SLC9A4 (solute carrier family 9 member A4) - Rat Genome Database

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Gene: SLC9A4 (solute carrier family 9 member A4) Canis lupus familiaris
Analyze
Symbol: SLC9A4
Name: solute carrier family 9 member A4
RGD ID: 12313203
Description: ENCODES a protein that exhibits antiporter activity (inferred); sodium:proton antiporter activity (inferred); INVOLVED IN gastric acid secretion (ortholog); glandular epithelial cell development (ortholog); ASSOCIATED WITH Acidoses (ortholog); aortic dissection (ortholog); FOUND IN basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium/hydrogen exchanger 4; solute carrier family 9 (sodium/hydrogen exchanger), member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,492,031 - 40,560,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,492,613 - 40,560,472 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,413,457 - 40,486,515 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,358,013 - 41,426,831 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,358,399 - 41,426,351 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,068,471 - 41,141,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,349,102 - 41,422,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,541,819 - 41,614,694 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC9A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,492,031 - 40,560,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,492,613 - 40,560,472 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,413,457 - 40,486,515 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,358,013 - 41,426,831 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,358,399 - 41,426,351 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,068,471 - 41,141,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,349,102 - 41,422,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,541,819 - 41,614,694 (-)NCBIUU_Cfam_GSD_1.0
SLC9A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,473,226 - 102,533,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,473,226 - 102,533,972 (+)EnsemblGRCh38hg38GRCh38
GRCh372103,089,685 - 103,150,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,456,194 - 102,516,863 (+)NCBINCBI36Build 36hg18NCBI36
Celera297,290,912 - 97,351,604 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef296,854,147 - 96,914,821 (+)NCBIHuRef
CHM1_12103,094,074 - 103,154,769 (+)NCBICHM1_1
T2T-CHM13v2.02102,932,202 - 102,992,943 (+)NCBIT2T-CHM13v2.0
Slc9a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,619,146 - 40,670,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,619,241 - 40,669,885 (+)EnsemblGRCm39 Ensembl
GRCm38140,579,986 - 40,630,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,580,081 - 40,630,725 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,637,072 - 40,687,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,524,747 - 40,574,199 (+)NCBIMGSCv36mm8
Celera140,395,812 - 40,446,178 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.51NCBI
Slc9a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,320,948 - 50,375,336 (+)NCBIGRCr8
mRatBN7.2942,825,334 - 42,879,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,825,064 - 42,879,422 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,327,359 - 51,376,047 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,450,043 - 56,498,733 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,725,727 - 54,774,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,281,821 - 47,334,755 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,281,961 - 47,328,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,965,557 - 47,018,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,725,135 - 39,773,368 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,726,548 - 39,774,782 (+)NCBI
Celera940,568,530 - 40,616,779 (+)NCBICelera
Cytogenetic Map9q22NCBI
Slc9a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554707,936,532 - 7,984,777 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554707,936,677 - 7,989,946 (+)NCBIChiLan1.0ChiLan1.0
SLC9A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,165,483 - 25,228,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A25,168,248 - 25,231,359 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A99,280,738 - 99,341,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A103,566,298 - 103,626,975 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,566,128 - 103,626,975 (+)Ensemblpanpan1.1panPan2
Slc9a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629289,943,031 - 89,999,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367131,134,059 - 1,186,145 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367131,134,059 - 1,186,145 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,687,642 - 51,749,636 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1351,686,001 - 51,749,996 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,166,243 - 54,230,077 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,136,179 - 6,197,632 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,137,368 - 6,195,786 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041173,819,885 - 173,879,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,972,904 - 7,024,665 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247496,972,364 - 7,025,929 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC9A4
908 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
5 18 15 10 2 10 5 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000047526   ⟹   ENSCAFP00000042570
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1040,492,613 - 40,560,472 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845018117   ⟹   ENSCAFP00845014119
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1041,358,399 - 41,426,351 (-)Ensembl
RefSeq Acc Id: XM_003431517   ⟹   XP_003431565
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11040,492,031 - 40,560,423 (-)NCBI
Dog10K_Boxer_Tasha1040,413,457 - 40,486,515 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038488933   ⟹   XP_038344861
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11041,068,471 - 41,141,354 (-)NCBI
RefSeq Acc Id: XM_038550909   ⟹   XP_038406837
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01041,541,819 - 41,614,694 (-)NCBI
RefSeq Acc Id: XM_038614817   ⟹   XP_038470745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01041,349,102 - 41,422,016 (-)NCBI
RefSeq Acc Id: XM_038680192   ⟹   XP_038536120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01041,358,013 - 41,426,831 (-)NCBI
RefSeq Acc Id: XP_003431565   ⟸   XM_003431517
- UniProtKB: A0A8C0KC56 (UniProtKB/TrEMBL),   A0A8C0NYK3 (UniProtKB/TrEMBL),   A0A8I3ND07 (UniProtKB/TrEMBL),   A0A8C0QL67 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000042570   ⟸   ENSCAFT00000047526
RefSeq Acc Id: XP_038344861   ⟸   XM_038488933
RefSeq Acc Id: XP_038470745   ⟸   XM_038614817
RefSeq Acc Id: XP_038536120   ⟸   XM_038680192
- UniProtKB: A0A8C0KC56 (UniProtKB/TrEMBL),   A0A8C0NYK3 (UniProtKB/TrEMBL),   A0A8I3ND07 (UniProtKB/TrEMBL),   A0A8C0QL67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406837   ⟸   XM_038550909
- UniProtKB: A0A8C0QL67 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845014119   ⟸   ENSCAFT00845018117

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029466 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021430 UniProtKB/TrEMBL
  ENSCAFG00040007913 UniProtKB/TrEMBL
  ENSCAFG00845010292 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047526.3 UniProtKB/TrEMBL
  ENSCAFT00030039289.1 UniProtKB/TrEMBL
  ENSCAFT00040014730.1 UniProtKB/TrEMBL
  ENSCAFT00845018117 ENTREZGENE
  ENSCAFT00845018117.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1330 UniProtKB/TrEMBL
  6.10.250.1040 UniProtKB/TrEMBL
  6.10.250.2020 UniProtKB/TrEMBL
InterPro Cation/H_exchanger UniProtKB/TrEMBL
  Cation/H_exchanger_CPA1 UniProtKB/TrEMBL
  NaH_exchanger UniProtKB/TrEMBL
  NHE-2/4 UniProtKB/TrEMBL
  NHE_CaM-bd UniProtKB/TrEMBL
NCBI Gene SLC9A4 ENTREZGENE
PANTHER PTHR10110 UniProtKB/TrEMBL
  PTHR10110:SF103 UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/TrEMBL
  NEXCaM_BD UniProtKB/TrEMBL
PRINTS NAHEXCHNGR UniProtKB/TrEMBL
  NAHEXCHNGR2 UniProtKB/TrEMBL
UniProt A0A8C0KC56 ENTREZGENE
  A0A8C0NYK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QL67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3ND07 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:108217 ENTREZGENE