Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1) Rattus norvegicus
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
RGD ID: 727915
Description: Enables Hsp70 protein binding activity; cholesterol 26-hydroxylase activity; and vitamin D3 25-hydroxylase activity. Involved in cholesterol metabolic process. Located in mitochondrial inner membrane. Biomarker of extrahepatic cholestasis. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; Cyp27; cytochrome P-450c27/25; cytochrome P450 27; P450C27; sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; vitamin D(3) 25-hydroxylase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2976,264,655 - 76,294,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,709,826 - 84,739,736 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,838,774 - 89,868,679 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,224,941 - 88,254,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Celera973,837,312 - 73,867,002 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(5alpha)-cholestan-3beta-ol  (ISO)
(S)-amphetamine  (EXP)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3beta-hydroxycholest-5-en-26-oic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Augmentin  (ISO)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
caesium atom  (EXP)
calciol  (EXP)
calcitriol  (EXP,ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clavulanic acid  (ISO)
clofibric acid  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
deoxycholic acid  (EXP,ISO)
desmosterol  (ISO)
dexamethasone  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
diosgenin  (EXP)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
elemental selenium  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
ethanol  (ISO)
eugenol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
isoniazide  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lanosterol  (ISO)
lead diacetate  (ISO)
levofloxacin  (EXP)
Licochalcone B  (ISO)
linalool  (ISO)
lithocholic acid  (ISO)
melatonin  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP)
methyltestosterone  (ISO)
metronidazole  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
NS-398  (ISO)
obeticholic acid  (ISO)
oleanolic acid  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
physcion  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium dodecyl sulfate  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
taurocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
triolein  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
trovafloxacin  (ISO)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zymosterol  (ISO)


References - curated
# Reference Title Reference Citation
1. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
2. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. Cali JJ, etal., J Biol Chem. 1991 Apr 25;266(12):7779-83.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Jiao N, etal., Gut. 2018 Oct;67(10):1881-1891. doi: 10.1136/gutjnl-2017-314307. Epub 2017 Aug 3.
5. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. Kitanaka S, etal., N Engl J Med. 1998 Mar 5;338(10):653-61.
6. Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model. Kovacs WJ, etal., Mol Cell Biol. 2004 Jan;24(1):1-13.
7. The upstream open reading frame mediates constitutive effects on translation of cytochrome p-450c27 from the seventh in-frame AUG codon in rat liver. Lodhi KM, etal., J Biol Chem. 2003 Oct 17;278(42):40647-57. Epub 2003 Aug 7.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Localization of a transcription promoter within the second exon of the cytochrome P-450c27/25 gene for the expression of the major species of two-kilobase mRNA. Mullick J, etal., Biochemistry 1995 Oct 24;34(42):13729-42.
10. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
11. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Sequence complementarity between the 5'-terminal regions of mRNAs for rat mitochondrial cytochrome P-450c27/25 and a growth hormone-inducible serine protease inhibitor. A possible gene overlap. Shayiq RM and Avadhani NG, J Biol Chem 1992 Feb 5;267(4):2421-8.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. A cDNA encoding a rat mitochondrial cytochrome P450 catalyzing both the 26-hydroxylation of cholesterol and 25-hydroxylation of vitamin D3: gonadotropic regulation of the cognate mRNA in ovaries. Su P, etal., DNA Cell Biol 1990 Nov;9(9):657-67.
21. Molecular cloning of cDNA for vitamin D3 25-hydroxylase from rat liver mitochondria. Usui E, etal., FEBS Lett 1990 Mar 12;262(1):135-8.
22. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1α. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
Additional References at PubMed
PMID:9660774   PMID:11412116   PMID:12077124   PMID:12865426   PMID:14651853   PMID:15465040   PMID:15489334   PMID:17118558   PMID:18614015   PMID:19665519   PMID:24280213  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2976,264,655 - 76,294,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,709,826 - 84,739,736 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,838,774 - 89,868,679 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,224,941 - 88,254,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Celera973,837,312 - 73,867,002 (+)NCBICelera
Cytogenetic Map9q33NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382218,782,147 - 218,815,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,781,749 - 218,815,293 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,646,870 - 219,680,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,354,949 - 219,388,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,472,209 - 219,505,520NCBI
Celera2213,414,219 - 213,447,784 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,499,575 - 211,533,141 (+)NCBIHuRef
CHM1_12219,653,385 - 219,686,914 (+)NCBICHM1_1
T2T-CHM13v2.02219,268,705 - 219,301,851 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39174,752,311 - 74,777,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,752,733 - 74,777,051 (+)EnsemblGRCm39 Ensembl
GRCm38174,713,148 - 74,737,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,713,574 - 74,737,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,760,148 - 74,784,464 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,646,781 - 74,671,097 (+)NCBIMGSCv36mm8
Celera175,268,638 - 75,292,903 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545314,601,444 - 14,647,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,601,495 - 14,647,383 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12B121,430,782 - 121,464,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,042,235 - 106,076,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,637,238 - 224,671,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,637,238 - 224,671,474 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13725,366,475 - 25,401,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,366,472 - 25,401,509 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,186,269 - 26,221,708 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,381,673 - 25,417,125 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,382,000 - 25,602,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,286,426 - 25,321,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,221,115 - 25,256,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,241,871 - 25,277,345 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303174,870,819 - 174,907,409 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,213,573 - 1,250,589 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365691,213,700 - 1,250,181 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15120,809,959 - 120,852,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,809,886 - 120,852,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,798,107 - 133,831,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110104,682,437 - 104,723,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,682,673 - 104,726,687 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,685,776 - 94,722,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248236,200,047 - 6,258,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,199,807 - 6,258,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cyp27a1
141 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:44
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,291,609 - 76,292,002 (+)MAPPERmRatBN7.2
Rnor_6.0981,995,272 - 81,995,664NCBIRnor6.0
Rnor_5.0981,757,654 - 81,758,046UniSTSRnor5.0
RGSC_v3.4974,065,707 - 74,066,099UniSTSRGSC3.4
Celera973,864,061 - 73,864,453UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,265,766 - 76,265,939 (+)MAPPERmRatBN7.2
Rnor_6.0981,969,430 - 81,969,602NCBIRnor6.0
Rnor_5.0981,731,812 - 81,731,984UniSTSRnor5.0
RGSC_v3.4974,039,865 - 74,040,037UniSTSRGSC3.4
Celera973,838,219 - 73,838,391UniSTS
RH 3.4 Map9768.59UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,291,248 - 76,291,771 (+)MAPPERmRatBN7.2
Rnor_6.0981,994,911 - 81,995,433NCBIRnor6.0
Rnor_5.0981,757,293 - 81,757,815UniSTSRnor5.0
RGSC_v3.4974,065,346 - 74,065,868UniSTSRGSC3.4
Celera973,863,700 - 73,864,222UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,294,203 - 76,294,408 (+)MAPPERmRatBN7.2
Rnor_6.0981,997,866 - 81,998,070NCBIRnor6.0
Rnor_5.0981,760,248 - 81,760,452UniSTSRnor5.0
RGSC_v3.4974,068,301 - 74,068,505UniSTSRGSC3.4
Celera973,866,655 - 73,866,859UniSTS
RH 3.4 Map9713.19UniSTS
Cytogenetic Map9q33UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 21 43 35 7 35 7 10 7 20 11 7
Low 1 22 14 6 12 6 1 1 56 28 21 1
Below cutoff 18


RefSeq Acc Id: ENSRNOT00000023152   ⟹   ENSRNOP00000023152
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)Ensembl
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)Ensembl
RefSeq Acc Id: NM_178847   ⟹   NP_849178
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,264,860 - 76,294,551 (+)NCBI
Rnor_6.0981,968,523 - 81,998,213 (+)NCBI
Rnor_5.0981,730,705 - 81,760,595 (+)NCBI
RGSC_v3.4974,039,204 - 74,068,648 (+)RGD
Celera973,837,312 - 73,867,002 (+)NCBI
RefSeq Acc Id: XM_039083360   ⟹   XP_038939288
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,264,655 - 76,294,551 (+)NCBI
RefSeq Acc Id: XR_357087
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,265,077 - 76,294,551 (+)NCBI
Rnor_6.0981,968,285 - 81,998,213 (+)NCBI
Rnor_5.0981,730,705 - 81,760,595 (+)NCBI
RefSeq Acc Id: NP_849178   ⟸   NM_178847
- UniProtKB: Q64615 (UniProtKB/Swiss-Prot),   Q64639 (UniProtKB/Swiss-Prot),   P17178 (UniProtKB/Swiss-Prot),   A0A0H2UHN7 (UniProtKB/TrEMBL),   A6JVV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023152   ⟸   ENSRNOT00000023152
RefSeq Acc Id: XP_038939288   ⟸   XM_039083360
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17178-F1-model_v2 AlphaFold P17178 1-533 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727915 AgrOrtholog
BioCyc Gene G2FUF-27119 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
Ensembl Genes ENSRNOG00000017188 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023152 ENTREZGENE
  ENSRNOP00000023152.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023152 ENTREZGENE
  ENSRNOT00000023152.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301517 UniProtKB/Swiss-Prot
  PTHR24279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp27a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CP27A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64615 UniProtKB/Swiss-Prot
  Q64639 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp27a1  cytochrome P450, family 27, subfamily a, polypeptide 1  Cyp27    Symbol updated 1299863 APPROVED