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Gene: Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Description: Exhibits Hsp70 protein binding activity; cholesterol 26-hydroxylase activity; and vitamin D3 25-hydroxylase activity. Involved in cholesterol metabolic process. Localizes to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; Cyp27; cytochrome P-450c27/25; cytochrome P450 27; P450C27; sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; vitamin D(3) 25-hydroxylase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)Ensembl
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Celera973,837,312 - 73,867,002 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Cyp27a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727915
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.