viewer  
  EDL99168 (Get FASTA)   NCBI Sequence Viewer  
  EDL99169 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059258
GenBank Protein P26434 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000059258   ⟸   ENSRNOT00000065234
RefSeq Acc Id: NP_001400246   ⟸   NM_001413317
- Peptide Label: precursor
- UniProtKB: G3V9T3 (UniProtKB/TrEMBL),   A6INP1 (UniProtKB/TrEMBL),   A6INP2 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-P26434-F1-model_v2 AlphaFold P26434 1-717 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696633
Promoter ID:EPDNEW_R7158
Type:single initiation site
Name:Slc9a4_1
Description:solute carrier family 9 member A4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0947,281,938 - 47,281,998EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27720 BioCyc
Ensembl Genes ENSRNOG00000015306 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065234 ENTREZGENE
Gene3D-CATH 6.10.140.1330 UniProtKB/Swiss-Prot
  6.10.250.1040 UniProtKB/Swiss-Prot
  6.10.250.2020 UniProtKB/Swiss-Prot
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot
  Na/H_exchanger_2 UniProtKB/Swiss-Prot
  NaH_exchanger UniProtKB/Swiss-Prot
  NHE_CaM-bd UniProtKB/Swiss-Prot
NCBI Gene 24785 ENTREZGENE
PANTHER PTHR10110 UniProtKB/Swiss-Prot
  PTHR10110:SF103 UniProtKB/Swiss-Prot
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot
  NEXCaM_BD UniProtKB/Swiss-Prot
PhenoGen Slc9a4 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot
  NAHEXCHNGR2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015306 RatGTEx
UniProt A6INP1 ENTREZGENE, UniProtKB/TrEMBL
  A6INP2 ENTREZGENE, UniProtKB/TrEMBL
  G3V9T3 ENTREZGENE, UniProtKB/TrEMBL
  P26434 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc9a4  solute carrier family 9 member A4  Slc9a4  solute carrier family 9 member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-24 Slc9a4  solute carrier family 9 member 4  Slc9a4  solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc9a4  solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4  Slc9a4  solute carrier family 9 (sodium/hydrogen exchanger), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Slc9a4  solute carrier family 9 (sodium/hydrogen exchanger), member 4  Slc9a4  solute carrier family 9, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Slc9a4  solute carrier family 9, member 4    Solute carrier family 9 (sodium/hydrogen exchanger), isoform 4  Name updated 629478 APPROVED
2002-06-10 Slc9a4  Solute carrier family 9 (sodium/hydrogen exchanger), isoform 4      Symbol and Name status set to approved 70586 APPROVED